Nitro Compounds

Name
Nitro Compounds
Accession Number
DBCAT000765
Description

Compounds having the nitro group, -NO2, attached to carbon. When attached to nitrogen they are nitramines and attached to oxygen they are NITRATES.

Drugs
DrugDrug Description
TolcaponeA catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease.
NitrofuralA topical antibacterial for the prevention and treatment of bacterial infections of the skin.
NitrofurantoinAn antibiotic used to treat urinary tract infections.
NitroglycerinA nitrate vasodilator used to treat or prevent angina, heart failure, hypertension, and anal fissures.
MetronidazoleA nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.
PretomanidPart of a three-drug regimen used for the treatment of extensively drug-resistant and multidrug-resistant pulmonary tuberculosis.
Chloramphenicol succinateA broad-spectrum antibiotic agent used for the treatment of acute and severe infections caused by susceptible bacterial strains.
NifurtimoxAn antiparasitic drug used for the treatment of Chagas disease (Trypanosoma cruzi infection).
FexinidazoleAn orally bioavailable 2-substituted 5-nitroimidazole used to treat early- and late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense.
SecnidazoleA nitroimidazole antibiotic used to treat bacterial vaginosis.
ChloramphenicolA broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity.
FurazolidoneA drug for the treatment of infectious diarrhea.
TinidazoleA nitroimidazole used to treat trichomoniasis, giardiasis, amebiasis, and bacterial vaginosis.
NitroxolineNitroxoline is an antibiotic agent.
1,3-DinitrobenzeneNot Available
Picric acidUsed as antiseptic, astringent, and stimulant for epitheliazation.
4-Nitrophenyl PhosphateNot Available
P-NitrophenolNot Available
2,4-DinitrophenolA toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman,...
EvofosfamideInvestigated for use/treatment in solid tumors.
BromamphenicolNot Available
ThiamphenicolA semisynthetic derivative of chloramphenicol with a broad spectrum of antibacterial activity.
EfonidipineFor the treatment of hypertension.
ManidipineA dihydropyridine calcium channel blocker used to treat hypertension.
FlorfenicolFlorfenicol is a fluorinated synthetic analog of thiamphenicol.
NifurpirinolNot Annotated
DelamanidAn antibiotic used to treat multidrug resistant tuberculosis.
MisonidazoleMisonidazole is under investigation in clinical trial NCT00038038 (Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole).
DinitrochlorobenzeneDinitrochlorobenzene has been used in trials studying the treatment of HIV Infections.
BenznidazoleA trypanocidal agent used to treat Chagas disease.
NimorazoleNimorazole has been used in trials studying the treatment of Hypoxia, Radiotherapy, Hypoxic Modification, Gene Profile, Gene Signature, and Head and Neck Squamous Cell Carcinoma, among others.
PimonidazolePimonidazole is under investigation for the diagnostic of Prostate Cancer and Head and Neck Cancer.
EtanidazoleEtanidazole has been used in trials studying the diagnostic of Adult Ependymoma, Malignant Ascites, Adult Gliosarcoma, Adult Mixed Glioma, and Adult Glioblastoma, among others.
OrnidazoleA nitroimidazole agent indicated in the treatment of infections such as trichomoniasis, amebiasis, and giardiasis.
AzidamfenicolNot Annotated
NifurzideNot Annotated
AzanidazoleNot Annotated
FurazidinNot Annotated
ClefamideNot Annotated
NifuratelA nitrofuran derivative indicated in the treatment of leucorrhea, vulvovaginal infections, and urinary tract infections.
NifurtoinolNot Annotated
NifuroxazideAn antibiotic indicated in the treatment of susceptible gastrointestinal infections.
NS-398NS-398 is a COX-2 inhibitor. It was developed as part of the mechanistic study of the cyclooxygenases.
Chloramphenicol palmitateNot Annotated
MorinidazoleMorinidazole is under investigation in clinical trial NCT03380793 (A Trial to Assess the Efficacy and Safety of Morinidazole in Patients With Appendicitis).
Fluoroazomycin arabinoside F-18Fluoroazomycin arabinoside F-18 is under investigation in clinical trial NCT03257150 (A Study of the Use of Irreversible Electroporation in Pancreatic Ductal Cancer).
Metronidazole benzoateNot Annotated
FuraltadoneIndicated in combination with other drugs for the treatment of otitis media and externa.
Drugs & Drug Targets
DrugTargetType
TolcaponeCatechol O-methyltransferasetarget
TolcaponeCytochrome P450 2C9enzyme
NitrofuralGlutathione reductasetarget
NitrofuralXanthine dehydrogenase/oxidaseenzyme
Nitrofurantoin30S ribosomal protein S10target
NitrofurantoinOxygen-insensitive NADPH nitroreductasetarget
NitrofurantoinProbable pyruvate-flavodoxin oxidoreductasetarget
NitrofurantoinATP-binding cassette sub-family G member 2transporter
NitrofurantoinNADPH--cytochrome P450 reductaseenzyme
NitrofurantoinBile salt export pumptransporter
NitrofurantoinP-glycoprotein 1transporter
NitrofurantoinCanalicular multispecific organic anion transporter 1transporter
NitroglycerinAtrial natriuretic peptide receptor 1target
NitroglycerinAldehyde dehydrogenase, mitochondrialenzyme
MetronidazoleOxygen-insensitive NADPH nitroreductasetarget
MetronidazoleCytochrome P450 2C9enzyme
MetronidazoleCytochrome P450 3A4enzyme
MetronidazoleCytochrome P450 2C8enzyme
MetronidazoleUDP-glucuronosyltransferase 1-1enzyme
MetronidazoleAnaerobic bacterial DNAtarget
MetronidazoleProtozoal DNAtarget
MetronidazoleP-glycoprotein 1transporter
MetronidazoleCytochrome P450 2A6enzyme
MetronidazoleCytochrome P450 3A5enzyme
MetronidazoleCytochrome P450 3A7enzyme
PretomanidDeazaflavin-dependent nitroreductaseenzyme
PretomanidSolute carrier family 22 member 8transporter
PretomanidCytochrome P450 3A4enzyme
PretomanidFatty acid synthetasetarget
PretomanidUncharacterized MFS-type transporter EfpAtarget
PretomanidNucleoid-associated protein Lsr2target
PretomanidCyd operon, Mycobacterium tuberculosistarget
PretomanidEnoyl-[acyl-carrier-protein] reductase [NADH]target
Chloramphenicol succinateDr hemagglutinin structural subunittarget
Chloramphenicol succinateSerum albumincarrier
Chloramphenicol succinateP-glycoprotein 1transporter
Chloramphenicol succinateChloramphenicol acetyltransferase 3enzyme
NifurtimoxATP-binding cassette sub-family G member 2transporter
NifurtimoxNitroreductasestarget
NifurtimoxNitroreductasesenzyme
NifurtimoxSerum albumincarrier
NifurtimoxGlyceraldehyde-3-phosphate dehydrogenase, glycosomaltarget
FexinidazoleCytochrome P450 1A2enzyme
FexinidazoleCytochrome P450 2B6enzyme
FexinidazoleCytochrome P450 2C19enzyme
FexinidazoleCytochrome P450 3A4enzyme
FexinidazoleCytochrome P450 3A5enzyme
FexinidazoleDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
FexinidazoleCytochrome P450 2D6enzyme
FexinidazoleSolute carrier organic anion transporter family member 1B1transporter
FexinidazoleSolute carrier organic anion transporter family member 1B3transporter
FexinidazoleSolute carrier family 22 member 2transporter
FexinidazoleSolute carrier family 22 member 6transporter
FexinidazoleSolute carrier family 22 member 8transporter
FexinidazoleMultidrug and toxin extrusion protein 1transporter
FexinidazoleMultidrug and toxin extrusion protein 2transporter
SecnidazoleCytochrome P450 3A4enzyme
SecnidazoleCytochrome P450 3A5enzyme
SecnidazoleCytochrome P450 2C19enzyme
ChloramphenicolComplement decay-accelerating factortarget
ChloramphenicolDr hemagglutinin structural subunittarget
ChloramphenicolCytochrome P450 2C19enzyme
ChloramphenicolCytochrome P450 3A4enzyme
ChloramphenicolCytochrome P450 3A5enzyme
ChloramphenicolCytochrome P450 3A7enzyme
ChloramphenicolSolute carrier family 22 member 6transporter
Chloramphenicol50S ribosomal protein L16target
ChloramphenicolChloramphenicol acetyltransferase 3enzyme
ChloramphenicolChloramphenicol acetyltransferaseenzyme
ChloramphenicolChloramphenicol 3-O phosphotransferaseenzyme
FurazolidoneDNAtarget
FurazolidoneAmine oxidase [flavin-containing] Benzyme
FurazolidoneAmine oxidase [flavin-containing] Aenzyme
TinidazoleCytochrome P450 3A4enzyme
TinidazoleDNAtarget
TinidazoleBile salt export pumptransporter
NitroxolineMethionine aminopeptidase 2target
NitroxolineMagnesium cationtarget
NitroxolineManganese cationtarget
1,3-DinitrobenzeneMannan endo-1,4-beta-mannosidasetarget
Picric acidPentaerythritol tetranitrate reductasetarget
4-Nitrophenyl PhosphateLow molecular weight phosphotyrosine protein phosphatasetarget
4-Nitrophenyl PhosphateDual specificity protein phosphatase 23target
P-NitrophenolSulfotransferase 1A1target
P-NitrophenolAlpha-amylase 2Btarget
2,4-DinitrophenolPentaerythritol tetranitrate reductasetarget
BromamphenicolDr hemagglutinin structural subunittarget
ThiamphenicolDr hemagglutinin structural subunittarget
EfonidipineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
EfonidipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
EfonidipineCytochrome P450 3A4enzyme
EfonidipineVoltage gated L-type calcium channeltarget
EfonidipineVoltage-dependent calcium channeltarget
EfonidipineVoltage-dependent T-type calcium channeltarget
EfonidipineVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
EfonidipineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
ManidipineVoltage-dependent L-type calcium channeltarget
ManidipineVoltage-dependent T-type calcium channeltarget
ManidipineCytochrome P450 2C9enzyme
ManidipineCytochrome P450 2D6enzyme
ManidipineCytochrome P450 1A1enzyme
ManidipineCytochrome P450 2B6enzyme
ManidipineCytochrome P450 2C19enzyme
ManidipineCytochrome P450 3A4enzyme
ManidipineVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
ManidipineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
ManidipineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DelamanidDeazaflavin-dependent nitroreductaseenzyme
DelamanidCytochrome P450 3A4enzyme
DelamanidSerum albumincarrier
DelamanidAlpha-1-acid glycoprotein 1carrier
DinitrochlorobenzeneMethylated-DNA--protein-cysteine methyltransferasetarget
DinitrochlorobenzeneGlutathione S-transferase Ptarget
NS-398Cyclooxygenase 2target
NS-398Prostaglandin G/H synthase 2enzyme