NAV

Glycylglutamine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Glycylglutamine is an ingredient in amino acid solutions for parenteral nutrition.

Generic Name
Glycylglutamine
DrugBank Accession Number
DB15990
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 203.198
Monoisotopic: 203.090605911
Chemical Formula
C7H13N3O4
Synonyms
  • Gly-gln
  • Glycyl-glutamine
  • Glycyl-L-glutamine
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Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Glycylglutamine monohydrate668A00JUHO172669-64-6KLFWVRQACSYLOH-WCCKRBBISA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
GLAMIN SOLUTION FOR INFUSIONGlycylglutamine (30.27 g/1000ml) + Alanine (16 g/1000ml) + Arginine (11.3 g/1000ml) + Aspartic acid (3.4 g/1000ml) + Glutamic acid (5.6 g/1000ml) + Glycyltyrosine (3.45 g/1000ml) + Histidine (6.8 g/1000ml) + Isoleucine (5.6 g/1000ml) + Leucine (7.9 g/1000ml) + Lysine acetate (12.7 g/1000ml) + Methionine (5.6 g/1000ml) + Phenylalanine (5.85 g/1000ml) + Proline (6.8 g/1000ml) + Serine (4.5 g/1000ml) + Threonine (5.6 g/1000ml) + Tryptophan (1.9 g/1000ml) + Valine (7.3 g/1000ml)InjectionIntravenousFRESENIUS KABI (SINGAPORE) PTE LTD1998-07-27Not applicableSingapore flag
Glavamin InfusionslösungGlycylglutamine (30.27 g/l) + Alanine (16 g/l) + Arginine (11.3 g/l) + Aspartic acid (3.4 g/l) + Glutamic acid (5.6 g/l) + Glycyltyrosine (3.45 g/l) + Histidine (6.8 g/l) + Isoleucine (5.6 g/l) + Leucine (7.9 g/l) + Lysine acetate (12.7 g/l) + Methionine (5.6 g/l) + Phenylalanine (5.85 g/l) + Proline (6.8 g/l) + Serine (4.5 g/l) + Threonine (5.6 g/l) + Tryptophan (1.9 g/l) + Valine (7.3 g/l)SolutionParenteralFresenius Kabi Austria Gmb H1996-03-29Not applicableAustria flag
Trimix MOF Emulsion zur InfusionGlycylglutamine monohydrate (15.135 g/1000mL) + Alanine (8 g/1000mL) + Arginine (5.65 g/1000mL) + Aspartic acid (1.7 g/1000mL) + D-glucose monohydrate (110 g/1000mL) + Fish oil (7.5 g/1000mL) + Glutamic acid (2.8 g/1000mL) + Glycyltyrosine dihydrate (1.725 g/1000mL) + Histidine (3.4 g/1000mL) + Isoleucine (2.8 g/1000mL) + Leucine (3.95 g/1000mL) + Levocarnitine (1 g/1000mL) + Lysine acetate (6.35 g/1000mL) + Medium-chain triglycerides (15 g/1000mL) + Methionine (2.8 g/1000mL) + Olive oil (12.5 g/1000mL) + Phenylalanine (2.925 g/1000mL) + Proline (3.4 g/1000mL) + Serine (2.25 g/1000mL) + Soybean oil (15 g/1000mL) + Threonine (2.8 g/1000mL) + Tryptophan (0.95 g/1000mL) + Valine (3.65 g/1000mL)EmulsionParenteralFresenius Kabi Austria Gmb H2012-09-21Not applicableAustria flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
H7125Z98HT
CAS number
13115-71-4
InChI Key
PNMUAGGSDZXTHX-BYPYZUCNSA-N
InChI
InChI=1S/C7H13N3O4/c8-3-6(12)10-4(7(13)14)1-2-5(9)11/h4H,1-3,8H2,(H2,9,11)(H,10,12)(H,13,14)/t4-/m0/s1
IUPAC Name
(2S)-2-(2-aminoacetamido)-4-carbamoylbutanoic acid
SMILES
NCC(=O)N[C@@H](CCC(N)=O)C(O)=O

References

General References
  1. BASG: Glavamin (Amino Acids) Intravenous Solution [Link]
ChemSpider
110444
ChEBI
74392
ChEMBL
CHEMBL330038
ZINC
ZINC000002555108

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
InjectionIntravenous16 g/1000ml
SolutionParenteral
EmulsionParenteral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility17.4 mg/mLALOGPS
logP-3.4ALOGPS
logP-5.1Chemaxon
logS-1.1ALOGPS
pKa (Strongest Acidic)3.48Chemaxon
pKa (Strongest Basic)8.14Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count4Chemaxon
Polar Surface Area135.51 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity45.91 m3·mol-1Chemaxon
Polarizability19.22 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-4920000000-149a4867d3feacfde830
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004l-1900000000-a6c82dd6a199e5b7bbca
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-7900000000-a5196ffbcd548e4ea685
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-004l-4900000000-6e8721e117210e25aaa4
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0532-9100000000-b12529e49de8a6bbe2a8
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9100000000-7a5ebba9b8f5377b9270
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-151.5940688
predicted
DarkChem Lite v0.1.0
[M-H]-140.80574
predicted
DeepCCS 1.0 (2019)
[M+H]+153.2183688
predicted
DarkChem Lite v0.1.0
[M+H]+143.20131
predicted
DeepCCS 1.0 (2019)
[M+Na]+152.4777688
predicted
DarkChem Lite v0.1.0
[M+Na]+149.26062
predicted
DeepCCS 1.0 (2019)

Drug created at December 10, 2020 16:54 / Updated at May 05, 2021 20:31