Olive oil

Identification

Name
Olive oil
Accession Number
DB09567
Description

Oil extracted from olives 1. Consists primarily of the glycerides of the fatty acids linoleic, oleic and palmitic. Used as a source of fatty acids in total parenteral nutrition and as an additive in some cosmetic products Label.

Type
Small Molecule
Groups
Approved
Synonyms
Not Available

Pharmacology

Indication

For use in adults as a source of calories and fatty acids in total parenteral nutrition Label. Sometimes used as an additive in cosmetic products.

Associated Therapies
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics

Provides a source of calories and fatty acids Label.

Mechanism of action

Fatty acids act as a substrate in energy production through beta-oxidation as well as important components of cell membrane structures and prescursors for bioactive molecules like prostaglandins Label.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Metabolized to carbon dioxide and water used as a substrate in energy production Label. Carbon dioxide is eliminated via expiration while water is eliminated through expiration, evaporation, and urination. Some lipids are excreted in bile.

Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity

Fat overload sydrome is the primary form of toxicity characterized by a sudden deterioration in the patient's condition accompanied by fever, anemia, leukopenia, thrombocytopenia, coagulation disorders, hyperlipidemia, liver fatty infiltration, deteriorating liver function, and central nervous system manifestations such as coma Label. The precise cause of this is unclear. While it is most likely to occur during overdosage of lipids some occurences have been reported when lipids are administered appropriately. Intraperitoneal LD50 in mice of >50g/kg and intravenous LD50 in rats of 1320mg/kg 1.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Purchasing individual compounds or compound libraries for your research?
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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Intensive Treatment Bodyoil for Mommy To Be All SkinOil49.742 g/100mLTopicalIn This Morning2018-12-112019-12-25US flag
Additional Data Available
  • Application Number
    Application Number
    Available for Purchase

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code
    Available for Purchase

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Clinoleic 20%Olive oil (16 %) + Soybean oil (4 %)EmulsionIntravenousBaxter Laboratories2012-03-28Not applicableCanada flag
ClinolipidOlive oil (16 g/100mL) + Soybean oil (4 g/100mL)Injection, emulsionIntravenousBaxter Healthcare Corporation2016-01-01Not applicableUS flag
Olimel 3.3% EOlive oil (32 g) + Alanine (4.76 g) + Arginine (3.22 g) + Aspartic acid (0.95 g) + Calcium chloride (0.52 g) + Dextrose, unspecified form (126.5 g) + Glutamic acid (1.64 g) + Glycine (2.28 g) + Histidine (1.96 g) + Isoleucine (1.64 g) + L-Lysine acetate (2.59 g) + Leucine (2.28 g) + Magnesium chloride (0.81 g) + Methionine (1.64 g) + Phenylalanine (2.28 g) + Potassium chloride (2.24 g) + Proline (1.96 g) + Serine (1.30 g) + Sodium acetate trihydrate (1.50 g) + Sodium glycerophosphate (3.67 g) + Soybean oil (8 g) + Threonine (1.64 g) + Tryptophan (0.55 g) + Tyrosine (0.08 g) + Valine (2.1 g)EmulsionIntravenousBaxter LaboratoriesNot applicableNot applicableCanada flag
Olimel 4.4%Olive oil (32 g) + Alanine (6.41 g) + Arginine (4.34 g) + Aspartic acid (1.28 g) + Dextrose, unspecified form (154 g) + Glutamic acid (2.21 g) + Glycine (3.07 g) + Histidine (2.64 g) + Isoleucine (2.21 g) + L-Lysine acetate (3.48 g) + Leucine (3.07 g) + Methionine (2.21 g) + Phenylalanine (3.07 g) + Proline (2.64 g) + Serine (1.75 g) + Soybean oil (8 g) + Threonine (2.21 g) + Tryptophan (0.74 g) + Tyrosine (0.11 g) + Valine (2.83 g)EmulsionIntravenousBaxter Laboratories2011-09-29Not applicableCanada flag
Olimel 4.4% EOlive oil (32 g) + Alanine (6.41 g) + Arginine (4.34 g) + Aspartic acid (1.28 g) + Calcium chloride (0.52 g) + Dextrose, unspecified form (154 g) + Glutamic acid (2.21 g) + Glycine (3.07 g) + Histidine (2.64 g) + Isoleucine (2.21 g) + L-Lysine acetate (3.48 g) + Leucine (3.07 g) + Magnesium chloride (0.81 g) + Methionine (2.21 g) + Phenylalanine (3.07 g) + Potassium chloride (2.24 g) + Proline (2.64 g) + Serine (1.75 g) + Sodium acetate trihydrate (1.50 g) + Sodium glycerophosphate (3.67 g) + Soybean oil (8 g) + Threonine (2.21 g) + Tryptophan (0.74 g) + Tyrosine (0.11 g) + Valine (2.83 g)EmulsionIntravenousBaxter Laboratories2011-02-26Not applicableCanada flag
Olimel 5.7%Olive oil (32 g) + Alanine (8.24 g) + Arginine (5.58 g) + Aspartic acid (1.65 g) + Dextrose, unspecified form (121 g) + Glutamic acid (2.84 g) + Glycine (3.95 g) + Histidine (3.4 g) + Isoleucine (2.84 g) + L-Lysine acetate (4.48 g) + Leucine (3.95 g) + Methionine (2.84 g) + Phenylalanine (3.95 g) + Proline (3.40 g) + Serine (2.25 g) + Soybean oil (8 g) + Threonine (2.84 g) + Tryptophan (0.95 g) + Tyrosine (0.15 g) + Valine (3.64 g)EmulsionIntravenousBaxter Laboratories2011-03-01Not applicableCanada flag
Olimel 5.7% EOlive oil (32 g) + Alanine (8.24 g) + Arginine (5.58 g) + Aspartic acid (1.65 g) + Calcium chloride (0.52 g) + Dextrose, unspecified form (121 g) + Glutamic acid (2.84 g) + Glycine (3.95 g) + Histidine (3.40 g) + Isoleucine (2.84 g) + L-Lysine acetate (4.48 g) + Leucine (3.95 g) + Magnesium chloride (0.81 g) + Methionine (2.84 g) + Phenylalanine (3.95 g) + Potassium chloride (2.24 g) + Proline (3.40 g) + Serine (2.25 g) + Sodium acetate trihydrate (1.50 g) + Sodium glycerophosphate (3.67 g) + Soybean oil (8 g) + Threonine (2.84 g) + Tryptophan (0.95 g) + Tyrosine (0.15 g) + Valine (3.64 g)EmulsionIntravenousBaxter Laboratories2011-01-19Not applicableCanada flag
Olimel 7.6%Olive oil (28 g) + Alanine (10.99 g) + Arginine (7.44 g) + Aspartic acid (2.2 g) + Dextrose, unspecified form (80.67 g) + Glutamic acid (3.79 g) + Glycine (5.26 g) + Histidine (4.53 g) + Isoleucine (3.79 g) + L-Lysine acetate (5.97 g) + Leucine (5.26 g) + Methionine (3.79 g) + Phenylalanine (5.26 g) + Proline (4.53 g) + Serine (3 g) + Soybean oil (7 g) + Threonine (3.79 g) + Tryptophan (1.26 g) + Tyrosine (0.2 g) + Valine (4.86 g)EmulsionIntravenousBaxter LaboratoriesNot applicableNot applicableCanada flag
Olimel 7.6% EOlive oil (28 g) + Alanine (10.99 g) + Arginine (7.44 g) + Aspartic acid (2.2 g) + Calcium chloride (0.52 g) + Dextrose, unspecified form (80.67 g) + Glutamic acid (3.79 g) + Glycine (5.26 g) + Histidine (4.53 g) + Isoleucine (3.79 g) + L-Lysine acetate (5.97 g) + Leucine (5.26 g) + Magnesium chloride (0.81 g) + Methionine (3.79 g) + Phenylalanine (5.26 g) + Potassium chloride (2.24 g) + Proline (4.53 g) + Serine (3 g) + Sodium acetate trihydrate (1.5 g) + Sodium glycerophosphate (3.67 g) + Soybean oil (7 g) + Threonine (3.79 g) + Tryptophan (1.26 g) + Tyrosine (0.2 g) + Valine (4.86 g)EmulsionIntravenousBaxter Laboratories2018-10-25Not applicableCanada flag
Periolimel 2.5% EOlive oil (24 g) + Alanine (3.66 g) + Arginine (2.48 g) + Aspartic acid (0.73 g) + Calcium chloride (0.30 g) + Dextrose, unspecified form (82.50 g) + Glutamic acid (1.26 g) + Glycine (1.76 g) + Histidine (1.51 g) + Isoleucine (1.26 g) + L-Lysine acetate (1.99 g) + Leucine (1.76 g) + Magnesium chloride (0.45 g) + Methionine (1.26 g) + Phenylalanine (1.76 g) + Potassium chloride (1.19 g) + Proline (1.51 g) + Serine (1.0 g) + Sodium acetate trihydrate (1.16 g) + Sodium glycerophosphate (1.91 g) + Soybean oil (6 g) + Threonine (1.26 g) + Tryptophan (0.42 g) + Tyrosine (0.06 g) + Valine (1.62 g)EmulsionIntravenousBaxter Laboratories2011-02-28Not applicableCanada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Intensive Treatment Bodyoil for Mommy To Be All SkinOlive oil (49.742 g/100mL)OilTopicalIn This Morning2018-12-112019-12-25US flag
Rhodd Ato Repair Body So ApOlive oil (13.0 g/100g) + Chamaecyparis obtusa leaf (2.0 g/100g) + Evening primrose oil (6.0 g/100g)SoapTopicalSJ NATURAL2018-08-01Not applicableUS flag

Categories

Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
6UYK2W1W1E
CAS number
8001-25-0
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
  1. ChemIDPlus: Olive Oil [Link]
PubChem Substance
347910464
RxNav
1309250
Wikipedia
Olive_oil
FDA label
Download (304 KB)
MSDS
Download (47.3 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedHealth Services ResearchSepsis Newborn1
4CompletedPreventionCholestasis / Psychomotor Disorders, Developmental1
4CompletedSupportive CareDietary and Nutritional Therapies1
4CompletedSupportive CareGastric Resection / Malnutrition1
4CompletedTreatmentDisorder Related to Renal Transplantation1
4CompletedTreatmentDry Eye Syndrome (DES) / Sjögren's Syndrome1
4CompletedTreatmentHepatic Function / Inflammatory Responses1
4CompletedTreatmentParenteral Nutrition1
4Not Yet RecruitingSupportive CarePreterm, Infant1
4Not Yet RecruitingTreatmentEssential Fatty Acid Deficiency (EFAD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CapsuleOral700 mg
InjectionIntravenous16 g/100ml
EmulsionParenteral4 g/l
EmulsionIntravenous
EmulsionParenteral3.99 g/1085ml
EmulsionParenteral2.05 g/1085ml
OilTopical49.742 g/100mL
SolutionIntravenous16 g/L
Injection, emulsionParenteral2.33 g
Injection, emulsionIntravenous1.03 g
Injection, emulsionIntravenous1.83 g
EmulsionIntravenous1.83 g
InjectionIntravenous1.03 g
Injection, emulsionIntravenous1.6 g/100mL
Injection, emulsion; injection, solutionIntravenous3.2 g/100mL
Injection, emulsionIntravenous12 g/1500ml
Injection, emulsionIntravenous32 g/1000ml
Injection, emulsionIntravenous0.52 g/1000ml
Injection, emulsionIntravenous0.42 g/1000ml
Injection, emulsionIntravenous1.6 g
InjectionIntravenous2.27 g/l
InjectionIntravenous4.12 g/l
SolutionIntravenous7.14 g
SolutionIntravenous9.52 g
SolutionIntravenous11.9 g
EmulsionIntravenous6.41 g
EmulsionIntravenous9.61 g
EmulsionIntravenous12.82 g
Injection, emulsionIntravenous6.41 g/1000ml
SolutionIntravenous8.24 g
SolutionIntravenous12.36 g
SolutionIntravenous16.48 g
Injection, emulsionIntravenous8.24 g/1000ml
LiquidTopical100 mL/100mL
SolutionOral100 mL/100mL
EmulsionParenteral1.26 g
Injection, emulsionIntravenous3.66 g
Injection, emulsionIntravenous5.5 g
Injection, emulsionIntravenous7.33 g
Injection, emulsionIntravenous9.16 g
Injection, emulsionIntravenous3.66 g/1000ml
Injection, solution95 mL/100mL
SolutionIntravenous3.2 g/100mL
SolutionIntravenous1.6 g/100mL
SoapTopical
SolutionTopical50 mL/100mL
PlasterTopical
EmulsionParenteral1.6 g/l
EmulsionParenteral0.66 g/2531ml
EmulsionParenteral0.61 g/l
EmulsionParenteral440 mg
Injection, emulsionIntravenous4.4 g/1000ml
EmulsionParenteral0.71 g
EmulsionParenteral3.1 g
Injection, emulsionIntravenous7.1 g/1000ml
EmulsionParenteral50 g
Injection, emulsionIntravenous
Injection, emulsionIntravenous3 g/100mL
Injection, solutionIntravenous5 %
EmulsionParenteral30 g
EmulsionParenteral18.75 g
EmulsionParenteral0.45 g
EmulsionParenteral2.24 g
EmulsionParenteral4.34 g
EmulsionParenteral3.95 g
EmulsionParenteral7 g
EmulsionParenteral28 g/1000ml
PasteTopical8 g/100g
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US5840757No1998-11-242015-11-24US flag
Additional Data Available
  • Filed On
    Filed On
    Available for Purchase

    The date on which a patent was filed with the relevant government.

    Learn more

Properties

State
Liquid
Experimental Properties
PropertyValueSource
water solubilityInsolubleMSDS
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on November 30, 2015 12:10 / Updated on June 12, 2020 10:52

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