Olive oil

Identification

Brand Names
Clinoleic, Clinolipid, Olimel, Periolimel
Generic Name
Olive oil
DrugBank Accession Number
DB09567
Background

Oil extracted from olives 1. Consists primarily of the glycerides of the fatty acids linoleic, oleic and palmitic. Used as a source of fatty acids in total parenteral nutrition and as an additive in some cosmetic products Label.

Type
Biotech
Groups
Approved
Synonyms
  • Olive oil

Pharmacology

Indication

For use in adults as a source of calories and fatty acids in total parenteral nutrition Label. Sometimes used as an additive in cosmetic products.

Pharmacology
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Drug Discovery
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Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Pharmacodynamics

Provides a source of calories and fatty acids Label.

Mechanism of action

Fatty acids act as a substrate in energy production through beta-oxidation as well as important components of cell membrane structures and prescursors for bioactive molecules like prostaglandins Label.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Metabolized to carbon dioxide and water used as a substrate in energy production Label. Carbon dioxide is eliminated via expiration while water is eliminated through expiration, evaporation, and urination. Some lipids are excreted in bile.

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Fat overload sydrome is the primary form of toxicity characterized by a sudden deterioration in the patient's condition accompanied by fever, anemia, leukopenia, thrombocytopenia, coagulation disorders, hyperlipidemia, liver fatty infiltration, deteriorating liver function, and central nervous system manifestations such as coma Label. The precise cause of this is unclear. While it is most likely to occur during overdosage of lipids some occurences have been reported when lipids are administered appropriately. Intraperitoneal LD50 in mice of >50g/kg and intravenous LD50 in rats of 1320mg/kg 1.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products
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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Intensive Treatment Bodyoil for Mommy To Be All SkinOil49.742 g/100mLTopicalIn This Morning2018-12-112019-12-25US flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
CLINOLEIC %20 IV İNFÜZYONLUK LİPİD EMÜLSİYON, 100 MLOlive oil (16 g/100ml) + Soybean oil (4 g/100ml)InjectionIntravenousEİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.2020-08-14Not applicableTurkey flag
CLINOLEIC %20 IV İNFÜZYONLUK LİPİD EMÜLSİYON, 1000 MLOlive oil (16 g/100ml) + Soybean oil (4 g/100ml)InjectionIntravenousEİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.2020-08-14Not applicableTurkey flag
CLINOLEIC %20 IV İNFÜZYONLUK LİPİD EMÜLSİYON, 250 MLOlive oil (16 g/100ml) + Soybean oil (4 g/100ml)InjectionIntravenousEİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.2020-08-14Not applicableTurkey flag
CLINOLEIC %20 IV İNFÜZYONLUK LİPİD EMÜLSİYON, 500 MLOlive oil (16 g/100ml) + Soybean oil (4 g/100ml)InjectionIntravenousEİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.2020-08-14Not applicableTurkey flag
Clinoleic 20%Olive oil (16 % w/w) + Soybean oil (4 % w/w)EmulsionIntravenousBaxter Laboratories2012-03-28Not applicableCanada flag
ClinolipidOlive oil (16 g/100mL) + Soybean oil (4 g/100mL)Injection, emulsionIntravenousBaxter Healthcare Corporation2016-01-01Not applicableUS flag
NEONUTRİVEN I.V. İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 1000 MLOlive oil (16 g/L) + Alanine (0.456 g/100mL) + Arginine (0.253 g/100mL) + Calcium chloride dihydrate (0.03 g/100mL) + Dextrose, unspecified form (8 g/100mL) + Glycine (0.227 g/100mL) + Histidine (0.106 g/100mL) + Isoleucine (0.132 g/100mL) + Leucine (0.161 g/100mL) + Lysine (0.128 g/100mL) + Magnesium chloride hexahydrate (0.045 g/100mL) + Methionine (0.088 g/100mL) + Phenylalanine (0.123 g/100mL) + Potassium chloride (0.119 g/100mL) + Proline (0.15 g/100mL) + Serine (0.11 g/100mL) + Sodium acetate trihydrate (0.098 g/100mL) + Sodium glycerophosphate hydrate (0.214 g/100mL) + Soybean oil (4 g/L) + Threonine (0.092 g/100mL) + Tryptophan (0.04 g/100mL) + Tyrosine (0.009 g/100mL) + Valine (0.128 g/100mL)SolutionIntravenousTURKTIPSAN SAĞLIK TURİZM EĞİTİM VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
NEONUTRİVEN I.V. İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 1500 MLOlive oil (16 g/L) + Alanine (0.456 g/100mL) + Arginine (0.253 g/100mL) + Calcium chloride dihydrate (0.03 g/100mL) + Dextrose, unspecified form (8 g/100mL) + Glycine (0.227 g/100mL) + Histidine (0.106 g/100mL) + Isoleucine (0.132 g/100mL) + Leucine (0.161 g/100mL) + Lysine (0.128 g/100mL) + Magnesium chloride hexahydrate (0.045 g/100mL) + Methionine (0.088 g/100mL) + Phenylalanine (0.123 g/100mL) + Potassium chloride (0.119 g/100mL) + Proline (0.15 g/100mL) + Serine (0.11 g/100mL) + Sodium acetate trihydrate (0.098 g/100mL) + Sodium glycerophosphate hydrate (0.214 g/100mL) + Soybean oil (4 g/L) + Threonine (0.092 g/100mL) + Tryptophan (0.04 g/100mL) + Tyrosine (0.009 g/100mL) + Valine (0.128 g/100mL)SolutionIntravenousTURKTIPSAN SAĞLIK TURİZM EĞİTİM VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
NEONUTRİVEN I.V. İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 2000 MLOlive oil (16 g/L) + Alanine (0.456 g/100mL) + Arginine (0.253 g/100mL) + Calcium chloride dihydrate (0.03 g/100mL) + Dextrose, unspecified form (8 g/100mL) + Glycine (0.227 g/100mL) + Histidine (0.106 g/100mL) + Isoleucine (0.132 g/100mL) + Leucine (0.161 g/100mL) + Lysine (0.128 g/100mL) + Magnesium chloride hexahydrate (0.045 g/100mL) + Methionine (0.088 g/100mL) + Phenylalanine (0.123 g/100mL) + Potassium chloride (0.119 g/100mL) + Proline (0.15 g/100mL) + Serine (0.11 g/100mL) + Sodium acetate trihydrate (0.098 g/100mL) + Sodium glycerophosphate hydrate (0.214 g/100mL) + Soybean oil (4 g/L) + Threonine (0.092 g/100mL) + Tryptophan (0.04 g/100mL) + Tyrosine (0.009 g/100mL) + Valine (0.128 g/100mL)SolutionIntravenousTURKTIPSAN SAĞLIK TURİZM EĞİTİM VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
NUMETA PED G 19 % E INFÜZYON IÇIN EMÜLSIYON, 1000 MLOlive oil (22.48 g) + Alanine (1.83 g) + Arginine (1.92 g) + Aspartic acid (1.37 g) + Calcium chloride dihydrate (0.56 g) + Cysteine (0.43 g) + D-glucose monohydrate (210.65 g) + Glutamic acid (2.29 g) + Glycine (0.91 g) + Histidine (0.87 g) + Isoleucine (1.53 g) + Leucine (2.29 g) + Lysine (2.82 g) + Magnesium acetate tetrahydrate (0.55 g) + Methionine (0.55 g) + Ornithine hydrochloride (0.73 g) + Phenylalanine (0.96 g) + Potassium acetate (3.14 g) + Proline (0.69 g) + Serine (0.91 g) + Sodium chloride (1.79 g) + Sodium glycerophosphate hydrate (2.21 g) + Soybean oil (5.62 g) + Taurine (0.14 g) + Threonine (0.85 g) + Tryptophan (0.46 g) + Tyrosine (0.18 g) + Valine (1.74 g)EmulsionIntravenousEİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.2020-08-14Not applicableTurkey flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Intensive Treatment Bodyoil for Mommy To Be All SkinOlive oil (49.742 g/100mL)OilTopicalIn This Morning2018-12-112019-12-25US flag
Rhodd Ato Repair Body So ApOlive oil (13.0 g/100g) + Chamaecyparis obtusa leaf (2.0 g/100g) + Evening primrose oil (6.0 g/100g)SoapTopicalSJ NATURAL2018-08-01Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
6UYK2W1W1E
CAS number
8001-25-0

References

General References
  1. ChemIDPlus: Olive Oil [Link]
PubChem Substance
347910464
RxNav
1309250
Wikipedia
Olive_oil
FDA label
Download (304 KB)
MSDS
Download (47.3 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedHealth Services ResearchSepsis Newborn1
4CompletedPreventionCholestasis / Psychomotor Disorders, Developmental1
4CompletedSupportive CareDietary and Nutritional Therapies1
4CompletedSupportive CareGastric Resection / Malnutrition1
4CompletedTreatmentDisorder Related to Renal Transplantation1
4CompletedTreatmentDry Eye Syndrome (DES) / Sjögren's Syndrome1
4CompletedTreatmentHepatic Function / Inflammatory Responses1
4CompletedTreatmentParenteral Nutrition1
4Not Yet RecruitingSupportive CarePreterm, Infant1
4RecruitingSupportive CareMalnutrition, Child1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CapsuleOral
InjectionIntravenous
EmulsionParenteral
OilTopical49.742 g/100mL
Injection, emulsionParenteral
EmulsionIntravenous
Injection, emulsion; injection, solutionIntravenous
SolutionIntravenous
SoapTopical
PlasterTopical
Injection, emulsionIntravenous
Injection, solutionIntravenous
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US5840757No1998-11-242015-11-24US flag

Properties

State
Liquid
Experimental Properties
PropertyValueSource
water solubilityInsolubleMSDS

Drug created on November 30, 2015 19:10 / Updated on March 26, 2021 03:55