Olive oil

Identification

Brand Names
Clinoleic, Clinolipid, Olimel, Periolimel
Generic Name
Olive oil
DrugBank Accession Number
DB09567
Background

Oil extracted from olives 1. Consists primarily of the glycerides of the fatty acids linoleic, oleic and palmitic. Used as a source of fatty acids in total parenteral nutrition and as an additive in some cosmetic products Label.

Type
Biotech
Groups
Approved
Synonyms
  • Olive oil

Pharmacology

Indication

For use in adults as a source of calories and fatty acids in total parenteral nutrition Label. Sometimes used as an additive in cosmetic products.

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Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Provides a source of calories and fatty acids Label.

Mechanism of action

Fatty acids act as a substrate in energy production through beta-oxidation as well as important components of cell membrane structures and prescursors for bioactive molecules like prostaglandins Label.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Metabolized to carbon dioxide and water used as a substrate in energy production Label. Carbon dioxide is eliminated via expiration while water is eliminated through expiration, evaporation, and urination. Some lipids are excreted in bile.

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Fat overload sydrome is the primary form of toxicity characterized by a sudden deterioration in the patient's condition accompanied by fever, anemia, leukopenia, thrombocytopenia, coagulation disorders, hyperlipidemia, liver fatty infiltration, deteriorating liver function, and central nervous system manifestations such as coma Label. The precise cause of this is unclear. While it is most likely to occur during overdosage of lipids some occurences have been reported when lipids are administered appropriately. Intraperitoneal LD50 in mice of >50g/kg and intravenous LD50 in rats of 1320mg/kg 1.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe therapeutic efficacy of Abciximab can be decreased when used in combination with Olive oil.
AcenocoumarolThe therapeutic efficacy of Acenocoumarol can be decreased when used in combination with Olive oil.
AlteplaseThe therapeutic efficacy of Alteplase can be decreased when used in combination with Olive oil.
AncrodThe therapeutic efficacy of Ancrod can be decreased when used in combination with Olive oil.
AnistreplaseThe therapeutic efficacy of Anistreplase can be decreased when used in combination with Olive oil.
Food Interactions
No interactions found.

Products

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Intensive Treatment Bodyoil for Mommy To Be All SkinOil49.742 g/100mLTopicalIn This Morning2018-12-112019-12-25US flag
LiquidLiquid1 g/4gCutaneousShantou Youjia E-Commerce Co., Ltd.2024-02-012024-12-31US flag
MediORO Signature Essence MistSpray1.60 g/160mLVaginalMEDIFUN Inc.2022-06-01Not applicableUS flag
MediORO WSpray0.12 g/10mLVaginalMEDIFUN Inc.2021-10-01Not applicableUS flag
OilOil22.5 mg/150mgCutaneousShantou Youjia E-Commerce Co., Ltd.2024-02-012024-12-31US flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ArganOlive oil (10 mg/100mL) + Argan oil (30 mg/100mL) + Avocado (30 mg/100mL) + Coconut oil (20 mg/100mL)OilCutaneousShantou Youjia E-Commerce Co., Ltd.2024-02-012024-12-31US flag
aspen nutrition Omega 3-6-9Olive oil (35 mg) + Lecithin (5 mg) + Linseed oil (100 mg) + Omega-3 fatty acids (700 mg) + Safflower oil (150 mg)CapsuleOralASPEN SARL SDN BHD2020-09-082021-12-12Malaysia flag
CLINOLEIC %20 IV İNFÜZYONLUK LİPİD EMÜLSİYON, 100 MLOlive oil (16 g/100ml) + Soybean oil (4 g/100ml)InjectionIntravenousEİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.2020-08-14Not applicableTurkey flag
CLINOLEIC %20 IV İNFÜZYONLUK LİPİD EMÜLSİYON, 1000 MLOlive oil (16 g/100ml) + Soybean oil (4 g/100ml)InjectionIntravenousEİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.2020-08-14Not applicableTurkey flag
CLINOLEIC %20 IV İNFÜZYONLUK LİPİD EMÜLSİYON, 250 MLOlive oil (16 g/100ml) + Soybean oil (4 g/100ml)InjectionIntravenousEİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.2020-08-14Not applicableTurkey flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Intensive Treatment Bodyoil for Mommy To Be All SkinOlive oil (49.742 g/100mL)OilTopicalIn This Morning2018-12-112019-12-25US flag
MediORO Signature Essence MistOlive oil (1.60 g/160mL)SprayVaginalMEDIFUN Inc.2022-06-01Not applicableUS flag
MediORO WOlive oil (0.12 g/10mL)SprayVaginalMEDIFUN Inc.2021-10-01Not applicableUS flag
Rhodd Ato Repair Body So ApOlive oil (13.0 g/100g) + Chamaecyparis obtusa leaf (2.0 g/100g) + Evening primrose oil (6.0 g/100g)SoapTopicalSJ NATURAL2018-08-01Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
6UYK2W1W1E
CAS number
8001-25-0

References

General References
  1. ChemIDPlus: Olive Oil [Link]
PubChem Substance
347910464
RxNav
1309250
Wikipedia
Olive_oil
FDA label
Download (304 KB)
MSDS
Download (47.3 KB)

Clinical Trials

Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package
PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
4CompletedHealth Services ResearchSepsis Newborn1somestatusstop reasonjust information to hide
4CompletedPreventionCholestasis / Psychomotor Disorders, Developmental1somestatusstop reasonjust information to hide
4CompletedPreventionInfection in Solid Organ Transplant Recipients1somestatusstop reasonjust information to hide
4CompletedSupportive CareDietary and Nutritional Therapies1somestatusstop reasonjust information to hide
4CompletedSupportive CareGastric Resection / Malnutrition1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
InjectionIntravenous
CreamCutaneous
PatchTopical
GelCutaneous
StickCutaneous
OilTopical49.742 g/100mL
LiquidCutaneous
LiquidCutaneous1 g/4g
SprayVaginal1.60 g/160mL
SprayVaginal0.12 g/10mL
OilTopical
Injection, emulsionParenteral
EmulsionIntravenous
EmulsionIntravenous0.466 g
Injection, emulsion; injection, solutionIntravenous
OilCutaneous
OilCutaneous22.5 mg/150mg
EmulsionIntravenous176 g/l
SolutionIntravenous
SoapTopical
CapsuleOral
PlasterTopical
ShampooTopical
EmulsionIntravenous13.000 g
EmulsionParenteral42.00 g
Injection, emulsionIntravenous14 g/1000ml
Injection, emulsionIntravenous
Injection, solutionIntravenous
LipstickCutaneous0.45 g/3g
LipstickCutaneous2.55 g/17g
SoapCutaneous15 g/50g
EmulsionParenteral
LiquidTopical
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US5840757No1998-11-242015-11-24US flag

Properties

State
Liquid
Experimental Properties
PropertyValueSource
water solubilityInsolubleMSDS

Drug created at November 30, 2015 19:10 / Updated at March 26, 2021 03:55