Identification
- Brand Names
- Clinoleic, Clinolipid, Olimel, Periolimel
- Generic Name
- Olive oil
- DrugBank Accession Number
- DB09567
- Background
Oil extracted from olives 1. Consists primarily of the glycerides of the fatty acids linoleic, oleic and palmitic. Used as a source of fatty acids in total parenteral nutrition and as an additive in some cosmetic products Label.
- Type
- Biotech
- Groups
- Approved
- Synonyms
- Olive oil
Pharmacology
- Indication
For use in adults as a source of calories and fatty acids in total parenteral nutrition Label. Sometimes used as an additive in cosmetic products.
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- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Provides a source of calories and fatty acids Label.
- Mechanism of action
Fatty acids act as a substrate in energy production through beta-oxidation as well as important components of cell membrane structures and prescursors for bioactive molecules like prostaglandins Label.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
Metabolized to carbon dioxide and water used as a substrate in energy production Label. Carbon dioxide is eliminated via expiration while water is eliminated through expiration, evaporation, and urination. Some lipids are excreted in bile.
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Fat overload sydrome is the primary form of toxicity characterized by a sudden deterioration in the patient's condition accompanied by fever, anemia, leukopenia, thrombocytopenia, coagulation disorders, hyperlipidemia, liver fatty infiltration, deteriorating liver function, and central nervous system manifestations such as coma Label. The precise cause of this is unclear. While it is most likely to occur during overdosage of lipids some occurences have been reported when lipids are administered appropriately. Intraperitoneal LD50 in mice of >50g/kg and intravenous LD50 in rats of 1320mg/kg 1.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab The therapeutic efficacy of Abciximab can be decreased when used in combination with Olive oil. Acenocoumarol The therapeutic efficacy of Acenocoumarol can be decreased when used in combination with Olive oil. Alteplase The therapeutic efficacy of Alteplase can be decreased when used in combination with Olive oil. Ancrod The therapeutic efficacy of Ancrod can be decreased when used in combination with Olive oil. Anistreplase The therapeutic efficacy of Anistreplase can be decreased when used in combination with Olive oil. Antithrombin Alfa The therapeutic efficacy of Antithrombin Alfa can be decreased when used in combination with Olive oil. Antithrombin III human The therapeutic efficacy of Antithrombin III human can be decreased when used in combination with Olive oil. Apixaban The therapeutic efficacy of Apixaban can be decreased when used in combination with Olive oil. Ardeparin The therapeutic efficacy of Ardeparin can be decreased when used in combination with Olive oil. Argatroban The therapeutic efficacy of Argatroban can be decreased when used in combination with Olive oil. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Intensive Treatment Bodyoil for Mommy To Be All Skin Oil 49.742 g/100mL Topical In This Morning 2018-12-11 2019-12-25 US 
MediORO Signature Essence Mist Spray 1.60 g/160mL Vaginal MEDIFUN Inc. 2022-06-01 Not applicable US MediORO W Spray 0.12 g/10mL Vaginal MEDIFUN Inc. 2021-10-01 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image CLINOLEIC %20 IV İNFÜZYONLUK LİPİD EMÜLSİYON, 100 ML Olive oil (16 g/100ml) + Soybean oil (4 g/100ml) Injection Intravenous EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş. 2020-08-14 Not applicable Turkey 
CLINOLEIC %20 IV İNFÜZYONLUK LİPİD EMÜLSİYON, 1000 ML Olive oil (16 g/100ml) + Soybean oil (4 g/100ml) Injection Intravenous EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş. 2020-08-14 Not applicable Turkey CLINOLEIC %20 IV İNFÜZYONLUK LİPİD EMÜLSİYON, 250 ML Olive oil (16 g/100ml) + Soybean oil (4 g/100ml) Injection Intravenous EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş. 2020-08-14 Not applicable Turkey CLINOLEIC %20 IV İNFÜZYONLUK LİPİD EMÜLSİYON, 500 ML Olive oil (16 g/100ml) + Soybean oil (4 g/100ml) Injection Intravenous EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş. 2020-08-14 2022-04-11 Turkey Clinoleic 20 % - Emulsion zur Infusion Olive oil (16 g/l) + Soybean oil (4 g/l) Emulsion Parenteral Baxter Healthcare Gmb H 1998-01-26 Not applicable Austria 
Clinoleic 20% Olive oil (16 % w/w) + Soybean oil (4 % w/w) Emulsion Intravenous Baxter Laboratories 2012-03-28 Not applicable Canada 
Clinolipid Olive oil (16 g/100mL) + Soybean oil (4 g/100mL) Injection, emulsion Intravenous Baxter Healthcare Corporation 2016-01-01 Not applicable US Finomel Emulsion zur Infusion Olive oil (10.3 g/1085ml) + Alanine (11.41 g/1085ml) + Arginine (6.34 g/1085ml) + Calcium chloride dihydrate (0.41 g/1085ml) + D-glucose monohydrate (151.5 g/1085ml) + Fish oil (8.24 g/1085ml) + Glycine (5.68 g/1085ml) + Histidine (2.64 g/1085ml) + Isoleucine (3.31 g/1085ml) + Leucine (4.02 g/1085ml) + Lysine hydrochloride (3.99 g/1085ml) + Magnesium sulfate heptahydrate (1.36 g/1085ml) + Medium-chain triglycerides (10.3 g/1085ml) + Methionine (2.2 g/1085ml) + Phenylalanine (3.09 g/1085ml) + Potassium chloride (2.47 g/1085ml) + Proline (3.75 g/1085ml) + Serine (2.76 g/1085ml) + Sodium acetate trihydrate (3.1 g/1085ml) + Sodium glycerophosphate hydrate (3.26 g/1085ml) + Soybean oil (12.36 g/1085ml) + Threonine (2.31 g/1085ml) + Tryptophan (0.99 g/1085ml) + Tyrosine (0.22 g/1085ml) + Valine (3.2 g/1085ml) + Zinc sulfate heptahydrate (0.013 g/1085ml) Emulsion Parenteral Baxter Healthcare Gmb H 2019-05-14 Not applicable Austria Finomel Peri Emulsion zur Infusion Olive oil (7.65 g/1085ml) + Alanine (7.08 g/1085ml) + Arginine (3.93 g/1085ml) + Calcium chloride dihydrate (0.25 g/1085ml) + D-glucose monohydrate (84.4 g/1085ml) + Fish oil (6.12 g/1085ml) + Glycine (3.52 g/1085ml) + Histidine (1.64 g/1085ml) + Isoleucine (2.05 g/1085ml) + Leucine (2.5 g/1085ml) + Lysine hydrochloride (2.48 g/1085ml) + Magnesium sulfate heptahydrate (0.84 g/1085ml) + Medium-chain triglycerides (7.65 g/1085ml) + Methionine (1.37 g/1085ml) + Phenylalanine (1.92 g/1085ml) + Potassium chloride (1.53 g/1085ml) + Proline (2.33 g/1085ml) + Serine (1.71 g/1085ml) + Sodium acetate trihydrate (1.92 g/1085ml) + Sodium glycerophosphate hydrate (2.03 g/1085ml) + Soybean oil (9.18 g/1085ml) + Threonine (1.44 g/1085ml) + Tryptophan (0.62 g/1085ml) + Tyrosine (0.14 g/1085ml) + Valine (1.98 g/1085ml) + Zinc sulfate heptahydrate (0.008 g/1085ml) Emulsion Parenteral Baxter Healthcare Gmb H 2019-05-14 Not applicable Austria NEONUTRİVEN I.V. İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 1000 ML Olive oil (16 g/L) + Alanine (0.456 g/100mL) + Arginine (0.253 g/100mL) + Calcium chloride dihydrate (0.03 g/100mL) + Dextrose, unspecified form (8 g/100mL) + Glycine (0.227 g/100mL) + Histidine (0.106 g/100mL) + Isoleucine (0.132 g/100mL) + Leucine (0.161 g/100mL) + Lysine (0.128 g/100mL) + Magnesium chloride hexahydrate (0.045 g/100mL) + Methionine (0.088 g/100mL) + Phenylalanine (0.123 g/100mL) + Potassium chloride (0.119 g/100mL) + Proline (0.15 g/100mL) + Serine (0.11 g/100mL) + Sodium acetate trihydrate (0.098 g/100mL) + Sodium glycerophosphate hydrate (0.214 g/100mL) + Soybean oil (4 g/L) + Threonine (0.092 g/100mL) + Tryptophan (0.04 g/100mL) + Tyrosine (0.009 g/100mL) + Valine (0.128 g/100mL) Solution Intravenous TURKTIPSAN SAĞLIK TURİZM EĞİTİM VE TİC. A.Ş. 2020-08-14 Not applicable Turkey - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Intensive Treatment Bodyoil for Mommy To Be All Skin Olive oil (49.742 g/100mL) Oil Topical In This Morning 2018-12-11 2019-12-25 US MediORO Signature Essence Mist Olive oil (1.60 g/160mL) Spray Vaginal MEDIFUN Inc. 2022-06-01 Not applicable US MediORO W Olive oil (0.12 g/10mL) Spray Vaginal MEDIFUN Inc. 2021-10-01 Not applicable US Rhodd Ato Repair Body So Ap Olive oil (13.0 g/100g) + Chamaecyparis obtusa leaf (2.0 g/100g) + Evening primrose oil (6.0 g/100g) Soap Topical SJ NATURAL 2018-08-01 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- 6UYK2W1W1E
- CAS number
- 8001-25-0
References
- General References
- ChemIDPlus: Olive Oil [Link]
- External Links
- FDA label
- Download (304 KB)
- MSDS
- Download (47.3 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Health Services Research Sepsis Newborn 1 4 Completed Prevention Cholestasis / Psychomotor Disorders, Developmental 1 4 Completed Supportive Care Dietary and Nutritional Therapies 1 4 Completed Supportive Care Gastric Resection / Malnutrition 1 4 Completed Treatment Disorder Related to Renal Transplantation 1 4 Completed Treatment Dry Eye Syndrome (DES) / Sjogren's Syndrome (SS) 1 4 Completed Treatment Essential Fatty Acid Deficiency (EFAD) 1 4 Completed Treatment Hepatic Function / Inflammatory Responses 1 4 Completed Treatment Parenteral Nutrition 1 4 Not Yet Recruiting Other Children - Malnutrition / Malnutrition 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral Injection Intravenous Oil Topical 49.742 g/100mL Spray Vaginal 1.60 g/160mL Spray Vaginal 0.12 g/10mL Injection, emulsion Parenteral Emulsion Intravenous Emulsion Intravenous 0.466 g Injection, emulsion; injection, solution Intravenous Emulsion Intravenous 176 g/l Solution Intravenous Soap Topical Plaster Topical Emulsion Intravenous 13.000 g Emulsion Parenteral 42.00 g Injection, emulsion Intravenous 14 g/1000ml Injection, emulsion Intravenous Injection, solution Intravenous Emulsion Parenteral - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US5840757 No 1998-11-24 2015-11-24 US
Properties
- State
- Liquid
- Experimental Properties
Property Value Source water solubility Insoluble MSDS
Drug created at November 30, 2015 19:10 / Updated at March 26, 2021 03:55