Colorectal Cancer (CRC) Completed Phase 2 Trials for Fluorouracil (DB00544)

Also known as: Malignant Neoplasm of Colorectum / CRC, Colorectal Cancer / Colorectal Cancer / Cancer, Colorectal / CRC (Colorectal Cancer) / Colorectal, Cancer / Colo-rectal Cancer / Colorectal Cancers / A. Colorectal Cancer / Cancer Colorectal / Gastrointestinal Cancers - Colorectal / CRC / CRCS / Malignant colorectal neoplasm / Malignant neoplasm of cecum and/or colon and/or rectum / Malignant neoplasm of caecum and/or colon and/or rectum / Malignant neoplasm of cecum and/or colon and/or rectum (disorder) / Malignant neoplasm of large intestine / Malignant tumor of large intestine / Malignant tumour of large intestine / Malignant neoplasm of large intestine (disorder) / Malignant neoplasm of colon, unspecified / Malignant large intestinal neoplasm NOS / Cancer of large intestine / Malignant neoplasm of large intestine, NOS / Cancer of large bowel / CA - Cancer of large bowel / Colorectal neoplasms malignant / Malignant neoplasm of colon and/or rectum (disorder) / Large intestine carcinoma / Colorectal carcinoma / Colorectal cancer NOS

IndicationStatusPhase
DBCOND0031867 (Colorectal Cancer (CRC))Completed2
clinicaltrials.gov IdentifierTitlePurposeDrugs
NCT01836653
Achievement of Improved Survival by Molecular Targeted Chemotherapy and Liver Resection for Not Optimally Resectable Colorectal Liver MetastasesTreatment
NCT00707889
Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal CancerTreatment
NCT03929666
A Safety and Efficacy Study of ZW25 (Zanidatamab) Plus Combination Chemotherapy in HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal CancerTreatment
NCT00286000
High Dose Simplified Folfiri in Advanced Colorectal Cancer: a Multicentre Phase II StudyTreatment
NCT05593328
Study of Onvansertib in Combination With FOLFIRI and Bevacizumab Versus FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer in Participants With a Kirsten Rat Sarcoma Virus Gene (KRAS) or Neuroblastoma-RAS (NRAS) MutationTreatment
NCT05480306
Phase 2 Study of DKN-01 in Colorectal CancerTreatment
NCT04895137
mFOLFOX6+Bevacizumab+PD-1 Monoclonal Antibody in Local Advanced MSS CRCTreatment
NCT04072198
Nivolumab Plus FOLFOXIRI/Bevacizumab in First Line Chemotherapy of Advanced Colorectal Cancer RASm/BRAFm PatientsTreatment
NCT03984578
Window of Opportunity Study in Colorectal CancerTreatment
NCT03693807
A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or CholangiocarcinomaTreatment
NCT03530267
Aflibercept and 5-FU vs. FOLFOX as 1st Line Treatment for Elderly or Frail Elderly Patients With Met. Colorectal CancerTreatment
NCT03366155
Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the LiverTreatment
NCT03414983
An Investigational Immunotherapy Study of Nivolumab With Standard of Care Therapy vs Standard of Care Therapy for First-Line Treatment of Colorectal Cancer That Has SpreadTreatment
NCT02705300
Side Effects to FOLFOXIRI + Tocotrienol/Placebo as First Line Treatment of Metastatic Colorectal CancerTreatment
NCT02494973
Postoperative Hepatic Arterial Chemotherapy in High-risk Patients as Adjuvant Treatment After Resection of Colorectal Liver MetastasesTreatment
NCT02291289
A Study of Biomarker-Driven Therapy in Metastatic Colorectal Cancer (mCRC)Treatment
NCT00321828
Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colon Cancer That Cannot Be Removed By SurgeryTreatment
NCT00098787
Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal CancerTreatment
NCT00268333
Combination Chemotherapy and Radiation Therapy in Treating Patients With Recurrent Metastatic Colorectal CancerTreatment
NCT00080951
Irinotecan, Fluorouracil, Leucovorin, and Oxaliplatin as First-Line Therapy in Treating Patients With Metastatic Colorectal CancerTreatment
NCT00851045
Ph II Trial of a Novel Anti-angiogenic Agent in Combination With Chemotherapy for the Second-line Treatment of Metastatic Colorectal CancerTreatment
NCT00021398
Radiation Therapy and Chemotherapy Followed by Surgery and Combination Chemotherapy in Treating Patients With Rectal CancerTreatment
NCT00004005
Irinotecan Followed By Fluorouracil and Leucovorin in Treating Patients With Stage III or Stage IV Colorectal Carcinoma (Cancer), Other Refractory Carcinoma, or Metastatic Adenoma (Cancer) of Unknown Primary OriginTreatment
NCT00111761
Evaluating Panitumumab (ABX-EGF) in Patients With Metastatic Colorectal CancerTreatment
NCT01205711
Irinotecan Hydrochloride, Fluorouracil, and Leucovorin Calcium With or Without Zibotentan in Treating Patients With Metastatic Colorectal CancerTreatment
NCT00354978
Study of FOLFIRI Plus Bevacizumab in Colorectal Cancer PatientsTreatment
NCT01227707
A Study of Avastin (Bevacizumab) Plus Xeloda (Capecitabine) in Patients With Locally Advanced Rectal Cancer.Treatment
NCT01260415
A Study of Perioperative Chemotherapy Plus Panitumumab in Patients With Colorectal Cancer Liver MetastasesTreatment
NCT00025142
Gefitinib and Combination Chemotherapy in Treating Patients With Advanced Solid Tumors or Colorectal CancerTreatment
NCT00467142
Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by SurgeryTreatment
NCT00544349
Leucovorin, Fluorouracil, Cetuximab, and Oxaliplatin in Treating Patients With Stage IV Colorectal Cancer and Liver Metastases That Cannot Be Removed by SurgeryTreatment
NCT01251536
Cetuximab Standard or Dose Escalation in First Line Colorectal CancerTreatment
NCT00556413
Cetuximab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal CancerTreatment
NCT01212718
Response Prediction in Metastasized Colorectal Cancer Using Intratumoral Thymidylate SynthaseTreatment
NCT01226719
FOLFOXIRI Plus Panitumumab Patients With Metastatic KRAS Wild-Type Colorectal Cancer With Liver Metastases OnlyTreatment
NCT00003834
Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal CancerTreatment
NCT00308516
5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal CancerTreatment
NCT00332163
Skin Toxicity Treatment in Metastatic Colorectal Cancer (mCRC) Patients Receiving Panitumumab + Irinotecan-based TherapyTreatment
NCT00612586
Study of Enzastaurin With 5-Fluorouracil/Leucovorin (5-FU/LV) Plus Bevacizumab as Maintenance Regimen Following First Line Therapy for Metastatic Colon CancerTreatment
NCT00006786
Combination Chemotherapy Plus Bevacizumab in Treating Patients With Advanced Colorectal CancerTreatment
NCT01077739
A Study of Avastin (Bevacizumab) With XELOX or FOLFOX in Patients With Metastatic Colorectal Cancer and Disease Progression Under First-line FOLFIRI and AvastinTreatment
NCT00541125
G-CSF in Preventing Neutropenia During First-Line Treatment With Chemotherapy and Bevacizumab in Patients With Metastatic Colorectal CancerSupportive Care
NCT01374425
Study of Bevacizumab + mFOLFOX6 Versus Bevacizumab + FOLFIRI With Biomarker Stratification in Participants With Previously Untreated Metastatic Colorectal Cancer (mCRC)Treatment
NCT01490866
A Trial of Single Agent Axitinib as Maintenance Therapy for Patients With First Line Metastatic Colorectal Cancer (mCRC)Treatment
NCT00006366
Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the RectumTreatment
NCT00384176
First Line Metastatic Colorectal Cancer Therapy in Combination With FOLFOXTreatment
NCT00336960
Celecoxib, Fluorouracil, and Radiation Therapy in Treating Patients With Stage II or Stage III Rectal Cancer That Can Be Removed By SurgeryTreatment
NCT00381862
Phase II Trial of Aprepitant & Palonosetron for CINV Prevention w FOLFOXSupportive Care
NCT00613080
Combination Chemotherapy and Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Locally Advanced Rectal CancerTreatment
NCT00952029
Combination Chemotherapy and Bevacizumab With or Without Bevacizumab Maintenance Therapy in Treating Patients With Metastatic Colorectal CancerTreatment
NCT00081289
Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy in Treating Patients Who Are Undergoing Surgical Resection for Locally Advanced Rectal CancerTreatment
NCT00003446
Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal CancerTreatment
NCT01327612
Open Label Extension Study of Conatumumab and Ganitumab (AMG 479)Treatment
NCT00628810
Combination Chemotherapy and Bevacizumab in Treating Patients With Metastatic Colorectal CancerTreatment
NCT00640081
Combination Chemotherapy and Cetuximab as First-Line Therapy in Treating Patients With Advanced and/or Metastatic Colorectal CancerTreatment
NCT00039208
Combination Chemotherapy in Treating Patients With Colorectal CancerTreatment
NCT00786643
Study of Gamma Interfereon in Metastatic Colorectal CarcinomaTreatment
NCT00004102
Combination Chemotherapy in Treating Patients With Advanced Colorectal CancerTreatment
NCT00557102
Cetuximab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver and/or LungTreatment
NCT00202787
Safety and Efficacy Study of Combination Therapy With Cetuximab and FOLFOX4 in Patients With Colorectal CancerTreatment
NCT00003254
SWOG-S9635 Fluorouracil Plus Ethynyluracil in Advanced Colorectal Cancer Not Responded to FluorouracilTreatment
NCT00023751
Surgery With or Without Chemotherapy and Radiation Therapy in TreatingPatients With Stage I Rectal CancerTreatment
NCT00153998
Cetuximab in Neoadjuvant Treatment of Non-Resectable Colorectal Liver Metastases (CELIM)Treatment
NCT00016198
Fluorouracil and Leucovorin With or Without Oxaliplatin in Treating Patients With Recurrent Metastatic Colorectal CancerTreatment
NCT00103298
Isolated Hepatic Perfusion With Melphalan Followed by Combination Chemotherapy in Treating Patients With Unresectable Liver Metastases From Colorectal CancerTreatment
NCT00975897
Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal CancerDiagnostic
NCT01263171
Oxaliplatin, Leucovorin, and Fluorouracil Before and After Radiation Therapy and Surgery in Treating Patients With Rectal Cancer That Can Be Removed by SurgeryTreatment
NCT00016978
Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer Previously Treated With IrinotecanTreatment
NCT01383707
A Study of Bevacizumab and Modified FOLFOX-6 (mFOLFOX-6) in Participants With Metastatic Colorectal CancerTreatment
NCT00885885
Safety and Efficacy Study of FOLFOX4+Panitumumab vs.FOLFIRI+Panitumumab in Subjects WT KRAS Colorectal Cancer and Liver-only MetastasesTreatment
NCT02439385
Avastin/FOLFIRI in Combination With Curcumin in Colorectal Cancer Patients With Unresectable MetastasisTreatment
NCT01068132
Prognostic Factors for Patients With Advanced Colorectal Cancer Treated With Cetuximab.Treatment
NCT00016952
Irinotecan or Fluorouracil Plus Leucovorin in Treating Patients With Previously Treated Metastatic Colorectal CancerTreatment
NCT01326000
A Study of RO5083945 in Combination With FOLFIRI Versus FOLFIRI Plus Cetuximab or FOLFIRI Alone as Second Line Treatment in Patients With Metastatic Colorectal CancerTreatment
NCT00192075
A Randomized Trial of Avastin + Gemcitabine + 5-Fluorouracil (5FU)/Folinic Acid Versus Avastin + Oxaliplatin + 5FU/Folinic Acid in Metastatic Colorectal CancerTreatment
NCT00752570
A Phase 2, Randomized, Double Blind, Placebo Controlled Study of AMG 386 in Combination With FOLFIRI in Subjects With Previously Treated Metastatic Colorectal CarcinomaTreatment
NCT00002842
Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal CancerTreatment
NCT00004142
Radiofrequency Ablation Followed By Hepatic Artery Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the LiverTreatment
NCT01442649
Efficacy of Chemotherapy, Associated to Either Cetuximab or Bevacizumab, in KRAS Wild-type Metastatic Colorectal Cancer Patients With Progressive Disease After Receiving First-line Treatment With BevacizumabTreatment
NCT00551213
A Study to Determine the Activity of Robatumumab (SCH 717454, MK-7454) in Participants With Relapsed or Recurrent Colorectal Cancer (P04721, MK-7454-003)Treatment
NCT00559741
Cetuximab and Combination Chemotherapy in Treating Patients With Advanced or Metastatic Colorectal CancerTreatment
NCT00020917
Cetuximab Plus Combination Chemotherapy in Treating Patients With Stage IV Colorectal CancerTreatment
NCT00454116
A Phase II, Double Blind Study of 2 Doses of ZACTIMAâ„¢(ZD6474) in Combination With FOLFIRI vs FOLFIRI Alone for the Treatment of Colorectal Cancer in PatientsTreatment
NCT00967616
Study of CS-7017 in Combination With FOLFIRI in Subjects With Metastatic Colorectal Cancer Who Failed First-Line TherapyTreatment
NCT00423696
Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By SurgeryTreatment
NCT01632722
Perioperative vs Postoperative Chemotherapy + Bevacizumab in Colorectal Cancer, Liver MetsTreatment
NCT00056030
Combination Chemotherapy Plus Cetuximab in Treating Patients With Liver Metastases From Colorectal CancerTreatment
NCT00066274
Comparison of Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal CancerTreatment
NCT01652482
Safety and Efficacy Study of MEHD7945A + FOLFIRI Versus Cetuximab + FOLFIRI as Second Line Therapy in Participants With KRAS Wild-Type Metastatic Colorectal Cancer (mCRC)Treatment
NCT00208260
Intensified Chemotherapy in CRC After Resection of Liver MetastasesTreatment
NCT01417494
1st Line Chemotherapy Alone or With Bevacizumab in Treating Older Patients With Metastatic Colorectal CancerTreatment
NCT00278889
Second Line ColoRectal Cancer Therapy in Combination With Combination of FOL- Folinic Acid(Leucovorin), F - Fluorouracil and OX - Oxaliplatin (FOLFOX)Treatment
NCT00866944
Study of Adecatumumab Relative to FOLFOX After R0 Resection of Colorectal Liver MetastasesTreatment
NCT00066846
Bevacizumab Plus Fluorouracil and Leucovorin in Treating Patients With Locally Advanced or Metastatic Stage IV Colorectal Cancer That Has Progressed After Standard ChemotherapyTreatment
NCT00831181
Neo-adjuvant Chemoradiation With Oxaliplatin/5-FU in Rectal CancerTreatment
NCT00006050
Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the LiverTreatment
NCT00411450
Panitumumab Regimen Evaluation in Colorectal Cancer to Estimate Primary Response to TreatmentTreatment
NCT00262808
GM-CSF and Combination Chemotherapy in Treating Patients Who Are Undergoing Surgery for Stage II or Stage III Colon CancerTreatment
NCT00418938
SPIRITT - Second-Line Panitumumab Irinotecan Treatment TrialTreatment
NCT01378143
Using OCZ103-OS in Patients With Unresectable and Locally Recurrent or Metastatic Colorectal Cancer Undergoing Standard ChemotherapyTreatment
NCT01276379
Study Evaluating Biomarkers in Patients With Colorectal Cancer and Native KRAS Treated With Chemotherapy + CetuximabScreening