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Displaying results 131 - 140 of 220 in total
  1. Pathway

    Norepinephrine Neurological

    smpdb.ca/view/SMP0130946
    Physiological

    system, and inhibits voiding of the bladder and gastrointestinal motility. … In the brain, norepinephrine increases arousal and alertness, promotes vigilance, enhances formation and retrieval of memory, and focuses attention; it also increases restlessness and anxiety.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +3 more
    Enzymes: Sodium-dependent noradrenaline transporter
  2. Indication

    Nasal Congestion

    go.drugbank.com/conditions/DBCOND0035647
    Drugs: Acetaminophen · Ammonium chloride · Bromhexine · Budesonide · Camphor · Chlorpheniramine +36 more
  3. Pathway

    Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway

    smpdb.ca/view/SMP0126078
    Drug action

    associated symptoms of lightheadedness, dizziness, blurred vision, and syncope through the induction of tachycardia (increased heart rate) and hypertension. … Some side effects of using droxidopa may include headache, dizziness, nausea, high blood pressure, and fainting.

    Drugs: Pyridoxal phosphate · ATP · Norepinephrine · Calcium · Droxidopa
    Enzymes: Sodium/calcium exchanger 1, Sodium-dependent noradrenaline transporter
  4. Pathway

    Amitriptyline Norepinephrine Reuptake Inhibitor Action Pathway

    smpdb.ca/view/SMP0125187
    Drug action

    The norepinephrine is released into the synapse and acts on α1, β1 and β2receptors which contribute to mood improvements. … Amitriptyline by blocking the reuptake of both serotonin and norepinephrine neurotransmitters. In adrenergic neurons, norepinephrine is synthesized from tyrosine and stored in synaptic vesicles.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Amitriptyline · Sapropterin · Norepinephrine +5 more
    Enzymes: Sodium-dependent noradrenaline transporter
  5. Pathway

    Maprotiline Action Pathway

    smpdb.ca/view/SMP0126344
    Drug action

    Maprotiline acts as an antagonist at central presynaptic α2-adrenergic inhibitory autoreceptors and hetero-receptors, an action that is postulated to result in an increase in central noradrenergic and … This tetracyclic molecule strongly inhibits neuronal norepinephrine reuptake in the brain and peripheral tissues.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Sapropterin · Norepinephrine · Maprotiline +5 more
    Enzymes: Sodium-dependent noradrenaline transporter
  6. Pathway

    Milnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway

    smpdb.ca/view/SMP0126429
    Drug action

    Milnacipran is a serotonin and norepinephrine reuptake inhibitor (SNRI). … It is generally believed that 5HT and NE participate in the modulation of endogenous analgesic mechanisms by way of the descending inhibitory pain pathways in the brain and spinal cord.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +4 more
    Enzymes: Sodium-dependent noradrenaline transporter
  7. Pathway

    Levomilnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway

    smpdb.ca/view/SMP0126430
    Drug action

    It is generally believed that 5HT and NE participate in the modulation of endogenous analgesic mechanisms by way of the descending inhibitory pain pathways in the brain and spinal cord. … Levomilnacipran (the more active 1S, 2R - enantiomer of milnacipran) is a serotonin and norepinephrine reuptake inhibitor (SNRI).

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +4 more
    Enzymes: Sodium-dependent noradrenaline transporter
  8. Pathway

    Metoclopramide - Dopamine Antagonist Action Pathway

    smpdb.ca/view/SMP0126993
    Drug action

    Metoclopramide is a dopamine receptor antagonist and has been approved by the FDA to treat nausea and vomiting in patients with gastroesophageal reflux disease or diabetic gastroparesis by increasing gastric … Consequently, it increases the resting tone of the lower esophageal sphincter while simultaneously relaxing the duodenal bulb and pyloric sphincter, thereby increasing the peristalsis of the duodenum and

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Dopamine · Metoclopramide · Levodopa +2 more
    Enzymes: Sodium-dependent dopamine transporter
  9. Indication

    Zollinger-Ellison Syndrome

    go.drugbank.com/conditions/DBCOND0000825
    Drugs: Esomeprazole · Famotidine · Lansoprazole · Omeprazole · Pantoprazole · Rabeprazole +2 more
  10. Indication

    Allergic Rhinitis (AR)

    go.drugbank.com/conditions/DBCOND0053380
    Drugs: Ambrosia artemisiifolia pollen · Amidephrine · Azelastine · Brompheniramine · Budesonide · Carbinoxamine +34 more