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Ibandronate Action Pathway
smpdb.ca/view/SMP0000079Drug actionThe action of ibandronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and...
Drugs: Cholecalciferol · ATP · Ibandronate · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 morePravastatin Action Pathway
smpdb.ca/view/SMP0000089Drug actionPravastatin inhibits cholesterol synthesis via the mevalonate pathway by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase is the enzyme responsible for the conversion of HMG-CoA to mevalonic acid, t...
Drugs: Cholecalciferol · ATP · Pravastatin · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 moreRosuvastatin Action Pathway
smpdb.ca/view/SMP0000092Drug actionRosuvastatin, sold as Crestor, Rosulip and Zuvamor, belongs to the class of drugs known as statins. It is taken orally to inhibit the endogenous production of cholesterol in the liver. Statins do this by inhibiting the enzyme 3-hydroxy-3...
Drugs: Cholecalciferol · ATP · Rosuvastatin · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 moreRisedronate Action Pathway
smpdb.ca/view/SMP0000112Drug actionRisedronate (also named Actonel, Atelvia or Benet.) is a type of medication that used to treat numbers of bone diseases because of its affinity for hydroxyapatite. Risedronate targets farnesyl pyrophosphate (FPP) synthase by inhibiting t...
Drugs: Cholecalciferol · ATP · Risedronic acid · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 moreGlycerol Phosphate Shuttle
smpdb.ca/view/SMP0000124MetabolicThe glycerol phosphate shuttle also known as the glycerophosphate shuttle. It shuttles electrons to mitochondrial carriers in the oxidative phosphorylation pathway from cytosolic NADH. This shuttle relies on mitochondrial glycerol-3-phos...
3-Methylglutaconic Aciduria Type III
smpdb.ca/view/SMP0000140Disease3-Methylglutaconic aciduria type 3 (Costeff syndrome; Optic atrophy plus syndrome) is an autosomal recessive disease caused by a deficiency in the OPA3 code which does for optic atrophy 3 protein. A deficiency of this enzyme results in a...
3-Methylglutaconic Aciduria Type IV
smpdb.ca/view/SMP0000141Disease3-Methylglutaconic Aciduria Type IV, also called MGA, Type IV and MGA4, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder and caused by a defective methylglutaconyl-CoA hydratase. Methylglutaconyl-CoA hydratase ...
5-Oxoprolinuria
smpdb.ca/view/SMP0000143Disease5-Oxoprolinuria (5-Oxoprolinase deficiency) is a result of a defect in the gamma-glutamyl cycle due to either 5-oxoprolinase or glutathione synthetase deficiency. In the case of glutathione synthetase deficiency, the glycine is not incor...
Adenosine Deaminase Deficiency
smpdb.ca/view/SMP0000144DiseaseAdenosine deaminiase deficiency (immunodeficiency) is an autosomal recessive disease caused by a muation in the ADA gene which codes for adenosine deaminase. A deficiency in this enzyme results in immunodeficiency and a decreased concent...
Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +24 moreAlkaptonuria
smpdb.ca/view/SMP0000169DiseaseAlkaptonuria (Homogentisic acid oxidase deficiency) is an autosomal recessive disease caused by a mutation in the HGD gene which codes for homogentisate 1,2-dioxygenase. A mutation in this enzyme results in accumulation of homogentisic a...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more