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Major histocompatibility complex class I-related protein 1
go.drugbank.com/bio_entities/BE0003573TargetHumansIn complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1.2 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers … Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such
Bifunctional FAD diphosphatase/FAD synthase
go.drugbank.com/bio_entities/BE0017310EnzymeHumansFAD synthase cannot convert 8-demethyl-8-amino-riboflavin mononucleotide (AFMN) to 8-demethyl-8-amino-riboflavin adenine dinucleotide (AFAD); AFMN is produced by riboflavin kinase when acting on the antibiotic … 8-demethyl-8-amino-riboflavin (AF) (PubMed:21924249)
Broad substrate specificity ATP-binding cassette transporter ABCG2
go.drugbank.com/bio_entities/BE0001067TargetTransporterCarrierHumansMediates the secretion of the vitamins riboflavin and biotin into milk (By similarity). … Involved in the excretion of the riboflavin-derived compound lumichrome into the intestinal lumen and in its secretion into milk (PubMed:39337371).
6,7-dimethyl-8-ribityllumazine synthase
go.drugbank.com/bio_entities/BE0001449TargetAquifex aeolicus (strain VF5)This is the penultimate step in the biosynthesis of riboflavin.
6,7-dimethyl-8-ribityllumazine synthase 2
go.drugbank.com/bio_entities/BE0001793TargetBrucella suis biovar 1 (strain 1330)This is the penultimate step in the biosynthesis of riboflavin.
Flavin reductase (NADPH)
go.drugbank.com/bio_entities/BE0000595TargetEnzymeHumansHas a broad specificity oxidoreductase activity by catalyzing the NAD(P)H-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline
6,7-dimethyl-8-ribityllumazine synthase
go.drugbank.com/bio_entities/BE0001270TargetMycobacterium tuberculosisThis is the penultimate step in the biosynthesis of riboflavin.
Phospholipid Biosynthesis
smpdb.ca/view/SMP0000025MetabolicThis pathway describes the synthesis of the common phospholipids, including phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol and cardiolipins. Phospholipid synthesis is mediated by two possible mech...
Drugs: Choline · Phosphatidyl serine · NADH · Calcium · Magnesium cation · sn-glycerol 3-phosphate +5 moreCaffeine Metabolism
smpdb.ca/view/SMP0000028MetabolicCaffeine is obtained from diet including coffee and other beverages and is absorbed in the stomach and small intestine. In the liver, the cytochrome P450 oxidase enzyme system and specifically CYP1A2 metabolizes caffeine into paraxanthin...
Drugs: NADH · Caffeine · Theophylline · Theobromine · Mesoheme · Flavin adenine dinucleotide +1 moreNicotinate and Nicotinamide Metabolism
smpdb.ca/view/SMP0000048MetabolicNicotinate (niacin) and nicotinamide - more commonly known as vitamin B3 - are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). NAD+ synthesis occurs either de ...