Search
Metabolism and Physiological Effects of Indolelacetyl glutamine
smpdb.ca/view/SMP0126755Metabolic, and indole lactic acid. … retardation and pellagra like skin rash.
Metabolism and Physiological Effects of 3-Methylhistidine
smpdb.ca/view/SMP0126757Metabolichistidine-containing peptides (such as anserine and ophidine/balenine). … synthesized only in the muscle by the methylation of one histidine residue in actin and in varying amounts in myosin depending on the type of muscle.
Metabolism and Physiological Effects of O-Sulfotyrosine
smpdb.ca/view/SMP0126811MetabolicO-Sulfotyrosine belongs to the class of organic compounds known as phenylalanine and derivatives. … Secreted proteins and extracellular parts of membrane proteins that pass through the Golgi apparatus may be sulfated.
Metabolism and Physiological Effects of S-Adenosylhomocysteine
smpdb.ca/view/SMP0127690MetabolicThe reaction is catalyzed by S-adenosylhomocysteine hydrolase and is reversible with the equilibrium favoring formation of SAH. … Chronically high levels of S-adenosylhomocysteine are associated with S-adenosylhomocysteine (SAH) hydrolase deficiency and adenosine deaminase deficiency.
Alpha Linolenic Acid and Linoleic Acid Metabolism
smpdb.ca/view/SMP0000018MetabolicBoth LNA and ALA are essential dietary requirements for all mammals since they cannot be synthesized natively in the body. … LNA enters the cell and is catalyzed to gamma-linolenic acid (GLA) by acyl-CoA 6-desaturase (delta-6-desaturase/fatty acid desaturase 2).
Metabolism and Physiological Effects of Quinolinic Acid
smpdb.ca/view/SMP0123249MetabolicQuinolinic acid is shown to have major neurotoxic effects on the brain by acting as an NMDA receptor agonist, causing excessive glutamate release and lipid peroxidation. … When this compound enters into systemic circulation it is shown to be a major uremic toxin when high levels of it are retained in the blood and not excreted in urine.
Drugs: Tryptophan · Quinolinic Acid · Kynurenine · Mesoheme · Flavin adenine dinucleotide · 3-hydroxyanthranilic acid +1 moreEnzymes: Neutral and basic amino acid transport protein rBATMetabolism and Physiological Effects of Uric acid
smpdb.ca/view/SMP0124845MetabolicUric acid can enter the blood and produce toxic effects on the cardiovascular, renal and joints, leading to cardiovascular disease, kidney disease and arthritis/ gout. … The purines are guanine and adenine. These undergo metabolism in the liver to form uric acid. Adenine forms adenosine through the enzyme purine nucleoside phosphorylase.
Metabolism and Physiological Effects of Oxalic acid
smpdb.ca/view/SMP0124875MetabolicGlyoxylate is generated through glycine and hydroxyproline catabolism and can be converted to oxalate. In humans, this process takes place in the liver. … Glycine and hydroxyproline comes from protein sources in the diet such as red meat and eggs. Glycine Is converted into glyoxylate in the peroxisome by the enzyme d-amino acid oxidase.
Drugs: Pyridoxal phosphate · Ascorbic acid · Succinic acid · Glutamic acid · Glycine · Proline +4 moreEnzymes: Sodium- and chloride-dependent transporter XTRP3, Sodium- and chloride-dependent creatine transporter 1Metabolsim and Physiological Effects of Argininic acid
smpdb.ca/view/SMP0125504MetabolicArginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … Argininic acid is a uremic toxin that is toxic to the nervous system, and it causes various neurlogical disorders such as variable degree of mental retardation, epilepsy and progressive spasticity.
Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 moreMetabolism and Physiological Effects of 3-Deoxyglucosone
smpdb.ca/view/SMP0125516MetabolicThe maillard reaction pathway is a non-enzymatic reaction which outside the body happens through heating. … It normally is synthesized and accumulates with high serum glucose due to diabetes. 3-deoxyglucosone causes cell apoptosis and neurotoxicity.