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Displaying drugs 351 - 375 of 14417 in total

Isocarboxazid

Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor. It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic disorders. It was first introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and first FDA approved as a prescription...
Approved
Matched Description: … is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and ... [T115] It was first introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and …

Iodixanol

Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents.
Approved

Nialamide

Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine.
Approved
Withdrawn
Matched Description: … Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing …

Urethane

Urethane, formerly marketed as an inactive ingredient in Profenil injection, was determined to be carcinogenic and was removed from the Canadian, US, and UK markets in 1963.
Approved
Withdrawn
Matched Description: … was removed from the Canadian, US, and UK markets in 1963. ... formerly marketed as an inactive ingredient in Profenil injection, was determined to be carcinogenic and …

Maribavir

Maribavir is an inhibitor of the cytomegalovirus (CMV; HHV5) pUL97 kinase which is used to treat CMV infections in patients post-transplantation. Most standard CMV therapies, such as ganciclovir or foscarnet, target CMV DNA polymerase - while generally effective, these medications tend to promote the development of CMV resistance to DNA...
Approved
Investigational
Matched Description: … their use is often limited by toxicities like myelosuppression and renal injury. ... these medications tend to promote the development of CMV resistance to DNA polymerase-based therapies, and ... [L39327] The drug was also approved by Health Canada in September 2022 [L43262] and by European Commission …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …

Gallium citrate Ga-67

Gallium citrate Ga 67 is the citrate salt of the radioisotope gallium Ga 67. Although the mechanism is unknown, gallium Ga 67 concentrates in lysosomes and is bound to a soluble intracellular protein in certain viable primary and metastatic tumors and focal sites of inflammation, allowing scintigraphic localization. Ga-67 scintigraphy...
Approved
Matched Description: … intracellular protein in certain viable primary and metastatic tumors and focal sites of inflammation ... Although the mechanism is unknown, gallium Ga 67 concentrates in lysosomes and is bound to a soluble ... Ga-67 scintigraphy (GS) cannot differentiate between tumor and acute inflammation. [NCI Thesaurus] …

Unoprostone

Unoprostone isopropyl is a prostaglandin analogue. Ophthalmic Solution 0.15% is a synthetic docosanoid. Unoprostone isopropyl has the chemical name isopropyl (+)-(Z)-7-[(1R,2R,3R,5S)-3,5 dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoate. The main indication of Unoprostane is treatment of glucoma.
Approved
Investigational
Matched Categories: … Antiglaucoma Preparations and Miotics …

Gadoteric acid

Gadoteric acid, commonly used in the salt form gadoterate meglumine, is a macrocyclic, ionic gadolinium-based contrast agent (GBCA). It is composed of the organic acid DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) used for its chelating properties, and gadolinium (Gd3+). Gadoterate meglumine has one of the highest thermodynamic stability, apparent stability, and kinetic stability,...
Approved
Matched Description: … associated tissues in adult and pediatric patients (2 years of age and older) to detect and visualize ... areas with disruption of the blood-brain barrier (BBB) and/or abnormal vascularity. ... DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) used for its chelating properties, and …

Iomeprol

Iomeprol has been investigated for the diagnostic of Coronary Artery Disease.
Approved
Investigational

Mandelic acid

Mandelic acid is an approved aromatic, alpha hydroxy acid . Mandelic acid is used as an ingredient in cosmetics and drug products applied topically.
Approved
Matched Description: … Mandelic acid is used as an ingredient in cosmetics and drug products applied topically. …
Matched Categories: … Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …

Sodium feredetate

Approved
Matched Categories: … Blood and Blood Forming Organs …

Pentetic acid

Pentetic acid, also known as diethylenetriaminepentaacetic acid (DTPA), is a synthetic polyamino carboxylic acid with eight coordinate bond forming sites that can sequester metal ions and form highly stable DTPA-metal ion complexes. DTPA, along with its calcium and zinc trisodium salts, are the only FDA approved agents for the treatment...
Approved
Matched Description: … [L2242] DPTA was developed by the pharmaceutical company CIS US and FDA approved on April 14, 2004. ... DTPA, along with its calcium and zinc trisodium salts, are the only FDA approved agents for the treatment ... synthetic polyamino carboxylic acid with eight coordinate bond forming sites that can sequester metal ions and …

Chromium gluconate

Approved

Edetate disodium anhydrous

Edetate disodium anhydrous is a polyvalent chelating agent used to treat hypercalcemia and digitalis toxicity associated ventricular arrhythmias.
Approved
Vet approved
Matched Description: … Edetate disodium anhydrous is a polyvalent chelating agent used to treat hypercalcemia and digitalis …

Cabergoline

Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Approved
Matched Description: … It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. ... Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. …
Matched Categories: … Ergot Alkaloids and Derivatives ... Genito Urinary System and Sex Hormones …

Travoprost

Travoprost is a synthetic isopropyl ester prodrug of a prostaglandin F2alpha (F2α) analogue and selective FP prostanoid receptor agonist. It is used to decrease intraocular pressure in open-angle glaucoma and ocular hypertension. Unlike other prostaglandin analogues, travoprost demonstrates full agonism and high selectivity at the prostanoid receptor, reporting a higher...
Approved
Matched Description: … It is used to decrease intraocular pressure in open-angle glaucoma and ocular hypertension. ... Travoprost is a synthetic isopropyl ester prodrug of a prostaglandin F2alpha (F2α) analogue and selective ... [L49434] Unlike other prostaglandin analogues, travoprost demonstrates full agonism and high selectivity …
Matched Categories: … Antiglaucoma Preparations and Miotics …

Stavudine

A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
Approved
Investigational
Matched Description: … A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. …
Matched Categories: … stavudine and lamivudine ... stavudine, lamivudine and nevirapine ... Nucleic Acids, Nucleotides, and Nucleosides ... Nucleoside and Nucleotide Reverse Transcriptase Inhibitors …

Leucovorin

Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. In vitro, the...
Approved
Matched Description: … Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary ... activity, the two commercially available forms have been shown to be pharmacokinetically identical and ... As folate analogs, leucovorin and levoleucovorin are both used to counteract the toxic effects of folic …
Matched Categories: … Enzymes and Coenzymes ... Folic Acid and Derivatives …

Cyclopentolate

A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.
Approved
Matched Categories: … Mydriatics and Cycloplegics …

Auranofin

Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme oxygenase 1 is...
Approved
Investigational
Matched Description: … Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and …
Matched Categories: … Antiinflammatory and Antirheumatic Products …

Hydroxyurea

Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, hydroxyurea...
Approved
Matched Description: … adherence, the need for therapeutic monitoring, and serious side effects of secondary cancer and birth ... conditions exists, hydroxyurea is used sparingly in clinical settings, largely due to lack of knowledge and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Dinoprost tromethamine

The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. Dinoprost tromethamine may also be known as dinoprost trometamol, PGF2 alpha THAM, or prostaglandin F2 alpha tromethamine.
Approved
Vet approved

Iodipamide

Iodipamide is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.
Approved
Matched Description: … Iodipamide is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography …

Tafluprost

A prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Chemically, tafluprost is a fluorinated analog of prostaglandin F2-alpha. Tafluprost was approved for use in the U.S. on February 10, 2012.
Approved
Matched Description: … prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and …
Matched Categories: … Antiglaucoma Preparations and Miotics …

Inositol nicotinate

Inositol nicotinate, also known as Inositol hexaniacinate/hexanicotinate or "no-flush niacin", is a niacin ester and vasodilator. It is used in food supplements as a source of niacin (vitamin B3), where hydrolysis of 1 g (1.23 mmol) inositol hexanicotinate yields 0.91 g nicotinic acid and 0.22 g inositol. Niacin exists in...
Approved
Withdrawn
Matched Description: … nicotinate, also known as Inositol hexaniacinate/hexanicotinate or "no-flush niacin", is a niacin ester and ... Niacin exists in different forms including nicotinic acid, nicotinamide and other derivatives such as ... vitamin B3), where hydrolysis of 1 g (1.23 mmol) inositol hexanicotinate yields 0.91 g nicotinic acid and …
Matched Categories: … Nicotinic Acid and Derivatives …
Displaying drugs 351 - 375 of 14417 in total