Tumor Suppressor Proteins

Name
Tumor Suppressor Proteins
Accession Number
DBCAT003114
Description

Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.

Drugs
DrugDrug Description
IsoxaflutoleBalance has been investigated for the treatment of Chronic Renal Failure and Peritoneal Membrane Disorder.
ErdafitinibA fibroblast growth factor receptor tyrosine kinase inhibitor used to treat locally advanced or metastatic urothelial carcinoma.
TAK-448TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.
Kisspeptin-10Kisspeptin-10 is under investigation in clinical trial NCT03771326 (KP-10 and Insulin Secretion in Men).
Drugs & Drug Targets
DrugTargetType
ErdafitinibCytochrome P450 2C9enzyme
ErdafitinibCytochrome P450 3A4enzyme
ErdafitinibFibroblast growth factor receptor 1target
ErdafitinibFibroblast growth factor receptor 2target
ErdafitinibFibroblast growth factor receptor 3target
ErdafitinibFibroblast growth factor receptor 4target
ErdafitinibP-glycoprotein 1transporter
ErdafitinibSolute carrier family 22 member 2transporter
ErdafitinibRET proto-oncogenetarget
ErdafitinibMacrophage colony-stimulating factor 1 receptortarget
ErdafitinibPlatelet-derived growth factor receptor alphatarget
ErdafitinibPlatelet-derived growth factor receptor betatarget
ErdafitinibMast/stem cell growth factor receptor Kittarget
ErdafitinibVascular endothelial growth factor receptor 2target
Erdafitinibalpha1-acid glycoproteincarrier