Hemophilia B (DBCOND0001612)

Identifiers

Synonyms
Christmas Disease / Haemophilia B / Hemophilia Bs / Bs, Hemophilia / Hereditary factor IX deficiency / Factor IX deficiency (disorder) / Factor IX deficiency / Congenital factor IX disorder / Hemophilia B (disorder) / Hemophilia B (Factor IX) / Haemophilia B (Factor IX) / Christmas disease (Factor IX)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Albutrepenonacog alfa
A recombinant Factor IX fused to recombinant human albumin used to treat hemophilia B.
Coagulation Factor IX (Recombinant)
A form of recombinant human coagulation Factor IX used to treat hemophilia B.
Coagulation factor VIIa Recombinant Human
A form of recombinant human coagulation Factor VII used to treat hemophilia A and B.
Etranacogene dezaparvovec
An adeno-associated virus vector-based gene therapy used for the treatment of hemophilia B (congenital factor IX deficiency).
No drug targets
Factor IX Complex (Human)
A Factor IX complex used to prevent and treat bleeding episodes in hemophilia B or vitamin K antagonist therapy.
No drug targets
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04106323
A Study of Factor Inhibitors in Adult Patients With Hemophilia and Von Willebrand's Disease in Upper EgyptNo drug interventionsNot AvailableNot Availableunknown_status
NCT03055611
A Study to Evaluate the Real-world Usage and Effectiveness of Elocta and Alprolix in Patients With Haemophilia A or BNot AvailableNot Availablecompleted
NCT06285071
Post-Marketing Surveillance (All Case Surveillance) on Treatment With Alhemo® in Patients With Haemophilia A or Haemophilia B With InhibitorsNot AvailableNot Availableenrolling_by_invitation
NCT01562587
Pharmacokinetics of Single Bolus Dose of NovoSeven® in Paediatric and Adult Patients With Haemophilia A or B in a Non- Bleeding Statetreatment1completed
NCT03875547
Post-marketing Surveillance (Use Result Surveillance) With Refixia®Not AvailableNot Availableenrolling_by_invitation
NCT00956345
Safety of 40K Pegylated Recombinant Factor IX in Non-Bleeding Patients With Haemophilia Btreatment1completed
NCT02263456
A Study to Compare the Pharmacokinetics and Safety of Replenine®-VF, Replenine® or Other Factor IX in Haemophilia Btreatment3completed
NCT01988532
Impact of Pain on Functional Impairment and Quality of Life in Adults With HemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT01272206
Investigating Safety and Pharmacokinetics of NNC 0128-0000-2011 Compared to NNC 0128-0000-2021 in Healthy Male SubjectsNo drug interventionstreatment1completed
NCT01555749
Investigation of the Pharmacokinetics of NNC172-2021, at Two Different Dose Levels, in Healthy Japanese SubjectsNo drug interventionstreatment1completed
NCT02300519
Thrombin Generation Numerical Models Validation in Haemophilic CaseNo drug interventionsNot AvailableNot Availablecompleted
NCT05365217
A Research Study Investigating Nonacog Beta Pegol (N9-GP) for Treatment and Prevention of Bleedings in Chinese People With Haemophilia Btreatment3completed
NCT03276130
Management of Health-Related QoL Impairment, Including Pain, Depression and Anxiety, in People With Haemophilia A and BNo drug interventionsNot AvailableNot Availablecompleted
NCT02141074
Safety and Efficacy of Nonacog Beta Pegol (N9-GP) in Previously Untreated Patients With Haemophilia Btreatment3completed
NCT03660774
A Study of the Impact of Hemophilia and Its Treatment on Brain Development, Thinking and Behaviour in Children With HemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT00951873
A Single Dose Trial Investigating Safety and Local Tolerability of Ascending Doses of Long Acting Activated Recombinant Human Factor VII in Healthy Male Volunteerstreatment1completed
NCT02250560
A Study to Investigate the Safety and Efficacy of Replenine®-VF in Haemophilia B Patients Undergoing Major Surgery.Not Available3completed
NCT00922792
Safety and Mode of Action of a Single Dose and Multiple Doses of Long Acting Activated Recombinant Human Factor VII in Patients With Haemophilia A and Btreatment1completed
NCT01949792
A Trial Investigating the Pharmacokinetics and Pharmacodynamics of rFVIIa in Patients With Haemophilia A or B With or Without Inhibitorstreatment1completed
NCT02231944
An Open Study to Investigate the Safety and Efficacy of Replenine®-VF in Severe Haemophilia B Patientstreatment3completed
NCT01503567
Epidemiological Study on Haemophilia Care and Orthopaedic Status in Developing CountriesNo drug interventionsNot AvailableNot Availablecompleted
NCT01228669
Safety of NNC 0172-0000-2021 in Healthy Male Subjects and Subjects With Haemophilia A or BNo drug interventionstreatment1completed
NCT01395810
Safety and Efficacy of NNC-0156-0000-0009 After Long-Term Exposure in Patients With Haemophilia B: An Extension to Trials NN7999-3747 and NN7999-3773treatment3completed
NCT03741881
A Study Following People With Haemophilia A and B, With or Without Inhibitors, When on Usual Treatment (Explorer™6)No drug interventionsNot AvailableNot Availablecompleted
NCT02568202
Bridging Hemophilia B Experiences, Results and Opportunities Into Solutions (B-HERO-S)No drug interventionsNot AvailableNot Availablecompleted
NCT01234545
Observational Study Describing the Usual Clinical Practice Use of NovoSeven® in the Home Treatment of Joint Bleeds in Patients With Haemophilia A or B and InhibitorsNot AvailableNot Availablecompleted
NCT01386528
Efficacy and Safety of NNC-0156-0000-0009 During Surgical Procedures in Subjects With Haemophilia Btreatment3completed
NCT01333111
Safety and Efficacy of NNC-0156-0000-0009 in Haemophilia B Patientstreatment3completed
NCT00486278
Haemophilia Patients With Inhibitors Being Treated for Acute Joint Bleedstreatment2completed
NCT05086575
Observatory of Patients With Haemophilia B Treated by IdElvion®No drug interventionsNot AvailableNot Availablerecruiting
NCT03075670
A Trial Comparing Nonacog Beta Pegol (N9-GP) and ALPROLIX® in Patients With Haemophilia Btreatment1completed
NCT02049099
A Non-interventional Retrospective Study of the Current Treatment Practice in European Haemophilia CareNo drug interventionsNot AvailableNot Availablecompleted
NCT03690336
Adverse Event Data Collection From External Registries on Nonacog Beta PegolNot AvailableNot Availableenrolling_by_invitation
NCT01220141
Observational Study on Safety of Room Temperature Stable NovoSeven® in Patients With Haemophilia A or BNot AvailableNot Availablecompleted
NCT03745924
A Study Following Males With Haemophilia B on Prophylaxis With Refixia/REBINYNNot AvailableNot Availableenrolling_by_invitation
NCT00853086
Post-marketing Safety Surveillance of NovoSeven® in Patients With Haemophilia and Inhibitors by Means of the UK Haemophilia DatabaseNot AvailableNot Availablecompleted
NCT01562457
Intra-subject Variability Following Administrations of Activated Recombinant Human Factor VII in Haemophilia Patients in a Non-bleeding Statetreatment1completed
NCT01322620
Survey Evaluating the Psychosocial Effects of Living With HaemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT02250573
An Open-study to Investigate the Safety and Efficacy of Replenine®-VF in Haemophilia B Subjects Undergoing Surgerytreatment3completed
NCT01467427
Safety, Efficacy and Pharmacokinetics of NNC-0156-0000-0009 in Previously Treated Children With Haemophilia B.treatment3completed
NCT02241694
To Quantify the Range of Main Psychosocial Factors Affecting Patients and Caregivers in Their Daily LivesNo drug interventionsNot AvailableNot Availablecompleted
NCT01288391
Investigating Safety and Pharmacokinetics of 2 Different Single Doses of NNC128-0000-2011 in Haemophilia A or B PatientsNo drug interventionstreatment1completed
NCT03655340
A Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B in FranceNot AvailableNot Availablecompleted
NCT00638001
Impact of Conservative Treatment by Custom-made Orthoses in Patients With Haemophilic Ankle ArthropathyNo drug interventionstreatment4completed
NCT02263469
A Study to Investigate the Safety and Efficacy of Replenine®-VF in Haemophilia B Patients Under the Age of 6 YearsNot Available3completed
NCT02084810
Investigating the Bioequivalence of Eptacog Alfa A 6 mg and NovoSeven® in Healthy Male Subjectstreatment1withdrawn
NCT01959555
Project to Update the Study of Congenital Haemophilia in SpainNo drug interventionsNot AvailableNot Availablecompleted
NCT04645199
National Longitudinal Cohort of Hematological DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT05932914
Liver Biopsy Following Gene Therapy For HemophiliaNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06399289
Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Chinese Subjects With Hemophilia B Previously Treated With FIX Therapyprevention3recruiting
NCT06568302
The Long-term Safety and Efficacy of SerpinPC in Subjects with Hemophilia Who Completed a Sponsored SerpinPC Clinical Trialtreatment3recruiting
NCT03307980
Long-term Safety and Efficacy Study and Dose-Escalation Substudy of PF 06838435 in Individuals With Hemophilia Btreatment2active_not_recruiting
NCT03587116
A Study to Evaluate Prospective Efficacy and Safety Data of Current FIX Prophylaxis Replacement Therapy in Adult Hemophilia B Subjects (FIX:C≤2%) or Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A Subjects (FVIII:C≤1%)No drug interventionsother3active_not_recruiting
NCT03938792
Study of the Efficacy and Safety PF-06741086 in Adult and Teenage Participants With Severe Hemophilia A or Moderately Severe to Severe Hemophilia Btreatment3active_not_recruiting
NCT05145127
Open-Label Extension Study of Marstacimab in Hemophilia Participants With or Without Inhibitorstreatment3recruiting
NCT05568719
Safety and Effectiveness of Giroctocogene Fitelparvovec or Fidanacogene Elaparvovec in Patients With Hemophilia A or B RespectivelyNo drug interventionsother3recruiting
NCT05611801
A Clinical Trial of Study Medicine (Marstacimab) in Pediatric Patients With Hemophilia A or Hemophilia Btreatment3recruiting
NCT05962398
Long-term Follow-up Study of Male Adults With Hemophilia B Previously Treated With Etranacogene Dezaparvovec (CSL222)No drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT06634836
Patient Interview Study to Explore the Impact of Gene Therapy in Hemophilia A & BNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03861273
A Study to Evaluate the Efficacy and Safety of Factor IX Gene Therapy With PF-06838435 in Adult Males With Moderately Severe to Severe Hemophilia Btreatment3active_not_recruiting
NCT04731701
Psychometric Validation of the Hemophilia Functional Ability Scoring Tool (Hemo-FAST)No drug interventionsNot AvailableNot Availablecompleted
NCT05568459
A Trial That Evaluates Disease Characteristics in Hemophilia B Adult Male Participants Receiving Prophylaxis With Standard of Care Factor IX Protein (FIX) Replacement TherapyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05605678
Hemophilia Non-Interventional Study Prior to SerpinPC Intervention (PRESent-5)No drug interventionsNot AvailableNot Availablerecruiting
NCT05789524
The Efficacy and Safety of SerpinPC in Participants With Severe Hemophilia A or Moderately Severe to Severe Hemophilia Btreatment2recruiting
NCT05789537
A Study of SerpinPC in Participants with Hemophilia B (HemB) with Inhibitorstreatment2recruiting
NCT06025552
Study of TU7710 in Warfarin Anti-coagulated Healthy Male SubjectsNo drug interventionstreatment1completed
NCT06611436
BeCoMe-9: a Clinical Study of BE-101 for the Treatment of Adults with Moderately Severe or Severe Hemophilia BNo drug interventionstreatment1 / 2not_yet_recruiting
NCT06349473
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B)No drug interventionstreatment1recruiting
NCT06379789
A Trial to Learn if REGV131-LNP1265 is Safe and Works to Help the Body Make Clotting Factor in Pediatric, Adolescent and Adult Patients With Hemophilia BNo drug interventionstreatment1 / 2recruiting
NCT00195221
Study to Describe the Allergic Reactions to Factor IX in Patients With Hemophilia BNo drug interventionsNot AvailableNot Availablecompleted
NCT03327779
World Bleeding Disorders RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT01286779
BAX 326 (rFIX) Continuation Studytreatment3completed
NCT00768287
Study of Recombinant Factor IX Product, IB1001, in Subjects With Hemophilia Bsupportive_care2 / 3completed
NCT05889754
Reliability and Validity of the Turkish Version of the PedHALNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03091751
Efficacy and Safety of AlphaNine Versus BeneFIX in Patients With Severe Hereditary Haemophilia Btreatment2completed
NCT05441553
A Study to Evaluate the Safety and Efficacy of VGB-R04 in Adult Hemophilia B PatientsNo drug interventionstreatment1 / 2not_yet_recruiting
NCT02807753
The Hemophilia Ultrasound ProjectNo drug interventionsNot AvailableNot Availableterminated
NCT03186677
Dose-escalation Study to Investigate the Safety, PK, and PD of ISU304/CB2679d in Hemophilia B Patientstreatment1completed
NCT05980377
Patterns of Hemophilia Care in Assiut Children PatientsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01460147
Osteoporosis and MRI Study in HemophiliaNo drug interventionsdiagnosticNot Availableterminated
NCT03417245
A Study of Fitusiran (ALN-AT3SC) in Severe Hemophilia A and B Patients Without Inhibitorstreatment3completed
NCT00936845
Females With Severe or Moderate Hemophilia A or B: A Multi-Center StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT02035605
A Phase 1 Study of an Investigational Drug, ALN-AT3SC, in Healthy Volunteers and Hemophilia A or B Patientstreatment1completed
NCT03185897
Global Epidemiologic Study of Preexisting Immunity to AAV in Adults With Severe HemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT01335061
Study To Compare On-Demand Treatment To A Prophylaxis Regimen Of BeneFIX In Subjects With Moderately Severe to Severe Hemophilia Btreatment3completed
NCT02048111
Study of Recombinant Factor IX Product, IB1001, in Previously Treated Subjects With Hemophilia Bsupportive_care3withdrawn
NCT00947193
Study of Ataluren (PTC124) in Hemophilia A and Btreatment2terminated
NCT00093171
Study Evaluating rFIX; BeneFIX® in Hemophilia BNo drug interventionstreatment3completed
NCT02336178
Safety and Efficacy of Benefix in Patients With Hemophilia B in Usual Care Settings in Chinatreatment4completed
NCT02392156
Fc factOrs and Real-World hemophiliA Patient-ReporteD OutcomesNot AvailableNot Availableterminated
NCT00484185
Post Marketing Surveillance To Observe Safety and Efficacy Of BeneFIX In Patients With Hemophilia BNot AvailableNot Availablecompleted
NCT02618915
Safety and Dose Finding Study of DTX101 (AAVrh10FIX) in Adults With Moderate/Severe to Severe Hemophilia BNo drug interventionstreatment1 / 2terminated
NCT03565237
RIXUBIS PMS India (RIXUBIS PMS)prevention4completed
NCT05152732
Safety and Tolerability of VGB-R04 in Patients With Haemophilia BNo drug interventionstreatment0recruiting
NCT00212459
The Effect of Patient Counseling on Adolescent Hemophilia Patient Compliance With Bleeding LogsNo drug interventionsNot AvailableNot Availablecompleted
NCT05439642
Validation and Reliability of the CHO-KLAT in TurkishNo drug interventionsdiagnosticNot Availableunknown_status
NCT02396342
Trial of AAV5-hFIX in Severe or Moderately Severe Hemophilia BNo drug interventionstreatment1 / 2completed
NCT05360706
Study of AAV5-hFIX in Severe or Moderately Severe Haemophilia BNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00866606
Study Evaluating On-Demand Treatment With BeneFIX In Chinese Subjectstreatment3completed
NCT05879549
Comparison of Efficiency of Closed Kinetic Chain Exercises Versus Proprioceptive Exercises Patient With HemophiliaNo drug interventionstreatmentNot Availablerecruiting
NCT05187936
Pre-clinical Models for Mesenchymal Stem Cell Therapy in Hemophilic ArthropathyNo drug interventionsNot AvailableNot Availableunknown_status
NCT05981313
Viscoelastic Properties of Lower Extremity Muscles in Patients With HemophiliaNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02740413
Treatment Patterns And Outcomes In Patients Treated With Benefix Or Refacto/Refacto AF - A Swedish Cohort StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT01510418
Socialization of Adult Men With Congenital Hemophilia A or BNo drug interventionsNot AvailableNot Availablecompleted
NCT02199717
An Institutional Pilot Study to Investigate Physical Activity Patterns in Boys With HemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT06158334
Study of Surgical Practices in Patients With Haemophilia A or B Treated With an Extended Half-life Recombinant Factor VIII-Fc or IX-Fc (ELOCTA®, ALPROLIX®)Not AvailableNot Availablerecruiting
NCT00716716
Phase I/IIa Study of FIXFc in Hemophilia B Patientstreatment1completed
NCT01507896
BAX 326 Surgery Study in Hemophilia B Patientstreatment3completed
NCT04394286
A Phase 1/2 Study of SHP648, an Adeno-Associated Viral Vector for Gene Transfer in Hemophilia B SubjectsNo drug interventionstreatment1 / 2terminated
NCT01361126
A Safety and Efficacy Study of a Recombinant Factor IX in Patients With Severe Hemophilia Btreatment1 / 2completed
NCT00581126
Study Evaluating BENEFIX in Previously Treated Patients With Hemophilia Btreatment4completed
NCT01496274
A Safety and Efficacy Study of a Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Patients With Hemophilia BNo drug interventionstreatment2 / 3completed
NCT06120582
Study of the Safety, Pharmacodynamics and Efficacy of ANB-002 in Patients With Hemophilia B (SAFRAN)No drug interventionstreatment1 / 2recruiting
NCT03507582
Virtual Reality for HemophiliaNo drug interventionsotherNot Availablecompleted
NCT01662531
A Safety, Efficacy and Pharmacokinetics Study of a Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Children With Hemophilia BNo drug interventionstreatment3completed
NCT01154231
BeneFIX Drug Use Results Survey [All-Case Surveillance]Not AvailableNot Availablecompleted
NCT00749476
Study Evaluating BeneFIX in Patients With Haemophilia B, Previously Treated With Plasma Derived Factor IXNot Available4completed
NCT03489291
Dose Confirmation Trial of AAV5-hFIXco-PaduaNo drug interventionstreatment2completed
NCT03569891
HOPE-B: Trial of AMT-061 in Severe or Moderately Severe Hemophilia B Patientstreatment3active_not_recruiting
NCT03818529
ATHN 8: Previously Untreated Patients (PUPs) Matter StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT02484092
A Gene Therapy Study for Hemophilia Btreatment2completed
NCT00927992
Study Evaluating Liver Transplantation in Haemophilia Patients in SpainNo drug interventionsNot AvailableNot Availablecompleted
NCT01233440
Safety and Pharmacokinetic Study of a Recombinant Coagulation Factor IX Albumin Fusion Protein in Subjects With Hemophilia Btreatment1completed
NCT05606640
Gaining Insight Into the Complexity of Pain in Patients With HaemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT03533504
Web Accessible Population Pharmacokinetics Service - Hemophilia: Sources of VariabilityNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT02061072
Web-based Application for the Population Pharmacokinetic Service - Phase 1No drug interventionsNot AvailableNot Availablecompleted
NCT01271868
Study of Recombinant Factor IX Product, IB1001, in Previously Treated Pediatric Subjects With Hemophilia Btreatment3terminated
NCT00835068
Post Marketing Observational Study of Reformulated BeneFIXNo drug interventionsNot AvailableNot Availablecompleted
NCT02571569
A Single Escalating Dose and Multiple Dose Study of BAY 1093884 in Subjects With Severe Hemophilia Types A or B, With or Without Inhibitorsbasic_science1completed
NCT02971969
Long-Term Safety, Tolerability, and Efficacy of DTX101 (AAVrh10FIX) in Adults With Moderate/Severe to Severe Hemophilia BNo drug interventionsNot AvailableNot Availablecompleted
NCT00936312
Females With Severe or Moderate Hemophilia A or B: an International Multi-center StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT00515710
LTFU for Gene Transfer Subjects With Hemophilia BNo drug interventionsNot AvailableNot Availablecompleted
NCT02234310
Study to Determine the Safety and Efficacy of rFIXFc in Previously Untreated Males With Severe Hemophilia Btreatment3completed
NCT05641610
A Study to Evaluate the Safety and Efficacy of ZS801 in Adult Hemophilia B PatientsNo drug interventionstreatment1 / 2not_yet_recruiting
NCT06565481
Measurement Properties in People With HemophiliaNo drug interventionsotherNot Availablenot_yet_recruiting
NCT06147414
Development of Non-Invasive Prenatal Diagnosis for Single Gene DisordersNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01921855
Study of FVIIa Variant BAY86-6150 (B0189) in Subjects With Moderate or Severe Hemophilia Types A or B With or Without Inhibitorstreatment1completed
NCT02213250
An Open-Label, Single Dose Pharmacokinetic Study of Benefix (Recombinant Factor IX) in Male Chinese Subjects With Hemophilia Btreatment1completed
NCT03655223
Early Check: Expanded Screening in NewbornsNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT01687608
Open-Label Single Ascending Dose of Adeno-associated Virus Serotype 8 Factor IX Gene Therapy in Adults With Hemophilia Btreatment1 / 2active_not_recruiting
NCT02912143
German Pediatric Hemophilia Research DatabaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT03961243
Lentiviral FIX Gene TherapyNo drug interventionstreatment1unknown_status
NCT03641703
A Long-Term Follow-Up Study of Haemophilia B Patients Who Have Undergone Gene Therapytreatment1 / 2terminated
NCT00851721
Efficacy and Safety Study of Prophylactic Versus On-Demand Treatment With Feiba NF in Subjects With Hemophilia A or B and a High Titer Inhibitortreatment3completed
NCT03417102
A Study of Fitusiran (ALN-AT3SC) in Severe Hemophilia A and B Patients With Inhibitorstreatment3completed
NCT03995784
Study of Next-Generation Recombinant Factor IX Variant in Adult Subjects With Hemophilia Btreatment2completed
NCT03946384
Mutation p.Ile112Thr : Discrepancy Between Factor IX Level and Bleeding PhenotypeNo drug interventionsNot AvailableNot Availableunknown_status
NCT05203679
Evaluation of the Safety and Efficacy of Hemophilia B Gene Therapy DrugNo drug interventionstreatment3active_not_recruiting
NCT06003387
Efficacy and Safety of CSL222 (Etranacogene Dezaparvovec) Gene Therapy in Adults With Hemophilia B With Pretreatment Adeno-associated Virus Serotype 5 (AAV5) Neutralizing Antibodies (Nabs)No drug interventionsprevention3recruiting
NCT02061033
Global Hemostatic Methods in Hemophilia and Von Willebrand's DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT04272554
AAV Gene Therapy Screening/Observational Protocol (ECLIPSE)No drug interventionsNot AvailableNot Availablecompleted
NCT05630651
The Efficacy and Safety of ZS801 in Chinese Hemophilia B Patients.No drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03615053
Personalized Medicine for Canadians With HemophiliaNo drug interventionsotherNot Availablerecruiting
NCT05044845
Needs Assessment of Knowledge, Beliefs, and Attitudes of Patients With Hemophilia B About Gene TherapyNo drug interventionsNot AvailableNot Availablerecruiting
NCT04073498
The Safety and Tolerability of SerpinPC in Healthy Men and in Men With Severe Blood Disorders (Haemophilia A and B)treatment1 / 2active_not_recruiting
NCT00824798
Gait Evaluation in Haemophiliac PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT01757405
Recombinant Factor VIIa BI (rFVIIa BI) Treatment of Acute Bleeding Episodes Per an On-demand Regimentreatment3completed
NCT05442528
Lead-in Study of VGB-R04 Gene Therapy for Hemophilia B-- An Observational Survey Analysis StudyNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00139828
Post Marketing Study in Haemophilia B Patients Using Nonafact® (Human Coagulation Factor IX)treatment4completed
NCT02418793
A Study of a Long-Acting r-Factor 7a (Factor VIIa) in Adult Men With Hemophilia A or Btreatment1completed
NCT05164471
Phase 1/2 Dose Confirmation Study of FLT180a in Hemophilia BNo drug interventionsother1 / 2terminated
NCT04628871
Long Term Follow-up (LTFU) of Subjects Who Received SB-318, SB-913, or SB-FIXNot AvailableNot Availableactive_not_recruiting
NCT05709288
Gene Therapy for Hemophilia B Patients Aged 12-18 Years Oldtreatment1recruiting
NCT02938156
UK - EHL Outcomes RegistryNo drug interventionsNot AvailableNot Availableunknown_status
NCT00714415
Registry For Patients Treated With BeneFix In Usual Care Setting In GermanyNot AvailableNot Availablecompleted
NCT04072237
Study of Coagulation Faction VIIa Variant Marzeptacog Alfa (Activated) in Adult Subjects With HemophiliaNo drug interventionsdiagnostic1completed
NCT04135300
Gene Therapy for Chinese Hemophilia BNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT04541875
Medication Adherence and Non-adherence in Adults With Rare DiseaseNo drug interventionsNot AvailableNot Availablewithdrawn
NCT01090206
Correlation Between Vitamin D Status and Bone Mineral Density in Patients With HemophiliaNo drug interventionsscreeningNot Availablecompleted
NCT02190149
Study of Prophylaxis, ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated With ADVATE or RIXUBISNot AvailableNot Availablecompleted
NCT03358836
Joint Health StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT02634918
Ultrasonography in Hemophilic Joint Disease and Serum MarkersNo drug interventionsNot AvailableNot Availablecompleted
NCT03248141
Understanding Hemophilia A and B Drug Dosage Administration PatternsNo drug interventionsNot AvailableNot Availableterminated
NCT05804734
Vitamin K Antagonist Versus Direct Oral Anticoagulant Treatments in HemophiliaNot AvailableNot Availablecompleted
NCT01589848
Study on Von Willebrand Disease and Hemophilia in Cuenca, EcuadorNo drug interventionsNot AvailableNot Availablecompleted
NCT00037557
Study Evaluating rFIX; BeneFIX in Severe Hemophilia Btreatment3completed
NCT00076557
Safety of a New Type of Treatment Called Gene Transfer for the Treatment of Severe Hemophilia BNo drug interventionstreatment1 / 2terminated
NCT05856266
An 18-month Low-interventional Study to Assess Joint Health in Haemophilia A and B Patients on Prophylaxis With Efmoroctocog Alfa or Eftrenonacog AlfaNo drug interventionsother4terminated
NCT05687474
Baby Detect : Genomic Newborn ScreeningNo drug interventionsNot AvailableNot Availablerecruiting
NCT06014320
Alterations in Coagulation Factor Levels in Patients With End Stage Liver DiseaseNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00364182
Study Comparing On-Demand Treatment With Two Prophylaxis Regimens Of BeneFIX In Patients With Severe Hemophilia Bprevention3completed
NCT02937831
RIXUBIS Drug Use-Result Survey (Japan)Not AvailableNot Availablecompleted
NCT02922231
Post-Marketing Surveillance (Usage Results Study) of RIXUBIS in Adult and Pediatric Patients With Haemophilia B in South KoreaNot AvailableNot Availablecompleted
NCT02554773
An Open-label Extension Study of an Investigational Drug, Fitusiran, in Patients With Moderate or Severe Hemophilia A or Btreatment1 / 2completed
NCT00167973
Prospective Registry of European Hemophilia B Patients Receiving BeneFIX® for Usual UseNo drug interventionsNot AvailableNot Availablecompleted
NCT05487976
Clinical Study of Recombinant Human Activated Coagulation Factor VII for Injection in Patients With Hemophilia With Inhibitortreatment3unknown_status
NCT02695160
Ascending Dose Study of Genome Editing by Zinc Finger Nuclease Therapeutic SB-FIX in Subjects With Severe Hemophilia Btreatment1terminated
NCT01488994
BAX 326 Pediatric Studytreatment2 / 3completed
NCT03855280
Evaluation of a Recombinant Factor IX Product, APVO101, in Previously-Treated Pediatric Patients With Hemophilia Btreatment3completed
NCT02402829
A Study Comparing Factor Level and Inhibitor Titer Testing Results Drawn From Central Venous Lines and VenipunctureNo drug interventionsNot AvailableNot Availableterminated
NCT03054389
Non-Interventional Study to Capture the Patient Experience on Gene Therapy for Hemophilia Within the AskBio009-101 Study Through Patient and Investigator InterviewsNo drug interventionsNot AvailableNot Availablecompleted
NCT02053792
A Safety and Efficacy Extension Study of a Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Patients With Hemophilia BNo drug interventionstreatment3completed
NCT03369444
A Factor IX Gene Therapy Study (FIX-GT)treatment1 / 2terminated
NCT00004801
Phase I/II Study of Monoclonal Factor IX Concentrate for Factor IX Deficiencytreatment1 / 2completed
NCT01620801
Hemophilia B Gene Therapy With AAV8 Vectortreatment1terminated
NCT01748201
Viscosupplementation in Patients With Hemophilic ArthropathyNo drug interventionstreatment4completed
NCT01440946
Study of Recombinant Coagulation Factor IX Fc Fusion Protein, BIIB029, in Previously Treated Pediatric Participants With Hemophilia Btreatment3completed
NCT01174446
Pivotal Study (Pharmacokinetics, Efficacy, Safety) of BAX 326 (rFIX) in Hemophilia B Patientstreatment3completed
NCT04286412
Nonacog Alfa Prophylaxis And Treatment Of Bleeding Episodes In Previously Treated Patients With Hemophilia Btreatment4completed
NCT00093210
Study Evaluating of Recombinant Human Factor IX (BeneFIX) and a New Formulation of BeneFIX (rFIX-R) in Moderate to Severe Hemophilia BNo drug interventionstreatment3completed
NCT01128881
IMMUNINE Pre-Treatment Studytreatment4completed
NCT00244114
Study Evaluating Allergic Reactions To Benefix In Hemophilia B PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT03901755
An International Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia BNot AvailableNot Availableactive_not_recruiting
NCT01217255
Comparing the Burden of Illness of Hemophilia in the Developing and the Developed WorldNo drug interventionsNot AvailableNot Availablecompleted
NCT00979238
Dose-Escalation Study Of A Self Complementary Adeno-Associated Viral Vector For Gene Transfer in Hemophilia BNo drug interventionsother1active_not_recruiting
NCT06008938
An Observational Cohort Study to Characterize the Effectiveness and Safety of HEMGENIX® in Patients With Hemophilia BNot AvailableNot Availablerecruiting
NCT00581438
Study Evaluating Approach to Treatment of Haemophilia A and B in SpainNo drug interventionsNot AvailableNot Availablecompleted