Cutaneous Leishmaniasis (DBCOND0028439)

Identifiers

Synonyms
Leishmaniasis, Cutaneous / Cutaneous leishmaniasis / Cutaneous leishmaniasis (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Miltefosine
An antileishmanial agent used to treat leishmaniasis, a group of disease caused by parasites of the Leishmania type.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00111553
Study to Evaluate the Leish-111F + MPL-SE Vaccine in the Treatment of Cutaneous LeishmaniasisNo drug interventionstreatment1completed
NCT03303898
ASYMPTOMATIC CARRIER OF LEISHMANIA INFANTUM, MEDISERRANEAN VISCERAL LEISHMANIOSIS AGENT: STUDY OF IMMUNE RESPONSE -No drug interventionsotherNot Availablecompleted
NCT03445897
Miltefosine Plus IL Pentamidine for Bolivian CLtreatment2completed
NCT00480883
Treatment of Cutaneous Leishmaniasis With Meglumine Antimoniate Versus Meglumine Antimoniate and AllopurinoltreatmentNot Availablecompleted
NCT03294161
Fourth-generation Immucillin Derivative DI4G Associated Therapy in Cutaneous Leishmaniasistreatment2completed
NCT03762070
Evaluation of a Diagnostic Device, CL Detect™ Rapid Test, for the Diagnosis of Cutaneous Leishmaniasis in PeruNo drug interventionsNot AvailableNot Availableunknown_status
NCT05708625
Intralesional Voriconazole, or Intralesional Cryotherapy, or Oral Doxycycline in the Treatment of Cutaneous Leishmaniasistreatment3recruiting
NCT04888130
Investigation of an Outbreak Situation of Cutaneous Leishmaniasis Among Military Personnel in French Guiana (CEFELEISH)No drug interventionsNot AvailableNot Availablecompleted
NCT04072874
Evaluation of the Safety and Clinical Activity of Curaleish in the Topical Treatment of Cutaneous Leishmaniasis.No drug interventionstreatment1 / 2withdrawn
NCT01140191
Safety, Efficacy, and PK of Topical Paromomycin/Gentamicin Cream for Treatment of Cutaneous Leishmaniasistreatment2terminated
NCT00469495
Antihelminthic Therapy Combined With Antimony in the Treatment of Cutaneous LeishmaniasistreatmentNot Availablecompleted
NCT03999970
A Clinical Study to Develop an Uninfected Sand Fly Biting ProtocolNo drug interventionsotherNot Availablecompleted
NCT03969134
A Study to Assess the Safety, Efficacy and Immunogenicity of Leishmania Vaccine ChAd63-KH in PKDLNo drug interventionstreatment2completed
NCT01641796
Paromomycin for Individuals With Uncomplicated Cutaneous LeishmaniasisNot AvailableNot Availableno_longer_available
NCT00508963
Compassionate Use of Sodium Stibogluconate (Pentostam) for Cutaneous and Mucocutaneous New World LeishmaniasisNot AvailableNot Availableno_longer_available
NCT04841239
Development of Topical Herbal Formulations for Treatment of Cutaneous LeishmaniasisNo drug interventionstreatmentNot Availablecompleted
NCT03096457
Topical Paromomycin for Cutaneous Leishmaniasis in Boliviatreatment2 / 3completed
NCT01032382
Safety, Efficacy and Pharmacokinetics (PK) Study of WR 279,396 Versus Paromomycin for Treatment of Cutaneous Leishmaniasis (Peru-PK)treatment2completed
NCT01083576
Pharmacokinetics, Safety, and Efficacy Trial of WR 279,396 (Paromomycin + Gentamicin Topical Cream) and Paromomycin Topical Cream for the Treatment of Cutaneous Leishmaniasis in Panamatreatment2completed
NCT05094908
Arnica Tincture Fot the Treatment of Cutaneous Leishmaniasistreatment1recruiting
NCT02894008
A Study of a New Leishmania Vaccine Candidate ChAd63-KHNo drug interventionstreatment2completed
NCT02979002
Accuracy of a Rapid Diagnostic Test for Cutaneous Leishmaniasis in MoroccoNo drug interventionsNot AvailableNot Availablecompleted
NCT00344084
Surveillance for Leishmaniasis Skin Lesions in MaliNo drug interventionsNot AvailableNot Availablecompleted
NCT03023111
Miltefosine and GM-CSF in Cutaneous Leishmaniasistreatment3completed
NCT01011309
A Study of the Efficacy and Safety of the LEISH-F2 + MPL-SE Vaccine for Treatment of Cutaneous Leishmaniasistreatment2completed
NCT00840359
Study of the Efficacy of Daylight Activated Photodynamic Therapy in the Treatment of Cutaneous LeishmaniasisNo drug interventionstreatment2unknown_status
NCT01790659
Phase 3 Study of Walter Reed (WR) 279,396 and Paromomycin Alone for the Treatment of Cutaneous Leishmaniasis in Panamatreatment3completed
NCT01300975
Intralesional Antimony for Bolivian Cutaneous Leishmaniasistreatment2completed
NCT00703924
Topical Treatment of Cutaneous Leishmaniasis With WR 279,396: A Phase 2 Study in the Old Worldtreatment2completed
NCT01661296
Efficacy of Radio-frequency Induced Heat (RFH)Therapy in Treatment of Cutaneous Leishmaniasis in Indiatreatment4completed
NCT00737386
Frequency of Parasite Infection in Hyraxes and Sandflies During Outbreak of Leishmania Tropica Epidemic in The West BankNo drug interventionsNot AvailableNot Availableunknown_status
NCT00351520
Efficacy Trial on Oral Miltefosine in Comparison With Glucantime in the Treatment of ACL Caused by L. TropicaNo drug interventionstreatment3completed
NCT01845727
Topical 3% Amphotericin B Cream for the Treatment of Cutaneous Leishmaniasis in Colombiatreatment1 / 2completed
NCT00606580
Phase 3 Study to Evaluate WR 279,396 vs. Paromomycin Alone to Treat Cutaneous Leishmaniasis (in Tunisia)treatment3completed
NCT00317629
Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasistreatment3terminated
NCT01380301
Treatment of Cutaneous Leishmaniasis With a Combination of Miltefosine and Antimonytreatment2terminated
NCT01494350
WR 279,396 Open Label Treatment Protocol in Tunisiatreatment2terminated
NCT00487253
Oral Miltefosine for the Treatment of Pediatric Cutaneous Leishmaniasis in Colombiatreatment3unknown_status
NCT00884377
Local Heat Therapy Versus Sodium Stibogluconate for the Treatment of Cutaneous Leishmaniasistreatment2completed
NCT01050777
Efficacy of Topical Liposomal Form of Drugs in Cutaneous Leishmaniasissupportive_care0completed
NCT00233545
Miltefosine to Treat Cutaneous Leishmaniasis in Boliviatreatment2completed
NCT00471705
Efficacy and Safety of Miltefosine or Thermotherapy for Cutaneous Leishmaniasis in Colombia.treatment3completed
NCT04699383
Documentation of Patient Outcomes for SSG/Allopurinol Combination Treatment in EthiopiaNot AvailableNot Availablecompleted
NCT00973128
Reduced Doses of Antimony Plus Ranulocyte Monocyte Colony Stimulating Factor (GM-CSF) for Cutaneous Leishmaniasistreatment2completed
NCT04340128
Efficacy of Intra-lesional Injections of Glucantime Once a Week or Twice a Week in the Treatment of Anthroponotic Cutaneous Leishmaniasis (ACL)treatment3completed
NCT02687971
Thermotherapy + a Short Course of Miltefosine for the Treatment of Uncomplicated Cutaneous Leishmaniasis in the New World¨treatment2completed
NCT01050907
Miltefosine to Treat Mucocutaneous Leishmaniasistreatment2completed
NCT00633009
Safety, False-Positive Reactions and Sensitizing Properties of Leishmania Tropica Skin Test AntigenNo drug interventionsscreening2completed
NCT01988909
WR 279,396 for the Treatment of Cutaneous LeishmaniasisNo drug interventionstreatment2completed
NCT00682656
Safety and Efficacy of Azithromycin to Treat Cutaneous Leishmaniasistreatment2 / 3terminated
NCT01462500
Pharmacokinetics of Miltefosine in Children and Adultstreatment4completed
NCT01464242
Add-on Study of Pentoxifylline in Cutaneous Leishmaniasistreatment2 / 3completed
NCT00001906
Safety and Immunogenicity of a Vaccine for Cutaneous Leishmaniasis Using Recombinant Human Interleukin-12 and Aluminum Hydroxide Gel as Adjuvantstreatment1completed
NCT00121849
Safety Study to Evaluate the Leish-111f + MPL-SE Vaccine in the Prevention of Cutaneous Leishmaniasis in Healthy Subjects Previously Exposed to the Leishmania ParasiteNo drug interventionsprevention1completed
NCT00657917
Topical Treatment of Recalcitrant Ulcerative Old World Leishmaniasis With WR 279,396treatment2terminated
NCT01301924
Comparison of Standard and Alternative Antimonial Dosage in Patients With American Cutaneous Leishmaniasistreatment2 / 3completed
NCT01277796
Pilot Study Using a Heat Pack to Treat Cutaneous LeishmaniasisNo drug interventionsNot AvailableNot Availableavailable
NCT00257530
Imiquimod Plus Antimony Immunochemotherapy for Cutaneous Leishmaniasistreatment3completed
NCT00490230
Cosmetic Outcome of Leishmaniasis Scar After WR279396 ApplicationNo drug interventionsNot AvailableNot Availablecompleted
NCT00121862
Study to Evaluate the Leish-111f + MPL-SE Vaccine in Healthy Adults Not Previously Exposed to Leishmania ParasiteNo drug interventionsprevention2completed
NCT00317980
Safety and Efficacy of Low-Dose Pentavalent Antimony for Treatment of Cutaneous Leishmaniasistreatment4completed
NCT01953744
High Dose Fluconazole in Cutaneous Leishmaniasis in Bahia and Manaustreatment3terminated
NCT02281669
Prospective Observational Study of Intralesional Treatment With Pentostam in Cutaneous Leishmaniasis Israeli PatientsNot AvailableNot Availableunknown_status
NCT01380314
Oral Miltefosine Plus Topical Imiquimod to Treat Cutaneous Leishmaniasistreatment2completed
NCT01381055
Antimony Plus Pentoxifylline in Cutaneous Leishmaniasistreatment2 / 3completed