NCT05776784
Status of Dental Care Practices in Patients With Hereditary Angioedema No drug interventions Not Available Not Available recruiting NCT04933721
Open-label Berotralstat Access to HAE Patients Previously Enrolled in Berotralstat Studies prevention 3 active_not_recruiting NCT03029728
Biomarker for Hereditary AngioEdema Disease No drug interventions Not Available Not Available completed NCT03485911
Efficacy and Safety Study of BCX7353 as an Oral Treatment for the Prevention of Attacks in HAE prevention 3 completed NCT02303626
12-Week Safety and Efficacy Study of BCX4161 as an Oral Prophylaxis Against HAE Attacks prevention 2 / 3 completed NCT05121376
A Gene Therapy Study of BMN 331 in Subjects With Hereditary Angioedema No drug interventions treatment 1 / 2 active_not_recruiting NCT04428632
Oral Berotralstat Expanded Access Program Not Available Not Available approved_for_marketing NCT02670720
Open-label, Long-term Safety Study of Avoralstat in Subjects With Hereditary Angioedema prevention 3 terminated NCT03472040
A Long Term Safety Study of BCX7353 in Hereditary Angioedema prevention 2 / 3 completed NCT03873116
Study to Evaluate the Efficacy and Safety of BCX7353 as an Oral Treatment for the Prevention of HAE Attacks in Japan prevention 3 completed NCT04057131
FIRAZYR General Drug Use-Results Survey (Japan) Not Available Not Available completed NCT05509569
A Survey of Icatibant in Pediatric Participants with Hereditary Angioedema Not Available Not Available recruiting NCT05469789
A Study of Lanadelumab in Teenagers and Adults With Hereditary Angioedema (HAE) No drug interventions Not Available Not Available recruiting NCT06587464
A Study to Explore Hereditary Angioedema (HAE) Symptoms and Treatment Patterns in Korean People No drug interventions Not Available Not Available not_yet_recruiting NCT02663687
Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of Recombinant Human C1 Esterase Inhibitor in Healthy Adult Subjects No drug interventions treatment 1 completed NCT04583007
Expanded Access for the Prevention of Acute Attacks of 1) Hereditary Angioedema (HAE) in Children and 2) Non-histaminergic Angioedema With Normal C1-Inhibitor (C1-INH) in Teenagers and Adults Not Available Not Available no_longer_available NCT00457015
Efficacy Study of DX-88 (Ecallantide) to Treat Acute Attacks of Hereditary Angioedema (HAE) treatment 3 completed NCT03845400
A Study of Lanadelumab in Persons With Hereditary Angioedema (HAE) Type I or II in North America No drug interventions Not Available Not Available completed NCT02584959
Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1 Esterase Inhibitor for the Prevention of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema prevention 3 completed NCT05819775
CSL312_3003 Safety and Pharmacokinetic Study in Subjects 2 to 11 Years of Age With Hereditary Angioedema treatment 3 recruiting NCT01826916
EDEMA2: Evaluation of DX-88's Effect in Mitigating Angioedema treatment 2 completed NCT02741596
Long-term Safety and Efficacy Study of DX-2930 (SHP643) to Prevent Acute Angioedema Attacks in Patients With Type I and Type II HAE prevention 3 completed NCT05460325
A Study of Lanadelumab (SHP643) in Chinese Participants With Hereditary Angioedema (HAE) treatment 3 completed NCT01253382
Study to Evaluate Ecallantide in Paediatric Patients With Acute Attacks of Hereditary Angioedema treatment 2 / 3 withdrawn NCT05397431
A Survey of Lanadelumab in Participants With Hereditary Angioedema Not Available Not Available recruiting NCT01034969
Firazyr® Patient Registry (Icatibant Outcome Survey - IOS) No drug interventions Not Available Not Available recruiting NCT04861090
A Study in Teenagers and Adults With Hereditary Angioedema (HAE) Type I or Type II Who Use Lanadelumab as Long-Term Prophylaxis No drug interventions Not Available Not Available completed NCT02045264
Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers treatment 1 completed NCT03240133
Study of BCX7353 as a Treatment for Attacks of Hereditary Angioedema treatment 2 completed NCT02586805
Efficacy and Safety Study of DX-2930 to Prevent Acute Angioedema Attacks in Patients With Type I and Type II HAE prevention 3 completed NCT01923207
A Single Increasing Dose Study to Assess Safety and Tolerability of DX-2930 in Healthy Subjects treatment 1 completed NCT06346899
A Study of Lanadelumab (Takhzyro) and Icatibant (Firazyr®) in Persons With HAE in China No drug interventions Not Available Not Available recruiting NCT02052141
Safety and Efficacy Study of CINRYZE for Prevention of Angioedema Attacks in Children Ages 6-11 With Hereditary Angioedema prevention 3 completed NCT05578417
A Study to Review the Treatment and Outcomes of Teenagers and Adults With Non-histaminergic Angioedema With Normal C1 Inhibitor in Canada No drug interventions Not Available Not Available completed NCT01386658
A Pharmacokinetic, Tolerability and Safety Study of Icatibant in Children and Adolescents With Hereditary Angioedema treatment 3 completed NCT04180163
Efficacy and Safety of Lanadelumab (SHP643) in Japanese Participants With Hereditary Angioedema (HAE) treatment 3 completed NCT01756157
Subcutaneous CINRYZE With Recombinant Human Hyaluronidase for Prevention of Angioedema Attacks prevention 2 completed NCT01059526
Observational Safety Study for KALBITOR (Ecallantide) in the Treatment of Acute Attacks of Hereditary Angioedema Not Available Not Available completed NCT02865720
Study of C1 Inhibitor (Human) for the Prevention of Angioedema Attacks and Treatment of Breakthrough Attacks in Japanese Subjects With Hereditary Angioedema (HAE) treatment 3 completed NCT04130191
A Study of Lanadelumab in Persons With Hereditary Angioedema (HAE) Type I or II No drug interventions Not Available Not Available active_not_recruiting NCT00262080
Efficacy and Safety Study of DX-88 to Treat Acute Attacks of Hereditary Angioedema (HAE) treatment 3 completed NCT05489640
A Study in Adults With Hereditary Angioedema (HAE) Who Currently Receive Icatibant at Home No drug interventions Not Available Not Available completed NCT02870972
Efficacy and Safety of BCX7353 to Prevent Angioedema Attacks in Subjects With Hereditary Angioedema prevention 2 completed NCT01095510
CINRYZE for the Treatment of Hereditary Angioedema Attacks in Children Under the Age of 12 treatment 2 completed NCT05147181
A Study With Lanadelumab in Persons With Hereditary Angioedema (HAE) in Poland No drug interventions Not Available Not Available active_not_recruiting NCT03888755
A Study of Icatibant for Acute Attacks of Hereditary Angioedema in Japanese Participants treatment 3 completed NCT01541423
A European Post-Authorisation Observational Study Of Patients With Hereditary Angioedema No drug interventions Not Available Not Available completed NCT02093923
A Double-Blind, Multiple Ascending Dose Study to Assess Safety, Tolerability and Pharmacokinetics of DX-2930 in Hereditary Angioedema Participants treatment 1 completed NCT00456508
Safety and Efficacy Study of Repeated Doses of DX-88 (Ecallantide) to Treat Attacks of Hereditary Angioedema (HAE) treatment 3 completed NCT06210698
Angioedema Biomarker Research Study No drug interventions Not Available Not Available not_yet_recruiting NCT04955964
A Study of Lanadelumab in Teenagers and Adults With Hereditary Angioedema (HAE) in Argentina No drug interventions Not Available Not Available completed NCT06007677
A Long-term Study of STAR-0215 in Participants with Hereditary Angioedema No drug interventions treatment 2 recruiting NCT06262399
Long-Term Follow-Up (LTFU) of Subjects Treated with NTLA 2002 No drug interventions Not Available Not Available enrolling_by_invitation NCT06343779
Study of Oral Deucrictibant Soft Capsule for On-Demand Treatment of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema No drug interventions treatment 3 recruiting NCT06634420
HAELO: a Phase 3 Study to Evaluate NTLA-2002 in Participants with Hereditary Angioedema (HAE) treatment 3 recruiting NCT06628713
Treatment of Angioedema Attacks in Adolescent and Adult Patients 12 Years and Older With HAE Type I or II With Sebetralstat Not Available Not Available available NCT05139810
OASIS-HAE: A Study to Evaluate the Safety and Efficacy of Donidalorsen (ISIS 721744 or IONIS-PKK-LRx) in Participants With Hereditary Angioedema (HAE) treatment 3 completed NCT05396105
Extension Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients with Hereditary Angioedema treatment 2 / 3 enrolling_by_invitation NCT06467084
Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) with HAE Type I or II treatment 3 recruiting NCT04739059
Long-term Safety and Efficacy of CSL312 (Garadacimab) in the Prophylactic Treatment of Hereditary Angioedema Attacks prevention 3 active_not_recruiting NCT05120830
NTLA-2002 in Adults With Hereditary Angioedema (HAE) treatment 1 / 2 active_not_recruiting NCT06573723
Institutional Registry of Rare Diseases No drug interventions Not Available Not Available recruiting NCT01188564
Efficacy, Safety and Immunogenicity Study of Recombinant Human C1 Inhibitor for the Treatment of Acute HAE Attacks No drug interventions treatment 3 completed NCT00748202
Berinert P Study of Subcutaneous Versus Intravenous Administration Not Available 3 completed NCT03202784
A Relative Bioavailability Study of Two Formulations of BCX7353 treatment 1 completed NCT02854397
Determination of Specific Biomarkers of Acute Attack of Angioedema Within Pediatric Population No drug interventions Not Available Not Available terminated NCT03712228
A Study to Investigate CSL312 in Subjects With Hereditary Angioedema (HAE) prevention 2 completed NCT00289211
C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks No drug interventions treatment 3 completed NCT05047185
Dose-ranging Study of Oral PHA-022121 for Prophylaxis Against Angioedema Attacks in Patients With Hereditary Angioedema Type I or Type II prevention 2 active_not_recruiting NCT06414252
Social Evaluated Cold Pressor Test in Hereditary Angioedema Patients No drug interventions Not Available Not Available completed NCT04349800
A Single Dose Safety, Tolerability, Pharmacokinetic and Food Effect Study of KVD900 in Healthy Volunteers treatment 1 completed NCT04656418
CSL312 (Garadacimab) in the Prevention of Hereditary Angioedema Attacks prevention 3 completed NCT05505916
An Open-label Extension Trial to Evaluate the Long-term Safety of KVD900 for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE) treatment 3 active_not_recruiting NCT05118958
Phase 1 Crossover Study in Healthy Subjects to Evaluate the PK Profile of KVD824 Following Single and Multiple Doses of Modified Release (MR) Formulations No drug interventions treatment 1 completed NCT01151735
C1-INH Compared to Placebo at the Time of Prodromal Symptoms for Hereditary Angioedema (HAE) Exacerbation No drug interventions treatment 4 withdrawn NCT01426763
A Study to Evaluate the Safety and Pharmacology of Subcutaneous Administration of CINRYZE With Recombinant Human Hyaluronidase other 2 completed NCT05511922
PK Subtrial in Adolescent Patients With HAE Type I or II Participating in the KVD900-302 Trial treatment 3 recruiting NCT02159430
Hereditary AngioEdema, Neurobiology and Psychopathology No drug interventions Not Available Not Available unknown_status NCT04070326
A Study of Lanadelumab to Prevent Hereditary Angioedema (HAE) Attacks in Children prevention 3 completed NCT05477160
A Study of STAR-0215 in Healthy Adult Participants No drug interventions treatment 1 completed NCT05453968
Berotralstat Treatment in Children With Hereditary Angioedema treatment 3 active_not_recruiting NCT01359969
Safety of Ruconest in 2-13 Year Old Hereditary Angioedema (HAE) Patients treatment 2 completed NCT04208412
A Phase II, Cross-over Clinical Trial Evaluating the Efficacy and Safety of KVD900 in the On-demand Treatment of Angioedema Attacks in Adult Subjects With Hereditary Angioedema Type I or II treatment 2 completed NCT01679912
A Call Center During HAE Attacks (SOS HAE) No drug interventions treatment 4 completed NCT00292981
C1 Esterase Inhibitor in Hereditary Angioedema (HAE)(Extension Study) treatment 3 completed NCT04307381
An Extension Study of Donidalorsen (IONIS-PKK-LRx) in Participants With Hereditary Angioedema treatment 2 active_not_recruiting NCT05392114
A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE) treatment 3 recruiting NCT00168103
Human C1 Esterase Inhibitor (C1-INH) in Subjects With Acute Abdominal or Facial Hereditary Angioedema (HAE) Attacks treatment 2 / 3 completed NCT02448264
First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BCX7353 in Healthy Western and Japanese Volunteers treatment 1 completed NCT01397864
C1 Inhibitor Registry in the Treatment of Hereditary Angioedema (HAE) Attacks Not Available Not Available recruiting NCT02819102
An Open-label Drug-Drug Interaction Study to Evaluate the Effect of BCX7353 on Cytochrome P450 Enzyme Activity Using Probe Substrates treatment 1 completed NCT03697187
Patient Registry to Evaluate the Real-world Safety of Ruconest® Not Available Not Available completed NCT04654351
A Study of Icatibant (TAK-667) in Japanese Children and Teenagers With Acute Attacks of Hereditary Angioedema treatment 3 completed NCT00225147
Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema treatment 2 / 3 completed NCT04030598
A Study to Assess the Clinical Efficacy of Donidalorsen (Also Known as IONIS-PKK-LRx and ISIS 721744) in Participants With Hereditary Angioedema treatment 2 completed NCT06408805
Autonomic Nervous System Profile in Hereditary Angioedema No drug interventions Not Available Not Available completed NCT01095497
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous CINRYZE Administration other 2 completed NCT05691361
Safety, Tolerability, PK, PD of ADX-324 in Healthy Volunteers and Hereditary Angioedema Patients No drug interventions treatment 1 recruiting NCT04618211
Dose-ranging Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema treatment 2 completed NCT00912093
A Study of Icatibant in Patients With Acute Attacks of Hereditary Angioedema (FAST-3) treatment 3 completed NCT01984788
Safety and Efficacy of Oral BCX4161 as a Prophylactic Treatment for HAE prevention 2 completed NCT01005888
C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks No drug interventions prevention 3 completed NCT00851409
A Study of the Safety and Immunogenicity of Repeated rhC1INH Administration treatment 2 completed NCT04898309
Efficacy and Safety of GNR-038 vs Berinert® in Patients With Hereditary Angioedema treatment 2 / 3 withdrawn NCT00462709
Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks No drug interventions prevention 3 completed NCT00500656
Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema (HAE) treatment 3 completed NCT00438815
Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks No drug interventions treatment 3 completed NCT04687137
Expanded Access Program With Lanadelumab for Japanese People With Hereditary Angioedema treatment 3 completed NCT03136237
A Drug-Drug Interaction Study to Evaluate Drug Transporter Interactions treatment 1 completed NCT04091113
Hereditary Angioedema Kininogen Assay No drug interventions Not Available Not Available terminated NCT04557319
Safety and Pharmacokinetics of GNR-038 in Healthy Volunteers No drug interventions other 1 completed NCT04957641
A Study of the Burden of Illness and Treatment Patterns in Teenagers and Adults With Hereditary Angioedema No drug interventions Not Available Not Available completed NCT05259917
A Phase III, Crossover Trial Evaluating the Efficacy and Safety of KVD900 for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE) treatment 3 completed NCT02247739
A Phase 2 HAE Prophylaxis Study With Recombinant Human C1 Inhibitor prevention 2 completed NCT01457430
Efficacy, Safety and Tolerability of Icatibant for the Treatment of HAE treatment 4 completed NCT05695248
A Study of STAR-0215 in Participants With Hereditary Angioedema No drug interventions treatment 1 / 2 active_not_recruiting NCT06415448
Donidalorsen Expanded Access Program for Patients With Hereditary Angioedema Not Available Not Available available NCT00914966
A Study to Evaluate the Safety and Effect of Escalating Doses of CINRYZE prevention 4 completed NCT02218294
Study to Determine How BCX4161 is Metabolized and Eliminated by the Body treatment 1 completed NCT02125162
A Study of the Relative Bioavailability of a New Formulation of BCX4161 and the Effect of Food on BCX4161 treatment 1 completed NCT00262301
Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema treatment 3 completed NCT00997204
EASSI - Evaluation of the Safety of Self-Administration With Icatibant treatment 3 completed NCT00432510
Pharmacokinetics of C1 Esterase Inhibitor in Hereditary Angioedema Subjects No drug interventions other 1 completed NCT05178355
A Single and Multiple Doses Safety, Tolerability, Pharmacokinetics and Food Effect Study of KVD824 in Healthy Volunteers No drug interventions treatment 1 completed NCT04888650
Assessment of the State of Health, Quality of Life and Expectations of Patients With Hereditary Angioedema No drug interventions Not Available Not Available completed