Human African Trypanosomiasis (HAT) (DBCOND0071671)
Identifiers
- Synonyms
- Human African Trypanosomiasis
Associated Data
- Indicated Drugs and Targets
Drug Description Targets Fexinidazole An orally bioavailable 2-substituted 5-nitroimidazole used to treat early- and late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense.- Cytochrome P450 1A2enzyme
- Cytochrome P450 2B6enzyme
- Cytochrome P450 2C19enzyme
- Cytochrome P450 3A4enzyme
- Cytochrome P450 3A5enzyme
- Flavin-containing monooxygenase 3enzyme
- Cytochrome P450 2D6enzyme
- Solute carrier organic anion transporter family member 1B1transporter
- Solute carrier organic anion transporter family member 1B3transporter
- Solute carrier family 22 member 2transporter
- Solute carrier family 22 member 6transporter
- Organic anion transporter 3transporter
- Multidrug and toxin extrusion protein 1transporter
- Multidrug and toxin extrusion protein 2transporter
- Clinical Trials
Identifier Title Drug(s) Purpose Phase Status NCT01685827 Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2 treatment 2 / 3 completed NCT02184689 Efficacy and Safety of Fexinidazole in Children at Least 6 Years Old and Weighing Over 20 kg With Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open Study, plug-in to the Pivotal Study treatment 2 / 3 completed NCT02169557 Efficacy and Safety of Fexinidazole in Patients With Stage 1 or Early Stage 2 Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open-label Cohort Study, plug-in to the Pivotal Study treatment 2 / 3 completed NCT01766830 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) No drug interventions diagnostic Not Available completed NCT06356974 Stop Transmission of Gambiense Human African Trypanosomiasis (STROgHAT) treatment 3 not_yet_recruiting NCT00906880 Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine (NECT) for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis (HAT) in the Meningo-encephalitic Phase treatment 4 completed NCT00982904 Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the Fexinidazole No drug interventions treatment 1 completed NCT04099628 Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP3 Post Elimination Monitoring No drug interventions diagnostic Not Available completed NCT05637632 Assessment of Recombinant HAT-RDT Specificity No drug interventions Not Available Not Available completed NCT05466630 Prospective Evaluation of the Specificity of Serological Tests for Human African Trypanosomiasis No drug interventions diagnostic Not Available completed NCT03394976 Prospective Evaluation of an RDT to Screen for Gambiense HAT and Diagnose P. Falciparum Malaria No drug interventions Not Available Not Available withdrawn