Nonalcoholic Fatty Liver (DBCOND0072734)

Identifiers

Synonyms
Fatty Liver, Nonalcoholic / Non Alcoholic Fatty Liver / Non-alcoholic Fatty Liver / Nonalcoholic fatty liver / Non-alcoholic fatty liver disease (disorder) / Fatty (change of) liver, not elsewhere classified / Nonalcoholic fatty liver disease / Non-alcoholic fatty liver (disorder) / Non-alcoholic Fatty Liver Disease

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Silibinin
A flavonolignan with hepatoprotective effects used to treat toxic liver damage and as an adjunct in the management of chronic conditions such as cirrhosis and hepatitis.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06215131
Feasibility of Immersive Virtual Reality Dietician Program in Metabolic-dysfunction Associated Steatotic Liver DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT06321211
Development of a Novel Asian Mediterranean Diet and Its Acceptability in NAFLDNo drug interventionsNot AvailableNot Availablerecruiting
NCT06596109
Lifestyle Changes in Fatty Liver; Additive Effect of Honey IntakeNo drug interventionstreatmentNot Availablerecruiting
NCT04702490
Study to Evaluate MET409 Alone or in Combination With Empagliflozin in Patients With Type 2 Diabetes and NASHtreatment2unknown_status
NCT03260543
Efficacy and Safety of Fermented Ginseng Powder on Liver FunctionNo drug interventionspreventionNot Availablecompleted
NCT05877547
A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013)treatment2active_not_recruiting
NCT04509245
The Effects of a Novel Lifestyle Intervention Program on Insulin Sensitivity in Type 2 DiabetesNo drug interventionsbasic_scienceNot Availablecompleted
NCT06445361
Prevalence of NAFLD in T1DM PatientsNo drug interventionsdiagnosticNot Availablerecruiting
NCT05560607
Knockdown of HSD17B13 mRNA, Pharmacokinetics, Safety, and Tolerability, of AZD7503 in Non-Alcoholic Fatty Liver DiseaseNo drug interventionsother1completed
NCT06117137
The Impact Of SGLT2 -I on Metabolic Dysfunction -Associated Steatotic Liver Disease In Patients With Type 2 Diabetes Mellitustreatment3not_yet_recruiting
NCT03319199
The Effect of Combination Therapy Amino Acid L-CARNITINE and Magnesium on Fatty LiverNo drug interventionstreatmentNot Availablecompleted
NCT05855239
Quantification of Hepatic Steatosis With Different Ultrasound FrequencyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04761848
Evaluation the Safety and Efficacy of Cilostazol in Treatment of Patients With Fatty Liver Diseasetreatment1 / 2active_not_recruiting
NCT06503120
Nutritional Education Program for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)No drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04462562
Quantitative US for Evaluation of Hepatic Steatosis in NAFLDNo drug interventionsdiagnosticNot Availablecompleted
NCT02132780
Autonomic Dysfunction in Non-Alcoholic Fatty Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03656744
A Study of HTD1801 in Adults With Nonalcoholic Steatohepatitis (NASH) and Type 2 Diabetes Mellitus (T2DM)No drug interventionstreatment2completed
NCT04067440
Characterization of the Microbiome in Peritoneum, Jejunum, Rectum and StoolNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT02983669
The Effects of Zataria Multiflora Boiss (Shirazi's Thyme) on Nonalcoholic Fatty Liver DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT03593343
Hepatic Glycogen and Fat OxidationNo drug interventionsbasic_scienceNot Availablecompleted
NCT04899102
Intermittent Fasting for NAFLD in AdultsNo drug interventionstreatmentNot Availablerecruiting
NCT05525884
Mechanism of Serum PRL in the Development of MAFLDNo drug interventionsNot AvailableNot Availableunknown_status
NCT02764047
Probiotics in the Treatment of NAFLDNo drug interventionstreatmentNot Availableunknown_status
NCT04054297
Glycemic Index/Saturated Fatty Acid Diet and Hepatic FatNo drug interventionsbasic_scienceNot Availablecompleted
NCT04452409
Enhanced Liver Function in Non-alcoholic Obese Fatty Liver Patients by Low Level Laser TherapyNo drug interventionssupportive_careNot Availablecompleted
NCT05220956
Impact of Time-restricted Feeding in NAFLDNo drug interventionsscreeningNot Availablerecruiting
NCT06257732
Different Exercise Modalities in the Treatment of NAFLD and Their Impact on MyokinesNo drug interventionstreatmentNot Availablerecruiting
NCT02366052
Nutritional Counseling vs. Nutritional Supplements for NASH - a Randomized Prospective, Open Label Pilot StudyNo drug interventionstreatment2completed
NCT04241575
Identification of Fatty Liver With Advanced Fibrosis in Type 2 Diabetes Using Simple Fibrosis Scores and Electronic Reminder MessagesNo drug interventionsscreeningNot Availablecompleted
NCT06491342
Probiotic Supplement Versus Placebo for the Treatment of Patients With Non-alcoholic Fatty Liver DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT03211299
Determinants of Liver Fat CompositionNo drug interventionsNot AvailableNot Availablecompleted
NCT02290106
Effects of Pitavastatin on Insulin Sensitivity and Liver FattreatmentNot Availablecompleted
NCT03784716
Ketogenic Diet in Non-alcoholic Fatty Liver DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT06445335
Prevalence of NAFLD in T2DM PatientsNo drug interventionsdiagnosticNot Availableactive_not_recruiting
NCT05041673
Anti-diabetic Drugs and Fatty Liver ManagementtreatmentNot Availableunknown_status
NCT05558592
Evaluation of the Effects of Orange Consumption on Carbohydrate and Lipid Metabolism in Subjects With MAFLD (Metabolic Associated Fatty Liver Disease)No drug interventionstreatmentNot Availablerecruiting
NCT05130346
Effects of Mindfulness Based Stress Reduction Intervention in Patients With Non-alcoholic Fatty Liver DiseaseNo drug interventionssupportive_careNot Availablewithdrawn
NCT03371355
Study of ISIS 703802 in Participants With Hypertriglyceridemia, Type 2 Diabetes Mellitus, and Nonalcoholic Fatty Liver DiseaseNo drug interventionstreatment2completed
NCT06594523
A Phase 3 Study Evaluating the Safety and Efficacy of Denifanstat in Patients With MASH and F2/F3 Fibrosistreatment3not_yet_recruiting
NCT02815891
A Longitudinal Observational Study of Patients With Nonalcoholic Steatohepatitis (NASH) and Related Conditions Across the Entire Spectrum of Nonalcoholic Fatty Liver Disease (NAFLD)No drug interventionsNot AvailableNot Availablerecruiting
NCT05364684
The Impact of Ibutamoren on Nonalcoholic Fatty Liver Diseasetreatment2active_not_recruiting
NCT03986684
Molecules Associated With the Presence and Severity of Nonalcoholic Fatty Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02365233
Fatty Liver Study in Patients With Type II Diabetestreatment4terminated
NCT04828551
Noninvasive Biomarkers of Metabolic Liver Disease 1.1No drug interventionsdiagnosticNot Availablecompleted
NCT03763877
A Study of the Efficacy and Safety of PXL770 Versus Placebo After 12 Weeks of Treatment in Patients With NAFLDNo drug interventionstreatment2completed
NCT03151798
The Liver Health Study for Patients With NAFLDNo drug interventionsotherNot Availablecompleted
NCT03282305
Great China Fatter Liver Consortium (GC_FLC) Study to Assess the Progress of NAFLD/NASH in ChineseNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03696797
Iron Reduction for the Treatment of Diabetes and Nonalcoholic Fatty Liver DiseaseNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT05493761
Effect of Anti-osteoporotic Medications on Nonalcoholic Fatty Liver Diseasetreatment4recruiting
NCT04389593
Comparative and Additive Diagnostic Performance of Magnetic Resonance Elastography (MRE) and Corrected-T1 (cT1) for Fibrosis and Inflammation in Nonalcoholic Steatohepatitis (NASH) Using Histology as ReferenceNo drug interventionsNot AvailableNot Availablerecruiting
NCT06335771
Harnessing Macrophage Lysosomal Lipid Metabolism in ObesityNo drug interventionsbasic_scienceNot Availablerecruiting
NCT05430178
Metabolic Pathology of Pediatric NAFLDNo drug interventionsbasic_scienceNot Availablerecruiting
NCT02908152
Curcumin Supplement in Nonalcoholic Fatty Liver PatientsNo drug interventionstreatment2 / 3completed
NCT02992470
Crassostrea Gigas for Liver HealthNo drug interventionssupportive_careNot Availableunknown_status
NCT05309642
Nonalcoholic Fatty Liver Disease - Intermittent Calorie Restriction (FLICR) StudyNo drug interventionstreatmentNot Availablecompleted
NCT05165706
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin ResistanceNo drug interventionspreventionNot Availablerecruiting
NCT03861819
Feasibility of VIIT in Adults With NASHNo drug interventionsotherNot Availablecompleted
NCT05986916
Accurate Point of Care Liver Disease DiagnosticsNo drug interventionsNot AvailableNot Availablerecruiting
NCT05199948
Weight, Energy, Lipids, and the Liver (WELL) StudyNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT03950882
A Study to Assess the Pharmacokinetics of PXL770 After 4 Weeks of Treatment in Subjects With NAFLDNo drug interventionstreatment1completed
NCT05792423
Conditionally Increased Output (CIO) Enhanced Ultrasound SystemNo drug interventionsotherNot Availablecompleted
NCT05680233
Safety Study of OA-235i in Subjects With Nonalcoholic SteatohepatitisNo drug interventionstreatment1recruiting
NCT05908877
Cardio-Metabolic Risk Evaluation in Overweight and Obese ChildrenNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04235205
Efficacy and Safety of Elobixibat in Combination With Cholestyramine for Nonalcoholic Fatty Liver Diseasetreatment2completed
NCT03084328
Vitamin D Replacement in Nonalcoholic Fatty Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT06523530
Effect of a GnRH Analog on Hepatic Steatosistreatment4not_yet_recruiting
NCT04887766
Study on GS300 on NAFLDNo drug interventionstreatmentNot Availableunknown_status
NCT04595474
Prevalence of NAFLD and Advanced Fibrosis in Patients With Type 1 DiabetesNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03725631
Non-invasive Evaluation of Liver Fibrosis, Steatosis, and NASH in NAFLDNo drug interventionsdiagnosticNot Availableunknown_status
NCT05081427
Non-invasive Biomarkers of Metabolic Liver Disease (NIMBLE) Study 1.2No drug interventionsNot AvailableNot Availablecompleted
NCT04031729
Aspirin for the Treatment of Nonalcoholic Fatty Liver Diseasetreatment1 / 2completed
NCT05084404
Efficacy and Safety of Guanabenz for Nonalcoholic Fatty Liver Diseasetreatment2unknown_status
NCT03625284
Oral Dietary Fucoxanthin Rich Supplement for Liver HealthNo drug interventionspreventionNot Availableunknown_status
NCT02030977
The Effects of Resveratrol Supplement on Biochemical Factors and Hepatic Fibrosis in Patients With Nonalcoholic SteatohepatitisNo drug interventionstreatment2 / 3completed
NCT03801577
Hepaxa Management of Non-alcoholic Fatty Liver DiseaseNo drug interventionstreatmentNot Availableunknown_status
NCT05523024
Effect of Probiotics or Berberine in Hepatic Steatosis Markers, Cardiometabolic and Microbiotic Profile in NAFL.No drug interventionstreatmentNot Availableunknown_status
NCT05822622
Relationship Between Heart Failure With Preserved Ejection Fraction and Nonalcoholic Fatty Liver Disease.No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04625166
Combi-elastography Assessment of Chronic Liver Disease Multi-center StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT04823676
Efficacy and Safety of a Probiotic Composition as Adjunct in MAFL ManagementNo drug interventionstreatmentNot Availablecompleted
NCT02923804
Evaluation of MF4637 for Correcting the Omega-3 Nutritional Deficiency in NAFLD PatientsNo drug interventionstreatmentNot Availablecompleted
NCT06138821
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled TrialNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06176079
Hyperpolarized Pyruvate (13C) Magnetic Resonance Imaging In Patients With Fatty Liver DiseaseNot AvailableNot Availablerecruiting
NCT06552377
Ultrasound and Attenuation ImagingNo drug interventionsNot AvailableNot Availablecompleted
NCT03186859
Effects of Dietary Intervention and Surgery on NAFLD (Non-Alcoholic Fatty Liver Disease)No drug interventionstreatmentNot Availablecompleted
NCT03222206
The Comparison of Effect Between Salsalate and Placebo in Osteoarthritis With Nonalcoholic Fatty Liver Diseasetreatment4completed
NCT04553796
Assessment of Nonalcoholic Fatty Liver Disease in Diabetic and Prediabetic Patients Using Noninvasive Methods.No drug interventionsNot AvailableNot Availableunknown_status
NCT05804422
Probiotic Lysate (Postbiotic and Metabiotic) Supplementation for Adults NAFLD Patients (DELI_NAFLD Study)No drug interventionstreatmentNot Availablecompleted
NCT06508190
Free Walking Exercise in Obstructive Sleep Apnea Patients With Non-alcoholic Fatty LiverNo drug interventionstreatmentNot Availablerecruiting
NCT04302051
Assessment of Fatty Liver With Thermo-acoustic DeviceNo drug interventionsNot AvailableNot Availablerecruiting
NCT04198805
Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD)treatment2completed
NCT04209816
Genetic Pathways Leading to Fatty Liver and Atherogenic DyslipidemiaNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03738358
Clinical Study of 12-week Trehalose Intake in Patients With Fatty Liver DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT06377631
Effect of Multi-ingredient on Visceral Adiposity & Non-alcoholic Fatty Liver Disease in Postmenopausal Women With Abdominal ObesityNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03849729
Effectiveness and Tolerability of Phentermine in Patients Under Bariatric Surgerytreatment4completed
NCT03953456
Study to Evaluate the Effect of Elafibranor on Hepatic Lipid Composition in Subjects With Nonalcoholic Fatty Liver (NAFL)treatment2terminated
NCT04190849
European Paediatric Non-Alcoholic Fatty Liver Disease Registry (EU-PNAFLD)No drug interventionsNot AvailableNot Availablerecruiting
NCT05357248
Nutritional Cognitive Behavioral Therapy Feasibility Study in NAFLD and NASHNo drug interventionstreatmentNot Availablecompleted
NCT01787591
Dairy Fat as a Mediator of Vitamin E Adequacy in Individuals With Metabolic SyndromeNo drug interventionsbasic_scienceNot Availablecompleted
NCT05485714
Non-invasive Prediction of Esophageal Varices in Patients With Non-Alcoholic Fatty Liver Disease With Advanced FibrosisNo drug interventionsNot AvailableNot Availablecompleted