Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP) (DBCOND0121724)

Identifiers

Synonyms
Chronic Rhinosinusitis With Nasal Polyps / Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) / Chronic Rhinosinusitis With Nasal Polyposis / Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP) / Chronic rhinosinusitis with multiple nasal polyps (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Dupilumab
A monoclonal antibody used to treat moderate to severe atopic dermatitis, asthma, and nasal polyps accompanied by chronic rhinosinusitis in adolescents and adults.
Mepolizumab
A fully-humanized monoclonal IgG1 kappa anti-IL-5 antibody used in conjunction with other therapies to treat severe asthma, eosinophilic granulomatosis with polyangiitis, and hypereosinophilic syndrome.
Mometasone furoate
A corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus.
Omalizumab
A monoclonal anti-immunoglobulin E (IgE) antibody used to treat asthma, chronic idiopathic urticaria, chronic rhinosinusitis with nasal polyps, and IgE-mediated food allergy.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05878093
Dupilumab in Chinese Adult Participants With CRSwNPtreatment3active_not_recruiting
NCT06454240
A Proof-of-concept Study of Lunsekimig Compared With Placebo in Adults With Chronic Rhinosinusitis With Nasal Polypstreatment2recruiting
NCT05895929
The Role of IL5 in Epithelial Cell Integritybasic_science0recruiting
NCT04823585
Aggravated Airway Inflammation: Research on Biological Treatment (Mepolizumab)treatmentNot Availableactive_not_recruiting
NCT05873803
The Study of GR1802 in Patients with Chronic Rhinosinusitis with Nasal PolypsNo drug interventionstreatment2active_not_recruiting
NCT05964465
Mechanisms of Smell Improvement With Dupilumab.treatment4recruiting
NCT05131464
The Study of CM310 in Patients With Chronic Rhinosinusitis With Nasal Polypstreatment2unknown_status
NCT06516302
A Study of GR1802 in Participants With Chronic Sinusitis With Nasal PolypsNo drug interventionstreatment3not_yet_recruiting
NCT05529784
Dupilumab in the Treatment of Severe Uncontrolled CRSwNP: a Multicentre Observational Real-life Study (DUPIREAL)Not AvailableNot Availableactive_not_recruiting
NCT06118554
3D Printing to Improve Nasal Irrigation OutcomeNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT05891483
Efficacy and Safety of SHR-1905 Injection in Patients With Chronic Rhinosinusitis With Nasal PolypsNo drug interventionstreatment2active_not_recruiting
NCT05598411
CST1-Guided Oral Glucocorticoids Management for CRSwNPtreatment4not_yet_recruiting
NCT02743871
Study Of PF-06817024 In Healthy Subjects, In Patients With Chronic Rhinosinusitis With Nasal Polyps And in Patients With Atopic DermatitisNo drug interventionstreatment1completed
NCT06188871
Early-onset Dupilumab Effects in CRSwNPbasic_science4withdrawn
NCT06372678
Study of CM326 in Participants With Chronic Rhinosinusitis With Nasal PolyposisNo drug interventionstreatment2not_yet_recruiting
NCT03725956
Polysomnographic Findings in Nasal PolyposisNo drug interventionsdiagnosticNot Availablerecruiting
NCT02170337
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 282 in Healthy Subjects and Subjects With Chronic Rhinosinusitis With Nasal Polypstreatment1completed
NCT06129552
Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal PolypsNo drug interventionsNot AvailableNot Availablerecruiting
NCT05708300
Biomarkers of Response to Mepolizumab Treatment in Patients With Nasal Polyps With or Without Bronchial AsthmaNot AvailableNot Availablerecruiting
NCT05642806
Comparison of Immune Profiles in Chronic Rhinosinusitis Patients After Mepolizumab Treatmenttreatment4recruiting
NCT04869436
Olfactory Outcomes of Dupilumab Treatment for Nasal Polyposistreatment4recruiting
NCT04147013
Effect of Celecoxib on Postoperative Analgesia and Disease Severity in AERD Patients With CRStreatment4recruiting
NCT05598424
CST1 Predictive Model of Oral Glucocorticoid Therapy Sensitivity for Chronic Rhinosinusitis With Polypstreatment4recruiting
NCT05009758
Moving Towards Precision Medicine in United Airways Disease: Unraveling Inflammatory Patterns in Asthmatic Patients With or Without Nasal PolypsNo drug interventionsscreeningNot Availablerecruiting
NCT05049122
Dupilumab in Japanese Patients With Chronic Rhinosinusitis With Nasal Polyp (SINUS-M52)treatment4completed
NCT05902325
Identifying Predictors Of Response To Mepolizumab In CRSwNPtreatment4recruiting
NCT05626257
Regulatory Post-Marketing Surveillance of Xolair® for Chronic Rhinosinusitis With Nasal PolypsNo drug interventionsNot AvailableNot Availablerecruiting
NCT06398873
Effect of Dupilumab on Nasal Epithelial Barrier Function in Patients With CRSwNPNot AvailableNot Availablerecruiting
NCT04104594
Olfaction and Inflammation in Chronic Rhinosinusitis With Nasal PolypsNo drug interventionsotherNot Availableterminated
NCT05931744
The Role of Budesonide Intrapolyp Injection in the Management of Type 2 Chronic Rhinosinusitistreatment2 / 3completed
NCT06451640
A Extension Clinical Study of TQC2731 Injection in the Treatment of Chronic Sinusitis With Nasal PolypsNo drug interventionstreatment2recruiting
NCT05246267
Dupilumab Treatment Effects in an Ethnically Diverse Population With Chronic Rhinosinusitis With Nasal PolyposisNot AvailableNot Availablerecruiting
NCT06107101
th2 Modulation CRSwNPbasic_science4not_yet_recruiting
NCT04998604
EValuating trEatment RESponses of Dupilumab Versus Omalizumab in Type 2 Patientstreatment4active_not_recruiting
NCT06164704
A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Participants With Chronic Rhinosinusitis With Nasal Polypstreatment2recruiting
NCT05938972
Real Life Study of Biologicals in Patients With Severe CRSwNPNot AvailableNot Availablerecruiting
NCT06556264
Immunologic Impact of Dupilumab in Patients Suffering From Asthma and Chronic Rhinosinusitis With Polypstreatment4not_yet_recruiting
NCT04851964
Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposistreatment3active_not_recruiting
NCT05143502
Role of Montelukast in the Management of Chronic Rhinosinusitis With Nasal Polyps.treatment1 / 2unknown_status
NCT05553951
Adherence in Global AirwaysNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT02668861
Effect of Oral Vitamin D3 on Chronic Rhinosinusitis Treatment in Adults With Lower Vitamin D Levelstreatment3unknown_status
NCT05355207
Study to Evaluate Safety and Activity of TRL1068 in Chronic Rhinosinusitistreatment1not_yet_recruiting
NCT05324137
A Study of CM326 in Patients With Chronic Rhinosinusitis With Nasal PolypsNo drug interventionstreatment1 / 2active_not_recruiting
NCT04267042
Comparing Budesonide Via MAD or INSI Prospective Cohort Studytreatment0unknown_status
NCT04628442
Tissue Immune Interaction in Nasal PolyposisNo drug interventionsNot AvailableNot Availablerecruiting
NCT04286542
Mediators in Nasal Hyperreactivity in Allergic Rhinitis and Chronic RhinosinusitisNo drug interventionsbasic_scienceNot Availableunknown_status
NCT05649813
A Study in Male and Female Adult Participants With Chronic Rhinosinusitis With Nasal Polyps In the Greater Gulf RegionNo drug interventionsNot AvailableNot Availablecompleted
NCT06217419
Proof of Concept of Remote Management of Chronic Inflammatory Airway Diseases for Patient EmpowermentNo drug interventionshealth_services_researchNot Availablenot_yet_recruiting
NCT05843019
Adherence in Global Airways - Steroid Intake and Effects on Chronic RhinosinosinutisNo drug interventionsNot AvailableNot Availablerecruiting
NCT05228041
BIOlogics in Severe Nasal POlyposis SurvEyNot AvailableNot Availablerecruiting
NCT05942222
A Randomized, Real-world Head-to-head Study of Dupilumab Versus Mepolizumab in Danish CRSwNP Patientstreatment4recruiting
NCT06459622
Predictive Factors in Chronic Rhinosinusitis With Nasal PolypsNo drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT06017427
Evaluation of Patient Satisfaction During Treatment With Dupilumab in Severe and Recurrent Nasosinusal Polyposis Despite Appropriate Medical and Surgical Treatment.No drug interventionsNot AvailableNot Availableterminated
NCT05979662
Endoscopic Frontal Sinus Surgery Draf III in Moderate to Severe Eosinophilic Chronic Rhinosinusitis With PolypsNo drug interventionstreatmentNot Availablerecruiting
NCT04596189
Dupilumab for Prevention of Recurrence of CRSwNP After ESStreatment4active_not_recruiting
NCT04783389
A Study to Evaluate CBP-201, Rademikibart, in Adult Patients With Chronic Rhinosinusitis With Nasal Polypstreatment2terminated
NCT04583501
Preclinical Studies of Omalizumab in Chronic Rhinosinusitis With Nasal Polyposisbasic_science0completed
NCT06258772
Mepolizumab in the Treatment of Patients With Severe Uncontrolled CRSwNP: a Multicentric Real Life Observational StudyNot AvailableNot Availablenot_yet_recruiting
NCT05157412
Role of Doxycycline in Chronic Rhinosinusitis With Nasal Polypstreatment3completed
NCT06069310
Mepolizumab Effectiveness in Patients With Chronic Rhinosinusitis, Nasal Polyps and Comorbid Severe Eosinophilic AsthmaNot AvailableNot Availablerecruiting
NCT05598814
Mepolizumab to CRSwNP Through 12 Months - Randomised to FESS and Non-FESS Within the First 2 Weekstreatment4recruiting
NCT06015243
The Study of Long-term Outcomes of GR1802 in Patients With Chronic Rhinosinusitis With Nasal PolypsNo drug interventionstreatment2not_yet_recruiting
NCT06617754
International Severe CRSwNP Registry 2024-2028No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03956862
GB001 in Adult Participants With Chronic RhinosinusitisNo drug interventionstreatment2completed
NCT06231004
Correlation Between the Microbiome and Type 2 Inflammatory Diseases of CRSwNPNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06338995
A Study of Lebrikizumab (LY3650150) in Adult Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)No drug interventionstreatment3recruiting
NCT06393946
Study in Adults With Severe Chronic Rhinosinusitis With Nasal Polyposis Treated With Dupilumab in FranceNot AvailableNot Availableactive_not_recruiting
NCT05436275
A Study of CM310 in Patients With Chronic Rhinosinusitis With Nasal Polyposis (CROWNS-2)treatment3unknown_status
NCT04959448
Study Assessing Long-teRm Outcomes of dupiluMAb (DUPIXENT®) Treatment in Adult Patients With Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)Not AvailableNot Availableactive_not_recruiting
NCT03975842
Chronic Otitis Media With Effusion in Chronic Sinusitis With PolypsNo drug interventionsNot AvailableNot Availablecompleted
NCT02898454
Controlled Clinical Study of Dupilumab in Patients With Nasal Polypstreatment3completed
NCT02912468
A Controlled Clinical Study of Dupilumab in Patients With Bilateral Nasal Polypstreatment3completed