Non-squamous Non-small-cell Lung Cancer (NSQ NSCLC) (DBCOND0132636)

Identifiers

Synonyms

Lung Cancer, Non-squamous, Non-small Cell / Non-Squamous Non-Small Cell Lung Carcinoma / Non-Squamous Non-Small Cell Lung Cancer / Non-squamous Cell NSCLC / Non-squamous NSCLC / Non-Small Cell Lung Cancer, Non-squamous / Non-Squamous Cell Non-small Cell Lung Cancer / Carcinoma, Non-Squamous Non-Small Cell Lung / Non-Squamous Non-Small Cell Lung Cancer (NSCLC) / Nonsquamous cell Non-small cell lung cancer / Non-small cell lung cancer / Non-small cell lung cancer (disorder) / Non-small cell lung cancer NOS / Carcinoma, Non-Small-Cell Lung

Associated Data

Indicated Drugs and Targets

Not Available

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06151574	Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment	Carboplatin Cisplatin Pembrolizumab Pemetrexed Zongertinib	treatment	3	recruiting
NCT04524689	Tusamitamab Ravtansine (SAR408701) in Combination With Pembrolizumab and Tusamitamab Ravtansine (SAR408701) in Combination With Pembrolizumab and Platinum-based Chemotherapy With or Without Pemetrexed in Patients With NSQ NSCLC	Carboplatin Cisplatin Pembrolizumab Pemetrexed Tusamitamab ravtansine	treatment	2	active_not_recruiting
NCT02193282	Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial)	Erlotinib	treatment	3	active_not_recruiting
NCT03793179	Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer	Carboplatin Pembrolizumab Pemetrexed	treatment	3	active_not_recruiting
NCT04267848	Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-Small Cell Lung Cancer, ALCHEMIST Trial	Carboplatin Chloride ion Cisplatin Gemcitabine Paclitaxel Pembrolizumab Pemetrexed Platinum	treatment	3	recruiting
NCT05198830	Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer	Carboplatin Chloride ion Cisplatin Durvalumab Methoxyamine Pemetrexed Platinum	treatment	2	recruiting
NCT03737994	Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer	Alectinib Brigatinib Carboplatin Ceritinib Chloride ion Cisplatin Crizotinib Ensartinib Lorlatinib Pemetrexed Platinum Tyrosine X-396	treatment	2	active_not_recruiting
NCT01532089	Erlotinib Hydrochloride With or Without Bevacizumab in Treating Patients With Stage IV Non-small Cell Lung Cancer With Epidermal Growth Factor Receptor Mutations	Bevacizumab Erlotinib	treatment	2	completed
NCT03976323	Study of Pembrolizumab With Maintenance Olaparib or Maintenance Pemetrexed in First-line (1L) Metastatic Non-squamous Non-Small-Cell Lung Cancer (NSCLC) (MK-7339-006, KEYLYNK-006)	Carboplatin Cisplatin Olaparib Pembrolizumab Pemetrexed	treatment	3	active_not_recruiting
NCT02029690	Ph 1 Study in Subjects With Tumors Requiring Arginine to Assess ADI-PEG 20 With Pemetrexed and Cisplatin	Pegargiminase	treatment	1	terminated
NCT04954885	Evaluating Modifiable Biomarkers for the Prediction of Immunotherapy Response and Toxicity	No drug interventions	Not Available	Not Available	recruiting
NCT02452463	Nintedanib Compared With Placebo in Treating Against Radiation-Induced Pneumonitis in Patients With Non-small Cell Lung Cancer That Cannot Be Removed by Surgery and Are Undergoing Chemoradiation Therapy	Durvalumab Nintedanib Tyrosine	supportive_care	2	terminated
NCT03366766	Nivolumab, Cisplatin, and Pemetrexed Disodium or Gemcitabine Hydrochloride in Treating Patients With Stage I-IIIA Non-small Cell Lung Cancer That Can Be Removed by Surgery	Cisplatin Gemcitabine Nivolumab Pemetrexed Platinum	treatment	2	completed
NCT02254512	METformin With a Cargohydrate Restricted Diet in Combination With Platinum Based Chemotherapy in Stage IIIB/IV Non-squamous Non-small Cell Lung Cancer	Carboplatin Metformin Pemetrexed	treatment	2	recruiting
NCT06643117	Similar Efficacy, Safety, and Immunogenicity of FYB206 in Comparison to Keytruda as add-on to Chemotherapy in Patients With Non-squamous Non-small Cell Lung Cancer (NSCLC)	No drug interventions	treatment	3	recruiting
NCT06313268	Safety of Effivia®, a Bevacizumab Biosimilar	Bevacizumab	Not Available	Not Available	completed
NCT06396065	Phase III Study of AK112 for NSCLC Patients	Carboplatin Ivonescimab Pemetrexed	treatment	3	active_not_recruiting
NCT03468426	A Study to Test Different Doses of BI 836880 Combined With Ezabenlimab in Patients With Advanced Non-small Cell Lung Cancer Followed by Other Types of Advanced Solid Tumours	BI-836880 Ezabenlimab	treatment	1	completed
NCT04716933	Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)-China Extension Study	Carboplatin Cisplatin Lenvatinib Pembrolizumab Pemetrexed	treatment	3	completed
NCT06627647	A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC	Carboplatin Cisplatin Pembrolizumab Pemetrexed Rilvegostomig	treatment	3	not_yet_recruiting
NCT04750824	Real-World Effectiveness of Afatinib (Gilotrif) Following Immunotherapy in the Treatment of Metastatic, Squamous Cell Carcinoma of the Lung: A Multi-Site Retrospective Chart Review Study in the U.S.	Afatinib	Not Available	Not Available	completed
NCT05403554	A Study of NI-1801 in Patients with Mesothelin Expressing Solid Cancers	Paclitaxel Pembrolizumab	treatment	1	recruiting
NCT06491862	RACE-2L: Real-World Assessment of Clinical Practice and Outcomes in Non-squamous NSCLC After Failure of Platinum-based Chemotherapy in Brazil	No drug interventions	Not Available	Not Available	recruiting
NCT01066884	A Study of First or Second Line Treatment With Tarceva (Erlotinib) in Patients With Advanced Non-Small Cell Lung Cancer	Erlotinib	treatment	4	completed
NCT00974584	A Study of the Safety and Pharmacology Of PI3-Kinase Inhibitor GDC-0941 In Combination With Either Paclitaxel And Carboplatin (With or Without Bevacizumab) or Pemetrexed, Cisplatin, And Bevacizumab in Patients With Advanced Non-Small Cell Lung Cancer	Bevacizumab Carboplatin Cisplatin Paclitaxel Pemetrexed Pictilisib	treatment	1	completed
NCT00883779	A Study of Tarceva (Erlotinib) or Placebo in Combination With Platinum-Based Therapy as First Line Treatment in Patients With Advanced or Recurrent Non-Small Cell Lung Cancer	Cisplatin Erlotinib Gemcitabine Platinum	treatment	3	completed
NCT01664533	An Observational Study of Erlotinib (Tarceva) as Second-line Treatment in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer After Failure of Pemetrexed in First-line Therapy	Erlotinib	Not Available	Not Available	completed
NCT05394233	Tislelizumab +Bevacizumab+pc for Untreated EGFR+ and High PD-L1 Non-squamous NSCLC	Bevacizumab Pemetrexed Platinum Tislelizumab	treatment	2	unknown_status
NCT01836133	An Observational Study of Tarceva (Erlotinib) in Participants With Locally Advanced or Metastatic Adenocarcinoma Non-Small Cell Lung Cancer (ELEMENT)	Erlotinib	Not Available	Not Available	completed
NCT02835833	Study of Nintedanib Plus Bevacizumab in Advanced Solid Tumors	Bevacizumab Nintedanib	treatment	1	completed
NCT00152477	A Study of Paclitaxel/Carboplatin With or Without CDP791 in Patients With Lung Cancer	Carboplatin Paclitaxel	treatment	2	completed
NCT00776698	A Study of Avastin (Bevacizumab) in Combination With Thoracic Radiation and Chemotherapy in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer.	Bevacizumab Cisplatin Etoposide	treatment	1	completed
NCT01204697	A Study of Erlotinib [Tarceva] as Monotherapy or Intermittent Dosing With Docetaxel in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer. (TALISMAN)	Docetaxel Erlotinib	treatment	2	completed
NCT03863483	A Study of Sintilimab or Placebo in Combination With Chemotherapy as Second-line Treatment for Patients With Stage IV Nonsquamous Non-small Cell Lung Cancer With Wild-type EGFR After Failure With Platinum-Containing Chemotherapy.	Docetaxel Pemetrexed Sintilimab	treatment	2	unknown_status
NCT01990261	A Study to Assess the Survival of Non-small Cell Lung Cancer Patients Treated With Tarceva After Failed Chemotherapy Treatment	Erlotinib	Not Available	Not Available	terminated
NCT00518011	A Study of Tarceva (Erlotinib) and Gemcitabine in Treatment-Naive Patients With Advanced Non-Small Cell Lung Cancer.	Erlotinib Gemcitabine	treatment	2	completed
NCT04958811	Tiragolumab With Atezolizumab Plus Bevacizumab in Previously-Treated Advanced Non-squamous NSCLC	Atezolizumab Bevacizumab Tiragolumab	treatment	2	recruiting
NCT05317078	A Phase 1 Safety, Tolerability, and Pharmacokinetics Study of AMG 794 With Claudin 6-positive Non-small Cell Lung Cancer, Epithelial Ovarian Cancer, and Other Malignant Solid Tumor Indications	No drug interventions	treatment	1	terminated
NCT02774278	A Study of Erlotinib (Tarceva) in Participants With Non-Small Cell Lung Cancer (NSCLC)	Erlotinib	treatment	2	completed
NCT01995188	A Study to Evaluate the Safety and Pharmacology of DNIB0600A in Participants With Platinum-Sensitive Ovarian Cancer or Non-Squamous Non-small Cell Lung Cancer	Bevacizumab Carboplatin Lifastuzumab vedotin	treatment	1	completed
NCT03992885	Clinical Study of Combination Therapy With Ectiecinib, Pemetrexed and Platinum in Patients With Metastatic Non-squamous Non-small Cell Lung Cancer With EGFR Mutations.	Icotinib Pemetrexed Platinum	treatment	3	recruiting
NCT01351415	A Study of Bevacizumab in Combination With Standard of Care Treatment in Participants With Advanced Non-squamous Non-small Cell Lung Cancer (NSCLC)	Bevacizumab Docetaxel Erlotinib Pemetrexed	treatment	3	completed
NCT01827852	AVAdeno Study: An Observational Study of First-Line Avastin (Bevacizumab) in Patients With Adenocarcinoma of the Lung	No drug interventions	Not Available	Not Available	completed
NCT01358942	An Observational Study of Lung Cancer Related Symptoms and Disease Control Rate in Patients With Non-Small Cell Lung Cancer Receiving First-Line Platinum-Based Chemotherapy With or Without Avastin (Bevacizumab)	No drug interventions	Not Available	Not Available	completed
NCT00451906	A Study of Avastin (Bevacizumab) in Combination With Platinum-Containing Chemotherapy in Patients With Advanced or Recurrent Non-Squamous Cell Lung Cancer.	Bevacizumab Platinum	treatment	4	completed
NCT04063449	Endostar/PD-1 Inhibitors Combined With PP for Advanced NSCLC	Endostatin	treatment	Not Available	unknown_status
NCT00988936	Efficacy Study of [F-18]RGD-K5 Positron Emission Tomography (PET) as a Tool to Monitor Response to an Anti-angiogenic Drug	No drug interventions	Not Available	2	completed
NCT01829113	Phase II Trial of Carboplatin and Pemetrexed +/- OGX-427 in Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer	Apatorsen	treatment	2	completed
NCT01077713	A Study of Avastin (Bevacizumab) in Combination With Gemcitabine With or Without Cisplatin in First-Line Treatment of Elderly Patients With Non-Small Cell Lung Cancer	Bevacizumab Cisplatin Gemcitabine	treatment	2	completed
NCT05338619	A Study of Lazertinib as Consolidation Therapy in Patients With Locally Advanced, Unresectable, EGFR-Mutant Non-Small Cell Lung Cancer (Stage III) Following Chemoradiation Therapy	Lazertinib	treatment	2	recruiting
NCT03127319	A Study of Apatinib Plus Docetaxel for Treatment of Advanced Non-squamous Non-small Cell Lung Cancer With Bone Metastases	Docetaxel Rivoceranib Zoledronic acid	treatment	2	unknown_status
NCT01790217	An Observational Study of Tarceva (Erlotinib) in First Line in Patients With Advanced EGFR Mutation-Positive Non-Small Cell Lung Cancer (GERTAC)	No drug interventions	Not Available	Not Available	completed
NCT04084717	Study of Crizotinib for ROS1 and MET Activated Lung Cancer	Crizotinib	treatment	2	recruiting
NCT04504916	A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002)	Zilovertamab vedotin	treatment	2	terminated
NCT02596958	Safety and Efficacy Study of Avastin in Locally Advanced Metastatic or Recurrent Non-small Lung Cancer (NSLC) Participants	Bevacizumab	Not Available	Not Available	completed
NCT01887886	A Study of Onartuzumab in Combination With Erlotinib in Patients With MET-Positive Stage IIIB or IV Non-Small Cell Lung Cancer Carrying an Activating Epidermal Growth Factor Receptor (EGFR) Mutation	Erlotinib Onartuzumab	treatment	3	completed
NCT01456325	A Study of Onartuzumab (MetMAb) in Combination With Tarceva (Erlotinib) in Participants With Met Diagnostic-Positive Non-Small Cell Lung Cancer Who Have Received Chemotherapy For Advanced or Metastatic Disease (MetLung)	Erlotinib Onartuzumab	treatment	3	completed
NCT06334757	Serplulimab Plus Bevacizumab and Chemotherapy for EGFR-mutant Metastatic NSCLC Patients After EGFR-TKI Treatment Failure	Bevacizumab Carboplatin Pemetrexed Serplulimab	treatment	2	recruiting
NCT01512420	An Observational Study of Tarceva (Erlotinib) in Previously Treated Patients With Advanced Non-Small Cell Lung Cancer With Wild-Type Epidermal Growth Factor Receptor (EGFR) Gene (WILT)	No drug interventions	Not Available	Not Available	completed
NCT02475382	Expanded Access Program With Nivolumab Therapy for Treatment of Advanced/Metastatic SqNSCLC or Non-SqNSCLC After One Prior Systemic Regimen	Nivolumab	Not Available	Not Available	no_longer_available
NCT01951482	Pemetrexed/Cisplatin With or Without Bevacizumab in Brain Metastases From Non Squamous Non-small Cell Lung Cancer	Bevacizumab Cisplatin Pemetrexed	treatment	2	unknown_status
NCT01488331	An Observational Study of Tarceva (Erlotinib) in Patients With Non-Small Cell Lung Cancer	No drug interventions	Not Available	Not Available	completed
NCT03602027	Phase I Study of the Combination of Anlotinib With Gefitinib	Anlotinib Gefitinib	treatment	Not Available	unknown_status
NCT01070927	An Exploratory Study of RO4929097 in Patients With Recurrent or Refractory Non-Small Cell Lung Cancer	RG-4733	treatment	2	completed
NCT03566576	Phase I Study of the Combination of Anlotinib With Pemetrexed or Docetaxel	Anlotinib Docetaxel Pemetrexed	treatment	Not Available	unknown_status
NCT01244191	Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer	Erlotinib Tivantinib	treatment	3	terminated
NCT01378962	A Study of Tarceva (Erlotinib) in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (TRIGGER)	Erlotinib	treatment	2	completed
NCT01535729	An Observational Study of Tarceva (Erlotinib) in Elderly Patients With Advanced Non-Small Cell Lung Cancer	No drug interventions	Not Available	Not Available	completed
NCT05086692	A Beta-only IL-2 ImmunoTherapY Study	Albumin human Human interleukin-2 Pembrolizumab	treatment	1 / 2	recruiting
NCT03802240	Sintilimab ± IBI305 Plus Chemotherapy (Pemetrexed + Cisplatin) for EGFRm + Locally Advanced or Metastasis Non-Squamous NSCLC Patients After EGFR-TKI Treatment Failure	Cisplatin Pemetrexed Sintilimab	treatment	3	completed
NCT05841472	Anti-PD-1 Antibody Therapies of Camrelizumab in Combination With Pemetrexed and Carboplatin as First-line Treatment in Patients With Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer	Camrelizumab Carboplatin Pemetrexed	treatment	2	recruiting
NCT01893268	An Observational Study of Avastin (Bevacizumab) in Elderly Patients With Non-Squamous Non-Small Cell Lung Cancer in Clinical Practice	No drug interventions	Not Available	Not Available	completed
NCT05184712	Phase 3 Clinical Study of AK112 for NSCLC Patients	Carboplatin Ivonescimab Pemetrexed	treatment	3	active_not_recruiting
NCT04698681	NGS Screening Protocol to Detect Mutation of KEAP1 or NRF2/NFE2L2 Genes for the KEAPSAKE (CX-839-014) Trial	No drug interventions	Not Available	Not Available	terminated
NCT01343914	An Observational Study on Patients With Non-Squamous NSCLC Who Reached A Long PFS After Avastin (Bevacizumab)-Based First-Line Therapy	No drug interventions	Not Available	Not Available	completed
NCT06335355	A Phase II/III Study of Adebrelimab in Combination With SHR-8068 and Chemotherapy in Advanced or Metastatic NSCLC Patients	Adebrelimab Camrelizumab Carboplatin Pemetrexed	treatment	2 / 3	not_yet_recruiting
NCT01194050	An Observational Study of Tarceva (Erlotinib) in Routine Practice For First Line Maintenance Therapy in Patients With Non Small Cell Lung Cancer	No drug interventions	Not Available	Not Available	completed
NCT00806923	A Study of Avastin (Bevacizumab) in Patients With Non-Squamous Non-Small Cell Lung Cancer (NSCLC)	Bevacizumab Cisplatin Gemcitabine	treatment	3	completed
NCT06417008	A Study of HS-20117 Combined With Aumolertinib in Participants With Advanced Non-Squamous Non-Small Cell Lung Cancer	Almonertinib	treatment	2 / 3	not_yet_recruiting
NCT03671538	Non Squamous NSCLC Patients With Anlotinib Combined With Pemetrexed and Cisplatin	Anlotinib Cisplatin Pemetrexed	treatment	Not Available	unknown_status
NCT04211090	Camrelizumab With AC in Patients With Brain Metastases of Driven Gene-negative,NSCLC	Camrelizumab Carboplatin Pemetrexed	treatment	2	active_not_recruiting
NCT02264990	Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Investigator's Choice of Standard Chemotherapy in Adults Receiving First Cytotoxic Chemotherapy for Metastatic or Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC) and Who Are Current or Former Smokers	Carboplatin Cisplatin Paclitaxel Pemetrexed Veliparib	treatment	3	completed
NCT04179890	The Study Observes How Long Patients With Non-small Cell Lung Cancer (NSCLC) Benefit From Treatment With Epidermal Growth Factor Tyrosine Kinase Inhibitor (EGFR-TKI) When Given Either for Uncommon Mutations or for Common Mutations in the Sequence Afatinib Followed by Osimertinib	Afatinib Erlotinib Gefitinib Osimertinib	Not Available	Not Available	completed
NCT05962021	Neoadjuvant Toripalimab for Non-squamous NSCLC With EGFR Mutation	Toripalimab	treatment	2	not_yet_recruiting
NCT01372384	A Study of Tarceva (Erlotinib) in Patients With Locally Advanced, Metastatic or Recurrent Non-Small Cell Cancer Who Present Epidermal Growth Factor Receptor Mutations	Erlotinib	treatment	2	completed
NCT05258279	Lenvatinib in Combination With Carboplatin Pemetrexed and Pembrolizumab for NSCLC With EGFR Mutations	Carboplatin Lenvatinib Pembrolizumab Pemetrexed	treatment	2	active_not_recruiting
NCT04206787	The START Study Observes Afatinib as First-line Treatment and Sequential Therapy in Patients With Epidermal Growth Factor Receptor (EGFR) Mutation-positive Advanced Nonsmall Cell Lung Cancer	Afatinib	Not Available	Not Available	completed
NCT04619433	A Study to Evaluate SHR-1210 in Combination With Famitinib Plus Chemotherapy in Subjects With NSCLC.	Camrelizumab Carboplatin Famitinib Pemetrexed	treatment	3	unknown_status
NCT01328951	A Study of First-line Maintenance Erlotinib Versus Erlotinib at Disease Progression in Participants With Advanced Non-Small Cell Lung Cancer (NSCLC) Who Have Not Progressed Following Platinum-Based Chemotherapy	Erlotinib	treatment	3	completed
NCT01185847	A Study of RO5083945 in Combination With Chemotherapy Versus Chemotherapy Alone in Patients With Advanced or Recurrent Non-Small Cell Lung Cancer	Cisplatin Gemcitabine Imgatuzumab Pemetrexed	treatment	2	completed
NCT04795245	Non-interventional Study for Real-world Data of Afatinib Treatment in First-line Setting and of Subsequent Therapies for Patients With Advanced Epidermal Growth Factor Receptor (EGFR) Mutation-positive Lung Adenocarcinoma	Afatinib	Not Available	Not Available	completed
NCT06173505	Study of Vudalimab or Pembrolizumab in Combination With Chemotherapy as First-line Treatment in Patients With Advanced NSCLC	Carboplatin Pembrolizumab Pemetrexed Vudalimab	treatment	1 / 2	recruiting
NCT04750083	HX008 Plus Chemotherapy VS Pembrolizumab Plus Chemotherapy As the First-line Treatment in Participants With Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer	Carboplatin Cisplatin Pembrolizumab Pemetrexed Pucotenlimab	treatment	2 / 3	unknown_status
NCT03830411	A Study of Sintilimab Compared With Docetaxel or Pemetrexed as Second-line Treatment for Patients With Stage IV Nonsquamous Non-small Cell Lung Cancer After Failure With Platinum-Containing Chemotherapy	Docetaxel Pemetrexed Sintilimab	treatment	2	unknown_status
NCT03329911	A Comparative Study of BAT1706 and EU Avastin® in Patients With Advanced Non Squamous Non Small Cell Lung Cancer	Bevacizumab Carboplatin Paclitaxel	treatment	3	completed
NCT05245071	Tusamitamab Ravtansine in NSQ NSCLC Participants With Negative or Moderate CEACAM5 Expression Tumors and High Circulating CEA	Tusamitamab ravtansine	treatment	2	active_not_recruiting
NCT01763671	Paclitaxel-bevacizumab in Advanced Lung Cancer	Bevacizumab Docetaxel Paclitaxel	treatment	3	completed
NCT01723878	ASPET Study: An Observational Study of Tarceva (Erlotinib) in First Line in Patients With Advanced Non-Small Cell Lung Cancer Harbouring EGFR Activating Mutations	No drug interventions	Not Available	Not Available	completed
NCT00773188	A Feasibility Trial of Avastin (Bevacizumab) in Combination With Concomitant Chemoradiation (Cisplatin and Vinorelbine) in Patients With Locally Advanced Non-Squamous Non-Small Cell Lung Cancer.	Bevacizumab Cisplatin Vinorelbine	treatment	1	completed
NCT01333007	An Observational Study of Avastin (Bevacizumab) in Combination With Chemotherapy in Patients With Metastatic or Recurrent Non-Squamous Non-Small Cell Lung Cancer	No drug interventions	Not Available	Not Available	completed
NCT00976456	Efficacy Study of Avastin® With Pemetrexed +/- Carboplatin to Treat Elderly Patients With Non-small Cell Lung Cancer	Bevacizumab Carboplatin Pemetrexed	treatment	3	completed
NCT04262856	Study to Evaluate Monotherapy and Combination Immunotherapies in Participants With PD-L1 Positive Non-small Cell Lung Cancer	Domvanalimab Etrumadenant Zimberelimab	treatment	2	active_not_recruiting
NCT00961415	AVAPERL1 Study: A Study of Avastin (Bevacizumab) With or Without Pemetrexed as Maintenance Therapy After Avastin in First Line in Patients With Non-Squamous Non-Small Cell Lung Cancer	Bevacizumab Cisplatin Pemetrexed	treatment	3	completed
NCT05338970	HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI Therapy	Platinum	treatment	3	active_not_recruiting
NCT01659970	PEPITA Study: An Observational Study of Tarceva (Erlotinib) in Second Line in Patients With Locally Advanced or Metastatic Squamous Non-Small Cell Lung Cancer	No drug interventions	Not Available	Not Available	completed
NCT01496742	A Study of Onartuzumab (MetMAb) in Combination With Bevacizumab (Avastin) Plus Platinum And Paclitaxel or With Pemetrexed Plus Platinum in Patients With Non-Squamous Non-Small Cell Lung Cancer	Bevacizumab Carboplatin Cisplatin Paclitaxel Pemetrexed	treatment	2	completed
NCT01310036	A Study of Tarceva (Erlotinib) as First Line Therapy in Participants With Non-Small Cell Lung Cancer Harbouring Epidermal Growth Factor Receptor (EGFR) Mutations	Erlotinib	treatment	2	completed
NCT01250119	A Study to Assess the Incidence of EGFR Mutation in Patients With Newly Diagnosed Locally Advanced or Metastatic Non-Small Cell Lung Cancer in the UK, And of Tarceva (Erlotinib) as First-Line Therapy in EGFR Mutation Positive Patients.	Erlotinib	treatment	2	completed
NCT04012619	Anlotinib Hydrochloride Combined With AP in Stage IIIB/IIIC/IV Non-squamous Non-small-cell Lung Cancer	Anlotinib Carboplatin Cisplatin Pemetrexed	treatment	1	completed
NCT03829319	Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)	Carboplatin Cisplatin Lenvatinib Pembrolizumab Pemetrexed	treatment	3	active_not_recruiting
NCT04265534	KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated, Nonsquamous NSCLC	Carboplatin Dexamethasone Pembrolizumab Pemetrexed Telaglenastat	treatment	2	terminated
NCT00642824	A Genetic Substudy Associated With the Avastin (Bevacizumab) Study MO19390 in Patients With Advanced or Recurrent Non-Squamous Cell Lung Cancer.	Bevacizumab	treatment	2	terminated
NCT03319316	Combination of Durvalumab and Tremelimumab as Maintenance Treatment in Patients With Non Squamous and Squamous (NSCLC)	Durvalumab Tremelimumab	treatment	2	withdrawn
NCT03169335	Efficacy and Safety of QL1101 and Avastin® Respectively Combined With Paclitaxel and Carboplatin in the First-line Treatment of Non-squamous Non-small Cell Lung Cancer	Bevacizumab Carboplatin Paclitaxel	treatment	3	completed
NCT01174563	A Study on the Correlation Between Tarceva (Erlotinib) - Induced Rash and Efficacy in EGFR Mutated Participants With Advanced Non-Small Cell Lung Cancer Receiving First-Line Therapy	Erlotinib	treatment	2	completed
NCT04396457	Pembrolizumab Plus Pemetrexed for Elderly Patients With Non-Sq NSCLC With PD-L1 < 50%: CJLSG1901	Pembrolizumab Pemetrexed	treatment	2	active_not_recruiting
NCT01366131	Study Evaluating the Safety and Efficacy of MEGF0444A in Combination With Carboplatin, Paclitaxel and Bevacizumab in Patients With Advanced or Recurrent Non-Squamous Non-Small Cell Lung Cancer Who Have Not Received Prior Chemotherapy for Advanced Disease (NILE)	Bevacizumab Carboplatin Paclitaxel Parsatuzumab	treatment	2	completed
NCT00642473	A Study of Metronidazole Cream in the Prevention and Treatment of Tarceva (Erlotinib)-Associated Rash	Erlotinib Metronidazole	treatment	2	completed
NCT04736173	Study Comparing the Combination Domvanalimab and Zimberelimab With Pembrolizumab in Untreated Locally Advanced or Metastatic PD-L1-High Non-Small Cell Lung Cancer	Carboplatin Domvanalimab Paclitaxel Pembrolizumab Pemetrexed Zimberelimab	treatment	3	active_not_recruiting
NCT02008227	A Study of Atezolizumab Compared With Docetaxel in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Failed Platinum-Containing Therapy	Atezolizumab Docetaxel	treatment	3	completed
NCT03376191	Apatinib in Advanced Non-squamous，NSCLC	Rivoceranib	Not Available	Not Available	unknown_status
NCT00760929	A Study of the Effect of R1507 in Combination With Tarceva (Erlotinib) on Progression-Free Survival in Patients With Stage IIIb/IV Non-Small Cell Lung Cancer (NSCLC).	Erlotinib Teprotumumab	treatment	2	terminated
NCT02633189	Study Comparing Bevacizumab + Erlotinib vs Erlotinib Alone as First Line Treatment of Patients With EGFR Mutated Advanced Non Squamous Non Small Cell Lung Cancer	Bevacizumab Erlotinib	treatment	3	active_not_recruiting
NCT01160601	Study of Paclitaxel/Carboplatin With or Without Bavituximab in Previously Untreated Non Small-Cell Lung Cancer	Bavituximab Carboplatin Paclitaxel	treatment	2	completed
NCT01519804	A Study of Onartuzumab (MetMAb) Versus Placebo in Combination With Paclitaxel Plus Platinum in Patients With Squamous Non-Small Cell Lung Cancer	Carboplatin Cisplatin Onartuzumab Paclitaxel	treatment	2	completed
NCT03646968	Study of Anlotinib Combined With Docetaxel in Non-Driver Mutation Non-squamous NSCLC: the Save Study	Anlotinib Docetaxel	treatment	2	recruiting
NCT05849246	The Study of Tusamitamab Ravtansine (IBI126) Combined With Sintilimab and Tusamitamab Ravtansine (IBI126) Combined With Sintilimab Plus Platinum-based Chemotherapy and Pemetrexed in Subjects With CEACAM5 Positive Expression Advanced/Metastatic Non-squamous Non-small-cell Lung Cancer (NSQ NSCLC)	Carboplatin Cisplatin Pemetrexed Sintilimab Tusamitamab ravtansine	treatment	2	terminated
NCT01057212	Trial of Bevacizumab and Ixabepilone for Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)	Bevacizumab Ixabepilone	treatment	2	terminated
NCT01260181	A Study of Erlotinib in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor Mutations	Erlotinib	treatment	2	completed
NCT01702714	A Study of RO5083945 in Combination With Cisplatin and Gemcitabine or Carboplatin and Paclitaxel in Patients With Advanced or Recurrent Non-Small Cell Lung Cancer of Squamous Histology Who Have Not Received Prior Chemotherapy for The Metastatic Disease	Carboplatin Cisplatin Gemcitabine Imgatuzumab Paclitaxel	treatment	1	withdrawn
NCT04453423	Combination Chemotherapy With or Without Anlotinib in the Maintenance Treatment of Non-Squamous Non-Small Cell Lung Cancer.	Anlotinib Carboplatin Pemetrexed	treatment	2	unknown_status
NCT04173338	Cabozantinib With Pemetrexed in Advanced Non-small Cell Lung Cancer, Urothelial Cancer and Malignant Mesothelioma	Cabozantinib Pemetrexed	treatment	1	terminated
NCT01609543	A Study of Tarceva (Erlotinib) in First Line in Patients With Locally Advanced or Metastatic Lung Adenocarcinoma With EGFR Mutations	Erlotinib	treatment	4	completed
NCT05318443	A Study Exploring Efficacy of SIBP04 in Subjects With Non-squamous Non-small Cell Lung Cancer	Bevacizumab Carboplatin Paclitaxel	treatment	3	completed
NCT04466917	A Study of ABP 215 Versus Bevacizumab in Chinese Subjects With Advanced Non-Squamous Non-Small Cell Lung Cancer	Bevacizumab Carboplatin Paclitaxel	treatment	3	withdrawn
NCT04413201	AFAMOSI: Efficacy and Safety of Afatinib Followed by Osimertinib Compared to Osimertinib in Patients With EGFRmutated/T790M Mutation Negative Nonsquamous NSCLC	Afatinib Osimertinib	treatment	4	active_not_recruiting
NCT03755869	Study of Anlotinib in Non-squamous NSCLC Patients Who Failed First-Line（ALTER-L020）	Anlotinib	treatment	4	unknown_status
NCT05261438	Atezolizumab Plus Bevacizumab and Chemotherapy in First-Line Metastatic Nonsquamous NSCLC	No drug interventions	Not Available	Not Available	completed
NCT05751187	Pembrolizumab Plus Bevacizumab and Chemotherapy for Non-Squamous NSCLC Patients	Bevacizumab Carboplatin Cisplatin Dexamethasone Pembrolizumab Pemetrexed	treatment	2	recruiting
NCT02454842	Study for Treatment With TH-4000 (Tarloxotinib) in Epidermal Growth Factor Receptor (EGFR) Mutant, T790M-negative Non-small Cell Lung Cancer (NSCLC) Patients	Tarloxotinib	treatment	2	terminated
NCT04447118	Phase 3 Study of Pyrotinib Versus Docetaxel in Patients With Advanced Non-squamous NSCLC Harboring a HER2 Exon 20 Mutation Who Failed Platinum Based Chemotherapy	Docetaxel Pyrotinib	treatment	3	active_not_recruiting
NCT05782426	Study of Polymeric Micellar Paclitaxel, Platinum Combined With Sindilizumab Injection for Advanced Non-squamous NSCLC	Paclitaxel Platinum	treatment	2	not_yet_recruiting
NCT06206850	Neo-Bio-ADAURA: A Phase II Study to Evaluate Mechanisms of Resistance to Neoadjuvant Osimertinib	Osimertinib	treatment	2	not_yet_recruiting
NCT04032704	A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors	Ladiratuzumab vedotin Pembrolizumab	treatment	2	terminated
NCT03790228	Anlotinib Combined With Pemetrexed And Carboplatin as First-line Treatment in Advanced Nonsquamous NSCLC	Anlotinib Carboplatin Pemetrexed	treatment	1	unknown_status
NCT03792074	To Evaluate the Efficacy and Safety of SCT510 in the Treatment of Non-small Cell Lung Cancer	Bevacizumab Carboplatin Paclitaxel	treatment	3	unknown_status
NCT01673867	Study of BMS-936558 (Nivolumab) Compared to Docetaxel in Previously Treated Metastatic Non-squamous NSCLC	Docetaxel Nivolumab	treatment	3	completed
NCT03778138	Study of Anlotinib Combined With Pemetrexed in Patients With Advanced Nonsquamous NSCLC	Anlotinib Pemetrexed	treatment	2	unknown_status
NCT02367781	A Study of Atezolizumab in Combination With Carboplatin Plus (+) Nab-Paclitaxel Compared With Carboplatin+Nab-Paclitaxel in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC)	Atezolizumab Carboplatin Paclitaxel Pemetrexed	treatment	3	completed
NCT05070247	A Study of TAK-500 With or Without Pembrolizumab in Adults With Select Locally Advanced or Metastatic Solid Tumors	Pembrolizumab	treatment	1 / 2	recruiting
NCT03041181	Single Agent Chemotherapy +/- Nivolumab in Patients With Advanced Squamous or Non-squamous NSCLC With Primary Resistance to Prior PD-1 or PDL-1 Inhibitor	Docetaxel Gemcitabine Nivolumab Pemetrexed	treatment	2	terminated