First-line Therapy (DBCOND0147336)

Identifiers

Synonyms

First-line treatment / First Line Treatment / First line treatment (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Eltrombopag	A thrombopoietin receptor agonist used to treat thrombocytopenia or aplastic anemia associated with various etiologies.	Thrombopoietin receptortarget Cytochrome P450 2C8enzyme Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme Solute carrier organic anion transporter family member 1B1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter UDP-glucuronosyltransferase 1A9enzyme
Tagraxofusp	A CD123-directed cytotoxin used to treat blastic plasmacytoid dendritic cell neoplasm.	Interleukin-3 receptor subunit alphatarget
Trastuzumab	A monoclonal anti-human epidermal growth factor receptor 2 protein antibody used to treat HER2-positive breast, gastroesophageal, and gastric cancers.	Receptor tyrosine-protein kinase erbB-2target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05299476	CAPOX + Bevacizumab + Tirelizumab Treating PDL1 CPS < 5 GEA	Bevacizumab Tislelizumab	treatment	2	recruiting
NCT06148779	Can Digitally Delivered First-line Osteoarthritis Treatment Improve Equal Access to Care	No drug interventions	Not Available	Not Available	recruiting
NCT05913661	Pemigatinib Combined With PD-1 Inhibitor in Unresectable or Metastatic Intrahepatic Cholangiocarcinoma	Pemigatinib Sintilimab	treatment	2	recruiting
NCT04836728	Study of Chemotherapy and PD-1 Inhibitor Combination With Autologous CIK Cell Immunotherapy to Treat Lung Cancer	Albumin human Carboplatin Paclitaxel Pemetrexed Sintilimab	treatment	2	unknown_status
NCT05221775	Safety of XELOX Combined With GLS-010 and Lenvatinib in Advanced AFP-positive Gastric Cancer Patients	Lenvatinib	treatment	1	unknown_status
NCT06278870	Disitamab Vedotin + Pyrotinib Versus THP in the First-line Treatment for HER2+ Advanced Breast Cancer Clinical Trial	Disitamab vedotin Pertuzumab Pyrotinib Trastuzumab	treatment	3	recruiting
NCT05077839	Trifluridine/Tipiracil Combined With Oxaliplatin and Bevacizumab Versus XELOX Plus Bevacizumab in mCRC	TAS-102 Tipiracil Trifluridine	treatment	2	recruiting
NCT05760053	Toripalimab Plus Etoposide and Platinum-based Chemotherapy for Genitourinary Small Cell Carcinoma	Carboplatin Cisplatin Etoposide Toripalimab	treatment	2	recruiting
NCT04271813	Anlotinib Plus Sintilimab as First-line Treatment for Patients With Advanced Colorectal Cancer (APICAL-CRC)	Anlotinib Sintilimab	treatment	2	completed
NCT03987867	Study of Autologous CIK Cell Immunotherapy Combination With PD-1 Inhibitor and Chemotherapy in the Advanced NSCLC	Carboplatin Paclitaxel Pemetrexed Sintilimab	treatment	1	unknown_status
NCT05256472	A Study of AK104 Monotherapy or AK104 Plus Axitinib in Advanced/Metastatic Renal Cell Carcinoma	Axitinib Cadonilimab	treatment	2	recruiting
NCT05808608	A Study of AK104 Plus Axitinib in Advanced/Metastatic Special Pathological Subtypes of Renal Cell Carcinoma	Axitinib Cadonilimab	treatment	1 / 2	not_yet_recruiting
NCT02055508	POSITIVE - Study (Part III) Heidelberg	No drug interventions	supportive_care	Not Available	completed
NCT06374160	Exercise in Patients With Advanced Non-small Cell Lung Cancer	No drug interventions	supportive_care	Not Available	not_yet_recruiting
NCT01980212	Tumor Relapsed Study of Serum Trxr Activity in Advanced Non-small Cell Lung Cancer	No drug interventions	Not Available	Not Available	completed