Onium Compounds

Name
Onium Compounds
Accession Number
DBCAT000267
Description

Ions with the suffix -onium, indicating cations with coordination number 4 of the type RxA+ which are analogous to QUATERNARY AMMONIUM COMPOUNDS (H4N+). Ions include phosphonium R4P+, oxonium R3O+, sulfonium R3S+, chloronium R2Cl+

Drugs
DrugDrug Description
SuccinylcholineA depolarizing skeletal muscle relaxant used adjunctly to anesthesia and for skeletal muscle relaxation during intubation, mechanical ventilation, and surgical procedures.
CarbamoylcholineA direct acting miotic agent administered ophthalmically to decrease intraocular pressure after cataract surgery, and to induce miosis during surgery.
DemecariumFor the topical treatment of chronic open-angle glaucoma.
GlycopyrroniumAn anticholinergic agent used to treat hyperhidrosis, severe drooling, COPD, used with other medications to treat ulcers, and used in anesthesia.
BethanecholA muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention.
MethacholineA parasympathomimetic bronchoconstrictor used to diagnose bronchial hyperreactivity in subjects who do not have clinically apparent asthma.
TridihexethylUsed as an adjunct in the treatment of peptic ulcer disease and in Acquired nystagmus
AmbenoniumA cholinesterase inhibitor that targets both muscarinic and nicotinic receptors indicated for the treatment of myasthenia gravis.
EmbutramideNot Available
IsopropamideA long-acting anticholinergic drug used to relieve symptoms of spastic and painful symptoms of gastrointestinal conditions and symptoms of flu, colds, and related conditions.
GhavamiolNot Available
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonateNot Available
DodecyltrimethylammoniumNot Available
TetramethylammoniumNot Available
DidecyldimethylammoniumA disinfectant and microbicidal agent used in a variety of products.
MethylnaltrexoneA μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy.
Ferric ammonium citrateNot Annotated
ThonzoniumA cationic surfactant used to disperse exudate and cellular debris, as well as enhance the penetration of antimicrobials.
Brilliant green cationAn ingredient used in topical medications to prevent infections of the umbilical cord.
IchthammolIchthammol is also referred to as ammonium bituminosulfonate or ammonium bituminosulphonate. It is an ammonium salt of dark sulfonated shale oil (bituminous schists) produced via distillation of the oil followed...
CetalkoniumAn antiseptic used as a preservative or to treat certain topical infections.
DomiphenAnti-infective (topical), it is used for the treatment of Acute Infectious Dental Diseases and other conditions.
MethylbenactyziumNot Annotated
ValethamateAn anticholinergic medication used to symptomatically manage conditions involving smooth muscle spasms including spastic constipation, dysmenorrhea, and gastrointestinal tract cramping.
OtiloniumA spasmolytic medication used to treat irritable bowel syndrome (IBS).
AlcuroniumA non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant.
PenthienateNot Annotated
DioctyldimoniumNot Annotated
DistearyldimoniumNot Annotated
CholineA nutrient found in a wide variety of vitamins including pre-natal formulations.
OxyphenoniumFor the treatment of visceral spasms
Metocurine iodideFor use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.
Gallamine triethiodideA nondepolarizing nerve blocker used in addition to anesthesia to cause skeletal muscle relaxation.
PropanthelineAn antimuscarinic agent used to treat urinary incontinence, hyperhidrosis, as well as cramps and spasms of the stomach, intestines, and bladder.
MethanthelineFor the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children.
HexafluroniumUsed as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations.
EdrophoniumA cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis.
TubocurarineTubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to...
DecamethoniumFor use as a skeletal muscle relaxant
OxtriphyllineA bronchodilator used for the treatment of asthma, bronchitis, COPD, and emphysema.
MetocurineMetocurine is a muscle relaxant.
NeostigmineA cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone.
Choline magnesium trisalicylateCholine magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.
CetrimoniumA compound that can be used as a topical antiseptic.
Platelet Activating FactorNot Available
N,N,N-Trimethyl-2-(phosphonooxy)ethanaminiumCalcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
ButyrylthiocholineA sulfur-containing analog of butyrylcholine which is hydrolyzed by butyrylcholinesterase to butyrate and thiocholine. It is used as a reagent in the determination of butyrylcholinesterase activity. [PubChem]
Betaine aldehydeNot Available
C31GInvestigated for use/treatment in contraception, HIV infection, and prevention of stdis.
PerifosineInvestigated for use/treatment in solid tumors, multiple myeloma, leukemia (unspecified), lung cancer, and brain cancer.
BetaineA methyl group donor used for the treatment of homocystinuria to decrease elevated homocysteine blood levels.
LauryldimethylbetaineNot Available
TetraethylammoniumTetraethylammonium is an experimental drug with no approved indication.
HexamethoniumA nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been...
MiltefosineAn antileishmanial agent used to treat leishmaniasis, a group of disease caused by parasites of the Leishmania type.
BenzalkoniumAn antiseptic agent used as a preservative in medications or as a disinfectant in cleaning products.
BenzethoniumA medication used as to clean hands and clean minor cuts and scrapes.
Light green SF yellowishLight green SF yellowish is a green triarylmethane dye that is used in the preparation of the staining solution which is widely used as a counterstain. It is used in...
Cocamidopropyl betaineCocamidopropyl betaine is a mixture of closely related organic compounds derived from coconut oil and dimethylaminopropylamine that typically acts as an amphoteric surfactant in cosmetics and personal care products. It...
CiticolineAn endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects.
BenzododeciniumBenzododecinium is used as an antiseptic/disinfectant compound. It has been marketed as a tincture for antiseptic product for wounds in the Czech Republic.
EmeproniumNot Annotated
BenzoxoniumAn antiseptic indicated in skin disinfection and prevention of infections.
GallamineNot Annotated
DecamethoxineNot Annotated
Choline salicylateThe oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due...
Cetyltrimethylammonium naproxenateAn anti-inflammatory and antiseptic agent indicated to treat mouth inflammation and pain , including that caused by tooth extraction.
Fluorocholine F-18A radiopharmaceutical indicated in PET scans of the prostate.
OleylphosphocholineNot Annotated
Visometin cationNot Annotated
DenatoniumNot Available
Drugs & Drug Targets
DrugTargetType
SuccinylcholineCholinesteraseenzyme
SuccinylcholineMuscarinic acetylcholine receptor M2target
SuccinylcholineMuscarinic acetylcholine receptor M3target
SuccinylcholineNeuronal Acetylcholine (nACh) Receptor Subunitstarget
CarbamoylcholineMuscarinic acetylcholine receptor M1target
CarbamoylcholineMuscarinic acetylcholine receptor M2target
CarbamoylcholineNeuronal acetylcholine receptor subunit alpha-2target
CarbamoylcholineCytosolic phospholipase A2enzyme
CarbamoylcholineMuscarinic acetylcholine receptor M3target
CarbamoylcholineMuscarinic acetylcholine receptor M4target
CarbamoylcholineAcetylcholinesteraseenzyme
DemecariumAcetylcholinesterasetarget
DemecariumCholinesterasetarget
GlycopyrroniumMuscarinic acetylcholine receptor M1target
GlycopyrroniumMuscarinic acetylcholine receptor M3target
GlycopyrroniumMuscarinic acetylcholine receptor M2target
GlycopyrroniumCytochrome P450 2D6enzyme
GlycopyrroniumCytochrome P450 1A2enzyme
GlycopyrroniumCytochrome P450 2B6enzyme
GlycopyrroniumCytochrome P450 2C9enzyme
GlycopyrroniumCytochrome P450 2C18enzyme
GlycopyrroniumCytochrome P450 2C19enzyme
GlycopyrroniumCytochrome P450 3A4enzyme
GlycopyrroniumSolute carrier family 22 member 2transporter
GlycopyrroniumMultidrug and toxin extrusion protein 1transporter
GlycopyrroniumMuscarinic acetylcholine receptor M4target
GlycopyrroniumMuscarinic acetylcholine receptor M5target
GlycopyrroniumSerum albumincarrier
Glycopyrroniumalpha1-acid glycoproteincarrier
BethanecholMuscarinic acetylcholine receptor M2target
BethanecholMuscarinic acetylcholine receptor M1target
BethanecholMuscarinic acetylcholine receptor M3target
BethanecholMuscarinic acetylcholine receptor M4target
BethanecholMuscarinic acetylcholine receptor M5target
MethacholineMuscarinic acetylcholine receptor M3target
MethacholineMuscarinic acetylcholine receptor M2target
MethacholineMuscarinic acetylcholine receptor M1target
MethacholineMuscarinic acetylcholine receptor M4target
MethacholineMuscarinic acetylcholine receptor M5target
MethacholineSolute carrier family 22 member 5transporter
TridihexethylMuscarinic acetylcholine receptor M1target
TridihexethylMuscarinic acetylcholine receptor M2target
TridihexethylMuscarinic acetylcholine receptor M3target
AmbenoniumAcetylcholinesterasetarget
AmbenoniumCholinesteraseenzyme
IsopropamideMuscarinic acetylcholine receptor M3target
IsopropamideMuscarinic acetylcholine receptor M4target
GhavamiolAlpha-mannosidase 2target
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonatePenton proteintarget
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonateInsulin-like growth factor Itarget
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonateAmine oxidase [flavin-containing] Btarget
DodecyltrimethylammoniumTyrosine-protein phosphatase non-receptor type 11target
TetramethylammoniumUDP-glucose 4-epimerasetarget
DidecyldimethylammoniumCyclopropane mycolic acid synthase 2target
DidecyldimethylammoniumPhospholipid membranetarget
MethylnaltrexoneMu-type opioid receptortarget
MethylnaltrexoneKappa-type opioid receptortarget
ThonzoniumV-type proton ATPase subunit C 1target
OtiloniumCytochrome P450 3A4enzyme
CholineCholine-phosphate cytidylyltransferase Btarget
CholineAcetylcholinesterasetarget
CholineCholine-phosphate cytidylyltransferase Atarget
CholinePhospholipase D2target
CholineCholinesterasetarget
CholinePhospholipase D1target
CholinePhosphoethanolamine/phosphocholine phosphatasetarget
CholineSolute carrier family 22 member 2transporter
CholineSolute carrier family 22 member 1transporter
CholineSolute carrier family 22 member 3transporter
CholineSolute carrier family 22 member 5transporter
CholineSolute carrier family 22 member 4transporter
CholineCholine/ethanolaminephosphotransferase 1enzyme
CholineCholine transporter-like protein 1transporter
CholineCholine transporter-like protein 4transporter
CholineCholine transporter-like protein 2transporter
CholineCholine transporter-like protein 3transporter
CholineCholine/ethanolamine kinaseenzyme
CholineCholine O-acetyltransferaseenzyme
CholineCholine kinase alphaenzyme
CholineCholine dehydrogenase, mitochondrialenzyme
CholineHigh affinity choline transporter 1transporter
CholineNeuronal acetylcholine receptor subunit alpha-7target
OxyphenoniumMuscarinic acetylcholine receptor M1target
Metocurine iodideNeuronal acetylcholine receptor subunit alpha-2target
Gallamine triethiodideNeuronal acetylcholine receptor subunit alpha-2target
Gallamine triethiodideMuscarinic acetylcholine receptor M2target
Gallamine triethiodideAcetylcholinesterasetarget
Gallamine triethiodideMuscarinic acetylcholine receptor M1target
Gallamine triethiodideMuscarinic acetylcholine receptor M5target
PropanthelineMuscarinic acetylcholine receptor M1target
MethanthelineMuscarinic acetylcholine receptor M1target
MethanthelineHistamine H2 receptortarget
MethanthelineMuscarinic acetylcholine receptor M2target
MethanthelineMuscarinic acetylcholine receptor M3target
MethanthelineMuscarinic acetylcholine receptor M4target
MethanthelineMuscarinic acetylcholine receptor M5target
MethanthelineAcetylcholinesteraseenzyme
HexafluroniumCholinesterasetarget
EdrophoniumAcetylcholinesterasetarget
EdrophoniumCholinesterasetarget
TubocurarineNeuronal acetylcholine receptor subunit alpha-2target
TubocurarineAcetylcholinesterasetarget
Tubocurarine5-hydroxytryptamine receptor 3Atarget
TubocurarineSolute carrier family 22 member 1transporter
TubocurarineSolute carrier family 22 member 2transporter
TubocurarineNeuronal acetylcholine receptor subunit alpha-7target
TubocurarineCholinesteraseenzyme
DecamethoniumNeuronal acetylcholine receptor subunit alpha-2target
DecamethoniumAcetylcholinesterasetarget
DecamethoniumCholinesteraseenzyme
DecamethoniumNeuronal acetylcholine receptor subunit alpha-4target
DecamethoniumNeuronal acetylcholine receptor subunit beta-2target
OxtriphyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
OxtriphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
OxtriphyllineAdenosine receptor A2atarget
OxtriphyllineAdenosine receptor A1target
OxtriphyllineCytochrome P450 1A2enzyme
OxtriphyllineSolute carrier family 22 member 7transporter
OxtriphyllineHistone deacetylase 2target
MetocurineNeuronal acetylcholine receptor subunit alpha-2target
MetocurineMuscarinic acetylcholine receptor M2target
NeostigmineAcetylcholinesterasetarget
NeostigmineCholinesteraseenzyme
Choline magnesium trisalicylateProstaglandin G/H synthase 1target
Choline magnesium trisalicylateProstaglandin G/H synthase 2target
CetrimoniumCyclopropane mycolic acid synthase MmaA2target
CetrimoniumCyclopropane mycolic acid synthase 1target
Platelet Activating FactorGanglioside GM2 activatortarget
Platelet Activating FactorP-glycoprotein 1transporter
Platelet Activating FactorPlatelet-activating factor receptortarget
N,N,N-Trimethyl-2-(phosphonooxy)ethanaminiumC-reactive proteintarget
N,N,N-Trimethyl-2-(phosphonooxy)ethanaminiumEpididymal sperm-binding protein 1target
N,N,N-Trimethyl-2-(phosphonooxy)ethanaminiumGamma-hemolysin component Btarget
ButyrylthiocholineCholinesterasetarget
ButyrylthiocholineCholinesteraseenzyme
Betaine aldehydeGamma-aminobutyraldehyde dehydrogenasetarget
C31GGag-Pol polyproteintarget
C31GCD9 antigentarget
PerifosineRAC-alpha serine/threonine-protein kinasetarget
PerifosineMitogen-activated protein kinase 1target
PerifosineProtein kinase C alpha typetarget
BetaineCholinesteraseenzyme
BetaineProline dehydrogenase 1, mitochondrialenzyme
BetaineSodium- and chloride-dependent betaine transportertransporter
BetaineBetaine--homocysteine S-methyltransferase 1target
LauryldimethylbetaineAppA proteintarget
TetraethylammoniumSolute carrier family 22 member 1transporter
TetraethylammoniumSolute carrier family 22 member 2transporter
TetraethylammoniumSolute carrier family 22 member 3transporter
TetraethylammoniumSolute carrier family 22 member 4transporter
TetraethylammoniumSolute carrier family 22 member 5transporter
TetraethylammoniumSolute carrier family 22 member 8transporter
TetraethylammoniumpH-gated potassium channel KcsAtarget
TetraethylammoniumNeuronal acetylcholine receptor subunit alpha-9target
TetraethylammoniumCalcium-activated potassium channel subunit alpha-1target
TetraethylammoniumPotassium voltage-gated channel subfamily A member 1target
TetraethylammoniumMultidrug and toxin extrusion protein 1transporter
HexamethoniumNeuronal acetylcholine receptor subunit alpha-2target
MiltefosinePhospholipase D1enzyme
MiltefosineP-glycoprotein 1target
CiticolineLicC proteintarget
Choline salicylateCholine-phosphate cytidylyltransferase Btarget
Choline salicylateAcetylcholinesterasetarget
Choline salicylateCholine-phosphate cytidylyltransferase Atarget
Choline salicylatePhospholipase D2target
Choline salicylateCholinesterasetarget
Choline salicylatePhospholipase D1target
Choline salicylateSolute carrier family 22 member 2transporter
Choline salicylateSolute carrier family 22 member 1transporter
Choline salicylateSolute carrier family 22 member 3transporter
Choline salicylateSolute carrier family 22 member 5transporter
Choline salicylateSolute carrier family 22 member 4transporter
Choline salicylateCholine/ethanolaminephosphotransferase 1enzyme
Choline salicylateCholine transporter-like protein 1transporter
Choline salicylateCholine transporter-like protein 4transporter
Choline salicylateCholine transporter-like protein 3transporter
Choline salicylateCholine/ethanolamine kinaseenzyme
Choline salicylateCholine O-acetyltransferaseenzyme
Choline salicylateCholine kinase alphaenzyme
Choline salicylateCholine dehydrogenase, mitochondrialenzyme
Choline salicylateHigh affinity choline transporter 1transporter
Choline salicylateNeuronal acetylcholine receptor subunit alpha-7target