Cytochrome P-450 CYP2C9 Inhibitors (strength unknown)
- Name
- Cytochrome P-450 CYP2C9 Inhibitors (strength unknown)
- Accession Number
- DBCAT004528
- Description
Not Available
- Drugs
Drug Drug Description Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Zafirlukast A leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma. Tamoxifen A selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women. Suprofen An NSAID used to prevent pupil constriction in ocular surgery. Metronidazole A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections. Sulfamethoxazole An oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract. Fluvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Sertraline A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. Phenytoin An anticonvulsant drug used in the prophylaxis and control of various types of seizures. Lansoprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Glyburide A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. Ginkgo biloba A herbal supplement found in over-the-counter or unapproved homeopathic products for various health conditions, such as cognitive, neurodegenerative, cardiovascular, and reproductive health disorders. Avasimibe Investigated for use/treatment in peripheral vascular disease. Lovastatin An HMG-CoA reductase inhibitor used to lower LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke. Simvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke. Cerivastatin A statin (or HMG CoA reductase inhibitor) used with dietary changes to decrease lipid levels and reduce the risk of cardiovascular events. Imatinib A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. Paroxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. Valsartan An angiotensin-receptor blocker used to manage hypertension alone or in combination with other antihypertensive agents and to manage heart failure in patients who are intolerant to ACE inhibitors. Bortezomib A proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. Nevirapine A non-nucleoside reverse transcriptase inhibitor used as part of a management regimen for HIV-1 virus infection. Azelastine A histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis. Fenofibrate A peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia. Phenylbutazone An NSAID used to treat backache and ankylosing spondylitis. Teniposide A cytotoxic drug used as an adjunct for chemotherapy induction in the treatment of refractory childhood acute lymphoblastic leukemia. Etravirine A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infections in combination with other antiretroviral agents. Sulfadiazine A sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid. Sulfisoxazole A sulfonamide antibiotic used with other antibiotics to prevent and treat a variety of bacterial infections. Leflunomide A pyrimidine synthesis inhibitor indicated to treat rheumatoid arthritis. Nilotinib A kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib. Sitaxentan Investigated for use/treatment in pulmonary hypertension, connective tissue diseases, hypertension, and congestive heart failure. Tranylcypromine A monoamine oxidase inhibitor used to treat major depressive disorder. Clopidogrel An antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease. Etoricoxib A selective COX-2 inhibitor used to relieve moderate post-surgical dental pain as a short-term treatment and inflammatory and painful symptoms of various forms of arthritis. Sulfamoxole For the treatment of bacterial infection. Amodiaquine An antimalarial drug. Anastrozole A competitive, selective, non-steroidal aromatase inhibitor used as adjuvant therapy for the treatment of hormone receptor-positive breast cancer in postmenopausal women. Atovaquone An antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria. Cimetidine A histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion. Cyclizine An antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo. Epinephrine A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. Ethanol For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical... Felodipine A calcium channel blocker used to treat hypertension. Flecainide A class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT). Medroxyprogesterone acetate A progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty. Modafinil A stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder. Nilutamide An antineoplastic hormone used to treat prostate cancer. Pranlukast A leukotriene receptor antagonist for the treatment of allergic rhinitis and asthma symptoms. Promethazine A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness. Sulfamethizole A sulfonamide antibiotic used to treat a wide variety of susceptible bacterial infections. Sulfapyridine A sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. Tolcapone A catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease. Bicalutamide An androgen receptor inhibitor used to treat Stage D2 metastatic carcinoma of the prostate. Rabeprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Armodafinil A stimulant used to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder. Diethylstilbestrol Used in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery. Agomelatine Agomelatine is indicated to treat major depressive episodes in adults. Noscapine A non-sedating isoquinoline alkaloid used primarily for its antitussive properties. Clevidipine A dihydropyridine L-type calcium channel blocker used to lower blood pressure when oral antihypertensive therapy is not feasible or not desirable. Cisplatin A platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. Sulconazole A topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains. Vismodegib A hedgehog pathway inhibitor used to treat patients with locally advanced or metastatic basal cell carcinoma. Gefitinib A tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria. Ceritinib An antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or intolerance to crizotinib. Belinostat A histone deacetylase (HDAC) inhibitor used for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). Lifitegrast A medication used to treat dry eye disease. Diacerein An slow-onset anthraquinone IL-1 inhibitor used in the treatment of degenerative joint diseases like osteoarthritis. Doconexent An omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. Topiroxostat Indicated for the treatment of gout and hyperurcemia in Japan. Stiripentol An antiepileptic agent used in combination with other anticonvulsants to treat seizures associated with Dravet syndrome. Lobeglitazone Lobeglitazone was approved by the Ministry of Food and Drug Safety (South Korea) in 2013, and is being monitored by postmarketing surveillance until 2019. Lobeglitazone is not approved for use... Dosulepin A tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential. Manidipine A dihydropyridine calcium channel blocker used to treat hypertension. Enasidenib An isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation. Rucaparib A poly (ADP-ribose) polymerase (PARP) inhibitor used to treat recurrent ovarian and prostate cancers in previously treated adults. Isavuconazole Indicated for patients 18 years of age and older for the treatment of invasive aspergillosis [FDA Label]. Indicated for patients 18 years of age and older for the treatment of... Black cohosh A herbal product indicated in the symptomatic treatment of menopause. Genistein Currently Genistein is being studied in clinical trials as a treatment for prostate cancer. Lenvatinib A receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. Vemurafenib A kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation. Fluorouracil A pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. Midostaurin An antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL). Atorvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Sulfaphenazole For the treatment bacterial infections. Sulfadimethoxine For use in the treatment of infections. Methimazole A thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism. Isoniazid An antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis. Ketoprofen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain. Estrone sulfate An estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders. Benzbromarone A uricosuric agent which is taken daily for the prevention of gout flares. Seproxetine Seproxetine is also known as (S)-norfluoxetine. It is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an... Oxandrolone An androgenic hormone used to treat muscle loss from prolonged corticosteroid treatment and to treat bone pain associated with osteoporosis. Rifamycin An antibacterial used to treat traveler's diarrhea. Torasemide A diuretic used to treat hypertension and edema associated with heart failure, renal failure, or liver disease. Triclabendazole An anthelmintic drug used to treat fascioliasis. Progesterone A hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. Pexidartinib An antitumor agent that is used for the treatment of rare disease tenosynovial giant cell tumors (TGCT) by inhibiting colony-stimulating factor 1 and its receptor. Probenecid A medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia. Nicardipine A calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. Aprepitant A substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. Levofloxacin A fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague. Cisapride A medication used to treat heartburn associated with GERD. Dexloxiglumide For the treatment of Irritable Bowel Syndrome (IBS) and Gastroesophageal Reflux Disease (GERD). Tienilic acid For the treatment of hypertension. Curcumin sulfate No approved therapeutic indications. Regorafenib A kinase inhibitor used to treat patients with metastatic colorectal cancer, unresectable, locally advanced, or metastatic gastrointestinal stromal tumors, and hepatocellular carcinoma. Lumacaftor A protein chaperone used in combination with ivacaftor for the treatment of cystic fibrosis in patients who are homozygous for the F508del mutation in the CFTR gene. Abemaciclib A medication used to treat HR+ HER2- advanced or metastatic breast cancer. Atazanavir An antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV. Elexacaftor A small molecule CFTR corrector used in combination with tezacaftor and ivacaftor for the treatment of cystic fibrosis patients with one F508del-CFTR mutation. Nifedipine A dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension. Methylene blue An oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia. Pralsetinib A RET receptor tyrosine kinase inhibitor for the treatment of metastatic RET-driven non-small cell lung cancer. Opicapone A catechol-O-methyltransferase inhibitor used as an adjunct treatment for Parkinson's Disease in adults currently receiving levodopa and a dopa decarboxylase inhibitor. Menadione The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. Rilpivirine A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1). Casimersen An antisense phosphorodiamidate morpholino oligonucleotide used to treat Duchenne muscular dystrophy patients with mutations amenable to exon 45 skipping. Diosmin A citrus flavonoid medication used to support vascular health. Rosiglitazone A thiazolidinedione indicated as an adjunct to diet and exercise to maintain glycemic control in type 2 diabetes. Brincidofovir An oral lipid prodrug of cidofovir used in the treatment of human smallpox disease. Avapritinib A selective tyrosine kinase inhibitor being investigated for the treatment of multidrug resistant gastrointestinal tumors. Avacopan An orally bioavailable complement 5a receptor (C5aR) antagonist for the treatment of severe anti-neutrophil cytoplasmic (auto)antibody (ANCA)-associated vasculitis. Asciminib An inhibitor of ABL/BCR-ABL1 tyrosine kinase for the treatment of patients with Philadelphia chromosome-positive CML, including those with the T315I mutation. Dronabinol A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. Cannabidiol An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. Cannabinol Cannabinol (CBN) is a physiologically inactive constituent of Cannabis sativa. Nabilone A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. Medical Cannabis The use of the plant species Cannabis sativa and Cannabis indica, popularly known as marijuana, has gained popularity in recent years for the management of a wide variety of medical... Abiraterone An antiandrogen used in the treatment of prostate cancer. Dabrafenib A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. Pirfenidone An agent used for the treatment of idiopathic pulmonary fibrosis (IPF). Telotristat ethyl A tryptophan hydroxylase inhibitor that is used to treat carcinoid syndrome diarrhea. Resveratrol Being investigated for the treatment of Herpes labialis infections (cold sores). Adagrasib A KRAS inhibitor indicated for the treatment of locally advanced or metastatic KRAS G12C-mutated non-small cell lung cancer in patients who have received at least one prior systemic therapy. Anacaulase A mix of proteolytic enzymes indicated for eschar removal in adults with deep partial thickness and/or full-thickness thermal burns. Pirtobrutinib A kinase inhibitor used to treat relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy. Amlodipine A calcium channel blocker used to treat hypertension and angina. - Drugs & Drug Targets