Antihistamines for Topical Use

Antihistamines for Topical Use
Accession Number

Not Available

ATC Classification
DrugDrug Description
TripelennamineA histamine H1 antagonist used to treat hypersensitivity reactions, coughs, and the common cold.
PheniramineAn antihistamine used to treat allergic rhinitis and pruritus.
MepyramineAn antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders.
DimetindeneA 1st generation selective H1 antagonist used topically as an antipruritic and orally to treat allergies.
ChlorphenoxamineAn antihistamine used as an antipruritic.
TolpropamineNot Annotated
ClemastineAn antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis.
PromethazineA first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
DiphenhydramineA H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
ThenalidineWithdrawn from the Canadian, US, and UK markets in 1963 due to concerns involving neutropenia.
ChloropyramineFor the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions.
IsothipendylA 1st generation histamine H1 antagonist primarily applied topically as an antipruritic.
ThonzylamineThozylamine is indicated for use in the symptomatic control of allergic rhinitis or other upper respiratory allergic symptoms [FDA Label]. It is typically a part of combination over the counter...
BamipineAn H1 antihistamine used topically to relieve mild to moderate symptoms associated with insect bites.
Drugs & Drug Targets
TripelennamineHistamine H1 receptortarget
TripelennamineCytochrome P450 2D6enzyme
TripelennamineSerum albumincarrier
PheniramineHistamine H1 receptortarget
PheniramineNuclear receptor subfamily 1 group I member 3target
PheniramineHistamine H4 receptortarget
MepyramineCytochrome P450 2D6enzyme
MepyramineHistamine H1 receptortarget
MepyramineSolute carrier family 22 member 4transporter
MepyramineSolute carrier family 22 member 5transporter
DimetindeneMuscarinic acetylcholine receptor M2target
DimetindeneHistamine H1 receptortarget
ClemastineHistamine H1 receptortarget
ClemastineCytochrome P450 2D6enzyme
PromethazineDopamine D2 receptortarget
PromethazineHistamine H1 receptortarget
PromethazineMuscarinic acetylcholine receptor M4target
PromethazineMuscarinic acetylcholine receptor M1target
PromethazineMuscarinic acetylcholine receptor M5target
PromethazineMuscarinic acetylcholine receptor M2target
PromethazineMuscarinic acetylcholine receptor M3target
PromethazineCytochrome P450 2D6enzyme
PromethazineCytochrome P450 2B6enzyme
PromethazineP-glycoprotein 1transporter
PromethazineCytochrome P450 2C9enzyme
PromethazineHistamine H2 receptortarget
PromethazineAlpha adrenergic receptortarget
PromethazineP2 Purinoceptorstarget
PromethazineVoltage-gated sodium channel alpha subunittarget
PromethazineVoltage-gated Potassium Channelstarget
PromethazineCanalicular multispecific organic anion transporter 2transporter
PromethazineMultidrug resistance-associated protein 4transporter
PromethazineSerum albumincarrier
DiphenhydramineHistamine H1 receptortarget
DiphenhydramineCytochrome P450 2D6enzyme
DiphenhydramineCytochrome P450 2C9enzyme
DiphenhydramineCytochrome P450 2C19enzyme
DiphenhydramineSolute carrier family 22 member 2transporter
DiphenhydramineSolute carrier family 22 member 5transporter
DiphenhydramineProstaglandin G/H synthase 1enzyme
DiphenhydramineMuscarinic acetylcholine receptor M2target
ChloropyramineHistamine H1 receptortarget
IsothipendylHistamine H1 receptortarget
ThonzylamineHistamine H1 receptortarget
ThonzylamineMuscarinic acetylcholine receptor M1target
ThonzylamineMuscarinic acetylcholine receptor M2target
ThonzylamineMuscarinic acetylcholine receptor M3target
ThonzylamineMuscarinic acetylcholine receptor M4target
ThonzylamineMuscarinic acetylcholine receptor M5target