Total parenteral nutrition therapy (DBCOND0023768)

Identifiers

Synonyms

Total Parenteral Nutrition / TPN / Administration of total parenteral nutrition (procedure) / Parenteral Nutrition, Total / Total parenteral nutrition (procedure) / Parenteral nutrition / Intravenous feeding of patient (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amino acids	Mixture of amino acids ; used for parenteral nutrition in infants.	No drug targets
Aspartic acid	An amino acid commonly found as a component in total parenteral nutrition.	Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrialtarget Aspartate aminotransferase, cytoplasmictarget Aspartoacylasetarget Asparagine synthetase [glutamine-hydrolyzing]target Argininosuccinate synthasetarget Aminoacylase-1target Aspartate aminotransferase, mitochondrialtarget Aspartate--tRNA ligase, cytoplasmictarget Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrialtarget Aspartyl/asparaginyl beta-hydroxylasetarget Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetasetarget Adenylosuccinate synthetase isozyme 2target Excitatory amino acid transporter 3target Aspartate--tRNA ligase, mitochondrialtarget Isoaspartyl peptidase/L-asparaginasetarget Ribonuclease pancreatictarget Lysozyme Ctarget Monocarboxylate transporter 10transporter Multifunctional protein CADenzyme Adenylosuccinate Synthetasestarget Glutamate receptor ionotropic, NMDA 2Atarget Glutamate receptor ionotropic, NMDA 2Btarget Glutamate receptor ionotropic, NMDA 1target
Calcium chloride	An ionic compound used for the treatment of hypocalcemia and hyperkalemia, and as an antidote to magnesium intoxication due to overdosage of magnesium sulfate.	Protein S100-A13target
Caprylic acid	Caprylic acid is an eight-carbon chain fatty acid, also known systematically as octanoic acid. It is found naturally in coconuts and breast milk. It is an oily liquid with a...	3-oxoacyl-[acyl-carrier-protein] synthase 1target Acyl-CoA thioesterase Itarget Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Peroxisome proliferator-activated receptor alphatarget
Chromic chloride	A supplement to intravenous solutions given for total parenteral nutrition (TPN).	Insulin receptortarget
Cupric Chloride	A transition metal found in a variety of supplements and vitamins, including intravenous solutions for total parenteral nutrition (TPN).	Vitamin K-dependent protein Ctarget Cystatin-Btarget
Cupric sulfate	A compound used as an intravenous copper supplement for Total Parenteral Nutrition (TPN).	Albumintransporter Ceruloplasmintransporter Phenylalanine-4-hydroxylaseenzyme Protein-lysine 6-oxidaseenzyme Cytochrome c oxidase subunit 1enzyme
Cysteine	An amino acid commonly found as a component of total parenteral nutrition and used as an antidote for acetaminophen overdose.	Cysteine--tRNA ligase, cytoplasmictarget Glutamate--cysteine ligase regulatory subunittarget Glutamate--cysteine ligase catalytic subunittarget Aspartate aminotransferase, cytoplasmictarget Cystathionine gamma-lyasetarget Cystathionine beta-synthasetarget Cysteine dioxygenase type 1target Methylated-DNA--protein-cysteine methyltransferasetarget Glutathione synthetasetarget Probable cysteine--tRNA ligase, mitochondrialtarget Cysteine sulfinic acid decarboxylasetarget Cysteine desulfurasetarget Monocarboxylate transporter 10transporter Aspartate aminotransferase, mitochondrialtarget
Cystine	An oxidated derivative of the amino acid cysteine found in various nutritional products, acne treatments, and creams to treat cervical injury or inflammation.	Cystine/glutamate transportertarget Cystinosintarget Monocarboxylate transporter 10transporter b(0,+)-type amino acid transporter 1transporter Amino acid transporter heavy chain SLC3A1transporter
Dextrose, unspecified form	A form of glucose used for caloric supply and the replenishment of fluid in total parenteral nutrition and other therapies as well as for the treatment of hypoglycemic episodes.	Hexokinase-4enzyme Hexokinase-1enzyme Solute carrier family 2, facilitated glucose transporter member 1transporter Solute carrier family 2, facilitated glucose transporter member 2transporter Solute carrier family 2, facilitated glucose transporter member 3transporter Solute carrier family 2, facilitated glucose transporter member 4transporter Solute carrier family 2, facilitated glucose transporter member 6transporter Solute carrier family 2, facilitated glucose transporter member 7transporter Solute carrier family 2, facilitated glucose transporter member 8transporter Solute carrier family 2, facilitated glucose transporter member 9transporter Solute carrier family 2, facilitated glucose transporter member 10transporter Solute carrier family 2, facilitated glucose transporter member 11transporter Solute carrier family 2, facilitated glucose transporter member 12transporter Sodium/glucose cotransporter 1transporter
Dipotassium phosphate	An ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.	No drug targets
Lysine	An amino acid commonly found as a component of total parenteral nutrition.	High affinity cationic amino acid transporter 1target Cationic amino acid transporter 4target Cationic amino acid transporter 3target Cationic amino acid transporter 2target Lysine--tRNA ligasetarget Monocarboxylate transporter 10transporter Solute carrier family 22 member 4transporter
Magnesium acetate tetrahydrate	An ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.	Glutamate (NMDA) receptortarget
Magnesium chloride	An ionic compound and source of magnesium used for electrolyte replenishment and conditions associated with magnesium deficiencies.	No drug targets
Manganese cation	A transition metal used for supplementation of manganese during Total Parenteral Nutrition (TPN).	Cytoplasmic aconitate hydrataseenzyme Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialtarget TGF-beta-activated kinase 1 and MAP3K7-binding protein 1target Arginase-1target Serotransferrincarrier Albumincarrier Metal cation symporter ZIP14transporter Superoxide dismutase [Mn], mitochondrialtarget Glutamine synthetasetarget Phosphoenolpyruvate Carboxykinasestarget Natural resistance-associated macrophage protein 2transporter Calcium/manganese antiporter SLC30A10transporter Ceruloplasmincarrier Transient receptor potential cation channel subfamily M member 7transporter Serine/threonine-protein phosphatase PP1-gamma catalytic subunittarget
Medium-chain triglycerides	A source of essential fatty acids used as a source of calories in parenteral nutrition.	Albumincarrier
Monopotassium phosphate	An ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.	No drug targets
Olive oil	In a clinical context, olive oil is used as a source of calories and fatty acids in patients requiring parenteral nutrition. A formulation called Clinolipid, comprising olive oil and soybean...	No drug targets
Phosphoric acid	An ingredient used for electrolyte replenishment and total parenteral nutrition (TPN) therapy, and for the relief of upset stomach associated with nausea.	No drug targets
Potassium cation	Potassium is used to regulate hypokalemia as a primary condition or secondary to other medical conditions.	Sodium/potassium-transporting ATPase subunit alpha-1target
Selenious acid	An ingredient found in supplements, vitamins, parenteral nutrition, and dandruff shampoo.	Glutathione peroxidase 1enzyme Selenoprotein Ptransporter Thioredoxin reductase 1, cytoplasmicenzyme
Serine	An amino acid commonly found as a component in total parenteral nutrition.	Cystathionine beta-synthasetarget L-serine dehydratase/L-threonine deaminasetarget Serine racemasetarget Serine palmitoyltransferase 2target Serine palmitoyltransferase 1target Serine--tRNA ligase, cytoplasmictarget Alanine--glyoxylate aminotransferasetarget Monocarboxylate transporter 10transporter
Sodium acetate	A compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.	Acetyl-coenzyme A synthetase, cytoplasmicenzyme
Sodium chloride	An ingredient found in a variety of nutritional products as a source of electrolytes and water.	No drug targets
Sodium fluoride	An ingredient of various dental preparations used to support tooth mineralization and the prevention of dental caries.	Hydroxyapatitetarget Enolase-phosphatase E1enzyme Enolaseenzyme Enolaseenzyme Enolaseenzyme Enolaseenzyme
Sodium glycerophosphate	A medication used to treat hypophosphatemia.	No drug targets
Sodium hydroxide	Used to destroy or kill the nail matrix (matrixectomies) .	No drug targets
Sodium iodide	A supplement used in total parenteral nutrition.	No drug targets
Sodium phosphate, dibasic	An osmotic laxative used to cleanse the colon before a colonoscopy.	Sodium-dependent phosphate transporter 1transporter Sodium-dependent phosphate transporter 2transporter Sodium-dependent phosphate transport protein 2Atransporter Sodium-dependent phosphate transport protein 2Btransporter Sodium-dependent phosphate transport protein 2Ctransporter Carbonic anhydrase 4target
Sodium phosphate, monobasic	A source of phosphorus used prevent or correct hypophosphatemia in patients with restricted or no oral intake.	Sodium-dependent phosphate transporter 1transporter Sodium-dependent phosphate transporter 2transporter Sodium-dependent phosphate transport protein 2Atransporter Sodium-dependent phosphate transport protein 2Btransporter Sodium-dependent phosphate transport protein 2Ctransporter
Soybean oil	An oil used as a source of calories and essential fatty acids in selected patients for total parenteral nutrition (TPN) therapy and prevention of essential fatty acid deficiency.	Peroxisome proliferator-activated receptor alphatarget
Taurine	An ingredient found in mixture products indicated for nutritional support.	Alpha-ketoglutarate-dependent taurine dioxygenasetarget Choloylglycine hydrolasetarget Glycine receptor subunit alpha-1target Proton-coupled amino acid transporter 1transporter Sodium- and chloride-dependent taurine transportertransporter Solute carrier family 15 member 1transporter Protein-glutamine gamma-glutamyltransferase 6enzyme Bile acid-CoA:amino acid N-acyltransferaseenzyme Glutamate receptor ionotropic, NMDA 2Btarget Glycine receptor subunit alpha-2target Glycine receptor subunit alpha-3target GABA(A) Receptortarget Gamma-aminobutyric acid type B receptor subunit 1target Glycine receptor subunit betatarget
Zinc chloride	A medication used to treat zinc deficiencies and associated symptoms and also in total parenteral nutrition.	B1 bradykinin receptortarget Methylated-DNA--protein-cysteine methyltransferasetarget Fructose-bisphosphate aldolase Atarget Elongation factor 1-alpha 1target Alpha-enolasetarget Glyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget Nucleoside diphosphate kinase Atarget Protein disulfide-isomerasetarget Protein disulfide-isomerase A3target Peroxiredoxin-1target Phosphoserine phosphatasetarget Triosephosphate isomerasetarget Elongation factor Tu, mitochondrialtarget Estrogen receptortarget Interleukin-3target Metallothionein-2target Copper chaperone for superoxide dismutasetarget Histone deacetylase 1target Histone deacetylase 4target DNA-3-methyladenine glycosylasetarget Semenogelin-1target Superoxide dismutase [Cu-Zn]target Histone deacetylase 8target Apoptosis regulatory protein Sivatarget Glycine receptor subunit alpha-1target E3 ubiquitin-protein ligase Mdm2target Insulintarget Utrophintarget Aspartoacylasetarget Protein S100-A8target Protein S100-A9target Matrix metalloproteinase-9target Tumor protein p73target Protein S100-A2target Cellular tumor antigen p53target Metallothionein-3target Metallothionein-1Atarget Alpha-2-macroglobulintarget Alpha-2-HS-glycoproteintarget Apolipoprotein A-Itarget Apolipoprotein B receptortarget Apolipoprotein Etarget Apolipoprotein L1target Complement C1q subcomponent subunit Btarget Complement C1q subcomponent subunit Ctarget Complement C1r subcomponenttarget Complement C1s subcomponenttarget Complement C3target Complement C4-Btarget C4b-binding protein alpha chaintarget C4b-binding protein beta chaintarget Complement C5target Lys-63-specific deubiquitinase BRCC36target Complement factor Htarget Clusterintarget Ceruloplasmintarget Carboxypeptidase N catalytic chaintarget Carboxypeptidase N subunit 2target Dermcidintarget Fibrinogen alpha chaintarget Fibronectintarget Hemoglobin subunit alphatarget Hemoglobin subunit betatarget Haptoglobintarget Insulin-like growth factor-binding protein complex acid labile subunittarget Inter-alpha-trypsin inhibitor heavy chain H1target Inter-alpha-trypsin inhibitor heavy chain H2target Inter-alpha-trypsin inhibitor heavy chain H3target Inter-alpha-trypsin inhibitor heavy chain H4target Immunoglobulin J chaintarget Plasma kallikreintarget Kininogen-1target Keratin, type I cytoskeletal 9target Alpha-1-acid glycoprotein 2target N-acetylmuramoyl-L-alanine amidasetarget Serum paraoxonase/arylesterase 1target Pregnancy zone proteintarget Protein S100-A7target Selenoprotein Ptarget Alpha-1-antitrypsintarget Alpha-1-antichymotrypsintarget Corticosteroid-binding globulintarget Heparin cofactor 2target Sex hormone-binding globulintarget Serotransferrintarget Transthyretintarget Vitronectintarget Amyloid beta precursor like protein 1target Amyloid beta precursor like protein 2target Amyloid-beta precursor proteintarget Poly [ADP-ribose] polymerase 1target Carboxypeptidase Eenzyme Alcohol dehydrogenase 1Cenzyme Insulin-degrading enzymeenzyme Superoxide dismutase [Cu-Zn]enzyme Carbonic anhydrase 2enzyme Albumincarrier Zinc transporter ZIP10transporter Zinc transporter 7transporter Probable proton-coupled zinc antiporter SLC30A4transporter Zinc transporter ZIP6transporter Zinc transporter ZIP5transporter Zinc transporter ZIP2transporter Proton-coupled zinc antiporter SLC30A9, mitochondrialtransporter Proton-coupled zinc antiporter SLC30A1transporter Proton-coupled zinc antiporter SLC30A2transporter Zinc transporter SLC39A7transporter Zinc transporter ZIP4transporter Probable proton-coupled zinc antiporter SLC30A3transporter Proton-coupled zinc antiporter SLC30A8transporter Zinc transporter ZIP12transporter Proton-coupled zinc antiporter SLC30A5transporter Calcium/manganese antiporter SLC30A10transporter Zinc transporter ZIP13transporter Metal cation symporter ZIP8transporter Zinc transporter ZIP1transporter Metal cation symporter ZIP14transporter Zinc transporter ZIP3transporter Zinc transporter ZIP9transporter Zinc transporter ZIP11transporter Zinc transporter 6transporter Apolipoprotein B-100target Hemopexintarget Histidine-rich glycoproteintarget Coagulation factor XItarget C->U-editing enzyme APOBEC-1target Semenogelin-2target
Zinc sulfate, unspecified form	A zinc supplement indicated in parenteral nutrition.	B1 bradykinin receptortarget Methylated-DNA--protein-cysteine methyltransferasetarget Fructose-bisphosphate aldolase Atarget Elongation factor 1-alpha 1target Alpha-enolasetarget Glyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget Nucleoside diphosphate kinase Atarget Protein disulfide-isomerasetarget Protein disulfide-isomerase A3target Peroxiredoxin-1target Phosphoserine phosphatasetarget Triosephosphate isomerasetarget Elongation factor Tu, mitochondrialtarget Estrogen receptortarget Interleukin-3target Metallothionein-2target Copper chaperone for superoxide dismutasetarget Histone deacetylase 1target Histone deacetylase 4target DNA-3-methyladenine glycosylasetarget Semenogelin-1target Superoxide dismutase [Cu-Zn]target Histone deacetylase 8target Apoptosis regulatory protein Sivatarget Glycine receptor subunit alpha-1target E3 ubiquitin-protein ligase Mdm2target Insulintarget Utrophintarget Aspartoacylasetarget Protein S100-A8target Protein S100-A9target Matrix metalloproteinase-9target Tumor protein p73target Protein S100-A2target Cellular tumor antigen p53target Metallothionein-3target Metallothionein-1Atarget Alpha-2-macroglobulintarget Alpha-2-HS-glycoproteintarget Apolipoprotein A-Itarget Apolipoprotein B receptortarget Apolipoprotein Etarget Apolipoprotein L1target Complement C1q subcomponent subunit Btarget Complement C1q subcomponent subunit Ctarget Complement C1r subcomponenttarget Complement C1s subcomponenttarget Complement C3target Complement C4-Btarget C4b-binding protein alpha chaintarget C4b-binding protein beta chaintarget Complement C5target Lys-63-specific deubiquitinase BRCC36target Complement factor Htarget Clusterintarget Ceruloplasmintarget Carboxypeptidase N catalytic chaintarget Carboxypeptidase N subunit 2target Dermcidintarget Fibrinogen alpha chaintarget Fibronectintarget Hemoglobin subunit alphatarget Hemoglobin subunit betatarget Haptoglobintarget Insulin-like growth factor-binding protein complex acid labile subunittarget Inter-alpha-trypsin inhibitor heavy chain H1target Inter-alpha-trypsin inhibitor heavy chain H2target Inter-alpha-trypsin inhibitor heavy chain H3target Inter-alpha-trypsin inhibitor heavy chain H4target Immunoglobulin J chaintarget Plasma kallikreintarget Kininogen-1target Keratin, type I cytoskeletal 9target Alpha-1-acid glycoprotein 2target N-acetylmuramoyl-L-alanine amidasetarget Serum paraoxonase/arylesterase 1target Pregnancy zone proteintarget Protein S100-A7target Selenoprotein Ptarget Alpha-1-antitrypsintarget Alpha-1-antichymotrypsintarget Corticosteroid-binding globulintarget Heparin cofactor 2target Sex hormone-binding globulintarget Serotransferrintarget Transthyretintarget Vitronectintarget Amyloid beta precursor like protein 1target Amyloid beta precursor like protein 2target Amyloid-beta precursor proteintarget Poly [ADP-ribose] polymerase 1target Carboxypeptidase Eenzyme Alcohol dehydrogenase 1Cenzyme Insulin-degrading enzymeenzyme Superoxide dismutase [Cu-Zn]enzyme Carbonic anhydrase 2enzyme Albumincarrier Zinc transporter ZIP10transporter Zinc transporter 7transporter Probable proton-coupled zinc antiporter SLC30A4transporter Zinc transporter ZIP6transporter Zinc transporter ZIP5transporter Zinc transporter ZIP2transporter Proton-coupled zinc antiporter SLC30A9, mitochondrialtransporter Proton-coupled zinc antiporter SLC30A1transporter Proton-coupled zinc antiporter SLC30A2transporter Zinc transporter SLC39A7transporter Zinc transporter ZIP4transporter Probable proton-coupled zinc antiporter SLC30A3transporter Proton-coupled zinc antiporter SLC30A8transporter Zinc transporter ZIP12transporter Proton-coupled zinc antiporter SLC30A5transporter Calcium/manganese antiporter SLC30A10transporter Zinc transporter ZIP13transporter Metal cation symporter ZIP8transporter Zinc transporter ZIP1transporter Metal cation symporter ZIP14transporter Zinc transporter ZIP3transporter Zinc transporter ZIP9transporter Zinc transporter ZIP11transporter Zinc transporter 6transporter Apolipoprotein B-100target Hemopexintarget Histidine-rich glycoproteintarget Coagulation factor XItarget C->U-editing enzyme APOBEC-1target Semenogelin-2target
alpha-D-glucose-1-phosphate	A type of glucose used for total parenteral nutrition and phosphate replacement therapy.	Phosphomannomutase/phosphoglucomutasetarget Glycogen phosphorylase, muscle formtarget Maltodextrin phosphorylasetarget Glucose-1-phosphatasetarget Glucose-1-phosphate thymidylyltransferasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02841813	Effects of Genomic and Metabolomic Variations of Choline on Risk of Preterm Birth and Clinical Outcomes in Preterms	No drug interventions	Not Available	Not Available	unknown_status
NCT04572373	Supplements SMOF in TPN for Liver Transplantation Recipients	No drug interventions	Not Available	Not Available	completed
NCT03652727	FX vs. ECG Guidance for PICC Insertion	No drug interventions	other	Not Available	completed
NCT04466332	Comparison of Two ECG Guided PICC Insertion Techniques	No drug interventions	other	Not Available	completed
NCT04977817	Probiotics/TPN in the NICU	No drug interventions	Not Available	Not Available	completed
NCT00734916	Immune Modulation by Parenteral Lipids	No drug interventions	treatment	Not Available	completed