Dandruff (DBCOND0005708)

Identifiers

Synonyms

Seborrhea capitis / Seborrhoea capitis / Seborrhoeic dermatitis capitis / Seborrheic dermatitis capitis / Seborrhoeic dermatitis of scalp / Pityriasis capitis (disorder) / Scurf / Pityriasis simplex

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Coal tar	Relieving itching, irritation, redness, dryness, scaling, and flaking of the skin caused by psoriasis, seborrhea, or eczema.	No drug targets
Dipyrithione	Scalp dandruff	Nitric oxide synthase, inducibletarget Prostaglandin G/H synthase 2target
Flutrimazole	A topical antifungal used to treat pityriasis capitis and seborrheic dermatitis.	No drug targets
Ketoconazole	A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.	Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A5enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C8enzyme Cytochrome P450 1A1enzyme Cytochrome P450 2D6enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 1B1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Lanosterol 14-alpha demethylasetarget Androgen receptortarget Steroid 17-alpha-hydroxylase/17,20 lyasetarget Steroid 21-hydroxylasetarget Voltage-gated inwardly rectifying potassium channel KCNH2target Nuclear receptor subfamily 1 group I member 2target Nuclear receptor subfamily 1 group I member 3target UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 2B7enzyme Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 4F12enzyme Cytochrome P450 4F2enzyme Albumincarrier Sex hormone-binding globulincarrier Aromataseenzyme UDP-glucuronosyltransferase 1A7enzyme Lanosterol 14-alpha demethylasetarget
Levomenthol	An organic compound used to treat mild to moderate muscle and joint pain.	Transient receptor potential cation channel subfamily A member 1target Transient receptor potential cation channel subfamily M member 8target Transient receptor potential cation channel subfamily V member 3target Kappa-type opioid receptortarget Voltage-dependent L-type calcium channeltarget Cytochrome P450 3A4enzyme
Pyrithione	An antimicrobial agent used for the treatment of dandruff and seborrheic dermatitis.	Potassium voltage-gated channel subfamily KQT member 1target
Salicylic acid	An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.	Albumincarrier Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Aldo-keto reductase family 1 member C1target Solute carrier family 22 member 6transporter Solute carrier family 22 member 10transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 2B1transporter Monocarboxylate transporter 1transporter Solute carrier family 22 member 7transporter Cytochrome P450 2C9enzyme Carbonic anhydrase 6target Carbonic anhydrase 12target Carbonic anhydrase 2target Carbonic anhydrase 4target Carbonic anhydrase 1target
Selenium Sulfide	An antifungal used to treat dandruff, seborrheic dermatitis of the scalp, and tinea capitis.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05989633	DERCOS DS DANDRUFF TREATMENT OBSERVATIONAL STUDY 2022	No drug interventions	Not Available	Not Available	completed
NCT05503706	Effects on the Scalp Lipids and TEWL of a 1% Selenium Disulfide and 1% Salicylic Acid Antidandruff Shampoo on Dandruff Scalp	No drug interventions	treatment	Not Available	unknown_status
NCT02448082	The Efficacy of Sodium Shale Oil Sulponate 1% Shampoo in the Treatment of Pityriasis Capitis	No drug interventions	treatment	2	completed
NCT05506592	Evaluation of the Efficacy of SeS2 Shampoo on Subjects Having Dandruff	No drug interventions	treatment	Not Available	unknown_status
NCT06052241	Artificial Intelligence-based Prescription of Personalized Scalp Cosmetics	Coconut oil Olive oil Rosemary oil Tea tree oil	treatment	Not Available	completed
NCT05319444	Cleansing Device for the Treatment of Scalp and Hair Conditions	No drug interventions	treatment	Not Available	recruiting
NCT06436495	Methodology Validation: Correlating Adherent Scalp Flaking Score (ASFS) With Phototrichogram for Scalp Dandruff Evaluation in Adult Subjects	No drug interventions	other	Not Available	completed