This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Paraoxon
- DrugBank Accession Number
- DB13495
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Paraoxon (DB13495)
- Weight
- Average: 275.195
Monoisotopic: 275.055873697 - Chemical Formula
- C10H14NO6P
- Synonyms
- Not Available
- External IDs
- E-600
- E600
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcebutolol Paraoxon may increase the bradycardic activities of Acebutolol. Acetylcholine The risk or severity of adverse effects can be increased when Paraoxon is combined with Acetylcholine. Aclidinium Paraoxon may increase the neuromuscular blocking activities of Aclidinium. Amantadine The therapeutic efficacy of Amantadine can be decreased when used in combination with Paraoxon. Amifampridine The risk or severity of adverse effects can be increased when Paraoxon is combined with Amifampridine. Amitriptyline The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Paraoxon. Amobarbital The therapeutic efficacy of Amobarbital can be decreased when used in combination with Paraoxon. Amoxapine The therapeutic efficacy of Amoxapine can be decreased when used in combination with Paraoxon. Anisotropine methylbromide The therapeutic efficacy of Anisotropine methylbromide can be decreased when used in combination with Paraoxon. Aripiprazole The therapeutic efficacy of Aripiprazole can be decreased when used in combination with Paraoxon. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Categories
- ATC Codes
- S01EB10 — Paraoxon
- Drug Categories
- Agrochemicals
- Antiglaucoma Preparations and Miotics
- Cholinergic Agents
- Cholinesterase Inhibitors
- Compounds used in a research, industrial, or household setting
- Enzyme Inhibitors
- Insecticides
- Neurotransmitter Agents
- Ophthalmologicals
- Organophosphates
- Organophosphorus Compounds
- Parasympathomimetics
- Pesticides
- Sensory Organs
- Toxic Actions
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as nitrobenzenes. These are compounds containing a nitrobenzene moiety, which consists of a benzene ring with a carbon bearing a nitro group.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Nitrobenzenes
- Direct Parent
- Nitrobenzenes
- Alternative Parents
- Phenoxy compounds / Nitroaromatic compounds / Dialkyl phosphates / Propargyl-type 1,3-dipolar organic compounds / Organic oxoazanium compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organic oxides / Hydrocarbon derivatives
- Substituents
- Alkyl phosphate / Allyl-type 1,3-dipolar organic compound / Aromatic homomonocyclic compound / C-nitro compound / Dialkyl phosphate / Hydrocarbon derivative / Nitroaromatic compound / Nitrobenzene / Organic 1,3-dipolar compound / Organic nitro compound
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- organophosphate insecticide, aryl dialkyl phosphate (CHEBI:27827) / a small molecule (PARAOXON)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Q9CX8P80JW
- CAS number
- 311-45-5
- InChI Key
- WYMSBXTXOHUIGT-UHFFFAOYSA-N
- InChI
- InChI=1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
- IUPAC Name
- diethyl 4-nitrophenyl phosphate
- SMILES
- CCOP(=O)(OCC)OC1=CC=C(C=C1)[N+]([O-])=O
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0013035
- KEGG Compound
- C06606
- ChemSpider
- 9026
- BindingDB
- 50240416
- ChEBI
- 27827
- ChEMBL
- CHEMBL23838
- ZINC
- ZINC000001530487
- Wikipedia
- Paraoxon
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 1.44 mg/mL ALOGPS logP 2.05 ALOGPS logP 2.43 ChemAxon logS -2.3 ALOGPS pKa (Strongest Basic) -9.2 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 3 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 87.9 Å2 ChemAxon Rotatable Bond Count 7 ChemAxon Refractivity 63.69 m3·mol-1 ChemAxon Polarizability 25.02 Å3 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available GC-MS Spectrum - GC-EI-TOF GC-MS splash10-0a4m-4910000000-9e80686be84777f12897 Mass Spectrum (Electron Ionization) MS splash10-054k-9840000000-ed91d6d60187378e30e6 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at June 23, 2017 20:43 / Updated at June 12, 2020 16:53