Organophosphates

Name
Organophosphates
Accession Number
DBCAT001125
Description

Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or more OXYGEN atoms of the P(=O)(O)3 structure. Note that several specific classes of endogenous phosphorus-containing compounds such as NUCLEOTIDES; PHOSPHOLIPIDS; and PHOSPHOPROTEINS are listed elsewhere.

Drugs
DrugDrug Description
AmifostineA cytoprotective adjuvant used for reduction in the cumulative renal toxicity in patients with ovarian cancer and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
BromofosBromofos is a small molecule drug. Bromofos has a monoisotopic molecular weight of 363.85 Da.
CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...
DichlorvosDichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products...
EchothiophateAn acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma.
FamphurNot Annotated
Farnesyl diphosphateNot Available
Farnesyl thiopyrophosphateNot Available
FenthionFenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is...
Geranylgeranyl diphosphateNot Available
GlyphosateNot Available
MalathionA parasympathomimetic organophosphate used to treat head lice.
ParaoxonNot Annotated
PhosmetPhosmet is a phthalimide-derived organophosphate. It is a non-specific insecticide. It is mainly used on apple trees to control codling moths. It is also used on other fruit crops, ornamentals,...
PhosphocysteamineNot Annotated
TemefosDiphos has been used in trials studying the treatment of Plasmodium Falciparum Malaria.
Drugs & Drug Targets
DrugTargetType
AmifostineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
AmifostineAlkaline phosphatase, germ cell typetarget
BromofosCytochrome P450 2B1enzyme
BromofosCholinesterasetarget
BromofosAcetylcholinesterasetarget
CoumaphosAcetylcholinesterasetarget
CoumaphosParathion hydrolaseenzyme
CoumaphosPhosphotriesteraseenzyme
DichlorvosCholinesterasetarget
DichlorvosSerotransferrintarget
DichlorvosAlbumincarrier
EchothiophateAcetylcholinesterasetarget
EchothiophateCholinesterasetarget
EchothiophateAlbumincarrier
Farnesyl diphosphateProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
Farnesyl diphosphateProtein farnesyltransferase subunit betatarget
Farnesyl diphosphateGTPase KRastarget
Farnesyl diphosphateFarnesyl pyrophosphate synthasetarget
Farnesyl diphosphateDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)target
Farnesyl diphosphateLantibiotic nisin-Ztarget
Farnesyl diphosphateGeranylgeranyl pyrophosphate synthasetarget
Farnesyl diphosphate(2Z,6E)-farnesyl diphosphate synthasetarget
Farnesyl diphosphateGeranylgeranyl transferase type-2 subunit alphatarget
Farnesyl diphosphateGeranylgeranyl transferase type-2 subunit betatarget
Farnesyl diphosphateSqualene synthasetarget
Farnesyl diphosphate2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthasetarget
Farnesyl thiopyrophosphateDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)target
Farnesyl thiopyrophosphateGeranylgeranyl pyrophosphate synthasetarget
Farnesyl thiopyrophosphateMevalonate kinasetarget
Farnesyl thiopyrophosphate4,4'-diapophytoene synthasetarget
FenthionCholinesterasetarget
FenthionAcetylcholinesterasetarget
Geranylgeranyl diphosphateGeranylgeranyl transferase type-2 subunit betatarget
Geranylgeranyl diphosphateGeranylgeranyl transferase type-2 subunit alphatarget
Geranylgeranyl diphosphateFarnesyl pyrophosphate synthasetarget
Geranylgeranyl diphosphateGeranylgeranyl pyrophosphate synthasetarget
Geranylgeranyl diphosphateProtein farnesyltransferase subunit betatarget
Geranylgeranyl diphosphateGeranylgeranyl transferase type-1 subunit betatarget
Geranylgeranyl diphosphateProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
Glyphosate3-phosphoshikimate 1-carboxyvinyltransferasetarget
Glyphosate3-phosphoshikimate 1-carboxyvinyltransferasetarget
GlyphosateAromatasetarget
GlyphosateAlbumincarrier
MalathionAcetylcholinesterasetarget
MalathionCytochrome P450 2B6enzyme
MalathionCytochrome P450 1A2enzyme
MalathionCholinesterasetarget
ParaoxonCarbonic anhydrase 1target
ParaoxonCannabinoid receptor 1target
ParaoxonAcetylcholinesterasetarget
ParaoxonCarbonic anhydrase 2target
PhosmetAcetylcholinesterasetarget
TemefosAcetylcholinesterasetarget