Bipolar 1 Disorder (DBCOND0020745)

Identifiers

Synonyms
Bipolar Disorder 1 / Bipolar Disease Type I / Bipolar Type I Disorder / Bipolar I disorder / Bipolar 1 disorder / Bipolar disorder / Bipolar I disorder (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Aripiprazole
An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome.
Asenapine
An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia.
Carbamazepine
An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
Cariprazine
An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder.
Fluoxetine
A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I.
Lamotrigine
A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
Lithium carbonate
A medication used to treat manic episodes of bipolar disorder.
Loxapine
A antipsychotic used for the treatment of schizophrenia.
Lumateperone
A novel 2nd generation antipsychotic used to manage both positive and negative symptoms in patients with schizophrenia.
Olanzapine
An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.
Quetiapine
An atypical antipsychotic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder.
Risperidone
A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression.
Samidorphan
A novel opioid-system modulator, similar to naltrexone, that functions primarily as a μ-opioid receptor antagonist in vivo and is used primarily in combination with antipsychotics to reduce their metabolic dysfunction-associated adverse effects.
Ziprasidone
An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05157620
Exercise-based Program for Rehabilitation of Veterans With Severe Mental IllnessNo drug interventionstreatmentNot Availablerecruiting
NCT00994630
Biomarkers for Bipolar Disorder: Chaperones and Reticulum Endoplasmatic Stress Response CHAP´s StudyNo drug interventionsNot AvailableNot Availablesuspended
NCT04578756
Open-Label, Flexible-dose Study to Evaluate the Long-Term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Participants With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disordertreatment3recruiting
NCT06605599
Study of Oral ABBV-932 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Bipolar I or II DisorderNo drug interventionstreatment2not_yet_recruiting
NCT06608641
Efficacy and Safety of Endoxifen in Bipolar I Disorder PatientsNo drug interventionstreatment3recruiting
NCT06273774
A Study of MK-8189 in Participants With Bipolar I Disorder (MK-8189-020)treatment1completed
NCT00177164
Risperdal Consta for Bipolar Disordertreatment3completed
NCT03334721
Gabapentin for Bipolar & Cannabis Use Disordersbasic_science2completed
NCT01824602
Efficacy and Safety of Eslicarbazepine Acetate (BIA 2-093) in Acute Manic Episodes Associated With Bipolar I Disordertreatment2terminated
NCT00709202
Efficacy and Tolerability Study of Betahistine to Ameliorate Antipsychotic Associated Weight Gaintreatment2completed
NCT04907279
Aripiprazole Once-Monthly in Hospitalized Patients (INITIATE)Not AvailableNot Availableunknown_status
NCT02147379
Lurasidone and Cognition in Bipolar I Disordertreatment3completed
NCT00958633
Mood Stabilizer (MS)+ Antidepressant vs MS + Placebo in Maintenance of Bipolar Disorder.treatment3completed
NCT02050854
Open-Label Observational Pilot Study to Evaluate the Pharmacokinetics of Aripiprazole in Subjects With Bipolar 1 Disorder or SchizophreniaNo drug interventionsNot AvailableNot Availablecompleted
NCT00606177
A Multicenter, Placebo-controlled, Double-blind Investigative Extension Trial of the Safety and Efficacy of Aripiprazole in the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episodetreatment3completed
NCT00227305
Quetiapine Fumarate (SEROQUEL) in the Treatment of Adolescent Patients With Schizophrenia and Bipolar I Disordertreatment3completed
NCT00141505
PK Effects of Bifeprunox & Valproate in Bipolar Itreatment2completed
NCT06494397
Pharmacokinetic Study of VHX-896 and Iloperidone Tablets Under Steady-State Conditionstreatment1not_yet_recruiting
NCT05956483
Study to Assess Accuracy of Rapid Mood Screener in Adult Participants With Unipolar Major Depressive Disorder or Bipolar 1 Disorder in Real World SettingNo drug interventionsNot AvailableNot Availablecompleted
NCT01575561
This is an Open-label, Multi-center, Extension Study Designed to Evaluate the Longer Term Safety, Tolerability and Effectiveness of Lurasidone, Flexibly Dosed, Adjunctive to Lithium or Divalproex for the Treatment of Subjects With Bipolar I Disorder Who Have Participated in Study D1050296treatment3completed
NCT04211428
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Bipolar DisorderNo drug interventionsNot AvailableNot Availableunknown_status
NCT03788811
ERG Components in Schizophrenia and Bipolar Disorder Type INo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00764478
Fixed-dose Safety and Efficacy Study of Asenapine for the Treatment of Acute Manic or Mixed Episode in Bipolar 1 Disorder (P05691)treatment3completed
NCT02491307
Ginger.io Behavioral Health StudyNo drug interventionspreventionNot Availableterminated
NCT05249309
Naturalistic Study of Ketamine in the Treatment of DepressionNot AvailableNot Availableactive_not_recruiting
NCT03854409
A Trial of Single- and Multiple-doses of Aripiprazole in Adult Subjects With Schizophrenia or Bipolar I Disorderbasic_science1completed
NCT01710709
Open-label Study to Evaluate the Effectiveness of an Intramuscular Formulation of Aripiprazole (OPC-14597) as Maintenance Treatment in Patients With Bipolar I Disordertreatment3completed
NCT01495156
Study of the Efficacy of Adjunctive Lithium Treatment for the Treatment of Psychotic Maniatreatment4withdrawn
NCT03943537
Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disordersother2recruiting
NCT01825837
Efficacy, Safety, and Tolerability of Eslicarbazepine Acetate in the Recurrence Prevention of Bipolar I Disordertreatment2completed
NCT06221852
Ketogenic and Nutritional Interventions for First Episode Bipolar DisorderNo drug interventionstreatmentNot Availablerecruiting
NCT03641300
Efficacy of Convulsive Therapies for Bipolar DepressionNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT04358900
Unobtrusive Monitoring of Affective Symptoms and Cognition Using Keyboard Dynamics (UnMASCK)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01977300
Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic Episodetreatment3completed
NCT00608075
Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar Disorderbasic_science4unknown_status
NCT04771299
Assessing the Role of Cariprazine in Improving Cognition in Euthymic Bipolar Patientstreatment3recruiting
NCT04058249
Accelerated Theta Burst Stimulation for Inpatients With Bipolar DisorderNo drug interventionstreatmentNot Availableterminated
NCT01731119
Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and Adolescentstreatment2completed
NCT01932541
Open-Label Study of Latuda for the Treatment of Mania in Children and Adolescents 6-17 Years Oldtreatment4withdrawn
NCT03822416
Treating Smokers With Mental Illnesstreatment2completed
NCT01998516
Emotional Intelligence in Schizophrenia and Bipolar-I- DisorderNo drug interventionsNot AvailableNot Availablecompleted
NCT04987658
Phase 1 Study of OLZ/SAM in Pediatric Subjects With Bipolar I DisorderNo drug interventionstreatment1completed
NCT00177463
L-Carnosine for Bipolar I DisordertreatmentNot Availablecompleted
NCT00114686
Efficacy and Safety of Quetiapine Fumarate (SEROQUEL®) in the Treatment of Alcohol Dependency in Patients With Bipolar Disordertreatment3completed
NCT04561622
Emotional Proactive Processing in Bipolar DisorderNo drug interventionsNot AvailableNot Availableunknown_status
NCT01655030
Creatine Monohydrate as Adjuvant Therapy for Bipolar DepressionNo drug interventionstreatmentNot Availablecompleted
NCT05878730
Melatonin and Response to LithiumNo drug interventionsNot AvailableNot Availablerecruiting
NCT00618748
Safety and Efficacy of Olanzapine in the Long-term Treatment for Bipolar I Disorder, Depressedtreatment3completed
NCT03201757
Study to Evaluate the Long-term Safety, Tolerability, and Durability of Treatment Effect of ALKS 3831No drug interventionstreatment3completed
NCT01358357
Bipolar Maintenance Study of Lurasidone Adjunctive to Lithium or Divalproextreatment3completed
NCT00982020
Study in Adolescents With Schizophrenia or Bipolar Disordertreatment4completed
NCT01879982
PSYCHE (Personalised Monitoring SYstems for Care in Mental Health)No drug interventionsNot AvailableNot Availableunknown_status
NCT00107731
Efficacy & Safety of Seroquel Plus Mood Stabilizer in the Maintenance of Bipolar I Disorderprevention3completed
NCT01828931
Lifestyle Intervention for Diabetes and Weight Management in PsychosisNo drug interventionstreatmentNot Availablecompleted
NCT05683431
Using Neuroplasticity-Based Computerized Training to Improve Emotion Regulation in Bipolar Disorder (BRAINS)No drug interventionstreatmentNot Availablecompleted
NCT04819776
Evaluation of Efficacy and Safety of Iloperidone in the Acute Treatment of Manic or Mixed Episodes Associated With Bipolar I Disordertreatment3completed
NCT03484494
Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar DepressionNo drug interventionsbasic_scienceNot Availableactive_not_recruiting
NCT05648591
Safety and Tolerability of Open-Labeled Iloperidone in Adolescentstreatment4recruiting
NCT01396291
Efficacy and Safety of Asenapine in the Prevention of Recurrence of Mood Episodes in Participants With Bipolar 1 Disorder (P06384)treatment3completed
NCT03088462
LiveWell: A Mobile Intervention for Bipolar DisorderNo drug interventionstreatmentNot Availablecompleted
NCT02642029
Targeting Cerebellum to Treat Psychosis: a Transcranial Magnetic Stimulation (TMS) StudyNo drug interventionsbasic_scienceNot Availablecompleted
NCT04315792
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder PatientsNo drug interventionstreatment3recruiting
NCT04209140
Optimizing Response to Li Treatment Through Personalized Evaluation of Individuals With Bipolar I Disorder: The R-LiNK InitiativeNot AvailableNot Availableunknown_status
NCT05956340
A Study of Spoken Language in ManiaNo drug interventionssupportive_careNot Availablerecruiting
NCT05870501
Synaptic Imaging and Network Activity in Treatment Resistant Depressionbasic_scienceNot Availablerecruiting
NCT05340504
Evaluating the Hypothesized Mechanism of Action of N-acetylcysteine for Bipolar Disordertreatment2completed
NCT03287869
A Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Participants With Bipolar I Disorder.treatment3completed
NCT01674010
Safety and Efficacy Study of ELND005 as an Adjunctive Maintenance Treatment in Bipolar I Disordertreatment2terminated
NCT00606281
A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group-comparison Trial of Aripiprazole in the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episodetreatment3completed
NCT03259555
A Trial to Assess Brexpiprazole Versus Placebo for the Treatment of Acute Manic Episodes Associated With Bipolar I Disordertreatment3completed
NCT00721955
Staccato Loxapine in Agitated Patients With Bipolar Disordertreatment3completed
NCT05427123
Children's Bipolar Network Treatment Trial INo drug interventionsNot AvailableNot Availablerecruiting
NCT05878808
Obsessions and Suicidality in Youth With Bipolar 1 DisorderNo drug interventionsNot AvailableNot Availablecompleted
NCT02593643
Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression.treatment0completed
NCT00746343
Reducing Medical Risks in Individuals With Bipolar Disorder - Full StudyNo drug interventionstreatmentNot Availablecompleted
NCT05303064
Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disordertreatment3recruiting
NCT06107764
Cerebellar Modulation of Cognition in PsychosisNo drug interventionsotherNot Availablerecruiting
NCT00046384
Study of Aripiprazole in the Treatment of Patients With Acute Symptoms of Bipolar Disordertreatment3completed
NCT04812379
Specified Drug-use Survey on Abilify Prolonged Release Aqueous Suspension for IM Injection (Prevention of Relapse of Mood Episodes in BP)Not AvailableNot Availableactive_not_recruiting
NCT03386851
Abilify Maintena PMS in Schizophrenia Patients or Bipolar 1 DisorderNo drug interventionsNot AvailableNot Availablecompleted
NCT05025605
Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disordertreatment1recruiting
NCT01207505
Emotion Regulation Group Therapy for Bipolar DisorderNo drug interventionstreatmentNot Availablecompleted
NCT03573297
A Cariprazine Study in the Prevention of Relapse in Bipolar I Disorder Patients Whose Current Episode is Manic or Depressive, With or Without Mixed Featurestreatment3completed
NCT04168697
Effect of Behavioral Intervention on Cannabinoid Receptors in BADNo drug interventionsbasic_scienceNot Availableunknown_status
NCT03603561
Continuous Theta Burst Stimulation as an add-on Treatment for Bipolar DepressionNo drug interventionstreatmentNot Availableunknown_status
NCT00761761
Sensoril(Ashwaganhda)for Bipolar DisorderNo drug interventionstreatment3completed
NCT00178061
Effects of Comorbid Personality Disorder on the Treatment of Bipolar I DisorderNo drug interventionstreatment4completed
NCT01981811
Adherence to Treatment, Safety and Tolerability Study of the Medical Information Device #1 (MIND1) in Subjects With Schizophrenia or Bipolar I Disordertreatment2withdrawn
NCT01822678
Efficacy and Safety of Eslicarbazepine Acetate (BIA 2-093) in Acute Manic Episodes Associated With Bipolar I Disordertreatment2completed
NCT00238485
An Open-label Extension Study to Evaluate the Safety and Tolerability of Licarbazepine 750-2000 mg/d in the Treatment of Manic Episodes of Bipolar I DisorderNo drug interventionsdiagnostic3completed
NCT05400785
Efficacy of the Mobile Application for Prediction and Prevention of Mood Episode Recurrence Based on Machine LearningNo drug interventionspreventionNot Availablerecruiting
NCT00094432
A Study of Aripiprazole in Patients With Bipolar I Disorder With a Major Depressive Episodetreatment3completed
NCT06129500
CBT for Problematic Impulsive Behaviours in Bipolar Disorder: A Case Series / CBT-PIBNo drug interventionstreatmentNot Availablerecruiting
NCT03643159
A Trial to Measure the Difference in All-cause Hospitalizations for Participants Who Are Using Abilify MyCite Versus Virtual Matched Controls in Adults With Schizophrenia, Bipolar 1 Disorder, and Major Depressive Disorderhealth_services_research4terminated
NCT01570959
Crossover Bioequivalence Study of Quetiapine Fumarate 300 mg Tablets Under Steady State Fasted ConditionstreatmentNot Availablecompleted
NCT00228059
An Open-label Extension Study to Evaluate the Safety and Tolerability of Licarbazepine in the Treatment of Manic Episodes of Bipolar I Disorder.No drug interventionstreatment3completed
NCT00857818
Trial Comparing the Effects of Aripiprazole With Those of Standard of Care on Non-HDL Cholesterol in Patients With Schizophrenia or Bipolar I Disorder Who Have Metabolic Syndrometreatment3terminated
NCT05064319
Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorderstreatment2recruiting
NCT01206517
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Sublingual Asenapine in a Pediatric Population With Schizophrenia or Bipolar I Disorder (P06522 AM1)treatment1completed
NCT04580134
CLOZAPINE Response in Biotype-1treatment4recruiting
NCT00402324
A Comparison of Olanzapine in Combination With a Mood Stabilizer vs Mood Stabilizer Alone, in Mixed Bipolar Patientstreatment4completed
NCT05004896
Ketamine for Treatment-Resistant Bipolar Disordertreatment2recruiting
NCT04127058
Evaluating a New Iloperidone Titration Scheme in Bipolar I Disorder or Schizophreniatreatment1completed
NCT06433635
Sequential Multiple Assignment Randomized Trial for Bipolar Depressiontreatment4not_yet_recruiting
NCT01710163
Potentiation of Quetiapine Treatment With Lithium or Aripiprazole in Bipolar 1 Nonresponders Patientstreatment4unknown_status
NCT05705063
Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar IllnessNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05340686
Braining- Aerobic Physical Activity as Add on Treatment in Bipolar DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT01059539
Long-term Safety and Tolerability of Cariprazine for Bipolar I Disordertreatment3completed
NCT03630822
Multicenter, Randomized, Comparative and Prospective Study Evaluating the Impact on the Care Path of an Editorial Program Accompanied by Advance Directives in Psychiatry (DAP) for People Suffering From Schizophrenia, Bipolar I Disorder or Schizoaffective DisorderNo drug interventionssupportive_careNot Availablecompleted
NCT03292848
Trial to Assess the Pharmacokinetics, Safety, Tolerability of Oral Brexpiprazole in Children (6 to <13 Years Old) With Central Nervous System Disorderstreatment1completed
NCT06560957
SYNCED - SYNChronized Eating in Bipolar Depression StudyNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04777357
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.treatment3recruiting
NCT01588457
Sequential Multiple Assignment Treatment for Bipolar Disordertreatment4completed
NCT00350857
The Young Adult and Pediatric Bipolar Studytreatment4completed
NCT03257865
A Trial to Assess Brexpiprazole Versus Placebo for the Treatment of Acute Manic Episodes, Associated With Bipolar I Disordertreatment3completed
NCT05934474
Biocollection on Peripheral InflammationNo drug interventionsNot AvailableNot Availablerecruiting
NCT05339074
Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depressiontreatment2recruiting
NCT00606320
A Multicenter, Investigative Study of the Safety and Efficacy of Extended Administration of Aripiprazole in Combination With Mood Stabilizer for the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episodetreatment3completed
NCT03192631
Financial Incentives to Improve Acceptance of Antipsychotic InjectionsNo drug interventionsotherNot Availableunknown_status
NCT01567527
Efficacy, Safety, and Tolerability of an Intramuscular Formulation of Aripiprazole (OPC-14597) as Maintenance Treatment in Bipolar I Patientstreatment3completed
NCT01765127
An Observational Modified Prescription-event Monitoring Study of Asenapine (Sycrest)No drug interventionsNot AvailableNot Availablecompleted
NCT03919760
Early Psychosis Intervention - Spreading Evidence-based TreatmentNo drug interventionsNot AvailableNot Availableunknown_status
NCT01570894
Crossover Bioequivalence Study of Quetiapine Fumarate 25 mg Tablets Under Fed ConditionstreatmentNot Availablecompleted
NCT00976794
Efficacy of Combined Treatment for Young Bipolar I Disordertreatment4completed
NCT00195780
A Study for the Treatment of Mania Associated With Bipolar I Disorder in Children and Adolescentstreatment3completed
NCT04987229
Long-term Safety Extension Study of OLZ/SAM in Pediatric SubjectsNo drug interventionstreatment3enrolling_by_invitation
NCT00606229
A Multicenter Investigative Study of the Safety and Efficacy of Long-term Administration of Aripiprazole in Combination With Mood Stabilizer for the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episodetreatment3completed
NCT05420792
The Effect of Interpersonal Relationships and Social Rhythm Therapy Individuals With Bipolar DisorderNo drug interventionssupportive_careNot Availableunknown_status
NCT01395992
Long-Term Safety Extension Trial of Asenapine in Bipolar 1 Disorder Participants Who Completed Protocol P05691 (P05692)treatment3completed
NCT02722967
Exploratory Trial to Assess the Functionality of an Integrated Call Center for the Digital Medicine Systemtreatment2completed
NCT06256367
Observational Study of Oral Cariprazine Capsules to Assess Change in Disease Activity in Adult Participants With Bipolar I DisorderNo drug interventionsNot AvailableNot Availablerecruiting
NCT06558201
Open Label Extension Study of NCT06221852No drug interventionstreatmentNot Availableenrolling_by_invitation
NCT03156504
The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.basic_science4completed
NCT05837104
Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disordertreatment2recruiting
NCT01058668
Safety and Efficacy of Cariprazine for Bipolar I Disordertreatment3completed
NCT03187769
Study to Evaluate the Efficacy of ALKS 3831 on Body Weight in Young Adults Who Have Been Recently Diagnosed With Schizophrenia, Schizophreniform, or Bipolar I Disordertreatment3completed
NCT05658510
Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia and Bipolar Disorder (SERENITY III)treatment3active_not_recruiting
NCT06372210
A Trial to Assess a Wearable Patch's Functioning to Detect Medication IngestionotherNot Availablecompleted
NCT03692910
A Study to Evaluate SAGE-217 in Participants With Bipolar I/II Disorder With a Current Major Depressive Episodetreatment2completed
NCT01075295
Prevention of Weight Gain in Early PsychosesNo drug interventionspreventionNot Availablecompleted
NCT01986114
A Long-Term Study of SM-13496 in Patients With Bipolar I Disorder.treatment3completed
NCT00232414
A Double-Blind Randomized Placebo Controlled Study of Quetiapine for the Treatment of Depression in Adolescents With Bipolar Disordertreatment3completed
NCT05375214
iTBS in Bipolar I DepressionNo drug interventionstreatmentNot Availablecompleted
NCT05977023
NMDA Receptor Modulation for the Treatment of Bipolar I DisorderNo drug interventionstreatment2recruiting
NCT04030143
A Trial of Multiple-doses of Aripiprazole in Adults With Schizophrenia or Bipolar 1 Disordertreatment1 / 2completed