Opioid Induced Constipation (OIC)

Also known as: Constipation, Opioid-Induced / Opioid Induced Constipation / Opioid-Induced Constipation / Opioid-Induced Constipation (OIC) / Constipation, unspecified / Constipation / Constipation (finding)

Drug	Drug Name	Drug Description
DB01046	Lubiprostone	A prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
DB06800	Methylnaltrexone	A μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy.
DB11691	Naldemedine	An opioid antagonist used to to treat opioid-induced constipation.
DB09049	Naloxegol	A peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
DB06480	Prucalopride	A 5-HT4 receptor agonist indicated to treat adults with chronic idiopathic constipation.

Drug	Drug Name	Target	Type
DB01046	Lubiprostone	Chloride channel protein 2	target
DB01046	Lubiprostone	Carbonyl reductase [NADPH] 1	enzyme
DB06800	Methylnaltrexone	Mu-type opioid receptor	target
DB06800	Methylnaltrexone	Kappa-type opioid receptor	target
DB06800	Methylnaltrexone	Melanocortin receptor 4	target
DB11691	Naldemedine	Cytochrome P450 3A Subfamily	enzyme
DB11691	Naldemedine	UDP-glucuronosyltransferase 1A3	enzyme
DB11691	Naldemedine	Mu-type opioid receptor	target
DB11691	Naldemedine	Delta-type opioid receptor	target
DB11691	Naldemedine	Kappa-type opioid receptor	target
DB11691	Naldemedine	ATP-binding cassette sub-family B member 5	transporter
DB09049	Naloxegol	Cytochrome P450 3A4	enzyme
DB09049	Naloxegol	Cytochrome P450 2D6	enzyme
DB09049	Naloxegol	Cytochrome P450 2C19	enzyme
DB09049	Naloxegol	Mu-type opioid receptor	target
DB06480	Prucalopride	5-hydroxytryptamine receptor 4	target
DB06480	Prucalopride	Cytochrome P450 3A4	enzyme
DB06480	Prucalopride	Albumin	carrier
DB06480	Prucalopride	ATP-dependent translocase ABCB1	transporter

Drug	Drug Name	Phase	Status	Count
DB06800	Methylnaltrexone	Not Available	Completed	1
DB09049	Naloxegol	Not Available	Completed	3
DB09049	Naloxegol	Not Available	Terminated	1
DB09049	Naloxegol	1	Completed	1
DB12013	Axelopran	1 / 2	Completed	1
DB11691	Naldemedine	1 / 2	Recruiting	1
DB12013	Axelopran	2	Completed	3
DB12464	Bevenopran	2	Completed	1
DB16543	Lactobacillus gasseri	2	Recruiting	1
DB08890	Linaclotide	2	Completed	1
DB06800	Methylnaltrexone	2	Completed	1
DB15241	Methylsamidorphan	2	Completed	2
DB11691	Naldemedine	2	Completed	1
DB09049	Naloxegol	2	Completed	1
DB01183	Naloxone	2	Completed	1
DB06800	Methylnaltrexone	2 / 3	Unknown Status	1
DB12464	Bevenopran	3	Terminated	4
DB06800	Methylnaltrexone	3	Completed	1
DB06800	Methylnaltrexone	3	Unknown Status	1
DB11691	Naldemedine	3	Completed	3
DB09049	Naloxegol	3	Completed	4
DB09049	Naloxegol	3	Terminated	1
DB01183	Naloxone	3	Unknown Status	1
DB06480	Prucalopride	3	Terminated	1
DB01079	Tegaserod	3	Terminated	2
DB00318	Codeine	4	Completed	1
DB09104	Magnesium hydroxide	4	Recruiting	1
DB06800	Methylnaltrexone	4	Completed	2
DB06800	Methylnaltrexone	4	Withdrawn	1
DB09049	Naloxegol	4	Completed	2
DB01183	Naloxone	4	Completed	1
DB00497	Oxycodone	4	Completed	1
DB09287	Polyethylene glycol	4	Completed	1
DB01046	Lubiprostone	Not Available	Recruiting	1
DB11691	Naldemedine	Not Available	Recruiting	1
DB09049	Naloxegol	Not Available	Active Not Recruiting	1
DB09049	Naloxegol	Not Available	Recruiting	1