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Displaying results 151 - 160 of 144405 in total
  1. Drug

    Etevritamab

    go.drugbank.com/drugs/DB17211
    Investigational

    Synonyms: IMMUNOGLOBULIN SCFV-SCFV, ANTI-(HOMO SAPIENS EGFR (EPIDERMAL GROWTH FACTOR RECEPTOR, RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1, ERBB1, HER1, HER-1, ERBB) VARIANT III (EGFRVIII)) AND ANTI-(HOMO SAPIENS CD3E
  2. Drug

    Acazicolcept

    go.drugbank.com/drugs/DB18410
    Investigational

    Synonyms: Fc fusion protein of a human inducible T cell costimulator ligand variant immunoglobulin domain designed to inhibit simultaneously the CD28 and ICOS inflammation pathwaysCategories: Amino Acids, Peptides, and Proteins
  3. Drug

    Petrolatum

    go.drugbank.com/drugs/DB11058
    ApprovedInvestigational

    It is used as an ointment base, topical protectant, and lubricant.

    Mixtures: A and D First Aid, A and D First AidCategories: Basic Ointments and Protectants
  4. Pathway

    Glutaminolysis and Cancer

    smpdb.ca/view/SMP0002298
    Disease

    The transportation of glutamine in and out regulates mTOR activation to coordinate cell growth and proliferation. … Once it reaches malic acid, it is transported outside the mitochondria and transformed into pyruvic acid and lactate.

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Succinic acid +9 more
  5. Drug

    Doxylamine

    go.drugbank.com/drugs/DB00366
    ApprovedInvestigationalVet approved

    It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.

    Mixtures: Daytime Cold and Flu and Nighttime Cold and Flu, Daytime Cold and Flu and Nigttime Cold and FluProducts: Berkley and Jensen Sleep Aid, Up and Up Nighttime Sleep Aid
  6. Pathway

    Nicotinate and Nicotinamide Metabolism

    smpdb.ca/view/SMP0000048
    Metabolic

    Nicotinate (niacin) and nicotinamide - more commonly known as vitamin B3 - are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP … The precursors are fed into the NAD+ biosynthetic pathwaythrough adenylation and phosphoribosylation reactions.

    Drugs: Ademetionine · L-Glutamine · Adenosine phosphate · Glutamic acid · NADH · ATP +8 more
  7. Pathway

    Fructose and Mannose Degradation

    smpdb.ca/view/SMP0000064
    Metabolic

    Fructose causes less of an insulin response compared to glucose and thus may be a preferred sugar for diabetics. … Fructose and mannose are monosaccharides that can be found in many foods. Fructose can join with glucose to form sucrose. Mannose can be converted to glucose. Both may be used as food sweeteners.

    Drugs: NADH · ATP · Magnesium cation · Zinc · Sorbitol · D-glyceraldehyde 3-phosphate +5 more
  8. Pathway

    Androgen and Estrogen Metabolism

    smpdb.ca/view/SMP0000068
    Metabolic

    This pathway describes the inactivation and catabolism of male (androgen) and female (estrogen) hormones. … Many steroid hormones are transformed by sulfatases, dehydrogenases and glucuronide transferases to enhance their solubility and to facilitate their elimination.

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
  9. Pathway

    NAD+ Signalling and Aging

    smpdb.ca/view/SMP0084271
    Signaling

    An interesting link has emerged between NAD+ metabolism, SIRT1, SIRT3, and mitochondrial function. … NR and PARP inhibitors increased life span in worms via activation of the mitochondrial unfolded protein response UPRmt by sir2.1.

    Drugs: 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · Nicotinamide · Flavin adenine dinucleotide
  10. Pathway

    Glycine and Serine Metabolism

    smpdb.ca/view/SMP0000004
    Metabolic

    This pathway describes the synthesis and breakdown of several small amino acids, including glycine, serine, and cysteine. … All of these compounds share common intermediates and almost all can be biosynthesized from one another. Serine and glycine are not essential amino acids and can be synthesized from several routes.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more