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Loteprednol
go.drugbank.com/drugs/DB00873ApprovedInvestigationalWithdrawnLoteprednol is a corticosteroid. A more commonly used formulation of loteprednol is its ester, loteprednol etabonate.
Categories: loteprednol and antiinfectives, AndrostanesFluid Loss
go.drugbank.com/conditions/DBCOND0062339Mild, moderate Metabolic Acidosis
go.drugbank.com/conditions/DBCOND0135808Neuron Function
smpdb.ca/view/SMP0000224PhysiologicalNeurons maintain a voltage gradient across their membrane using metabolically driven ion pumps and ion channels for charge-carrying ions, including sodium (Na+), potassium (K+), chloride (Cl−), and calcium … Once the interior of the neuron becomes more positively charged, the sodium channels close and the potassium channels open to allow potassium to move out of the cell to try and restore the resting membrane
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Digoxin Cardiac Action Pathway
smpdb.ca/view/SMP0125107Drug actionCommon side effects of digoxin include nausea, vomiting, and anorexia, rash, headache, gynecomastia and weakness. … Digoxin is a positive inotropic and negative chronotropic drug, meaning that it increases the force of the heartbeat and decreases the heart rate.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Kidney Function- Proximal Convoluted Tubule
smpdb.ca/view/SMP0121001PhysiologicalHowever, the reabsorption of chloride, as well as potassium, increases as the amount of water reabsorption increases due to solvent drag (also known as bulk transport). … Sodium and bicarbonate (hydrogen carbonate) are transported by a co-transporter that is responsible for the majority of sodium reabsorption.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATBupivacaine Action Pathway
smpdb.ca/view/SMP0000393Drug actionOnce inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Bupivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Bupivacaine diffuses across the neuronal plasma membrane in its uncharged base form.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Chloroprocaine Action Pathway
smpdb.ca/view/SMP0000394Drug actionOnce inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Chloroprocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Proparacaine Action Pathway
smpdb.ca/view/SMP0000403Drug actionOnce inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Proparacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Proparacaine diffuses across the neuronal plasma membrane in its uncharged base form.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1