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Hyper-IgD Syndrome
smpdb.ca/view/SMP0000509DiseaseHyperimmunoglobulinemia D syndrome, or HIDS, is a condition characterized by fevers that come and go, usually lasting 3-7 days, and other various symptoms such as rashes, vomiting, diarrhea and aphthous ulcers. These are usually noticed ...
Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 moreCongenital Disorder of Glycosylation CDG-IId
smpdb.ca/view/SMP0000579DiseaseThe congenital disorder of glycosylation type IID, also called CDG IId or CDG2D is a recessive genetic disorder caused by an autosomal mutation in the B4GALT1 gene which encodes the protein beta-1,4-galactosyltrasnferase 1. This protein ...
The Oncogenic Action of Fumarate
smpdb.ca/view/SMP0002295DiseaseHypoxia-inducible factor In many tumours, oxygen availability becomes limited (hypoxia) very quickly during cancer development. The major regulator of the response to hypoxia is the HIF transcription factor. Under normal oxygen levels, t...
NAD+ Signalling Pathway (Cancer)
smpdb.ca/view/SMP0083297SignalingNAD+-dependent signalling pathways regulate many fundamental processes such as DNA repair, DNA transcription, cell proliferation, cell survival, cell cycle progression, apoptosis, and metabolism. These pathways are all linked to cancer d...
Methylphenidate Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0125204Drug actionMethylphenidate, known commonly as Ritalin, is a central nervous system stimulant used mainly for ADHD, but also for narcolepsy. ADHD is caused by an abnormality in the dopamine transporter gene (DAT1), the D4 receptor gene (DRD-4), and/...
Methamphetamine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0125231Drug actionMethamphetamine (metamfetamine) is a psychostimulant and sympathomimetic drug. It is mainly taken recreationally but can be taken for ADHD and exogenous obesity in the form of a drug called Desoxyn. Methamphetamine induces effects of eup...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin +9 moreBupropion Action Pathway
smpdb.ca/view/SMP0125268Drug actionBupropion, known as the brand name Wellbutrin, is a norepinephrine/dopamine reuptake inhibitor (NDRI) used most commonly as a treatment for major depressive disorder (MDD), and seasonal affective disorder (SAD). It can also be used as a ...
Methyldopa Metabolism Pathway
smpdb.ca/view/SMP0125325MetabolicMethyldopa is a centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises. Methyldopa is incompletely absorbed from the gastrointestinal tra...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Methyldopa · Magnesium cation · Pyrroloquinoline Quinone +1 moreLevodopa Metabolism Pathway
smpdb.ca/view/SMP0125329MetabolicLevodopa is an oral drug used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. It is a dopamine precursor and is used to synthesize dopamine in dopam...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · NADH · Norepinephrine · Epinephrine +6 moreTyrosinemia, Transient, of the Newborn
smpdb.ca/view/SMP0125592DiseaseA transient defect in tyrosine metabolism is a common aminoacidopathy in the premature and full-term human infant. This disorder, termed neonatal tyrosinemia, was first described by Levine and Gordon in 1939. In the intervening years oth...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more