Search
Methotrexate Action Pathway
smpdb.ca/view/SMP0000432Drug actionMethotrexate is an antifolate antimetabolite used in the treatment of rheumatoid arthritis and cancer. Methotrexate is taken up into the cell by human reduced folate carriers (SLC19A1). In the cytoplasm, methotrexate is polyglutamated by...
Refsum Disease
smpdb.ca/view/SMP0000451DiseaseAdult Refsum Disease (Classic Refsum Disease; Phytanic Acid Oxidase Deficiency; Heredopathia Atactica Polyneurtiformis; Hereditary Motor and Sensory Neuropathy IV; HSMN4; Adult Refsum Disease I; Adult Refsum Disease II), can be caused by...
Mevalonic Aciduria
smpdb.ca/view/SMP0000510DiseaseMevalonic aciduria, also called MVA, is an extremely rare inherited inborn error of metabolism (IEM) and an autosomal recessive disorder caused by a defective mevalonate kinase gene. It is manifested by high levels of mevalonic acid in t...
Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 moreMethylenetetrahydrofolate Reductase Deficiency (MTHFRD)
smpdb.ca/view/SMP0000543DiseaseMethylenetetrahydrofolate reductase deficiency (MTHFRD; Homocystinuria due to defect of n(5,10)-methylene THF deficiency) is caused by a defect in the MTHFR gene which codes for methylenetetrahydrofolate reductase. Methylenetetrahydrofol...
The Oncogenic Action of Succinate
smpdb.ca/view/SMP0002292DiseaseHypoxia-inducible factor In many tumours, oxygen availability becomes limited (hypoxia) very quickly during cancer development. The major regulator of the response to hypoxia is the HIF transcription factor. Under normal oxygen levels, t...
NAD+ Signalling and Aging
smpdb.ca/view/SMP0084271SignalingAn interesting link has emerged between NAD+ metabolism, SIRT1, SIRT3, and mitochondrial function. NR and PARP inhibitors increased life span in worms via activation of the mitochondrial unfolded protein response UPRmt by sir2.1. Short-t...
Finasteride Action Pathway
smpdb.ca/view/SMP0125125Drug actionFinasteride is a synthetic 4-azasteroid molecule used as an antiandrogenic agent. This drug treats symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate. It can also treat male hair loss due to androgenetic alop...
Caffeine Vasodilation Action Pathway
smpdb.ca/view/SMP0125283Drug actionCaffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. The cardiovascular effects are extensive and can help with headaches, migraines, or other types of pain in certain ci...
Immunometabolism Pathway (Bacterial Activation)
smpdb.ca/view/SMP0125484DiseaseThe normal response to a bacterial infection involves bacteria activateing the Toll-like receptor TLR4 on the membranes of macrophages, T-cells and dendritic cells. TLR4 activates the production of interferon regulatory factor 3 (IRF3), ...
Tyrosinemia Type I
smpdb.ca/view/SMP0125591DiseaseTyrosinemia type I, also known as fumarylacetoacetase or FAH deficiency, is the most severe type of tyrosinemia, a buildup of tyrosine in the body. It is caused by an autosomal recessive mutation in the the FAH gene that encodes for fuma...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more