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Displaying results 51 - 60 of 135483 in total
  1. Pathway

    Roxatidine Acetate H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0123168
    Drug action

    Roxatidine Acetate is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). … After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epithelium.

    Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Roxatidine acetate
  2. Pathway

    Metabolism and Physiological Effects of Phenol sulphate

    smpdb.ca/view/SMP0126844
    Metabolic

    Phenylsulfates are compounds containing a sulfate group conjugated to a phenyl group. … Phenol sulphate can be found in most mammals (mice, rats, sheep, dogs, humans) and likely most animals. Phenol sulphate is a uremic toxin.

    Drugs: Tyrosine · Phenol
  3. Pathway

    Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126428
    Drug action

    Activation of L-type calcium channels allows the influx of calcium ions into the muscles upon depolarization and excitation of the channel. … Verapamil, known as the brand names Calan, Isoptin, Tarka, and Verelan, is a non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension.

    Drugs: Verapamil · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1G
  4. Pathway

    Glutaminolysis and Cancer

    smpdb.ca/view/SMP0002298
    Disease

    The transportation of glutamine in and out regulates mTOR activation to coordinate cell growth and proliferation. … Once it reaches malic acid, it is transported outside the mitochondria and transformed into pyruvic acid and lactate.

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Succinic acid +9 more
    Enzymes: 4F2 cell-surface antigen heavy chain
  5. Pathway

    Enflurane Calcium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126668
    Drug action

    My decreasing the amount of intracellular calcium available, calcium cannot readily bind to calmodulin and muscle contraction is inhibited. … Enflurane is a halogenated inhalational anesthetic agent used for the induction and maintenance of anesthesia and for analgesia during labor and delivery.

    Drugs: ATP · Enflurane · Epinephrine · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  6. Pathway

    Nicotinate and Nicotinamide Metabolism

    smpdb.ca/view/SMP0000048
    Metabolic

    Nicotinate (niacin) and nicotinamide - more commonly known as vitamin B3 - are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP … The precursors are fed into the NAD+ biosynthetic pathwaythrough adenylation and phosphoribosylation reactions.

    Drugs: Ademetionine · L-Glutamine · Adenosine phosphate · Glutamic acid · NADH · ATP +8 more
  7. Pathway

    Fructose and Mannose Degradation

    smpdb.ca/view/SMP0000064
    Metabolic

    Fructose causes less of an insulin response compared to glucose and thus may be a preferred sugar for diabetics. … Fructose and mannose are monosaccharides that can be found in many foods. Fructose can join with glucose to form sucrose. Mannose can be converted to glucose. Both may be used as food sweeteners.

    Drugs: NADH · ATP · Magnesium cation · Zinc · Sorbitol · D-glyceraldehyde 3-phosphate +5 more
  8. Pathway

    Androgen and Estrogen Metabolism

    smpdb.ca/view/SMP0000068
    Metabolic

    This pathway describes the inactivation and catabolism of male (androgen) and female (estrogen) hormones. … Many steroid hormones are transformed by sulfatases, dehydrogenases and glucuronide transferases to enhance their solubility and to facilitate their elimination.

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
    Enzymes: Steryl-sulfatase
  9. Pathway

    NAD+ Signalling and Aging

    smpdb.ca/view/SMP0084271
    Signaling

    An interesting link has emerged between NAD+ metabolism, SIRT1, SIRT3, and mitochondrial function. … NR and PARP inhibitors increased life span in worms via activation of the mitochondrial unfolded protein response UPRmt by sir2.1.

    Drugs: 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · Nicotinamide · Flavin adenine dinucleotide
  10. Pathway

    Glycine and Serine Metabolism

    smpdb.ca/view/SMP0000004
    Metabolic

    This pathway describes the synthesis and breakdown of several small amino acids, including glycine, serine, and cysteine. … All of these compounds share common intermediates and almost all can be biosynthesized from one another. Serine and glycine are not essential amino acids and can be synthesized from several routes.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more