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Anti-inflammatory pathway
smpdb.ca/view/SMP0125485DiseaseAs the bacteria are cleared, tryptophan levels continue to drop as the indole dioxygenase (IDO) enzyme becomes more active. IDO activation results in the generation (from tryptophan) of kynurenine (and its other metabolites) through a se...
Tyrosine Hydroxylase Deficiency
smpdb.ca/view/SMP0125611DiseaseTyrosine Hydroxylase (TH) Deficiency is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of catecholamines pathways. The disorder is caused by defects in the Tyrosine hydroxylase (TH) gene which encodes for the en...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 morePyruvate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0125772DiseasePyruvate dehydrogenase complex deficiency results from a mutation in the E1-alpha polypeptide gene (PDHA1). PDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA fo...
Loxoprofen Action Pathway
smpdb.ca/view/SMP0126099Drug actionThis trans-alcohol form targets the prostaglandin G/H synthase-1 (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. … Since loxoprofen is a prodrug, it is rapidly metabolized by the carbonyl reductase in the liver to its trans-alcohol form, which is a non-selective inhibitor of cyclooxygenase.
Stiripentol GABA(A) Antiepileptic Action Pathway
smpdb.ca/view/SMP0126168Drug actionStiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +4 moreBetamethasone Action Pathway
smpdb.ca/view/SMP0126176Drug actionBetamethasone is a long-acting and systemic corticosteroid used to relieve inflammation in various conditions, including allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders. It is available as ...
Betamethasone phosphate Action Pathway
smpdb.ca/view/SMP0126180Drug actionBetamethasone phosphate is a prodrug that is rapidly metabolized to betamethasone. It is used to treat many inflammatory conditions like allergic states, dermatologic diseases, hematologic disorders, renal diseases, respiratory diseases,...
Methotrexate Action Pathway (new)
smpdb.ca/view/SMP0126242Drug actionWhen taking this drug avoid substances such as alcohol, dairy products, St.John's wort and caffeine.
Racepinephrine A1-Adrenergic Vasoconstriction Action Pathway
smpdb.ca/view/SMP0126496Drug actionRacepinephrine is a bronchodilator used to treat asthma. It can be found under the brand name Asthmanefrin and is orally inhaled to act on both alpha and beta adrenergic receptors. This drug has a rapid onset and short duration and acts ...
Dipivefrin B2-Adrenergic Ciliary Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126568Drug actionDipivefrin is a prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma. It is available as ophthalmic solution (eye drops). Dipivefrin is a prodrug with little or no pharmacologi...