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Roflumilast

go.drugbank.com/drugs/DB01656
ApprovedInvestigational

Roflumilast is a highly selective phosphodiesterase-4 (PDE4) inhibitor. PDE4 is a major cyclic-3',5′-adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme expressed on nearly all immune and pro-inflammatory cells, in addition to structural cells like those of the smooth muscle or epithelium. The resultant in...

  1. Drug

    Apremilast

    go.drugbank.com/drugs/DB05676
    ApprovedInvestigational

    It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene.

  2. Indication

    Exacerbation of COPD

    go.drugbank.com/conditions/DBCOND0046788
    Drugs: Prednisolone · Roflumilast · Sparfloxacin · Tiotropium
  3. Indication

    Mild Atopic dermatitis

    go.drugbank.com/conditions/DBCOND0025273
    Drugs: Crisaborole · Desonide · Fusidic acid · Pimecrolimus · Roflumilast · Ruxolitinib
  4. Drug

    Piclamilast

    go.drugbank.com/drugs/DB01791
    Experimental

    The structure for piclamilast was first elucidated in a 1995 European patent application and exhibits the structural functionalities of cilomilast and roflumilast.

  5. Indication

    Moderate Atopic dermatitis

    go.drugbank.com/conditions/DBCOND0025271
    Drugs: Abrocitinib · Baricitinib · Crisaborole · Desonide · Dupilumab · Fusidic acid +5 more
  6. Indication

    Plaque Psoriasis

    go.drugbank.com/conditions/DBCOND0029615
    Drugs: Apremilast · Betamethasone · Calcipotriol · Desoximetasone · Etanercept · Flumethasone +7 more
  7. Indication

    Seborrheic Dermatitis

    go.drugbank.com/conditions/DBCOND0036095
    Drugs: Coal tar · Flutrimazole · Gentamicin · Ketoconazole · Levomenthol · Miconazole +8 more
  8. Indication

    Atopic Dermatitis

    go.drugbank.com/conditions/DBCOND0028414
    Drugs: Aloe vera leaf · Azathioprine · Bendazac · Betamethasone · Clioquinol · Clobetasone +29 more