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Displaying drugs 2726 - 2750 of 9713 in total

Milnacipran

Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the additional indication of...
Approved
Investigational
Matched Description: … robust evidence of efficacy, insufficient demonstration of maintenance of effect, and other concerns ... category was originally developed for and continues to be approved and indicated for the treatment of ... somewhat increased preference for noradrenaline reuptake inhibition - which is potentially a point of …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sumatriptan

Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.[L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines. Sumatriptan was granted FDA approval on 28 December 1992.
Approved
Investigational
Matched Description: … [L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available …
Matched Categories: … combinations of sulfonamides ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Benzocaine

Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first used for local anesthesia in dentistry.
Approved
Investigational
Matched Description: … Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve …
Matched Mixtures name: … Dermacaine-R …
Matched Categories: … Esters of Aminobenzoic Acid ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Dimetindene

Dimetindene (Fenistil) is an antihistamine/anticholinergic used orally and locally as an antipruritic.
Approved
Investigational

Icatibant

Icatibant is a synthetic decapeptide with 5 nonproteinogenic amino acid antagonist targeting the B2 receptors with a similar affinity to bradykinin. It is resistant to bradykinin-cleaving enzyme degradation and has a potency of 2-3 times higher than earlier B2 receptors antagonists, thus representing a new class of medication.[A4017,A263041] It was...
Approved
Investigational
Matched Description: … earlier B2 receptors antagonists, thus representing a new class of medication. ... It is resistant to bradykinin-cleaving enzyme degradation and has a potency of 2-3 times higher than ... [A4017,A263041] It was investigated as a potential treatment of hereditary angioedema (HAE) as bradykinin …

Cyanocobalamin

Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria , and is necessary for DNA synthesis and cellular energy production. Vitamin B12 has many forms, including the cyano-,...
Approved
Nutraceutical
Matched International brands: … Neuroforte-R …
Matched Description: … Several pharmaceutical forms of cyanocobalamin have been developed, including the tablet, injection, …
Matched Mixtures name: … Central-vite 18 Essential ... MIOBION(R) 1000 JERINGA PRELLENADA ... Harvest Of Values All B Complex Tab …

Sulfadoxine

A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.
Approved
Investigational
Matched Categories: … combinations of sulfonamides …

Estriol

A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is...
Approved
Investigational
Vet approved
Matched Description: … Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement ... During pregnancy, large amount of estriol is produced by the placenta. ... Isomers with inversion of the hydroxyl group or groups are called epiestriol. …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Mafenide

Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. In 1998, mafenide acetate was approved under the FDA’s accelerated approval regulations. In November 2022, the use of mafenide acetate (powder...
Approved
Vet approved
Withdrawn
Matched Description: … It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep ... In November 2022, the use of mafenide acetate (powder for 5% topical solution) was withdrawn by the FDA …
Matched Categories: … combinations of sulfonamides …

Isatuximab

Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic antibody targeted against CD38, a glycoprotein found on the...
Approved
Investigational
Matched Description: … [L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains ... [L12099] It is a cytolytic antibody targeted against CD38, a glycoprotein found on the surface of some ... ] isatuximab was granted Orphan Drug designation and approved on March 2nd, 2020, for the treatment of …
Matched Categories: … CD38 (Clusters of Differentiation 38) inhibitors …

Cloxacillin

A semi-synthetic penicillin antibiotic which is a chlorinated derivative of oxacillin.
Approved
Investigational
Vet approved
Matched Description: … A semi-synthetic penicillin antibiotic which is a chlorinated derivative of [oxacillin]. …
Matched Categories: … combinations of penicillins …

Iopromide

Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can cause several serious adverse effects, including...
Approved
Matched Description: … It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, ... permitting radiographic visualization of the internal structures until significant hemodilution occurs ... intrathecally inadvertently, it is still deemed to have a favorable safety profile, with only 0.7% of …
Matched Categories: … Diagnostic Uses of Chemicals …

Pramocaine

Pramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders. Pramocaine is available by itself and in combination with other medications...
Approved
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Pitavastatin

Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively...
Approved
Matched Description: … studies to significantly reduce the risk of development of CVD and all-cause mortality. ... and for people with a moderate to high risk of development of CVD, such as those with Type 2 Diabetes ... This is the third step in a sequence of metabolic reactions involved in the production of several compounds …
Matched Products: … PITALIP(R) …

Alteplase

Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplase and fibrin.[A252330,L43125] Alteplase...
Approved
Investigational
Matched Description: … In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the ... [A252270] The use of alteplase to manage AMI has decreased thanks to the availability of safer treatments ... [L43125] It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots …

Sodium fluoride

Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications, including dental care and radiographic imaging when it is used as Fluoride ion F-18. Sodium fluoride's benefits on dental health were first observed in the 1930s, when individuals in communities with fluoridated...
Approved
Matched Description: … , including dental care and radiographic imaging when it is used as [Fluoride ion F-18]. ... The use of fluoride in dental practice began in the 1940s. ... Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications …
Matched Products: … Ionite R ... POP Hint Of Mint …

Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen

Streptococcus pneumoniae type 18c capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of Streptococcus pneumoniae serotype 18c individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197). It is...
Approved
Matched Description: … protein, a nontoxic variant of diphtheria toxin isolated from cultures of *Corynebacterium diphtheriae ... the capsular antigens of *Streptococcus pneumoniae* serotype 18c individually conjugated to the CRM197 ... polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of …

Norgestrel

Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer (levonorgestrel) is biologically active.
Approved
Matched Description: … Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Mephentermine

A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra...
Approved
Matched Description: … Although the central stimulant effects of mephentermine are much less than those of amphetamine, its …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sulfamerazine

A sulfanilamide that is used as an antibacterial agent.
Approved
Vet approved
Matched Categories: … combinations of sulfonamides …

Gepirone

Gepirone, an azapirone, is a pharmacologic analog of buspirone that acts selectively on the pre- and post-synaptic 5HT1A receptors. Although earlier clinical trials showed promising results for gepirone, its formulation as an immediate-release tablet necessitates frequent administration due to the short half-lives. It was not until an extended-release formulation of...
Approved
Investigational
Matched Description: … side effects as that of the placebo. ... Gepirone, an azapirone, is a pharmacologic analog of [buspirone] that acts selectively on the pre- and ... It was not until an extended-release formulation of gepirone was made available that gepirone became …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Menotropins

Menotropins contains follicle stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of postmenopausal women. It is used as a fertility medication that is injected either subcutaneously or intramuscularly. It is composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with...
Approved
Matched Description: … Menotropins contains follicle stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of ... It is composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with 2 subunits …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Liothyronine

Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed...
Approved
Vet approved
Matched Description: … Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine …
Matched Categories: … combinations of levothyroxine and liothyronine …

Eslicarbazepine acetate

Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conventional therapy. Eslicarbazepine acetate is a prodrug that is rapidly converted to eslicarbazepine, the primary active metabolite in the body....
Approved
Matched Description: … activity by inhibiting repeated neuronal firing and stabilizing the inactivated state of voltage-gated ... Eslicarbazepine's mechanism of action is not well understood, but it is known that it does exert anticonvulsant ... numerous side effects including dizziness, drowsiness, nausea, vomiting, diarrhea, headache, aphasia, lack of …

Chromic chloride

Chromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).
Approved
Displaying drugs 2726 - 2750 of 9713 in total