Accession Number

Agents that act systemically to kill adult schistosomes.

DrugDrug Description
OxamniquineFor treatment of Schistosomiasis caused by Schistosoma mansoni
LucanthoneIntended for use as a radiation sensitizer in the treatment of brain cancer.
Sodium stibogluconateFor the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment...
ChloroxylenolAn antimicrobial used to treat cuts, bites, stings, abrasions, and used as an antiseptic hand cleaner.
OltiprazOltipraz has been used in trials studying the treatment and prevention of Lung Cancer, Liver Fibrosis, Liver Cirrhosis, and Non-alcoholic Fatty Liver Disease.
NiridazoleNot Annotated
ArtemotilArtemotil, also known as β-arteether, is a semi-synthetic derivative of artemisinin and a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria...
HycanthonePotentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. Hycanthone was approved by the FDA in 1975 but is no longer used.
ArtesunateArtesunate is an artemesinin derivative indicated for the initial treatment of severe malaria.
Antimony potassium tartrateAntimony potassium tartrate is a schistosomicide possibly useful against other parasites. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects.
Drugs & Drug Targets
OxamniquineCytochrome P450 2D6enzyme
LucanthoneDNA topoisomerase 2-alphatarget
LucanthoneDNA-(apurinic or apyrimidinic site) lyasetarget
LucanthoneDNA topoisomerase 1target
Sodium stibogluconateDNA topoisomerase 1target
HycanthoneP-glycoprotein 1target
HycanthoneP-glycoprotein 1transporter
ArtesunateMalaria protein EXP-1target
ArtesunateCytochrome P450 2A6enzyme
ArtesunateUDP-glucuronosyltransferase 2B7enzyme
ArtesunateUDP-glucuronosyltransferase 1-9enzyme
ArtesunateATP-binding cassette sub-family G member 2transporter
ArtesunateP-glycoprotein 1transporter
ArtesunateSolute carrier organic anion transporter family member 1B1transporter
ArtesunateSolute carrier family 22 member 8transporter
ArtesunateSerum albumincarrier