Colic (DBCOND0002278)

Identifiers

Synonyms

Abdominal colic / Colic abdominal / Abdominal colic (finding) / Infant colic / Three-month colic / Colic infantile / Infantile colic / Infantile colic (finding) / Unspecified abdominal pain / Gut pain / Pain abdominal / Abdominal Pain / Abdominal pain NOS / Abdominal pain (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Aluminum hydroxide	An antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.	No drug targets
Anise oil	Not Annotated	No drug targets
Calcium carbonate	An ionic compound used as a calcium supplement or antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.	No drug targets
Gentiana lutea extract	A medication used to treat bloating and gas.	No drug targets
Hyoscyamine	An anticholinergic indicated to treat functional gastrointestinal disorders, biliary and renal colic, and acute rhinitis.	Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Adenylate cyclase type 1target Muscarinic acetylcholine receptor M5target
Magnesium hydroxide	An inorganic compound used as a laxative and antacid.	No drug targets
Magnesium trisilicate	An antacid used for the symptomatic treatment of peptic ulcers.	No drug targets
Peppermint oil	An ingredient used in a variety of natural health products and is not an approved medication.	Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme
Pipenzolate	An antimuscarinic agent indicated in the treatment of gastrointestinal motility disorders and arrhythmia.	No drug targets
Simethicone	An anti-flatulence agent used to relieve pressure, bloating, and symptoms referred to as gas.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02577133	Prevention of Colic With the Probiotic Lactobacillus Reuteri	No drug interventions	prevention	2 / 3	unknown_status
NCT02586558	Effect of a Prebiotic on Colic and Crying and Fussing Behaviour in Infants	No drug interventions	treatment	Not Available	terminated
NCT05052476	First Line Dose-efficacy Study of Bactecal® D Liquid for Infant Colic	No drug interventions	treatment	Not Available	completed
NCT04537494	PRobiotics for EVEry Newborn Trial	No drug interventions	prevention	Not Available	unknown_status
NCT00929292	Safety and Tolerance Study of Alpha-Lactalbumin Enriched and Probiotic-Supplemented Infant Formula in Infants With Colic	No drug interventions	Not Available	3	completed
NCT02242292	Study to Evaluate Efficacy and Safety of Oral Doses of Hyoscine Butylbromide for the Treatment of Occasional Abdominal Pain, Cramping, and Discomfort	Butylscopolamine	treatment	2	completed
NCT00139646	Parecoxib in Renal Colic	Diclofenac Parecoxib	treatment	3	terminated
NCT01541046	Lactobacillus Reuteri DSM 17938 Versus Placebo in the Treatment of Infantile Colic	Lactobacillus reuteri	treatment	2	completed
NCT00796523	An Intervention to Decrease Infant Crying	No drug interventions	treatment	Not Available	completed
NCT02865564	Effect of Lactobacillus Reuteri DSM17938 in Neonates Treated With Antibiotics	Ampicillin Gentamicin	other	Not Available	completed
NCT01997593	Peritoneal Ropivacaine Infiltration on Postoperative Pain in Children Affected	Ropivacaine	treatment	2	completed
NCT05198700	The Effect of Probiotics on Symptoms of Infantile Colic	No drug interventions	supportive_care	2	withdrawn
NCT01532518	Preliminary Efficacy, Safety and Pharmacokinetics Study of Nepadutant in Infant With Feeding Intolerance	Nepadutant	treatment	2	completed
NCT00177086	Alfuzosin Hydrochloride to Promote Passage of Distal Ureteral Calculi	No drug interventions	treatment	3	completed
NCT05685030	Probiotics Strains for Infant Colic	No drug interventions	prevention	2	recruiting
NCT01279265	Effect of Lactobacillus Rhamnosus GG (LGG) on Infant Colic	No drug interventions	prevention	Not Available	completed
NCT01715220	Treatment of Suspected Cholelithiasis With Nitroglycerin	Nitroglycerin	treatment	2	unknown_status
NCT01067027	Control of Colic in Infants by Dietary Supplementation With the Probiotic Lactobacillus Reuteri	No drug interventions	treatment	4	unknown_status
NCT00922727	Safety of Lactobacillus Reuteri (L. Reuteri) in Healthy Adults	Lactobacillus reuteri Sunflower oil	treatment	1	completed
NCT05554991	Human Milk Oligosaccharide (HMO) Supplementation in Colic Management	No drug interventions	other	Not Available	terminated
NCT01849991	Safety and Effect of L. Reuteri on Biomarkers of Inflammation in Healthy Infants With Colic	Lactobacillus reuteri Sunflower oil	treatment	1	completed
NCT04983069	Neonatal Outcome of Children With Antenatal Colic Hyperechogenicity	No drug interventions	Not Available	Not Available	unknown_status