Recurrent Malignant Gliomas (DBCOND0039007)

Identifiers

Synonyms

Glioma, Recurrent Malignant / Recurrent Glioma, Malignant / Recurrent Malignant Glioma

Associated Data

Indicated Drugs and Targets

Not Available

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03434262	SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors	Filgrastim Gemcitabine Ribociclib Sonidegib Trametinib	treatment	1	completed
NCT04284774	Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial	Tipifarnib	treatment	2	active_not_recruiting
NCT04323046	Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults	Nivolumab	treatment	1	recruiting
NCT04388475	Open-label Study Investigating of OKN-007 Combined with Temozolomide in Patients with Recurrent Glioblastoma	Disufenton Temozolomide	treatment	2	active_not_recruiting
NCT05278208	Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors	Lutetium Lu 177 dotatate	treatment	1 / 2	recruiting
NCT03210714	Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)	Erdafitinib	treatment	2	active_not_recruiting
NCT03213704	Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)	Larotrectinib Sulfate ion	treatment	2	active_not_recruiting
NCT03598244	Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors	Savolitinib	treatment	1	recruiting
NCT04320888	Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial	Selpercatinib	treatment	2	active_not_recruiting
NCT03213652	Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)	Ensartinib X-396	treatment	2	recruiting
NCT03526250	Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)	Palbociclib	treatment	2	active_not_recruiting
NCT04195555	Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)	Ivosidenib	treatment	2	active_not_recruiting
NCT05045027	Simultaneous Multinuclear Metabolic MRI in Newly Diagnosed or Recurrent Glioma	No drug interventions	basic_science	0	recruiting
NCT02658279	Pembrolizumab (MK-3475) in Patients With Recurrent Malignant Glioma With a Hypermutator Phenotype	Pembrolizumab	treatment	Not Available	active_not_recruiting
NCT03893487	Fimepinostat in Treating Brain Tumors in Children and Young Adults	Fimepinostat	treatment	0	active_not_recruiting
NCT01144988	Avastin / Irinotecan in Patients With Recurrent or Progressive Malignant Glioma	Bevacizumab Irinotecan	diagnostic	2	unknown_status
NCT05139056	Multiple Doses of Neural Stem Cell Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas	No drug interventions	treatment	1	recruiting
NCT01672463	Clinical Trial of IV OKN-007 in a Pilot Cohort of Human Recurrent Malignant Glioma Patients	Disufenton	treatment	1	active_not_recruiting
NCT03213665	Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)	Tazemetostat	treatment	2	active_not_recruiting
NCT06193174	Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1)	No drug interventions	treatment	1	not_yet_recruiting
NCT05540873	A Clinical Study of IL13Rα2 Targeted CAR-T in Patients With Malignant Glioma (MAGIC-I)	No drug interventions	treatment	1	unknown_status
NCT02208362	Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma	No drug interventions	treatment	1	active_not_recruiting
NCT04214392	Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the Treatment of MMP2+ Recurrent or Progressive Glioblastoma	Chlorotoxin	treatment	1	recruiting
NCT03896568	MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma	Tasadenoturev	treatment	1	recruiting
NCT04521946	Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer	Antithymocyte immunoglobulin (rabbit) Beta-D-Glucose Etoposide Fludarabine Mechlorethamine Mycophenolate mofetil Tacrolimus Thiotepa Tromethamine	treatment	1	withdrawn
NCT01904123	STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Brain	WP-1066	treatment	1	completed
NCT02192359	Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas	Camptothecin Irinotecan	treatment	1	active_not_recruiting
NCT00378235	Phase I/II Trial of Intracerebral IL13-PE38QQR Infusions in Pediatric Patients With Recurrent Malignant Glioma	Cintredekin besudotox	treatment	1 / 2	withdrawn
NCT00595322	Bevacizumab in the Radiation Treatment of Recurrent Malignant Glioma	No drug interventions	treatment	Not Available	completed
NCT00848523	Study of LBH589 (Panobinostat) to Treat Malignant Brain Tumors	Panobinostat	Not Available	2	terminated