Prophylaxis of Venous Thromboembolic Events (DBCOND0051971)

Identifiers

Synonyms

Prophylaxis, Thromboembolism, Venous / VTE Prophylaxis / Prophylaxis of VTE / Prophylaxis of Venous Thromboembolism / Venous thromboembolism prophylaxis / Anticoagulant prophylaxis / Prescription of prophylactic anticoagulant (procedure) / Thrombosis prophylaxis / Thromboembolism prophylaxis / Anticoagulant prophylaxis (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Betrixaban	A Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients.	ATP-dependent translocase ABCB1transporter Coagulation factor Xtarget Voltage-gated inwardly rectifying potassium channel KCNH2transporter
Dalteparin	A low molecular weight heparin used for the prophylaxis of thrombotic events in certain patients and prevent acute cardiac ischemic events in patients with unstable angina and non-Q-wave myocardial infarction.	Vascular endothelial growth factor A, long formtarget Heparanaseenzyme Antithrombin-IIItarget P-selectintarget
Nadroparin	A low molecular weight heparin used for the prophylaxis of thrombotic events and deep vein thrombosis, and prevent unstable angina and non-Q-wave myocardial infarction.	Protein c-Fostarget Myc proto-oncogene proteintarget P-selectintarget Antithrombin-IIItarget
Rivaroxaban	A factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations.	Coagulation factor Xtarget Cytochrome P450 3A4enzyme Cytochrome P450 2J2enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 3A5enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter
Tinzaparin	A low molecular weight heparin used for the treatment of acute symptomatic deep vein thrombosis with or without pulmonary embolism when administered in conjunction with warfarin.	Antithrombin-IIItarget A disintegrin and metalloproteinase with thrombospondin motifs 4enzyme Integrin alpha-4target Stromal cell-derived factor 1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01344954	Single IV Administration of TB-402 for Prophylaxis of Venous Thromboembolic Events (VTE) After Total Hip Replacement Surgery	Rivaroxaban TB-402	prevention	2	completed
NCT01523418	Study to Observe Safety of Xarelto in VTE Prophlylaxis After Elective TKR (Total Knee Replacement) or THR (Total Hip Replacement)	Rivaroxaban	Not Available	Not Available	withdrawn
NCT03346083	Study Evaluating Betrixaban in Pediatric Participants	Betrixaban	treatment	1	terminated
NCT02438098	Rivaroxaban in Bariatric Surgery	Rivaroxaban	prevention	1	completed
NCT02832947	PK of Rivaroxaban in Bariatric Patients - Extension	Rivaroxaban	prevention	1	completed