Refractory Diffuse Large B Cell Lymphoma (DLBCL)

Also known as: Refractory Diffuse Large B-cell Lymphoma (DLBCL) / B Cell Refractory Diffuse Large B-Cell Lymphoma / Diffuse Large B Cell Lymphoma Refractory / Refractory Diffuse Large B-Cell Lymphoma / Diffuse Large B-cell Lymphoma Refractory / Refractory Diffuse Large B Cell Lymphoma

Drug	Drug Name	Drug Description
DB13915	Axicabtagene ciloleucel	A CAR T-cell therapy used to treat adults with large B-cell lymphomas and follicular lymphoma.
DB00480	Lenalidomide	A thalidomide derivative used to treat multiple myeloma and anemia in low to intermediate risk myelodysplastic syndrome.
DB16582	Lisocabtagene maraleucel	A CAR T-cell therapy for treatment resistant or more severe B-cell lymphomas.
DB16222	Loncastuximab tesirine	An antibody-drug conjugate used for the treatment of relapsed and refractory B-cell lymphomas.
DB13881	Tisagenlecleucel	A CAR T cell therapy for relapsed or refractory large B-cell lymphoma and diffuse large B-cell lymphoma.

Drug	Drug Name	Target	Type
DB13915	Axicabtagene ciloleucel	B-lymphocyte antigen CD19	target
DB00480	Lenalidomide	Prostaglandin G/H synthase 2	target
DB00480	Lenalidomide	Tumor necrosis factor ligand superfamily member 11	target
DB00480	Lenalidomide	Cadherin-5	target
DB00480	Lenalidomide	Protein cereblon	target
DB00480	Lenalidomide	P-glycoprotein 1	transporter
DB16582	Lisocabtagene maraleucel	B-lymphocyte antigen CD19	target
DB16222	Loncastuximab tesirine	B-lymphocyte antigen CD19	target
DB16222	Loncastuximab tesirine	P-glycoprotein 1	transporter
DB16222	Loncastuximab tesirine	Cytochrome P450 3A4	enzyme
DB16222	Loncastuximab tesirine	Cytochrome P450 3A5	enzyme
DB13881	Tisagenlecleucel	B-lymphocyte antigen CD19	target

Drug	Drug Name	Phase	Status	Count
DB11952	Duvelisib	0	Recruiting	1
DB09502	Fludeoxyglucose (18F)	0	Completed	1
DB13134	Fluorine F-18	0	Completed	1
DB13881	Tisagenlecleucel	0	Recruiting	1
DB05220	Alisertib	1	Completed	1
DB11595	Atezolizumab	1	Active Not Recruiting	1
DB11945	Avelumab	1	Active Not Recruiting	1
DB13915	Axicabtagene ciloleucel	1	Not Yet Recruiting	1
DB02379	Beta-D-Glucose	1	Active Not Recruiting	1
DB02379	Beta-D-Glucose	1	Completed	1
DB02379	Beta-D-Glucose	1	Withdrawn	1
DB09052	Blinatumomab	1	Active Not Recruiting	1
DB01008	Busulfan	1	Recruiting	1
DB00958	Carboplatin	1	Active Not Recruiting	3
DB00958	Carboplatin	1	Completed	1
DB08889	Carfilzomib	1	Active Not Recruiting	1
DB00262	Carmustine	1	Withdrawn	1
DB15694	Cedazuridine	1	Recruiting	1
DB12483	Copanlisib	1	Active Not Recruiting	1
DB00531	Cyclophosphamide	1	Active Not Recruiting	2
DB00531	Cyclophosphamide	1	Completed	1
DB00531	Cyclophosphamide	1	Not Yet Recruiting	1
DB00531	Cyclophosphamide	1	Recruiting	4
DB00531	Cyclophosphamide	1	Terminated	1
DB00987	Cytarabine	1	Withdrawn	1
DB01262	Decitabine	1	Recruiting	1
DB01234	Dexamethasone	1	Active Not Recruiting	1
DB01234	Dexamethasone	1	Unknown Status	1
DB11714	Durvalumab	1	Terminated	1
DB11952	Duvelisib	1	Active Not Recruiting	1
DB00773	Etoposide	1	Active Not Recruiting	2
DB00773	Etoposide	1	Completed	1
DB00773	Etoposide	1	Withdrawn	1
DB00099	Filgrastim	1	Active Not Recruiting	1
DB11891	Fimepinostat	1	Completed	1
DB01073	Fludarabine	1	Not Yet Recruiting	1
DB01073	Fludarabine	1	Recruiting	4
DB01073	Fludarabine	1	Terminated	1
DB00441	Gemcitabine	1	Active Not Recruiting	2
DB00441	Gemcitabine	1	Recruiting	1
DB00441	Gemcitabine	1	Unknown Status	1
DB09053	Ibrutinib	1	Active Not Recruiting	4
DB09053	Ibrutinib	1	Completed	2
DB01181	Ifosfamide	1	Active Not Recruiting	2
DB01181	Ifosfamide	1	Completed	1
DB06186	Ipilimumab	1	Completed	1
DB17232	JCAR014	1	Terminated	1
DB00480	Lenalidomide	1	Active Not Recruiting	3
DB00480	Lenalidomide	1	Terminated	1
DB00480	Lenalidomide	1	Unknown Status	1
DB16582	Lisocabtagene maraleucel	1	Recruiting	1
DB16222	Loncastuximab tesirine	1	Withdrawn	1
DB13982	Lutetium Lu-177	1	Completed	1
DB00888	Mechlorethamine	1	Recruiting	1
DB00888	Mechlorethamine	1	Withdrawn	1
DB00075	Muromonab	1	Active Not Recruiting	1
DB09035	Nivolumab	1	Active Not Recruiting	1
DB09035	Nivolumab	1	Completed	1
DB09035	Nivolumab	1	Recruiting	1
DB09035	Nivolumab	1	Terminated	1
DB08935	Obinutuzumab	1	Active Not Recruiting	1
DB09074	Olaparib	1	Recruiting	1
DB00526	Oxaliplatin	1	Active Not Recruiting	1
DB00526	Oxaliplatin	1	Unknown Status	1
DB14867	Parsaclisib	1	Completed	1
DB00019	Pegfilgrastim	1	Active Not Recruiting	1
DB09037	Pembrolizumab	1	Active Not Recruiting	1
DB09037	Pembrolizumab	1	Completed	1
DB11759	Pevonedistat	1	Active Not Recruiting	1
DB00073	Rituximab	1	Active Not Recruiting	5
DB00073	Rituximab	1	Completed	2
DB00073	Rituximab	1	Recruiting	2
DB00073	Rituximab	1	Terminated	1
DB00073	Rituximab	1	Unknown Status	1
DB06176	Romidepsin	1	Completed	1
DB12227	Tetulomab tetraxetan Lu-177	1	Completed	1
DB13881	Tisagenlecleucel	1	Recruiting	1
DB06273	Tocilizumab	1	Recruiting	1
DB15113	Utomilumab	1	Active Not Recruiting	1
DB11581	Venetoclax	1	Active Not Recruiting	2
DB11581	Venetoclax	1	Completed	1
DB02546	Vorinostat	1	Active Not Recruiting	1
DB02546	Vorinostat	1	Recruiting	1
DB17364	AUTO3	1 / 2	Active Not Recruiting	1
DB11595	Atezolizumab	1 / 2	Completed	1
DB13915	Axicabtagene ciloleucel	1 / 2	Active Not Recruiting	1
DB13915	Axicabtagene ciloleucel	1 / 2	Completed	1
DB02379	Beta-D-Glucose	1 / 2	Active Not Recruiting	2
DB02379	Beta-D-Glucose	1 / 2	Withdrawn	1
DB00958	Carboplatin	1 / 2	Active Not Recruiting	1
DB00262	Carmustine	1 / 2	Active Not Recruiting	1
DB00262	Carmustine	1 / 2	Withdrawn	1
DB12483	Copanlisib	1 / 2	Active Not Recruiting	1
DB00531	Cyclophosphamide	1 / 2	Active Not Recruiting	2
DB00531	Cyclophosphamide	1 / 2	Completed	1
DB00531	Cyclophosphamide	1 / 2	Recruiting	1
DB00987	Cytarabine	1 / 2	Active Not Recruiting	1
DB00987	Cytarabine	1 / 2	Withdrawn	1
DB00773	Etoposide	1 / 2	Active Not Recruiting	2
DB00773	Etoposide	1 / 2	Withdrawn	1
DB00099	Filgrastim	1 / 2	Not Yet Recruiting	1
DB00099	Filgrastim	1 / 2	Withdrawn	1
DB01073	Fludarabine	1 / 2	Active Not Recruiting	1
DB01073	Fludarabine	1 / 2	Completed	1
DB01073	Fludarabine	1 / 2	Recruiting	1
DB09053	Ibrutinib	1 / 2	Completed	2
DB01181	Ifosfamide	1 / 2	Active Not Recruiting	1
DB00480	Lenalidomide	1 / 2	Active Not Recruiting	2
DB00480	Lenalidomide	1 / 2	Completed	2
DB00888	Mechlorethamine	1 / 2	Active Not Recruiting	1
DB00888	Mechlorethamine	1 / 2	Withdrawn	1
DB12498	Mogamulizumab	1 / 2	Active Not Recruiting	1
DB15721	Natural Killer Cell	1 / 2	Withdrawn	1
DB06132	Nivolumab	1 / 2	Active Not Recruiting	1
DB09035	Nivolumab	1 / 2	Active Not Recruiting	1
DB01229	Paclitaxel	1 / 2	Not Yet Recruiting	1
DB09037	Pembrolizumab	1 / 2	Active Not Recruiting	1
DB00073	Rituximab	1 / 2	Active Not Recruiting	1
DB00073	Rituximab	1 / 2	Completed	1
DB00073	Rituximab	1 / 2	Not Yet Recruiting	1
DB00073	Rituximab	1 / 2	Recruiting	1
DB00073	Rituximab	1 / 2	Withdrawn	1
DB08877	Ruxolitinib	1 / 2	Not Yet Recruiting	1
DB14922	Tislelizumab	1 / 2	Recruiting	1
DB11581	Venetoclax	1 / 2	Active Not Recruiting	2
DB00026	Anakinra	2	Active Not Recruiting	1
DB00026	Anakinra	2	Recruiting	1
DB11595	Atezolizumab	2	Terminated	1
DB13915	Axicabtagene ciloleucel	2	Active Not Recruiting	1
DB13915	Axicabtagene ciloleucel	2	Not Yet Recruiting	1
DB13915	Axicabtagene ciloleucel	2	Recruiting	1
DB06769	Bendamustine	2	Terminated	1
DB02379	Beta-D-Glucose	2	Active Not Recruiting	1
DB02379	Beta-D-Glucose	2	Completed	1
DB02379	Beta-D-Glucose	2	Recruiting	1
DB00188	Bortezomib	2	Withdrawn	1
DB16741	Bortezomib D-mannitol	2	Withdrawn	1
DB08870	Brentuximab vedotin	2	Terminated	1
DB00958	Carboplatin	2	Active Not Recruiting	1
DB00958	Carboplatin	2	Recruiting	1
DB00958	Carboplatin	2	Unknown Status	1
DB00262	Carmustine	2	Active Not Recruiting	1
DB00262	Carmustine	2	Completed	1
DB14547	Chloride ion	2	Recruiting	1
DB00515	Cisplatin	2	Recruiting	1
DB12483	Copanlisib	2	Active Not Recruiting	1
DB00531	Cyclophosphamide	2	Active Not Recruiting	2
DB00531	Cyclophosphamide	2	Not Yet Recruiting	1
DB00531	Cyclophosphamide	2	Recruiting	3
DB00091	Cyclosporine	2	Terminated	1
DB00987	Cytarabine	2	Active Not Recruiting	1
DB00987	Cytarabine	2	Completed	1
DB00987	Cytarabine	2	Recruiting	1
DB01234	Dexamethasone	2	Recruiting	1
DB00773	Etoposide	2	Active Not Recruiting	2
DB00773	Etoposide	2	Completed	1
DB00773	Etoposide	2	Recruiting	1
DB00773	Etoposide	2	Unknown Status	1
DB00099	Filgrastim	2	Completed	1
DB01073	Fludarabine	2	Active Not Recruiting	1
DB01073	Fludarabine	2	Not Yet Recruiting	1
DB01073	Fludarabine	2	Recruiting	1
DB01073	Fludarabine	2	Terminated	1
DB00441	Gemcitabine	2	Recruiting	1
DB00441	Gemcitabine	2	Terminated	2
DB16371	Glofitamab	2	Recruiting	1
DB09053	Ibrutinib	2	Completed	1
DB01181	Ifosfamide	2	Active Not Recruiting	1
DB01181	Ifosfamide	2	Recruiting	1
DB01181	Ifosfamide	2	Unknown Status	1
DB00480	Lenalidomide	2	Completed	1
DB00480	Lenalidomide	2	Unknown Status	1
DB16582	Lisocabtagene maraleucel	2	Not Yet Recruiting	1
DB16222	Loncastuximab tesirine	2	Completed	1
DB16222	Loncastuximab tesirine	2	Not Yet Recruiting	1
DB16222	Loncastuximab tesirine	2	Recruiting	1
DB17339	Maveropepimut-S	2	Recruiting	1
DB00888	Mechlorethamine	2	Completed	1
DB01042	Melphalan	2	Active Not Recruiting	1
DB15434	Mosunetuzumab	2	Not Yet Recruiting	2
DB00075	Muromonab	2	Not Yet Recruiting	2
DB00688	Mycophenolate mofetil	2	Terminated	1
DB15721	Natural Killer Cell	2	Completed	1
DB09035	Nivolumab	2	Active Not Recruiting	3
DB08935	Obinutuzumab	2	Active Not Recruiting	1
DB08935	Obinutuzumab	2	Recruiting	1
DB06306	Onalespib	2	Terminated	1
DB00526	Oxaliplatin	2	Recruiting	1
DB00526	Oxaliplatin	2	Terminated	2
DB09037	Pembrolizumab	2	Active Not Recruiting	1
DB09037	Pembrolizumab	2	Recruiting	1
DB12257	Platinum	2	Recruiting	1
DB06809	Plerixafor	2	Active Not Recruiting	1
DB12240	Polatuzumab vedotin	2	Active Not Recruiting	1
DB12240	Polatuzumab vedotin	2	Not Yet Recruiting	1
DB00073	Rituximab	2	Active Not Recruiting	2
DB00073	Rituximab	2	Completed	1
DB00073	Rituximab	2	Recruiting	1
DB00073	Rituximab	2	Terminated	3
DB00073	Rituximab	2	Withdrawn	1
DB08877	Ruxolitinib	2	Completed	1
DB15765	Sintilimab	2	Not Yet Recruiting	1
DB13881	Tisagenlecleucel	2	Not Yet Recruiting	1
DB14989	Umbralisib	2	Completed	1
DB11930	Varlilumab	2	Active Not Recruiting	1
DB11581	Venetoclax	2	Withdrawn	1
DB00958	Carboplatin	3	Recruiting	1
DB00262	Carmustine	3	Terminated	1
DB00987	Cytarabine	3	Terminated	1
DB00773	Etoposide	3	Recruiting	1
DB00773	Etoposide	3	Terminated	1
DB00441	Gemcitabine	3	Recruiting	1
DB01181	Ifosfamide	3	Recruiting	1
DB16222	Loncastuximab tesirine	3	Recruiting	1
DB01042	Melphalan	3	Terminated	1
DB00526	Oxaliplatin	3	Recruiting	1
DB12240	Polatuzumab vedotin	3	Recruiting	1
DB00073	Rituximab	3	Recruiting	2
DB00073	Rituximab	3	Terminated	1
DB15134	Fluoroazomycin arabinoside F-18	Not Available	Recruiting	1