Androgen Deprivation Therapy (DBCOND0044812)

Identifiers

Synonyms

Hormone suppression therapy / Androgen-deprivation therapy / Androgen deprivation therapy / Antiandrogen therapy / Androgen deprivation therapy (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Abiraterone	An antiandrogen used in the treatment of metastatic castration-resistant prostate cancer and metastatic high-risk castration-sensitive prostate cancer.	Steroid 17-alpha-hydroxylase/17,20 lyasetarget Albumincarrier Alpha-1-acid glycoprotein 1carrier Cytochrome P450 3A4enzyme Sulfotransferase 2A1enzyme Multidrug resistance-associated protein 1transporter Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A5enzyme Solute carrier organic anion transporter family member 1B1transporter
Apalutamide	An androgen receptor inhibitor used to treat non-metastatic castration-resistant and metastatic castration-sensitive prostate cancer.	Androgen receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier family 22 member 2transporter Organic anion transporter 3transporter Multidrug and toxin extrusion protein 2transporter GABA(A) Receptortarget Multidrug and toxin extrusion protein 1transporter Albumincarrier
Denosumab	A RANK ligand (RANKL) inhibitor used for the management of osteoporosis in patients at high risk for bone fractures.	Tumor necrosis factor ligand superfamily member 11target
Lutetium Lu-177 vipivotide tetraxetan	A radioligand therapeutic agent used to treat prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer in adults.	Prostate-specific antigentarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06130995	Relugolix + Enzalutamide Study in High-Risk Prostate Cancer	Enzalutamide Relugolix	treatment	1	not_yet_recruiting
NCT05700903	Contributions to Hypertension With Androgen Deprivation Therapy	Bicalutamide Enzalutamide Flutamide Goserelin Leuprolide	basic_science	4	recruiting
NCT05781217	Short Versus Long-term Androgen Deprivation Therapy With Salvage Radiotherapy in Prostate Cancer. URONCOR 0624	Goserelin Leuprolide Triptorelin	treatment	3	recruiting
NCT03672396	Home-based Exercise Intervention for Patients With Metastatic Prostate Cancer	No drug interventions	health_services_research	Not Available	completed
NCT01711892	Health Effects of Soccer Training in Men With Prostate Cancer Receiving Androgen Deprivation Therapy	No drug interventions	supportive_care	Not Available	completed
NCT02631681	Supervised Group Based Exercise for Men With Prostate Cancer on Androgen Deprivation Therapy	No drug interventions	treatment	Not Available	completed
NCT03440879	Androgen Deprivation Therapy Muscle Protein Metabolism and Blood Glucose	Goserelin	basic_science	Not Available	terminated
NCT03845751	EvaluatioN of HIFU Hemiablation and Short Term AndrogeN Deprivation Therapy Combination to Enhance Prostate Cancer Control.	No drug interventions	prevention	2	recruiting
NCT00957606	Osteoporosis Among Men Treated With Androgen Deprivation for Prostate Cancer	No drug interventions	diagnostic	3	unknown_status
NCT03867357	Intramuscular Mechanisms of Androgen Deprivation-related Sarcopenia	Gonadorelin Goserelin	Not Available	Not Available	completed
NCT05327465	Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy	No drug interventions	supportive_care	Not Available	recruiting
NCT04062162	Walking Football as a Supportive Medicine for Patients With Prostate Cancer	No drug interventions	prevention	Not Available	unknown_status
NCT04500080	Feasibility and Safety of Physical Exercise in Men With Prostate Cancer	No drug interventions	supportive_care	Not Available	completed
NCT02895230	Androgen-Deprivation Therapy and Cardiovascular Risk: A Nationwide Population-based Cohort Study	No drug interventions	Not Available	Not Available	completed