Ovulation induction therapy (DBCOND0024290)

Identifiers

Synonyms

Ovulation Induction / Ovulation induction (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Choriogonadotropin alfa	A recombinant form of human chorionic gonadotropin used to treat female infertility by inducing ovulation.	Follicle-stimulating hormone receptortarget Lutropin-choriogonadotropic hormone receptortarget
Chorionic Gonadotropin (Human)	A naturally-occurring hormone produced during human placenta used for the treatment of prepubertal cryptorchidism and hypogonadotropic hypogonadism in selected males, and induction of pregnancy in selected infertile women.	Lutropin-choriogonadotropic hormone receptortarget
Gonadorelin	A synthetic GnRH used to test the function of gonadotropes and the pituitary.	Gonadotropin-releasing hormone receptortarget Putative gonadotropin-releasing hormone II receptortarget
Tamoxifen	A selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women.	Estrogen receptortarget Estrogen receptor betatarget Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2B6enzyme Liver carboxylesterase 1enzyme Cytochrome P450 3A5enzyme Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Flavin-containing monooxygenase 1enzyme Flavin-containing monooxygenase 3enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Aromataseenzyme Cytochrome P450 2A6enzyme Cytochrome P450 2E1enzyme UDP-glucuronosyltransferase 1A10enzyme Sulfotransferase 1A1enzyme ATP-binding cassette sub-family C member 2transporter 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerasetarget Protein kinase Ctarget Androgen receptortarget Voltage-gated inwardly rectifying potassium channel KCNH2target Nuclear receptor subfamily 1 group I member 2target Estrogen-related receptor gammatarget Sex hormone-binding globulintarget Bile salt export pumptransporter Thyroxine-binding globulincarrier Sulfotransferase 2A1enzyme Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B17enzyme Sulfotransferase 1E1enzyme Phospholipid-transporting ATPase ABCA1transporter Mitogen-activated protein kinase 8target Albumincarrier
Urofollitropin	A form of purified human follicle stimulating hormone used to treat infertility in females by inducing follicle development in women without primary ovarian failure.	Follicle-stimulating hormone receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01111084	A Prospective, Multi-centric Observational Study to Determine the Mono-bifollicular Development in Infertile Women Subjected to Ovulation Induction With Follitropin α	Follitropin	Not Available	Not Available	completed
NCT01183143	Convenience and Safety of Assisted Reproductive Technology Procedures Using a Gonal-F Filled by Mass (Fbm) Liquid Formulation Applied by Pen for Ovulation Induction and In-vitro Fertilization	Follitropin	treatment	3	completed
NCT03825445	GnRH Agonist Versus hCG Trigger in Ovulation Induction With Intrauterine Insemination.	Chorionic Gonadotropin (Human) Ranitidine Triptorelin	treatment	Not Available	completed
NCT01110707	A Randomised, Phase II, Comparative Study With a Parallel Control for Evaluating the Efficacy and Safety of Combined Treatment of Lutropin Alpha and Recombinant Human Luteinizing Hormone in the Middle of the Controlled Ovarian Stimulation Follicular Phase in Women With Reduced Ovarian Reserve	Benzalkonium Follitropin Luteinizing hormone Lutropin alfa	treatment	2	completed
NCT01075815	A Clinical Trial to Determine the Effect of Lutropin Alfa on Embryo Quality and Implantation Rate in Advanced Reproductive Age	Luteinizing hormone Lutropin alfa	treatment	2	terminated
NCT04610957	Effect of Adding Isoflavonoids to Clomiphene Citrate for Ovulation Induction in Women With Polycystic Ovary Syndrome	No drug interventions	treatment	Not Available	completed
NCT01152866	An Open Label, Canadian Phase IIIb Study With Ovidrel in Ovulation Induction (OI) and Assisted Reproductive Technique (ART)	Choriogonadotropin alfa Chorionic Gonadotropin (Human)	Not Available	Not Available	completed
NCT01185782	SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women	Follitropin Urofollitropin	treatment	3	completed
NCT03396380	Effect of Vitamin D Supplement in Induction of Ovulation in Overweight Women With Polycystic Ovary Syndrome	Calcium Clomifene Vitamin D	treatment	3	unknown_status
NCT04306692	Myo-inositol Versus Clomiphene Citrate in PCOS	Clomifene Inositol	treatment	4	terminated
NCT00823472	Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)	Follitropin Ganirelix	treatment	4	terminated
NCT02496754	The Application of a New Ovarian Stimulation Protocol in IVF	Gonadorelin	treatment	Not Available	unknown_status
NCT01079949	A Phase II Study to Assess the Efficacy and Safety of Luveris® (Lutropin Alfa) in Mid Follicular Phase for Controlled Ovarian Stimulation (COS) in Advanced Reproductive Age	Cetrorelix Choriogonadotropin alfa Gonadorelin Lutropin alfa	treatment	2	terminated
NCT01008319	Traditional Clomiphene Citrate Administration vs. Stair-step Approach	Clomifene	treatment	3	completed
NCT01645241	Evolutive Potential of Embryos Obtained From Oocytes After Luteal Phase Ovarian Stimulation	Ganirelix Gonadorelin Menthol	treatment	Not Available	completed
NCT01081639	To Evaluate the Convenience, Safety and Efficacy of Follitropin Alfa Liquid Pen Compared With Follitropin Beta Liquid Pen	Follitropin Salicylic acid	treatment	3	completed
NCT01081626	Recombinant Follicle Stimulating Hormone (FSH) (Gonal-f®): Use in Ovulation Induction	Follitropin	treatment	4	completed
NCT03307720	Agonist Versus Classical HCG Trigger (Poor Responders, Normoresponders and High Responders)	Chorionic Gonadotropin (Human) Ranitidine	treatment	Not Available	unknown_status
NCT04834791	Letrozole Versus Gonadotropins in Clomiphene Citrate Resistance	Letrozole	treatment	4	completed
NCT00553514	AS900672-Enriched in Ovulation Induction	Chorionic Gonadotropin (Human) Follitropin	treatment	2	terminated
NCT00697255	A Phase 2 Trial to Evaluate if Corifollitropin Alfa (Org 36286), Followed by a Low Daily Dose of hCG or Recombinant FSH Can Induce Monofollicular Growth in Women With WHO Group II Anovulatory Infertility (P05693)	Chorionic Gonadotropin (Human) Corifollitropin alfa Follitropin	treatment	2	terminated