Summary of information on human CYP enzymes: human P450 metabolism data.

Article Details

Citation

Rendic S

Summary of information on human CYP enzymes: human P450 metabolism data.

Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.

PubMed ID
11996015 [ View in PubMed
]
Abstract

This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of human CYP enzymes published previously by Rendic and DiCarlo (1), now covering selection of the literature through 2001 in the reference section. The data are presented in a tabular form (Table 1) to provide a framework for predicting and interpreting the new P450 metabolic data. The data are formatted in an Excel format as most suitable for off-line searching and management of the Web-database. The data are presented as stated by the author(s) and in the case when several references are cited the data are presented according to the latest published information. The searchable database is available either as an Excel file (for information contact the author), or as a Web-searchable database (Human P450 Metabolism Database, www.gentest.com) enabling the readers easy and quick approach to the latest updates on human CYP metabolic reactions.

DrugBank Data that Cites this Article

Drugs
Drug Enzymes
DrugEnzymeKindOrganismPharmacological ActionActions
1,2-BenzodiazepineCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Details
AceclofenacCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
AminophenazoneCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
AzatadineCytochrome P450 3A4ProteinHumans
Unknown
Inducer
Details
Beclomethasone dipropionateCytochrome P450 3A4ProteinHumans
No
Substrate
Inducer
Details
BenzphetamineCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
BrotizolamCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Details
BudesonideCytochrome P450 3A4ProteinHumans
No
Substrate
Inducer
Details
BudesonideCytochrome P450 3A5ProteinHumans
No
Inducer
Details
BupropionCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
CandesartanCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Inhibitor
Details
CarbamazepineCytochrome P450 2C8ProteinHumans
Unknown
Substrate
Inducer
Details
CarbamazepineCytochrome P450 2C9ProteinHumans
Unknown
Inducer
Details
CarbamazepineCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Inducer
Details
ChlorpromazineCytochrome P450 1A2ProteinHumans
Unknown
Substrate
Details
ClomethiazoleCytochrome P450 2A6ProteinHumans
Unknown
Substrate
Details
ClomethiazoleCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
ClomethiazoleCytochrome P450 2C19ProteinHumans
Unknown
Substrate
Details
ClomethiazoleCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Details
CyclophosphamideCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Inducer
Details
DesonideCytochrome P450 3A4ProteinHumans
No
Substrate
Inducer
Details
DextromethorphanCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
DextromethorphanCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
DiclofenacCytochrome P450 2E1ProteinHumans
Unknown
Inhibitor
Details
DolasetronCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
DorzolamideCytochrome P450 2C9ProteinHumans
No
Substrate
Details
EconazoleCytochrome P450 2E1ProteinHumans
No
Inhibitor
Details
EfavirenzCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Inducer
Details
Estradiol acetateCytochrome P450 2C8ProteinHumans
Unknown
Substrate
Details
Estradiol acetateCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
Estradiol benzoateCytochrome P450 2C8ProteinHumans
Unknown
Substrate
Details
Estradiol benzoateCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
Estradiol cypionateCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
Estradiol dienanthateCytochrome P450 2C8ProteinHumans
Unknown
Substrate
Details
Estradiol dienanthateCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
EstroneCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
EstroneCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
Estrone sulfateCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Inhibitor
Details
EthanolCytochrome P450 1A2ProteinHumans
Unknown
Substrate
Details
EthanolCytochrome P450 2B6ProteinHumans
Unknown
Inhibitor
Details
EthanolCytochrome P450 2C19ProteinHumans
Unknown
Inhibitor
Details
EthanolCytochrome P450 2E1ProteinHumans
Unknown
Substrate
Inducer
Details
EthanolCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Inhibitor
Inducer
Details
EthylmorphineCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
FludrocortisoneCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Details
FlunarizineCytochrome P450 2A6ProteinHumans
Unknown
Substrate
Details
FlunarizineCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
FlunitrazepamCytochrome P450 2A6ProteinHumans
Unknown
Substrate
Details
FlunitrazepamCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
FlunitrazepamCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
FluphenazineCytochrome P450 2E1ProteinHumans
Unknown
Inhibitor
Details
FlurazepamCytochrome P450 2E1ProteinHumans
Unknown
Inhibitor
Details
FomepizoleCytochrome P450 2A6ProteinHumans
Unknown
Inhibitor
Details
HalothaneCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
HalothaneCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
IfosfamideCytochrome P450 2A6ProteinHumans
Unknown
Substrate
Details
ImipramineCytochrome P450 2E1ProteinHumans
Unknown
Inhibitor
Details
ImiquimodCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Details
IndomethacinCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
IsofluraneCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Inducer
Details
KetoconazoleCytochrome P450 2A6ProteinHumans
Unknown
Inhibitor
Details
LercanidipineCytochrome P450 2D6ProteinHumans
Unknown
Inhibitor
Details
LercanidipineCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Inhibitor
Details
LidocaineCytochrome P450 2A6ProteinHumans
Unknown
Substrate
Details
LidocaineCytochrome P450 2C8ProteinHumans
Unknown
Substrate
Details
LidocaineCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
LornoxicamCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
LovastatinCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Inhibitor
Details
Medical CannabisCytochrome P450 2C9ProteinHumans
No
Substrate
Inhibitor
Details
MenadioneCytochrome P450 2A6ProteinHumans
Unknown
Inhibitor
Details
MephenytoinCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
MethadoneCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
MethimazoleCytochrome P450 2A6ProteinHumans
Unknown
Inhibitor
Details
MethimazoleCytochrome P450 2B6ProteinHumans
Unknown
Inhibitor
Details
MethimazoleCytochrome P450 2E1ProteinHumans
Unknown
Inhibitor
Details
MethoxyfluraneCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
MethyltestosteroneCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
MiconazoleCytochrome P450 11B1, mitochondrialProteinHumans
Unknown
Inhibitor
Details
MiconazoleCytochrome P450 2A6ProteinHumans
Unknown
Inhibitor
Details
MiconazoleCytochrome P450 2E1ProteinHumans
Unknown
Inhibitor
Details
MiconazoleCytochrome P450 3A4ProteinHumans
Unknown
Inhibitor
Details
MiconazoleLanosterol 14-alpha demethylaseProteinHumans
Unknown
Inhibitor
Details
MoclobemideCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
ModafinilCytochrome P450 2B6ProteinHumans
Unknown
Inhibitor
Inducer
Details
NelfinavirCytochrome P450 2B6ProteinHumans
Unknown
Inhibitor
Details
NicotineCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
OndansetronCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
OrphenadrineCytochrome P450 2B6ProteinHumans
Unknown
Inhibitor
Details
PhenacetinCytochrome P450 2A6ProteinHumans
Unknown
Substrate
Details
PhenacetinCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
PhencyclidineCytochrome P450 2B6ProteinHumans
Unknown
Inhibitor
Details
PhenylbutazoneCytochrome P450 3A4ProteinHumans
Unknown
Inducer
Details
PhenytoinCytochrome P450 2C8ProteinHumans
Unknown
Substrate
Inducer
Details
ProguanilCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
PropofolCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
RifabutinCytochrome P450 2B6ProteinHumans
No
Inducer
Details
RifabutinCytochrome P450 2C8ProteinHumans
No
Inducer
Details
RifamycinCytochrome P450 2B6ProteinHumans
No
Inhibitor
Inducer
Details
RifamycinCytochrome P450 2C8ProteinHumans
No
Inhibitor
Details
RifamycinCytochrome P450 2C9ProteinHumans
No
Inhibitor
Inducer
Details
RifamycinCytochrome P450 3A4ProteinHumans
No
Inhibitor
Inducer
Details
RifapentineCytochrome P450 2B6ProteinHumans
No
Inducer
Details
RifaximinCytochrome P450 2C8ProteinHumans
No
Inducer
Details
RifaximinCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Inducer
Details
RiluzoleCytochrome P450 1A1ProteinHumans
Unknown
Substrate
Details
SalbutamolCytochrome P450 3A4ProteinHumans
Unknown
Inhibitor
Details
SalmeterolCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Details
SelegilineCytochrome P450 2A6ProteinHumans
Unknown
Substrate
Inhibitor
Details
SelegilineCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
SelegilineCytochrome P450 2D6ProteinHumans
Unknown
Substrate
Inhibitor
Details
SeratrodastCytochrome P450 2A6ProteinHumans
Unknown
Inhibitor
Details
SeratrodastCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
SeratrodastCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
SertralineCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Inhibitor
Details
SevofluraneCytochrome P450 2A6ProteinHumans
Unknown
Substrate
Details
SildenafilCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Details
SpironolactoneCytochrome P450 11B1, mitochondrialProteinHumans
Unknown
Inducer
Details
SulfamethoxazoleCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Details
SulfinpyrazoneCytochrome P450 2C8ProteinHumans
Unknown
Inhibitor
Details
TacrolimusCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Details
TamoxifenCytochrome P450 2A6ProteinHumans
Unknown
Substrate
Details
TasosartanCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Details
TegafurCytochrome P450 2A6ProteinHumans
Yes
Substrate
Details
TemazepamCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
TerbinafineCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
TestosteroneCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
Testosterone cypionateCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
Testosterone cypionateCytochrome P450 2C8ProteinHumans
Unknown
Substrate
Details
Testosterone cypionateCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
Testosterone enanthateCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
Testosterone enanthateCytochrome P450 2C8ProteinHumans
Unknown
Substrate
Details
Testosterone enanthateCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
Testosterone undecanoateCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
Testosterone undecanoateCytochrome P450 2C8ProteinHumans
Unknown
Substrate
Details
Testosterone undecanoateCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
TheophyllineCytochrome P450 2D6ProteinHumans
Unknown
Substrate
Details
ThioridazineCytochrome P450 2E1ProteinHumans
Unknown
Inhibitor
Details
TiclopidineCytochrome P450 1A2ProteinHumans
Unknown
Inhibitor
Details
TolbutamideCytochrome P450 2C18ProteinHumans
Unknown
Substrate
Details
TolterodineCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
TretinoinCytochrome P450 2A6ProteinHumans
Unknown
Substrate
Details
TretinoinCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Details
TretinoinCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
TrimethoprimCytochrome P450 2C8ProteinHumans
Unknown
Substrate
Inhibitor
Details
TrimethoprimCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
TrimethoprimCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Details
TroglitazoneCytochrome P450 2B6ProteinHumans
Unknown
Inducer
Details
TroglitazoneCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Inhibitor
Details
Valproic acidCytochrome P450 2A6ProteinHumans
Unknown
Substrate
Details
VerapamilCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Activator
Details
VerapamilCytochrome P450 2C18ProteinHumans
Unknown
Substrate
Details
VerapamilCytochrome P450 2C19ProteinHumans
Unknown
Substrate
Details
VerapamilCytochrome P450 2C8ProteinHumans
Unknown
Substrate
Inhibitor
Details
VerapamilCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Inhibitor
Details
VerapamilCytochrome P450 2D6ProteinHumans
Unknown
Inhibitor
Details
VerapamilCytochrome P450 2E1ProteinHumans
Unknown
Substrate
Details
ZidovudineCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
ZopicloneCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details
Drug Reactions
Reaction
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Details
Drug Interactions
DrugsInteraction
Acenocoumarol
Sitaxentan
The serum concentration of Acenocoumarol can be increased when it is combined with Sitaxentan.
Acetaminophen
Pentobarbital
The metabolism of Acetaminophen can be increased when combined with Pentobarbital.
Acetaminophen
Letrozole
The metabolism of Acetaminophen can be decreased when combined with Letrozole.
Acetaminophen
Pilocarpine
The metabolism of Acetaminophen can be decreased when combined with Pilocarpine.
Acetaminophen
Seratrodast
The metabolism of Acetaminophen can be decreased when combined with Seratrodast.
Acetaminophen
Hydrocortisone
The metabolism of Acetaminophen can be increased when combined with Hydrocortisone.
Acetaminophen
Eletriptan
The metabolism of Acetaminophen can be increased when combined with Eletriptan.
Acetaminophen
Prednisolone phosphate
The metabolism of Acetaminophen can be increased when combined with Prednisolone phosphate.
Acetaminophen
Nevirapine
The metabolism of Acetaminophen can be decreased when combined with Nevirapine.
Acetohexamide
Bosentan
The metabolism of Acetohexamide can be increased when combined with Bosentan.
Interactions
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