Vulvovaginal Atrophy

Also known as: Vulvo-vaginal Atrophy / Vulvo Vaginal Atrophy / Atrophy;Vaginal / Vaginal Atrophy / Atrophic vulvovaginitis / Vulvovaginitis atrophy / Vulvovaginitis atrophic / Atrophic vulvovaginitis (disorder)

DrugDrug NameDrug Description
DB01395DrospirenoneA progestin used in oral contraceptive pills for the prevention of pregnancy and other conditions.
DB00783EstradiolAn estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.
DB04573EstriolA weak estrogen used to treat vaginal dryness and estrogen deficiency conditions, such as vaginitis and vulvar itching.
DB00655EstroneAn estrogen used to treat perimenopausal and postmenopausal symptoms.
DB00603Medroxyprogesterone acetateA progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty.
DB00717NorethisteroneA synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis.
DB12487PromestrieneA synthetic estrogen applied topically for the treatment of vulvovaginal atrophic symptoms and to speed wound healing following vulvovaginal surgery or trauma (e.g. post-partum).
DrugDrug NameTargetType
DB01395DrospirenoneProgesterone receptortarget
DB01395DrospirenoneMineralocorticoid receptortarget
DB01395DrospirenoneAndrogen receptortarget
DB01395DrospirenoneProstaglandin G/H synthase 2enzyme
DB01395DrospirenoneSerum paraoxonase/arylesterase 1enzyme
DB01395DrospirenoneGlucocorticoid receptortarget
DB01395DrospirenoneCytochrome P450 3A4enzyme
DB00783EstradiolEstrogen receptor alphatarget
DB00783EstradiolNuclear receptor subfamily 1 group I member 2target
DB00783EstradiolSex hormone-binding globulincarrier
DB00783EstradiolEstrogen receptor betatarget
DB00783EstradiolCytochrome P450 1A2enzyme
DB00783EstradiolUDP-glucuronosyltransferase 1-1enzyme
DB00783EstradiolSerum albumincarrier
DB00783EstradiolFatty acid-binding protein, intestinalcarrier
DB00783EstradiolCytochrome P450 3A4enzyme
DB00783EstradiolCytochrome P450 3A5enzyme
DB00783EstradiolCytochrome P450 3A7enzyme
DB00783EstradiolSolute carrier family 22 member 2transporter
DB00783EstradiolSolute carrier family 22 member 3transporter
DB00783EstradiolMultidrug resistance-associated protein 7transporter
DB00783EstradiolSolute carrier family 22 member 11transporter
DB00783EstradiolATP-binding cassette sub-family G member 2transporter
DB00783EstradiolSolute carrier organic anion transporter family member 1B1transporter
DB00783EstradiolP-glycoprotein 1transporter
DB00783EstradiolCytochrome P450 1A1enzyme
DB00783EstradiolCytochrome P450 1B1enzyme
DB00783EstradiolCytochrome P450 2C19enzyme
DB00783EstradiolCytochrome P450 2C8enzyme
DB00783EstradiolCytochrome P450 2C9enzyme
DB00783EstradiolSolute carrier family 22 member 8transporter
DB00783EstradiolSolute carrier organic anion transporter family member 1B3transporter
DB00783EstradiolSolute carrier organic anion transporter family member 1C1transporter
DB00783EstradiolNeuronal acetylcholine receptor subunit alpha-4target
DB00783EstradiolG-protein coupled estrogen receptor 1target
DB00783EstradiolATP synthase subunit atarget
DB00783EstradiolBeclin-1target
DB00783EstradiolUDP-glucuronosyltransferase 2B15enzyme
DB00783EstradiolCatechol O-methyltransferaseenzyme
DB00783EstradiolUDP-glucuronosyltransferases (UGTs)enzyme
DB04573EstriolEstrogen receptor alphatarget
DB04573EstriolSolute carrier organic anion transporter family member 1A2transporter
DB04573EstriolP-glycoprotein 1transporter
DB04573EstriolEstrogen receptor betatarget
DB04573EstriolSex hormone-binding globulintarget
DB00655EstroneEstrogen receptor alphatarget
DB00655EstroneCytochrome P450 1A2enzyme
DB00655EstroneCytochrome P450 1A1enzyme
DB00655EstroneSerum albumincarrier
DB00655EstroneSolute carrier organic anion transporter family member 2B1transporter
DB00655EstroneP-glycoprotein 1transporter
DB00655EstroneSolute carrier organic anion transporter family member 1A2transporter
DB00655EstroneATP-binding cassette sub-family G member 2transporter
DB00655EstroneSolute carrier organic anion transporter family member 1B1transporter
DB00655EstroneCytochrome P450 3A4enzyme
DB00655EstroneCytochrome P450 1B1enzyme
DB00655EstroneCytochrome P450 2B6enzyme
DB00655EstroneCytochrome P450 2C9enzyme
DB00655EstroneCytochrome P450 2E1enzyme
DB00655EstroneCytochrome P450 3A5enzyme
DB00655EstroneEstrogen receptor betatarget
DB00655EstroneAndrogen receptortarget
DB00655EstroneCytochrome P450 19A1target
DB00655EstroneSex hormone-binding globulintarget
DB00655EstroneSolute carrier family 22 member 8transporter
DB00603Medroxyprogesterone acetateProgesterone receptortarget
DB00603Medroxyprogesterone acetateEstrogen receptor alphatarget
DB00603Medroxyprogesterone acetateCytochrome P450 3A4enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 2C8enzyme
DB00603Medroxyprogesterone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 2C9enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 3A1enzyme
DB00603Medroxyprogesterone acetateSerum albumincarrier
DB00603Medroxyprogesterone acetateP-glycoprotein 1target
DB00603Medroxyprogesterone acetateGABA(A) Receptortarget
DB00603Medroxyprogesterone acetateP-glycoprotein 1transporter
DB00717NorethisteroneProgesterone receptortarget
DB00717NorethisteroneP-glycoprotein 1transporter
DB00717NorethisteroneCytochrome P450 2C19enzyme
DB00717NorethisteroneSerum albumincarrier
DB00717NorethisteroneSex hormone-binding globulincarrier
DB00717NorethisteroneAldo-keto reductase family 1 member C4enzyme
DB00717Norethisterone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB00717Norethisterone3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
DB00717Norethisterone3-oxo-5-beta-steroid 4-dehydrogenaseenzyme
DB00717NorethisteroneCytochrome P450 3A4enzyme
DB00717NorethisteroneCytochrome P450 1A2enzyme
DB00717NorethisteroneCytochrome P450 2A6enzyme
DB00717NorethisteroneGlucocorticoid receptortarget
DB00717NorethisteroneAndrogen receptortarget
DrugDrug NamePhaseStatusCount
DB01708Prasterone1Completed1
DB09495Avobenzone2Recruiting1
DB00783Estradiol2Completed2
DB00783Estradiol2Not Yet Recruiting1
DB04573Estriol2Completed2
DB04573Estriol2Withdrawn1
DB11064Homosalate2Recruiting1
DB11062Octisalate2Recruiting1
DB09535Octocrylene2Recruiting1
DB01428Oxybenzone2Recruiting1
DB00107Oxytocin2Completed4
DB09311Polycarbophil2Recruiting1
DB01708Prasterone2Recruiting1
DB00396Progesterone2Recruiting1
DB01266Sinecatechins2Recruiting1
DB13355Visnadine2Completed1
DB09321Zinc oxide2Not Yet Recruiting1
DB06401Bazedoxifene3Completed1
DB00286Conjugated estrogens3Completed1
DB00783Estradiol3Completed8
DB00783Estradiol3Terminated1
DB04573Estriol3Completed2
DB11062Octisalate3Completed1
DB11062Octisalate3Recruiting1
DB09535Octocrylene3Completed1
DB09535Octocrylene3Recruiting1
DB01708Prasterone3Completed5
DB01708Prasterone3Recruiting2
DB12487Promestriene3Completed1
DB09321Zinc oxide3Completed4
DB09321Zinc oxide3Recruiting1
DB00286Conjugated estrogens4Completed1
DB00783Estradiol4Recruiting2
DB04573Estriol4Completed1
DB04938Ospemifene4Completed1
DB00624Testosterone4Recruiting1
DB09321Zinc oxide4Completed2
DB09321Zinc oxide4Recruiting1
DB00783EstradiolNot AvailableCompleted1
DB04573EstriolNot AvailableCompleted1
DB04573EstriolNot AvailableRecruiting1
DB12487PromestrieneNot AvailableCompleted2
DB12487PromestrieneNot AvailableRecruiting1
DB09321Zinc oxideNot AvailableCompleted1
DB09321Zinc oxideNot AvailableRecruiting1