Peripheral alpha-1 blockers

Peripheral alpha-1 blockers
Accession Number

This category contains drugs that block the peripheral alpha-1 receptors selectively and non-selectively. This blockade may cause antihypertensive effects. Some of these drugs may also have beta-blocking effects.

DrugDrug Description
DoxazosinAn alpha-1 adrenergic receptor used to treat mild to moderate hypertension and urinary obstruction due to benign prostatic hyperplasia.
PrazosinAn alpha-blocker that causes a decrease in total peripheral resistance and is used to treat hypertension.
TerazosinAn alpha-1 adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia and management of hypertension.
AlfuzosinAn alpha-1 adrenergic antagonist used in the management of benign prostatic hypertrophy (BPH).
TamsulosinAn alpha-1A and alpha-1B adrenergic receptor antagonist used to treat benign prostatic hyperplasia, ureteral stones, prostatitis, and female voiding dysfunction.
SilodosinAn alpha-1 adrenergic receptor antagonist used to treat symptoms associated with benign prostatic hyperplasia (BPH).
PhenoxybenzamineAn alpha adrenergic agonist used to treat pheochromocytoma and episodes of hypertension and sweating.
PhentolamineAn alpha adrenergic antagonist used to reverse soft tissue anesthesia.
TolazolineA vasodilator used to treat pulmonary artery anomalies.
TrazodoneA serotonin uptake inhibitor used to treat major depressive disorder.
BunazosinBunazosin has been used in trials studying the treatment of High Blood Pressure.
LabetalolAn alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome.
TrimazosinTrimazosin is a sympatholytic alpha blocker.
IndoraminIndoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese. It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action.
UrapidilUrapidil has been investigated for the treatment of Hypertension During Pre-Eclampsia.
Drugs & Drug Targets
DoxazosinAlpha-1A adrenergic receptortarget
DoxazosinAlpha-1D adrenergic receptortarget
DoxazosinHERG human cardiac K+ channeltarget
DoxazosinP-glycoprotein 1transporter
DoxazosinCytochrome P450 2C19enzyme
DoxazosinCytochrome P450 2D6enzyme
DoxazosinSolute carrier family 22 member 1transporter
DoxazosinCytochrome P450 3A4enzyme
DoxazosinAlpha-1B adrenergic receptortarget
DoxazosinCytochrome P450 2C9enzyme
PrazosinAlpha-1A adrenergic receptortarget
PrazosinAlpha-1B adrenergic receptortarget
PrazosinAlpha-1D adrenergic receptortarget
PrazosinPotassium voltage-gated channel subfamily H member 2target
PrazosinAlpha-1-acid glycoprotein 1carrier
PrazosinSolute carrier family 22 member 1transporter
PrazosinSolute carrier family 22 member 3transporter
PrazosinP-glycoprotein 1transporter
PrazosinATP-binding cassette sub-family G member 2transporter
PrazosinAlpha-2A adrenergic receptortarget
PrazosinAlpha-2B adrenergic receptortarget
PrazosinAlpha-1 adrenergic receptorstarget
TerazosinAlpha-1A adrenergic receptortarget
TerazosinAlpha-1B adrenergic receptortarget
TerazosinAlpha-1D adrenergic receptortarget
TerazosinPotassium voltage-gated channel subfamily H member 2target
TerazosinPotassium voltage-gated channel subfamily H member 6target
TerazosinPotassium voltage-gated channel subfamily H member 7target
TerazosinP-glycoprotein 1transporter
TerazosinTransforming growth factor beta-1target
AlfuzosinAlpha-1A adrenergic receptortarget
AlfuzosinAlpha-1B adrenergic receptortarget
AlfuzosinAlpha-1D adrenergic receptortarget
AlfuzosinCytochrome P450 3A4enzyme
AlfuzosinPotassium voltage-gated channel subfamily H member 2target
TamsulosinAlpha-1A adrenergic receptortarget
TamsulosinAlpha-1D adrenergic receptortarget
TamsulosinAlpha-1B adrenergic receptortarget
TamsulosinAlpha-1-acid glycoprotein 1carrier
TamsulosinCytochrome P450 2D6enzyme
TamsulosinCytochrome P450 3A4enzyme
SilodosinAlpha-1D adrenergic receptortarget
SilodosinCytochrome P450 3A4enzyme
SilodosinP-glycoprotein 1transporter
SilodosinMultidrug resistance protein 3transporter
SilodosinAlpha-1A adrenergic receptortarget
SilodosinAlpha-1B adrenergic receptortarget
SilodosinUDP-glucuronosyltransferase 2B7enzyme
PhenoxybenzamineAlpha-1A adrenergic receptortarget
PhenoxybenzamineSolute carrier family 22 member 2transporter
PhenoxybenzamineSolute carrier family 22 member 1transporter
PhenoxybenzamineSolute carrier family 22 member 3transporter
PhenoxybenzamineAlpha-2A adrenergic receptortarget
PhenoxybenzamineAlpha-2C adrenergic receptortarget
PhenoxybenzamineAlpha-2B adrenergic receptortarget
PhenoxybenzamineBeta-2 adrenergic receptortarget
PhenoxybenzamineAlpha-1B adrenergic receptortarget
PhenoxybenzamineAlpha-1D adrenergic receptortarget
PhentolamineAlpha-2A adrenergic receptortarget
PhentolamineAlpha-1A adrenergic receptortarget
PhentolamineAlpha-1B adrenergic receptortarget
PhentolamineAlpha-1D adrenergic receptortarget
TolazolineAlpha-1A adrenergic receptortarget
TolazolineAlpha-2A adrenergic receptortarget
TolazolineHistamine H1 receptortarget
TolazolineHistamine H2 receptortarget
TolazolineAlpha-2C adrenergic receptortarget
TolazolineAlpha-2B adrenergic receptortarget
Trazodone5-hydroxytryptamine receptor 2Atarget
TrazodoneSodium-dependent serotonin transportertarget
TrazodoneAlpha-1A adrenergic receptortarget
TrazodoneAlpha-2A adrenergic receptortarget
TrazodoneHistamine H1 receptortarget
Trazodone5-hydroxytryptamine receptor 1Atarget
TrazodoneCytochrome P450 2D6enzyme
TrazodoneCytochrome P450 3A4enzyme
Trazodone5-hydroxytryptamine receptor 2Ctarget
TrazodoneCytochrome P450 3A5enzyme
TrazodoneCytochrome P450 3A7enzyme
TrazodoneP-glycoprotein 1transporter
Trazodone5-hydroxytryptamine receptor 1Ctarget
LabetalolAlpha-1 adrenergic receptorstarget
LabetalolBeta-1 adrenergic receptortarget
LabetalolBeta-2 adrenergic receptortarget
LabetalolCytochrome P450 2D6enzyme
LabetalolCytochrome P450 2C19enzyme
LabetalolSerum albumincarrier
Labetalolalpha1-acid glycoproteincarrier
LabetalolATP-binding cassette sub-family B member 5transporter
LabetalolUDP-glucuronosyltransferase 1-1enzyme
LabetalolUDP-glucuronosyltransferase 2B7enzyme
LabetalolUDP-glucuronosyltransferase 1-9enzyme
IndoraminAlpha-1A adrenergic receptortarget