Anti-Obesity Agents

Name
Anti-Obesity Agents
Accession Number
DBCAT000472
Description

Agents that increase energy expenditure and weight loss by neural and chemical regulation. Beta-adrenergic agents and serotoninergic drugs have been experimentally used in patients with non-insulin dependent diabetes mellitus (NIDDM) to treat obesity.

Drugs
DrugDrug Description
PhentermineA sympathomimetic anorectic agent used as a short-term adjunct therapy that is included in a regimen of weight reduction in cases of exogenous obesity.
TopiramateAn anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.
PhenylpropanolamineA sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy.
PhenmetrazineUsed as an anorectic in the treatment of obesity.
DiethylpropionAn appetite suppressant used for the short term treatment of exogenous obesity in addition to calorie restriction.
OrlistatA reversible inhibitor of gastrointestinal lipases indicated for weight loss and weight maintenance.
SibutramineA norepinephrine, serotonin and dopamine reuptake inhibitor indicated to assist with weight loss in obesity.
CathineUsed to decrease appetite.
Oleoyl-estroneFor the treatment of obesity.
PerflubronInvestigated for use/treatment in cardiac surgery, hemorrhage, and ileus.
BenfluorexBenfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier. The European Medicines Agency (EMA) recommended...
SetmelanotideSetmelanotide has been investigated for the treatment of obesity.
ExenatideA GLP-1 agonist used in the management of type 2 diabetes mellitus.
RimonabantFor use in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m2, or patients wih a BMI greater than 27 kg/m2 with associated...
CetilistatInvestigated for use/treatment in obesity.
Drugs & Drug Targets
DrugTargetType
PhentermineSodium-dependent noradrenaline transportertarget
PhentermineSodium-dependent dopamine transportertarget
PhentermineAmine oxidase [flavin-containing] Atarget
PhentermineAmine oxidase [flavin-containing] Btarget
PhentermineSodium-dependent serotonin transportertarget
PhenterminePro-neuropeptide Ytarget
PhentermineCytochrome P450 3A4enzyme
TopiramateGamma-aminobutyric acid receptor subunit alpha-1target
TopiramateVoltage-gated sodium channel alpha subunittarget
TopiramateCarbonic anhydrase 2target
TopiramateCarbonic anhydrase 4target
TopiramateKainate receptorstarget
TopiramateCytochrome P450 2C19enzyme
TopiramateCytochrome P450 3A4enzyme
TopiramateCarbonic anhydrase 1target
TopiramateCarbonic anhydrase 3target
TopiramateVoltage gated L-type calcium channeltarget
TopiramateVoltage-dependent R-type calcium channeltarget
TopiramateSerum albumincarrier
TopiramateP-glycoprotein 1transporter
Topiramate5'-AMP-activated protein kinasetransporter
PhenylpropanolamineAmine oxidase [flavin-containing] Aenzyme
PhenylpropanolamineDopamine D1 receptortarget
PhenylpropanolamineBeta-1 adrenergic receptortarget
PhenylpropanolamineBeta-2 adrenergic receptortarget
PhenylpropanolamineAlpha-2 adrenergic receptorstarget
PhenmetrazineSodium-dependent noradrenaline transportertarget
PhenmetrazineSodium-dependent dopamine transportertarget
DiethylpropionSodium-dependent noradrenaline transportertarget
DiethylpropionSodium-dependent dopamine transportertarget
OrlistatPancreatic triacylglycerol lipasetarget
OrlistatFatty acid synthasetarget
OrlistatGastric triacylglycerol lipasetarget
OrlistatCytochrome P450 3A4enzyme
OrlistatCytosolic phospholipase A2enzyme
SibutramineSodium-dependent serotonin transportertarget
SibutramineSodium-dependent noradrenaline transportertarget
SibutramineCytochrome P450 3A4enzyme
SibutramineSodium-dependent dopamine transportertarget
ExenatideGlucagon-like peptide 1 receptortarget
ExenatideSerum albumincarrier
ExenatideDipeptidyl peptidase 4enzyme
RimonabantCannabinoid receptor 1target
RimonabantCytochrome P450 3A4enzyme
RimonabantG-protein coupled receptor 55target
CetilistatPancreatic triacylglycerol lipasetarget