Hexafluronium bromide is a neuromuscular blocking agent used in anesthesiology to prolong and potentiate the skeletal muscle relaxing action of suxamethonium during surgery. It is known to bind and block...
- Mechanism
- Curator reviewed
Hexafluronium bromide is a non-competitive reversible inhibitor of human plasma cholinesterase or pseudocholinesterase. Hexafluornium probably binds to anionic side receptors near the active center, causing a conformational change in the enzyme, preventing acylation of the esteratic site. The esteratic site on cholistereases is where acetylcholine is hydrolyzed to acetic acid and choline.
- Primary indication
- Used as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations.Curator reviewed
- Formula / weight
- C36H42N2 · 502.745 g/mol (avg)
- Also known as
- Hexafluorenium
Resolves to
HDZAQYPYABGTCL-UHFFFAOYSA-NSMILESC[N+](C)(CCCCCC[N+](C)(C)C1C2=C(C=CC=C2)C2=C1C=CC=C2)C1C2=C(C=CC=C2)C2=C1C=CC=C2What you can answer from here — as of September 23, 2026
Which drugs share a target with Hexafluronium, and which of those have an active Phase 3 trial?
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