Accession Number

Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.

DrugDrug Description
CarbamoylcholineA direct acting miotic agent administered ophthalmically to decrease intraocular pressure after cataract surgery, and to induce miosis during surgery.
PilocarpineA muscarinic agonist used to treat dry mouth and various ophthalmic conditions, such as presbyopia, increased intraocular pressure, and angle-closure glaucoma.
PhysostigmineA cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity.
EchothiophateAn acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma.
MethacholineA parasympathomimetic bronchoconstrictor used to diagnose bronchial hyperreactivity in subjects who do not have clinically apparent asthma.
MoxisylyteAccording to the WHO, moxisylyte is indicated for the symptomatic management of sequelae of cerebral infarction or hemorrhage. The cerebral infarction is characterized by the blockage of the artery either...
AceclidineAceclidine has been marketed in Europe but has not been used clinically in the United States. It is used in the treatment of open-angle glaucoma and is a parasympathomimetic agent.
AcetylcholineA parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.
Drugs & Drug Targets
CarbamoylcholineMuscarinic acetylcholine receptor M1target
CarbamoylcholineMuscarinic acetylcholine receptor M2target
CarbamoylcholineNeuronal acetylcholine receptor subunit alpha-2target
CarbamoylcholineCytosolic phospholipase A2enzyme
CarbamoylcholineMuscarinic acetylcholine receptor M3target
CarbamoylcholineMuscarinic acetylcholine receptor M4target
PilocarpineMuscarinic acetylcholine receptor M1target
PilocarpineMuscarinic acetylcholine receptor M2target
PilocarpineCytochrome P450 2A6enzyme
PilocarpineMuscarinic acetylcholine receptor M3target
PilocarpineCytochrome P450 3A4enzyme
PilocarpineMuscarinic acetylcholine receptor M4target
PilocarpineMuscarinic acetylcholine receptor M5target
PilocarpineSerum paraoxonase/arylesterase 1enzyme
PhysostigmineNeuronal acetylcholine receptor subunit alpha-4target
PhysostigmineNeuronal acetylcholine receptor subunit beta-2target
EchothiophateSerum albumincarrier
MethacholineMuscarinic acetylcholine receptor M3target
MethacholineMuscarinic acetylcholine receptor M2target
MethacholineMuscarinic acetylcholine receptor M1target
MethacholineMuscarinic acetylcholine receptor M4target
MethacholineMuscarinic acetylcholine receptor M5target
MethacholineSolute carrier family 22 member 5transporter
MoxisylyteCytochrome P450 3A Subfamilyenzyme
MoxisylyteAlpha adrenergic receptortarget
AcetylcholineSolute carrier family 22 member 5transporter
AcetylcholineSolute carrier family 22 member 1transporter
AcetylcholineMuscarinic acetylcholine receptor M1target
AcetylcholineMuscarinic acetylcholine receptor M2target
AcetylcholineMuscarinic acetylcholine receptor M3target
AcetylcholineMuscarinic acetylcholine receptor M4target
AcetylcholineNeuronal acetylcholine receptor subunit alpha-7target