Adrenocortical Hyperfunction (DBCOND0059917)

Identifiers

Synonyms

Adrenal cortical hyperfunctions / Adrenocortical hyperfunction / Hypercorticoidism / Hyperadrenalcorticalism / Hyperadrenocorticalism / Hypercortisolaemia / Adrenal cortex hyperfunction / Hyperadrenalism / Hyperadrenocorticism / Hypercortisolemia / Adrenocortical hyperfunction (disorder) / Hypercortisolism / Hypercortisolism (disorder) / Hypercortisonism / Adrenal hypercorticism / Hypercorticism adrenal

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cortisone acetate	A steroid hormone used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses and endocrine disorders associated with inadequate production of steroid hormones.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Annexin A1target Corticosteroid-binding globulincarrier Albumincarrier Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Organic anion transporter 3transporter Steroid hormone receptor ERR1target Steroid hormone receptor ERR2target Estrogen-related receptor gammatarget
Dexamethasone	A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.	Glucocorticoid receptortarget Annexin A1target Nitric oxide synthase, inducibletarget Nuclear receptor subfamily 0 group B member 1target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Steroid 17-alpha-hydroxylase/17,20 lyaseenzyme Cytochrome P450 1A1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A43enzyme Cytochrome P450 4A11enzyme Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 11B1, mitochondrialenzyme Albumincarrier 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Organic anion transporter 3transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01707719	Isolated Erythrocyte Membrane Susceptibility to Photo-oxidative Stress in Alzheimer's Disease	No drug interventions	Not Available	Not Available	completed
NCT03718234	Subcutaneous Hydrocortisone Children With Congenital Adrenal Hyperplasia	Hydrocortisone	treatment	1	completed