Atrophic Vaginitis (DBCOND0001269)

Identifiers

Synonyms

Vaginitis Atropic / Atrophic vaginitis / Atrophic vaginitis (disorder) / Vaginitis atrophic / Postmenopausal atrophic vaginitis / Senile vaginitis / Atrophic vulvovaginitis / Vulvovaginitis atrophy / Vulvovaginitis atrophic / Atrophic vulvovaginitis (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Conjugated estrogens	A mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis.	Estrogen receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Catechol O-methyltransferaseenzyme ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 4transporter Multidrug resistance-associated protein 1transporter Solute carrier organic anion transporter family member 1A2transporter Hepatic sodium/bile acid cotransportertransporter Solute carrier family 22 member 10transporter Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 2B1transporter ATP-dependent translocase ABCB1transporter Solute carrier family 22 member 6transporter Organic solute transporter subunit alphatransporter Organic solute transporter subunit betatransporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 4A1transporter ATP-binding cassette sub-family C member 11transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 3A1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Thyroxine-binding globulincarrier Sex hormone-binding globulincarrier Albumincarrier Estrogen receptor betatarget
Estradiol	An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 3transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Neuronal acetylcholine receptor subunit alpha-4target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target UDP-glucuronosyltransferase 2B15enzyme Catechol O-methyltransferaseenzyme UDP-glucuronosyltransferases (UGTs)enzyme Aromataseenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03032848	Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients	Avobenzone Conjugated estrogens Estradiol Estriol Homosalate Octisalate Octocrylene Oxybenzone Promestriene	supportive_care	4	completed
NCT02460302	Vaginal Progesterone Versus Placebo for the Treatment of Vaginal Atrophy	Progesterone	treatment	2	withdrawn
NCT01370551	Clinical Study of Vaginal Lactobacilli and Estriol (Gynoflor®) for Atrophic Vaginitis in Breast Cancer Patients	No drug interventions	treatment	1	completed
NCT02313545	Phase I-B Study to Evaluate the Safety, Tolerability and Efficacy of IZN-6NVS for the Treatment of AV and DIV	No drug interventions	treatment	1 / 2	completed
NCT05396261	a Flexible Wound Dressing for the Management of Genital Skin Conditions	No drug interventions	treatment	Not Available	completed
NCT05118685	Estrogen and Platelet Rich Plasma in Treatment of Atrophic Vaginitis	Conjugated estrogens Estradiol Platelet Rich Plasma	treatment	1	recruiting
NCT00984399	Serum Estradiol Levels In Postmenopausal Women With Breast Cancer Receiving Adjuvant Aromatase Inhibitors and Vaginal Estrogen	Estradiol	treatment	Not Available	completed
NCT04079218	Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial	Estradiol	treatment	4	completed
NCT02195986	A Comparison of Estradiol Vaginal Cream to Estrace® Cream in 350 Postmenopausal Females With Atrophic Vaginitis	Estradiol	treatment	3	completed
NCT02869165	Vaginal and Urinary Microbiome Trial	Apricot kernel oil Conjugated estrogens Estradiol	basic_science	4	completed
NCT06176820	Vaginal Hyaluronic Acid, Arginine and Liposome Gel Versus Vaginal Lubricant in Postmenopausal Women With Genitourinary Syndrome of Menopause	No drug interventions	treatment	2 / 3	not_yet_recruiting
NCT02733731	The Treatment Effect of Chinese Herbal Compound Ointment on Atrophic Vaginitis	Estriol	treatment	1	unknown_status
NCT03294538	Study to Evaluate Equivalence of Estradiol Vaginal Cream 0.01% to Estrace® Cream 0.01% in Atrophic Vaginitis	Estradiol	treatment	3	completed
NCT05953090	VALOR: Vaginal Atrophy & Long-term Observation of Recovery	No drug interventions	treatment	Not Available	recruiting
NCT00167921	Study Comparing Premarin® Vaginal Cream Versus Premarin® Oral Tablets in Atrophic Vaginitis	Conjugated estrogens	Not Available	1	completed
NCT05432154	An Innovative Silicone Wound Dressing for the Management of Atrophic Vaginitis	No drug interventions	treatment	Not Available	completed
NCT02029053	Preliminary Study of a Vaginal Lubrication Ring to Treat the Symptoms of Vaginal Dryness	No drug interventions	supportive_care	0	completed
NCT04327947	Evaluation of Gynecological Acceptability of 3 Health Care Products	No drug interventions	treatment	Not Available	completed
NCT04219605	Evaluation of a Rapid Microscopic Diagnostic System for Different Vaginitis Conditions	No drug interventions	Not Available	Not Available	recruiting
NCT02014428	Oral Low-molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis	No drug interventions	Not Available	4	completed
NCT00137371	Study Evaluating Conjugated Estrogen Cream for Atrophic Vaginitis	No drug interventions	treatment	3	completed
NCT00816556	A Trial to Evaluate the Efficacy of Low Dose Vaginal Estrogens in the Treatment of Atrophic Vaginitis	Estradiol valerate Estriol Pyrithione	treatment	3	terminated
NCT02691936	Comparison of Vaginal Laser Therapy to Vaginal Estrogen Therapy	Conjugated estrogens Estradiol	treatment	Not Available	completed
NCT05058313	Evaluation of the Safety and Performance of the MILTA GYNECO Vaginal Probe in Postmenopausal Women With Vaginal Atrophy	No drug interventions	other	Not Available	completed
NCT03981458	Hyaluronate for the Treatment and Prevention of Recurrent Urinary Tract Infection in Women Suffering Atrophic Vaginitis	No drug interventions	treatment	Not Available	unknown_status
NCT04247022	Evaluation of Gynecological Acceptability of a Health Care Product	No drug interventions	treatment	Not Available	completed
NCT02995694	A Study Comparing Estradiol Vaginal Cream to Estrace® Cream in Females With Atrophic Vaginitis	Estradiol	other	3	completed
NCT06305494	Genitourinary Syndrome of Menopause in Thai Gynecologic Cancer Survivors	No drug interventions	Not Available	Not Available	recruiting